NO20076423L - Hydrazidkonjugater som billeddannende midler - Google Patents

Hydrazidkonjugater som billeddannende midler

Info

Publication number
NO20076423L
NO20076423L NO20076423A NO20076423A NO20076423L NO 20076423 L NO20076423 L NO 20076423L NO 20076423 A NO20076423 A NO 20076423A NO 20076423 A NO20076423 A NO 20076423A NO 20076423 L NO20076423 L NO 20076423L
Authority
NO
Norway
Prior art keywords
plaque
imaging
detecting
arterial
disclosure relates
Prior art date
Application number
NO20076423A
Other languages
English (en)
Inventor
Simon P Robinson
Thomas D Harris
Richard R Cesati
Padmaja Yalamanchili
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of NO20076423L publication Critical patent/NO20076423L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pyrane Compounds (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Foreliggende beskrivelse angår diagnostiske midler. Mer spesifikt angår beskrivelsen forbindelser, diagnostiske midler, preparater og sett for detektering og/eller avbildning og/eller overvåkning av en patologisk lidelse forbundet med koronar plaque, karotid plaque, aorta plaque, plaque i arterielle kar, aneurisme, vaskulitt og andre sykdommer i arterieveggen. I tillegg angår beskrivelsen metoder for detektering og/eller avbildning og/eller overvåkning av endringer på arterieveggen, omfattende ekspansiv og konstriktiv remodellering, totalt karvegg-areal, indre lumen størrelse og ytre arterie-perimeter.
NO20076423A 2005-06-30 2007-12-14 Hydrazidkonjugater som billeddannende midler NO20076423L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69549605P 2005-06-30 2005-06-30
PCT/US2006/025298 WO2007005491A1 (en) 2005-06-30 2006-06-28 Hydrazide conjugates as imaging agents

Publications (1)

Publication Number Publication Date
NO20076423L true NO20076423L (no) 2008-03-27

Family

ID=37137580

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076423A NO20076423L (no) 2005-06-30 2007-12-14 Hydrazidkonjugater som billeddannende midler

Country Status (9)

Country Link
US (1) US20070014721A1 (no)
EP (1) EP1896086A1 (no)
JP (1) JP2009500410A (no)
KR (1) KR20080022588A (no)
CN (1) CN101252954A (no)
AU (1) AU2006266074A1 (no)
CA (1) CA2613439A1 (no)
NO (1) NO20076423L (no)
WO (1) WO2007005491A1 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5730581B2 (ja) 2008-01-08 2015-06-10 ランセウス メディカル イメージング， インコーポレイテッド 造影剤としてのｎ−アルコキシアミド抱合体
EP2384323A4 (en) * 2008-11-11 2013-07-31 Univ Nanyang Tech INTRAVASCULAR CONTRASTING AGENTS
EP2451776B1 (en) 2009-07-08 2019-09-18 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
JP5765823B2 (ja) 2010-03-26 2015-08-19 国立大学法人徳島大学 頸動脈プラークのエコー画像生成方法及び評価装置
CN102558291B (zh) * 2010-12-17 2014-03-12 北京大学人民医院 一种双模分子影像探针
GB201102189D0 (en) 2011-02-08 2011-03-23 King S College London Materials and methods relating to cardiovascular imaging
WO2013070471A1 (en) 2011-11-11 2013-05-16 Lantheus Medical Imaging, Inc. Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging
ES2984980T3 (es) * 2015-04-17 2024-10-31 Symic Holdings Usa Inc Bioconjugados y usos de los mismos
EP3648774A4 (en) 2017-07-07 2021-04-21 Symic IP, LLC SYNTHETIC ORGANIC CONJUGATES
KR20200125923A (ko) 2017-10-16 2020-11-05 파에스 파마, 에스.에이. 빌라스틴 및 모메타손을 포함하는 수성 조성물
MX380340B (es) 2018-03-14 2025-03-11 Instituto Nac De Investigaciones Nucleares 177lu-dota-hynic-ipsma como un radiofarmaco terapeutico dirigido al antigeno prostatico especifico de membrana.
KR20230155494A (ko) * 2021-02-26 2023-11-10 테릭스 파마슈티컬스 (이노베이션스) 피티와이 엘티디 글루타메이트-우레아-라이신 유래(gul 유래) 전립선-특이적 막 항원(psma) 표적화 접합체의 고체상 합성 및 치료 및/또는 진단제의 전구체로서 이들의 용도

