NO20080059L - Indol-3-karbonyl-spiro-piperidinderivater som V1A-reseptorantagonister - Google Patents

Indol-3-karbonyl-spiro-piperidinderivater som V1A-reseptorantagonister

Info

Publication number: NO20080059L
Authority: NO; Norway
Prior art keywords: spiro; carbonyl; receptor antagonists; piperidine derivatives; indole
Prior art date: 2005-07-14

Application number

NO20080059A

Other languages

English (en)

Norwegian (no)

Inventor

Patrick Schnider

Hasane Ratni

Caterina Bissantz

Christophe Grundschober

Mark Rogers-Evans

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-14

Filing date

2008-01-04

Publication date

2008-04-02

2008-01-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-04-02 Publication of NO20080059L publication Critical patent/NO20080059L/no

Links

239000002464 receptor antagonist Substances 0.000 title abstract 2
229940044551 receptor antagonist Drugs 0.000 title abstract 2
JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical group C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010029164 Nephrotic syndrome Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 1
102000002852 Vasopressins Human genes 0.000 abstract 1
108010004977 Vasopressins Proteins 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
208000019425 cirrhosis of liver Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
229960003726 vasopressin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Gynecology & Obstetrics (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pregnancy & Childbirth (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO20080059A 2005-07-14 2008-01-04 Indol-3-karbonyl-spiro-piperidinderivater som V1A-reseptorantagonister NO20080059L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP05106443		2005-07-14
EP05109364		2005-10-07
PCT/EP2006/063846 WO2007006688A1 (en)	2005-07-14	2006-07-04	Indol-3-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists

Publications (1)

Publication Number	Publication Date
NO20080059L true NO20080059L (no)	2008-04-02

Family

ID=37001896

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20080059A NO20080059L (no)	2005-07-14	2008-01-04	Indol-3-karbonyl-spiro-piperidinderivater som V1A-reseptorantagonister

Country Status (25)

