NO20075193L - Fremgangsmater for behandling og forebygging av IL-21/IL-21R antagonister - Google Patents

Fremgangsmater for behandling og forebygging av IL-21/IL-21R antagonister

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Publication number
NO20075193L
NO20075193L NO20075193A NO20075193A NO20075193L NO 20075193 L NO20075193 L NO 20075193L NO 20075193 A NO20075193 A NO 20075193A NO 20075193 A NO20075193 A NO 20075193A NO 20075193 L NO20075193 L NO 20075193L
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NO
Norway
Prior art keywords
level
fibrosis
methods
treating
preventing
Prior art date
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NO20075193A
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English (en)
Inventor
Mary Collins
Deborah A Young
Thomas A Wynn
Michael J Grusby
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Us Gov Nat Inst Health
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Application filed by Us Gov Nat Inst Health filed Critical Us Gov Nat Inst Health
Publication of NO20075193L publication Critical patent/NO20075193L/no

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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K2319/00—Fusion polypeptide
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    • G—PHYSICS
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

SAMMENDRAG Foreliggende oppfinnelse tilveiebringer metoder for screening for preparater anvendelige for behandling, forbedring eller forhindring av fibrose og/eller fibrose-assosierte lidelser ved å måle endringer i nivået av IL-21 og/eller IL-21 reseptor (IL-21R) (f.eks. nivået av ekspresjon av IL-21 og/eller IL-21R protein og/eller mRNA, nivået av aktivitet til IL-21 og/eller IL-21R, nivået av interaksjon av IL-21 med IL-21R). Oppfinnelsen tilveiebringer videre antagonister av IL-21 eller IL-21R for behandling av fibrose og/eller fibrose-assosierte lidelser. Videre gitt her er metoder for diagnostisering, prognosering og overvåkning av utvikling (f.eks. behandlingsforløp) av fibrose og/eller fibrose-assosierte lidelser ved å måle nivået av IL-21 og/eller IL-21R (dvs. nivået av aktivitet til IL-21 og/eller IL-21R, nivået av ekspresjon av IL-21 og/eller IL-21R (f.eks. nivået av IL-21 og/eller IL-21R genprodukter) og/eller nivået av interaksjon av IL-21 med IL-21R).
NO20075193A 2005-04-14 2007-10-11 Fremgangsmater for behandling og forebygging av IL-21/IL-21R antagonister NO20075193L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67137405P 2005-04-14 2005-04-14
PCT/US2006/013829 WO2006113331A1 (en) 2005-04-14 2006-04-13 Methods for treating and preventing fibrosis by il-21 / il-21r antagonists

Publications (1)

Publication Number Publication Date
NO20075193L true NO20075193L (no) 2008-01-11

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Application Number Title Priority Date Filing Date
NO20075193A NO20075193L (no) 2005-04-14 2007-10-11 Fremgangsmater for behandling og forebygging av IL-21/IL-21R antagonister

Country Status (22)

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US (2) US7910105B2 (no)
EP (2) EP1871800A1 (no)
JP (1) JP2008538553A (no)
KR (1) KR20080017009A (no)
CN (1) CN101287759A (no)
AR (1) AR057274A1 (no)
AU (1) AU2006236755A1 (no)
BR (1) BRPI0609762A2 (no)
CA (1) CA2604604A1 (no)
CR (1) CR9428A (no)
GT (1) GT200600148A (no)
IL (1) IL186599A0 (no)
MX (1) MX2007012842A (no)
NI (1) NI200700259A (no)
NO (1) NO20075193L (no)
NZ (1) NZ562333A (no)
PE (1) PE20070316A1 (no)
RU (1) RU2419450C2 (no)
SG (1) SG161286A1 (no)
TW (1) TW200716171A (no)
WO (1) WO2006113331A1 (no)
ZA (1) ZA200708756B (no)

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KR20240142577A (ko) 2017-04-07 2024-09-30 바이오니즈 테라퓨틱스, 아이엔씨. 감마-c-사이토카인 활성의 안정한 조절자
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