NO20080665L - Fag-fremvisning i a benytte kontraslasjonell translokasjon av fusjonspolypeptider - Google Patents
Fag-fremvisning i a benytte kontraslasjonell translokasjon av fusjonspolypeptiderInfo
- Publication number
- NO20080665L NO20080665L NO20080665A NO20080665A NO20080665L NO 20080665 L NO20080665 L NO 20080665L NO 20080665 A NO20080665 A NO 20080665A NO 20080665 A NO20080665 A NO 20080665A NO 20080665 L NO20080665 L NO 20080665L
- Authority
- NO
- Norway
- Prior art keywords
- phage
- translocation
- polypeptides
- phage display
- contralateral
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 230000004927 fusion Effects 0.000 title abstract 2
- 238000002823 phage display Methods 0.000 title abstract 2
- 230000005945 translocation Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000724791 Filamentous phage Species 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 108010051611 Signal Recognition Particle Proteins 0.000 abstract 1
- 102000013598 Signal recognition particle Human genes 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Control Of Indicators Other Than Cathode Ray Tubes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05106236 | 2005-07-08 | ||
| PCT/EP2006/063729 WO2007006665A1 (en) | 2005-07-08 | 2006-06-30 | Phage display using cotranslational translocation of fusion polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20080665L true NO20080665L (no) | 2008-02-05 |
Family
ID=35063135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080665A NO20080665L (no) | 2005-07-08 | 2008-02-05 | Fag-fremvisning i a benytte kontraslasjonell translokasjon av fusjonspolypeptider |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8846577B2 (de) |
| EP (1) | EP1902131B1 (de) |
| JP (1) | JP5042218B2 (de) |
| KR (1) | KR101268939B1 (de) |
| CN (1) | CN101213299B (de) |
| AT (1) | ATE448305T1 (de) |
| AU (1) | AU2006268780B2 (de) |
| BR (1) | BRPI0613593A2 (de) |
| CA (1) | CA2614512C (de) |
| DE (1) | DE602006010386D1 (de) |
| DK (1) | DK1902131T3 (de) |
| ES (1) | ES2335136T3 (de) |
| IL (1) | IL188518A (de) |
| MX (1) | MX2008000345A (de) |
| NO (1) | NO20080665L (de) |
| NZ (1) | NZ564695A (de) |
| PL (1) | PL1902131T3 (de) |
| RU (1) | RU2412249C2 (de) |
| WO (1) | WO2007006665A1 (de) |
| ZA (1) | ZA200710687B (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003256299A1 (en) | 2002-07-01 | 2004-01-19 | Human Genome Sciences, Inc. | Antibodies that specifically bind to reg iv |
| CA2677179C (en) * | 2007-01-31 | 2016-02-16 | Dow Global Technologies Inc. | Bacterial leader sequences for increased expression |
| MX359570B (es) | 2008-11-03 | 2018-10-01 | Molecular Partners Ag | Proteinas de union que inhiben la interaccion en el receptor de vegf-a. |
| GB0917647D0 (en) * | 2009-10-08 | 2009-11-25 | Glaxosmithkline Biolog Sa | Expression system |
| SI2496601T1 (sl) | 2009-11-05 | 2017-09-29 | F. Hoffmann-La Roche Ag | Tehnike in sestavek za sekrecijo heterolognih polipeptidov |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| CN113278077A (zh) | 2010-11-26 | 2021-08-20 | 分子组合公司 | 设计的与血清白蛋白结合的重复蛋白 |
| KR20140010076A (ko) | 2011-02-15 | 2014-01-23 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체 |
| TW201302779A (zh) | 2011-04-13 | 2013-01-16 | Glaxosmithkline Biolog Sa | 融合蛋白質及組合疫苗 |
