NO20074825L - Piperidinylpiperazinderivater for anvendelse som inhibitorer av kjemokinreseptorer - Google Patents

Piperidinylpiperazinderivater for anvendelse som inhibitorer av kjemokinreseptorer

Info

Publication number
NO20074825L
NO20074825L NO20074825A NO20074825A NO20074825L NO 20074825 L NO20074825 L NO 20074825L NO 20074825 A NO20074825 A NO 20074825A NO 20074825 A NO20074825 A NO 20074825A NO 20074825 L NO20074825 L NO 20074825L
Authority
NO
Norway
Prior art keywords
compounds
inhibitors
compound
treatment
methods
Prior art date
Application number
NO20074825A
Other languages
English (en)
Inventor
Stuart W Mccombie
Wenqing Feng
Tze-Ming Chan
Kathleen Cox
Michael W Miller
Daniel Weston
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36540289&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20074825(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20074825L publication Critical patent/NO20074825L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ved de mange utførelsesformene av den foreliggende oppfinnelse tilveiebringes en ny klasse forbindelser med strukturformel IA eller IB hvor R1-R8 er som beskrevet, hvor IA eller IB er inhibitorer av CCR5-reseptorer, fremgangsmåter for fremstilling av slike forbindelser, farmasøytiske preparater inneholdende en eller flere slike forbindelser, fremgangsmåter for fremstilling av farmasøytiske formuleringer omfattende én eller flere slike forbindelser, og fremgangsmåter for behandling, forhindring, inhibering eller lindring av én eller flere sykdommer forbundet med CCR5 ved å anvende slike forbindelser eller farmasøytiske preparater. Oppfinnelsen angår også anvendelse av en kombinasjon av en forbindelse ifølge oppfinnelsen og ett eller flere antivirale eller andre midler som er anvendelige ved behandling av humant immunsviktvirus (HIV). Oppfinnelsen angår også anvendelse av en forbindelse ifølge oppfinnelsen, alene eller i kombinasjon med et annet middel, ved behandling av avvisning av transplantert fast organ, "graft vs. host disease", artritt, reumatoid artritt, inflammatorisk tarmsykdom, atopisk dermatitt, psoriasis, astma, allergier eller multippel sklerose.
NO20074825A 2005-02-23 2007-09-21 Piperidinylpiperazinderivater for anvendelse som inhibitorer av kjemokinreseptorer NO20074825L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65557205P 2005-02-23 2005-02-23
PCT/US2006/006333 WO2006091692A1 (en) 2005-02-23 2006-02-21 Piperidinyl piperazine derivatives useful as inhibitors of chemokine receptors

Publications (1)

Publication Number Publication Date
NO20074825L true NO20074825L (no) 2007-10-17

Family

ID=36540289

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074825A NO20074825L (no) 2005-02-23 2007-09-21 Piperidinylpiperazinderivater for anvendelse som inhibitorer av kjemokinreseptorer

Country Status (17)

Country Link
US (1) US7659275B2 (no)
EP (1) EP1858887A1 (no)
JP (1) JP4769257B2 (no)
KR (1) KR20070107085A (no)
CN (1) CN101163695A (no)
AR (1) AR054740A1 (no)
AU (1) AU2006216731A1 (no)
BR (1) BRPI0609251A2 (no)
CA (1) CA2598651A1 (no)
IL (1) IL185395A0 (no)
MX (1) MX2007010258A (no)
NO (1) NO20074825L (no)
PE (1) PE20061012A1 (no)
RU (1) RU2411241C2 (no)
TW (1) TW200640910A (no)
WO (1) WO2006091692A1 (no)
ZA (1) ZA200707019B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103012374B (zh) 2004-04-13 2015-05-20 因塞特公司 作为趋化因子受体拮抗剂的哌嗪基哌啶衍生物
RU2334515C2 (ru) * 2006-10-02 2008-09-27 ГОУ ВПО Военно-медицинская академия им. С.М. Кирова Применение "дневного" транквилизатора фенибута и антидепрессанта - селективного ингибитора обратного захвата серотонина триттико - при лечении псориаза
KR100861024B1 (ko) * 2007-07-20 2008-09-30 세크론 주식회사 반도체 제조 장치

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387930B1 (en) 1999-05-04 2002-05-14 Schering Corporation Piperidine derivatives useful as CCR5 antagonists
US6391865B1 (en) * 1999-05-04 2002-05-21 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
US6689765B2 (en) * 1999-05-04 2004-02-10 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
ATE289516T1 (de) * 1999-05-04 2005-03-15 Schering Corp Pegyliertes interferon alpha in kombination mit einem ccr5 antagonisten für eine hiv therapie
JP3894729B2 (ja) * 1999-05-04 2007-03-22 シェーリング コーポレイション Ｃｃｒ５アンタゴニストとして有用なピペラジン誘導体
ATE299865T1 (de) * 1999-05-04 2005-08-15 Schering Corp Piperazinderivate verwendbar als ccr5 antagonisten
AR033517A1 (es) * 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
CN100519554C (zh) 2001-03-29 2009-07-29 先灵公司 用於治疗爱滋病之ccr5拮抗剂
JP4303969B2 (ja) * 2001-03-29 2009-07-29 シェーリング コーポレイション Ｃｃｒ５アンタゴニストとして有用なアリールオキシム−ピペラジン
GB0223223D0 (en) * 2002-10-07 2002-11-13 Novartis Ag Organic compounds
PE20040769A1 (es) * 2002-12-18 2004-11-06 Schering Corp Derivados de piperidina utiles como antagonisas ccr5
JO2525B1 (en) * 2004-04-08 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin

Also Published As

Publication number Publication date
AR054740A1 (es) 2007-07-11
WO2006091692A1 (en) 2006-08-31
JP4769257B2 (ja) 2011-09-07
CA2598651A1 (en) 2006-08-31
US7659275B2 (en) 2010-02-09
RU2007135126A (ru) 2009-03-27
CN101163695A (zh) 2008-04-16
RU2411241C2 (ru) 2011-02-10
EP1858887A1 (en) 2007-11-28
TW200640910A (en) 2006-12-01
KR20070107085A (ko) 2007-11-06
MX2007010258A (es) 2007-09-11
ZA200707019B (en) 2008-10-29
AU2006216731A1 (en) 2006-08-31
US20060223821A1 (en) 2006-10-05
IL185395A0 (en) 2008-02-09
PE20061012A1 (es) 2006-10-03
BRPI0609251A2 (pt) 2010-03-09
JP2008531575A (ja) 2008-08-14

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