Country	Link
US (2)	US7332501B2 (pl)
EP (1)	EP1904477B1 (pl)
JP (1)	JP4927079B2 (pl)
KR (1)	KR100974967B1 (pl)
CN (1)	CN101253164B (pl)
AR (1)	AR054830A1 (pl)
AT (1)	ATE421511T1 (pl)
AU (1)	AU2006268724B2 (pl)
BR (1)	BRPI0612988A2 (pl)
CA (1)	CA2615726C (pl)
CY (1)	CY1108996T1 (pl)
DE (1)	DE602006004997D1 (pl)
DK (1)	DK1904477T3 (pl)
ES (1)	ES2317558T3 (pl)
IL (1)	IL188478A (pl)
MX (1)	MX2008000585A (pl)
MY (1)	MY144684A (pl)
NO (1)	NO20080059L (pl)
PL (1)	PL1904477T3 (pl)
PT (1)	PT1904477E (pl)
RU (1)	RU2414466C2 (pl)
SI (1)	SI1904477T1 (pl)
TW (1)	TWI312780B (pl)
WO (1)	WO2007006688A1 (pl)
ZA (1)	ZA200800320B (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2615726C (en) *	2005-07-14	2014-05-27	Caterina Bissantz	Indol-3-yl-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists
KR101018934B1 (ko) *	2005-09-28	2011-03-02	에프. 호프만-라 로슈 아게	바소프레신 수용체 길항물질로서인돌-3-일-카보닐-아자스피로 유도체
US7351706B2 (en) *	2006-01-05	2008-04-01	Hoffmann-La Roche Inc.	Indol-3-yl-carbonyl-spiro-piperidine derivatives
DE602007006990D1 (de) *	2006-12-07	2010-07-15	Hoffmann La Roche	Spiropiperidinderivate als antagonisten des via-rezeptors
KR101050558B1 (ko)	2006-12-08	2011-07-19	에프. 호프만-라 로슈 아게	Ｖ1ａ 수용체 길항제로서 작용하는 인돌
BRPI0721138A2 (pt) *	2006-12-22	2014-04-01	Hoffmann La Roche	Derivados de espiro-piperidina
CN101583615B (zh) *	2007-01-12	2012-07-04	弗·哈夫曼-拉罗切有限公司	螺哌啶甘氨酰胺衍生物
TW200940547A (en) *	2007-12-13	2009-10-01	Speedel Experimenta Ag	Organic compounds
WO2011137024A1 (en) *	2010-04-26	2011-11-03	Merck Sharp & Dohme Corp.	Novel spiropiperidine prolylcarboxypeptidase inhibitors
PH12013501831B1 (en)	2011-03-10	2019-06-14	Zoetis Services Llc	Spirocyclic isoxazoline derivatives as antiparasitic agents
RU2475489C1 (ru) *	2011-10-07	2013-02-20	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Чувашский государственный университет имени И.Н. Ульянова"	Способ получения 8-амино-1-имино-6-морфолин-4-ил-2-окса-7-азаспиро[4,4]нона-3,6,8-триен-9-карбонитрилов
WO2013138568A1 (en)	2012-03-16	2013-09-19	Vitae Pharmaceuticals, Inc.	Liver x reception modulators
CN104203951B (zh)	2012-03-16	2016-11-02	生命医药公司	肝x受体调节剂
JO3109B1 (ar) *	2012-05-10	2017-09-20	Ferring Bv	منبهات لمستقبلات v1a
KR101698124B1 (ko) *	2015-05-29	2017-01-19	한국외국어대학교 연구산학협력단	3-(메틸아미노)-3-((r)-피롤리딘-3-일)프로판니트릴 또는 이의 염의 제조방법
WO2017137334A1 (en) *	2016-02-08	2017-08-17	F. Hoffmann-La Roche Ag	Spiroindolinones as ddr1 inhibitors
US20180002344A1 (en)	2016-06-16	2018-01-04	Genentech, Inc.	Heteroaryl estrogen receptor modulators and uses thereof
RU2752088C1 (ru) *	2016-09-21	2021-07-22	Вектус Байосистемс Лимитед	Композиции для лечения гипертензии и/или фиброза
TW201938171A (zh)	2017-12-15	2019-10-01	匈牙利商羅特格登公司	作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu)	2017-12-15	2021-10-28	Richter Gedeon Nyrt.	Triazolobenzazepinek
CN113563255B (zh) *	2020-04-29	2023-08-18	成都倍特药业股份有限公司	瑞芬沙星中间体的制备方法

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5686624A (en) *	1992-01-30	1997-11-11	Sanofi	1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
WO1994013696A1 (en) *	1992-12-11	1994-06-23	Merck & Co., Inc.	Spiro piperidines and homologs which promote release of growth hormone
US7339791B2 (en) *	2001-01-22	2008-03-04	Morgan Advanced Ceramics, Inc.	CVD diamond enhanced microprocessor cooling system
CA2615726C (en) *	2005-07-14	2014-05-27	Caterina Bissantz	Indol-3-yl-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists

