NO20051626L - Azw-bicykloalkyletere og deres anvendelse som alfa-7-nAChR agonister - Google Patents

Azw-bicykloalkyletere og deres anvendelse som alfa-7-nAChR agonister

Info

Publication number
NO20051626L
NO20051626L NO20051626A NO20051626A NO20051626L NO 20051626 L NO20051626 L NO 20051626L NO 20051626 A NO20051626 A NO 20051626A NO 20051626 A NO20051626 A NO 20051626A NO 20051626 L NO20051626 L NO 20051626L
Authority
NO
Norway
Prior art keywords
alpha
azw
nachr agonists
bicycloalkyl
ethers
Prior art date
Application number
NO20051626A
Other languages
English (en)
Other versions
NO331556B1 (no
Inventor
Timothy John Ritchie
Konstanze Hurth
Dominik Feuerbach
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9943515&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20051626(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20051626L publication Critical patent/NO20051626L/no
Publication of NO331556B1 publication Critical patent/NO331556B1/no

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P25/16—Anti-Parkinson drugs
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • AIDS & HIV (AREA)
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  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører 1-aza-bicykloalkylderivater med formel I, 0'°>- N der X er CH2 eller en enkelt binding; Y er en gruppe med formelen eller (D og der R har betydningene som er definert i beskrivelsen, der forbindelsene er a7- nikotinacetylkolinreseptor- (nAChR) agonister; fremgangsmåter for deres fremstilling, deres anvendelse som legemidler og farmasøy- tiske sammensetninger som itmbefatter disse.
NO20051626A 2002-09-04 2005-04-01 Aza-bicykloalkylderivater, en farmasoytisk sammensetning inneholdende nevnte derivater, samt anvendelse derav i terapi NO331556B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0220581A GB0220581D0 (en) 2002-09-04 2002-09-04 Organic Compound
PCT/EP2003/009772 WO2004022556A1 (en) 2002-09-04 2003-09-03 Aza-bicycloalkyl ethers and their use as alpha7-nachr agonist

Publications (2)

Publication Number Publication Date
NO20051626L true NO20051626L (no) 2005-05-27
NO331556B1 NO331556B1 (no) 2012-01-23

Family

ID=9943515

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051626A NO331556B1 (no) 2002-09-04 2005-04-01 Aza-bicykloalkylderivater, en farmasoytisk sammensetning inneholdende nevnte derivater, samt anvendelse derav i terapi

Country Status (25)

Country Link
US (8) US20060167002A1 (no)
EP (3) EP2308876A1 (no)
JP (2) JP4348422B2 (no)
KR (2) KR20070058027A (no)
CN (1) CN1325493C (no)
AT (1) ATE448225T1 (no)
AU (1) AU2003260486C1 (no)
BR (2) BRPI0314325B8 (no)
CA (1) CA2495685C (no)
CY (1) CY1109765T1 (no)
DE (1) DE60330015D1 (no)
DK (1) DK1537104T3 (no)
EC (1) ECSP055621A (no)
ES (1) ES2336099T3 (no)
GB (1) GB0220581D0 (no)
IL (2) IL166918A (no)
MX (1) MXPA05002546A (no)
NO (1) NO331556B1 (no)
NZ (1) NZ538534A (no)
PL (1) PL209425B1 (no)
PT (1) PT1537104E (no)
RU (1) RU2352569C2 (no)
SI (1) SI1537104T1 (no)
WO (1) WO2004022556A1 (no)
ZA (1) ZA200500816B (no)

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