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859777A (en) * 1981-07-01 1989-08-22 Eastman Kodak Company Terpyridine chelating agents
US4452774A (en) * 1982-04-30 1984-06-05 President And Fellows Of Harvard College Isonitrile radionuclide complexes for labelling and imaging agents
WO1987002893A1 (en) * 1985-11-18 1987-05-21 Board Of Regents, The University Of Texas System Polychelating agents for image and spectral enhancement (and spectral shift)
CA1305160C (en) * 1985-12-23 1992-07-14 Paul Louis Bergstein Ether isonitriles and radiolabeled complexes thereof
US4913891A (en) * 1986-04-17 1990-04-03 The United States Of America As Represented By The United States Department Of Energy Positron emitter labeled enzyme inhibitors
US5252317A (en) * 1986-11-10 1993-10-12 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid
US5567411A (en) * 1986-11-10 1996-10-22 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group
US5064956A (en) * 1987-06-24 1991-11-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
US5026537A (en) * 1989-04-06 1991-06-25 Centocor, Inc. Methods for imaging atherosclerotic plaque
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
GB8923843D0 (en) * 1989-10-23 1989-12-13 Salutar Inc Compounds
GB9006977D0 (en) * 1990-03-28 1990-05-23 Nycomed As Compositions
PH29904A (en) * 1991-03-27 1996-09-16 Salutar Inc Contrast media
GB9209641D0 (en) * 1992-05-02 1992-06-17 Johnson Matthey Plc Improvements in radiolabelling
US5760191A (en) * 1993-02-05 1998-06-02 Nycomed Imaging As Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods
US5750088A (en) * 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
HU222574B1 (hu) * 1993-03-31 2003-08-28 Mallinckrodt Medical Inc. Redukálószerként foszfinokat tartalmazó radioaktív gyógyászati készítmények és az ezeket tartalmazó készletek
US5417959A (en) * 1993-10-04 1995-05-23 Mallinckrodt Medical, Inc. Functionalized aza-crytand ligands for diagnostic imaging applications
US5520904A (en) * 1995-01-27 1996-05-28 Mallinckrodt Medical, Inc. Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging
SE515621C2 (sv) * 1995-05-08 2001-09-10 Ericsson Telefon Ab L M Förfarande vid lägesbestämning
US5801228A (en) * 1995-06-07 1998-09-01 Nycomed Imaging As Polymeric contrast agents for medical imaging
IT1275571B (it) * 1995-07-19 1997-08-07 Consiglio Nazionale Ricerche Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori
AU726914B2 (en) * 1996-04-01 2000-11-23 Epix Pharmaceuticals, Inc. Bioactivated diagnostic imaging contrast agents
US5804161A (en) * 1996-05-14 1998-09-08 Nycomed Salutar Inc. Contrast agents
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
WO1999012579A1 (en) * 1997-09-08 1999-03-18 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US5980863A (en) * 1998-11-02 1999-11-09 Eagle Vision Pharmaceutical Corporation Manganese compositions and methods for MRI
US6254852B1 (en) * 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US20030004141A1 (en) * 2001-03-08 2003-01-02 Brown David L. Medical devices, compositions and methods for treating vulnerable plaque

Also Published As

Publication number Publication date
KR20080022588A (ko) 2008-03-11
CN101252954A (zh) 2008-08-27
JP2009500410A (ja) 2009-01-08
AU2006266074A1 (en) 2007-01-11
EP1896086A1 (en) 2008-03-12
WO2007005491A1 (en) 2007-01-11
WO2007005491B1 (en) 2007-04-12
CA2613439A1 (en) 2007-01-11
US20070014721A1 (en) 2007-01-18

Similar Documents

Publication Publication Date Title
WO2008042344A3 (en) Cardiovascular risk assessments using aortic calcification information derived from x-ray measurements
WO2006128167A3 (en) Optical coherence tomographic detection of cells and compositions
EA200700058A1 (ru) Соединения, композиции и способы их использования
UA117929C2 (uk) Сполуки піримідиндіону, спрямовані проти станів серцево-судинної системи
DE60301868D1 (de) Blutzuckerspiegelmessgerät
DK2044005T3 (da) Prolylhydroxylasehæmmere og fremgangsmåder til anvendelse af disse
RU2009106448A (ru) Стенд
EP2228441A4 (en) ENZYME INVOLVED IN THE SYNTHESIS OF EQUOL
DE602007011902D1 (de) Spiroindolinon-derivate
NO20076241L (no) Terapier for vaskulaere sykdommer
AP2359A (en) Sulfonamide derivatives for the treatment of diseases.
NO20076405L (no) Anvendelse av 24-nor-UDCA
EP2293077A3 (en) Methods for detecting coronary artery disease
FR2910230B3 (fr) Methodes de biofertilisations pour ameliorer la stabilite des rendements de grandes cultures agronomiques.
BRPI0906608A2 (pt) Métodos e composições para o tratamento de hemorragia subaracnóide aneurismal coronária e arterial.
USD748274S1 (en) Nasal alar photoplethysmography probe housing
IL190496A0 (en) Methods for reducing blood pressure
NO20062699L (no) Smelteblandingsdispergeringer
WO2007070626A3 (en) Certain chemical entities, compositions and methods
DK1856063T3 (da) 5-phenyl-pentansyrederivater som matrix- metalloproteinaseinhibitorer til behandlingen af astma og andre sygdomme
PT1895902E (pt) Monitor de perfusão cerebral
AU2003206069A1 (en) Ultrasonic imaging to detect coronary artery stenosis at rest
EP1722799A4 (en) TREATMENT OF PULMONARY ARTERIAL HYPERTENSION BY DHEA, ITS ANALOGUES OR DERIVATIVES
Schouten et al. Endovascular repair of abdominal aortic aneurysm
JP2009292766A5 (no)

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application