| WO2012149439A2 (en) | 2011-04-29 | 2012-11-01 | Janssen Biotech, Inc. | Il4/il13 binding repeat proteins and uses |
| MX350954B (es) | 2011-06-21 | 2017-09-26 | Immunogen Inc | Derivados de maitansinoides novedosos con enlazador de peptido y conjugados de estos. |
| EP2867360B1 (de) | 2012-06-28 | 2019-05-08 | Molecular Partners AG | Von blutplättchen abstammender wachstumsfaktor (pdgf)-bindende, konstruierte ankyrin-repeat-proteine |
| US9956341B2 (en) | 2012-07-03 | 2018-05-01 | Milestone Scientific, Inc. | Drug infusion with pressure sensing and non-continuous flow for identification of and injection into fluid-filled anatomic spaces |
| HK1211208A1 (zh) | 2012-08-22 | 2016-05-20 | Immunogen, Inc. | 細胞毒性苯並二氮呯衍生物 |
| EP2738180A1 (de) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Bindeproteine mit mindestens zwei Bindedomänen gegen HER2 |
| HK1219422A1 (zh) | 2013-02-28 | 2017-04-07 | Immunogen, Inc. | 包含细胞结合剂及细胞毒素剂的轭合物 |
| EP2961435B1 (de) | 2013-02-28 | 2019-05-01 | ImmunoGen, Inc. | Konjugate mit zellbindenden mitteln und zytostatika |
| WO2014194030A2 (en) | 2013-05-31 | 2014-12-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
| PL3116999T3 (pl) * | 2014-03-14 | 2021-12-27 | F.Hoffmann-La Roche Ag | Sposoby i kompozycje do wydzielania polipeptydów heterologicznych |
| MX2016012285A (es) | 2014-03-24 | 2017-01-23 | Genentech Inc | Tratamiento de cáncer con antagonista de c-met y correlación de estos con la expresión de hgf. |
| TW201613930A (en) | 2014-09-03 | 2016-04-16 | Immunogen Inc | Cytotoxic benzodiazepine derivatives |
| PT3189056T (pt) | 2014-09-03 | 2020-09-04 | Immunogen Inc | Derivados citotóxicos de benzodiazepina |
| BR112017020986A2 (pt) | 2015-04-02 | 2018-08-14 | Molecular Partners Ag. | proteínas de ligação recombinantes e seu uso |
| US10220180B2 (en) | 2015-10-16 | 2019-03-05 | Milestone Scientific, Inc. | Method and apparatus for performing a peripheral nerve block |
| EP3506917A4 (de) | 2016-08-31 | 2020-05-06 | President and Fellows of Harvard College | Manipulierte bakterienproduzierende therapeutische proteine und verfahren zur verwendung davon |
| ES2953516T3 (es) | 2016-09-22 | 2023-11-14 | Molecular Partners Ag | Proteínas de unión recombinantes y su uso |
| US10632255B2 (en) | 2017-02-15 | 2020-04-28 | Milestone Scientific, Inc. | Drug infusion device |
| CN116785450A (zh) | 2017-02-28 | 2023-09-22 | 伊缪诺金公司 | 具有自分解肽接头的类美登素衍生物和其缀合物 |
| TW201839001A (zh) | 2017-04-20 | 2018-11-01 | 美商伊繆諾金公司 | 細胞毒性苯并二氮平衍生物及其綴合物 |
| US11471595B2 (en) | 2017-05-04 | 2022-10-18 | Milestone Scientific, Inc. | Method and apparatus for performing a peripheral nerve block |
| EP3732178A1 (de) | 2017-12-28 | 2020-11-04 | ImmunoGen, Inc. | Benzodiazepinderivate |
| AU2020240310A1 (en) | 2019-03-21 | 2021-10-07 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| EP3947395A1 (de) | 2019-03-29 | 2022-02-09 | ImmunoGen, Inc. | Zytotoxische bis-benzodiazepinderivate und konjugate davon mit zellbindenden mitteln zur hemmung von abnormalem zellwachstum oder zur behandlung von proliferativen krankheiten |
| HUE065484T2 (hu) | 2019-04-26 | 2024-05-28 | Immunogen Inc | Camptothecin-származékok |