2006
- 2006-07-04 CA CA2615726A patent/CA2615726C/en not_active Expired - Fee Related
- 2006-07-04 AT AT06764048T patent/ATE421511T1/de active
- 2006-07-04 AU AU2006268724A patent/AU2006268724B2/en not_active Ceased
- 2006-07-04 RU RU2008100082/04A patent/RU2414466C2/ru not_active IP Right Cessation
- 2006-07-04 WO PCT/EP2006/063846 patent/WO2007006688A1/en not_active Ceased
- 2006-07-04 CN CN2006800321491A patent/CN101253164B/zh not_active Expired - Fee Related
- 2006-07-04 KR KR1020087002692A patent/KR100974967B1/ko not_active Expired - Fee Related
- 2006-07-04 EP EP06764048A patent/EP1904477B1/en not_active Not-in-force
- 2006-07-04 MX MX2008000585A patent/MX2008000585A/es active IP Right Grant
- 2006-07-04 DK DK06764048T patent/DK1904477T3/da active
- 2006-07-04 DE DE602006004997T patent/DE602006004997D1/de active Active
- 2006-07-04 SI SI200630231T patent/SI1904477T1/sl unknown
- 2006-07-04 BR BRPI0612988-9A patent/BRPI0612988A2/pt not_active IP Right Cessation
- 2006-07-04 PT PT06764048T patent/PT1904477E/pt unknown
- 2006-07-04 PL PL06764048T patent/PL1904477T3/pl unknown
- 2006-07-04 ES ES06764048T patent/ES2317558T3/es active Active
- 2006-07-04 JP JP2008520842A patent/JP4927079B2/ja not_active Expired - Fee Related
- 2006-07-10 US US11/483,462 patent/US7332501B2/en not_active Expired - Fee Related
- 2006-07-10 TW TW095125012A patent/TWI312780B/zh not_active IP Right Cessation
- 2006-07-11 MY MYPI20063280A patent/MY144684A/en unknown
- 2006-07-12 AR ARP060102988A patent/AR054830A1/es not_active Application Discontinuation
2007
- 2007-12-27 IL IL188478A patent/IL188478A/en not_active IP Right Cessation
2008
- 2008-01-04 NO NO20080059A patent/NO20080059L/no not_active Application Discontinuation
- 2008-01-10 ZA ZA200800320A patent/ZA200800320B/xx unknown
- 2008-01-24 US US12/018,823 patent/US7629353B2/en not_active Expired - Fee Related
2009
- 2009-04-14 CY CY20091100447T patent/CY1108996T1/el unknown

Also Published As

Publication number	Publication date
DK1904477T3 (da)	2009-03-16
TWI312780B (en)	2009-08-01
AR054830A1 (es)	2007-07-18
ES2317558T3 (es)	2009-04-16
DE602006004997D1 (de)	2009-03-12
RU2414466C2 (ru)	2011-03-20
SI1904477T1 (sl)	2009-06-30
ATE421511T1 (de)	2009-02-15
US7332501B2 (en)	2008-02-19
ZA200800320B (en)	2009-02-25
RU2008100082A (ru)	2009-08-20
AU2006268724B2 (en)	2011-06-02
WO2007006688A1 (en)	2007-01-18
PT1904477E (pt)	2009-03-12
IL188478A (en)	2012-01-31
TW200726469A (en)	2007-07-16
CN101253164A (zh)	2008-08-27
BRPI0612988A2 (pt)	2010-12-14
MY144684A (en)	2011-10-31
CA2615726A1 (en)	2007-01-18
MX2008000585A (es)	2008-03-14
IL188478A0 (en)	2008-04-13
EP1904477B1 (en)	2009-01-21
KR100974967B1 (ko)	2010-08-09
US20070027173A1 (en)	2007-02-01
JP2009501185A (ja)	2009-01-15
KR20080024231A (ko)	2008-03-17
PL1904477T3 (pl)	2009-07-31
US7629353B2 (en)	2009-12-08
CA2615726C (en)	2014-05-27
AU2006268724A1 (en)	2007-01-18
CN101253164B (zh)	2012-05-16
JP4927079B2 (ja)	2012-05-09
HK1123554A1 (en)	2009-06-19
CY1108996T1 (el)	2014-07-02
US20080146557A1 (en)	2008-06-19
EP1904477A1 (en)	2008-04-02

Legal Events

Date	Code	Title	Description
2017-10-09	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20080059L (no)	2008-04-02	Indol-3-karbonyl-spiro-piperidinderivater som V1A-reseptorantagonister
NO20082733L (no)	2008-10-02	Indol-3-yl-karbonyl-spiro-piperidinderivater
NO20080291L (no)	2008-03-06	Indol-3-yl-karbonyl-piperidin-benzomidazolderivater som Via reseptorantagonister
NO20080316L (no)	2008-02-13	Indol-3-yl-karbonylpiperidin- og piperazinderivater
NO20071660L (no)	2007-06-15	Nye pyridinonderivater og deres anvendelse som positive allosteriske modulatorer av MGLUR2-reseptorer
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