| US10646660B1 (en) | 2019-05-16 | 2020-05-12 | Milestone Scientific, Inc. | Device and method for identification of a target region |
| BR112022011177A2 (pt) | 2019-12-11 | 2022-09-27 | Molecular Partners Ag | Domínios de repetição de anquirina projetados com resíduos de superfície alterados |
| US20210330349A1 (en) | 2020-04-24 | 2021-10-28 | Milestone Scientific, Inc. | Device and Method for Needle/Catheter Location Utilizing Correlation Analysis |
| WO2021224686A1 (en) | 2020-05-06 | 2021-11-11 | Molecular Partners Ag | Novel ankyrin repeat binding proteins and their uses |
| EP4149959A1 (de) | 2020-05-14 | 2023-03-22 | Molecular Partners AG | Multispezifische proteine |
| IL305677A (en) | 2021-03-09 | 2023-11-01 | Molecular Partners Ag | Novel darpin based multi-specific t-cell engagers |
| WO2024216275A2 (en) * | 2023-04-13 | 2024-10-17 | 5Prime Biosciences, Inc. | Compositions and methods for upregulation of reverse transcription and reduction of sequence bias in rna sequencing |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1078051T3 (da) * | 1998-05-13 | 2008-04-07 | Domantis Ltd | Fagvisningsselektionssystem til selektion af korrekt foldede proteiner |
| JP2009500030A (ja) * | 2005-07-07 | 2009-01-08 | リボヴァクス ビオテクノロジー ソシエテ アノニム | 新規なファージディスプレイ技術 |
-
2006
- 2006-06-30 MX MX2008000345A patent/MX2008000345A/es active IP Right Grant
- 2006-06-30 BR BRPI0613593-5A patent/BRPI0613593A2/pt not_active Application Discontinuation
- 2006-06-30 ES ES06763985T patent/ES2335136T3/es active Active
- 2006-06-30 US US11/988,389 patent/US8846577B2/en active Active
- 2006-06-30 AU AU2006268780A patent/AU2006268780B2/en not_active Ceased
- 2006-06-30 NZ NZ564695A patent/NZ564695A/en not_active IP Right Cessation
- 2006-06-30 JP JP2008519913A patent/JP5042218B2/ja not_active Expired - Fee Related
- 2006-06-30 DK DK06763985.6T patent/DK1902131T3/da active
- 2006-06-30 PL PL06763985T patent/PL1902131T3/pl unknown
- 2006-06-30 RU RU2008104174/10A patent/RU2412249C2/ru not_active IP Right Cessation
- 2006-06-30 AT AT06763985T patent/ATE448305T1/de active
- 2006-06-30 CA CA2614512A patent/CA2614512C/en not_active Expired - Fee Related
- 2006-06-30 DE DE602006010386T patent/DE602006010386D1/de active Active
- 2006-06-30 EP EP06763985A patent/EP1902131B1/de active Active
- 2006-06-30 WO PCT/EP2006/063729 patent/WO2007006665A1/en not_active Ceased
- 2006-06-30 CN CN2006800243863A patent/CN101213299B/zh not_active Expired - Fee Related
-
2007
- 2007-12-07 ZA ZA200710687A patent/ZA200710687B/xx unknown
- 2007-12-31 IL IL188518A patent/IL188518A/en not_active IP Right Cessation
-
2008
- 2008-02-05 KR KR1020087003094A patent/KR101268939B1/ko not_active Expired - Fee Related
- 2008-02-05 NO NO20080665A patent/NO20080665L/no not_active Application Discontinuation
-
2014
- 2014-08-26 US US14/468,597 patent/US9447142B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2614512A1 (en) | 2007-01-18 |
| PL1902131T3 (pl) | 2010-05-31 |
| KR20080035603A (ko) | 2008-04-23 |
| IL188518A (en) | 2011-04-28 |
| JP5042218B2 (ja) | 2012-10-03 |
| BRPI0613593A2 (pt) | 2011-01-18 |
| EP1902131A1 (de) | 2008-03-26 |
| ATE448305T1 (de) | 2009-11-15 |
| CN101213299B (zh) | 2013-03-27 |
| AU2006268780B2 (en) | 2011-03-24 |
| ES2335136T3 (es) | 2010-03-22 |
| HK1122839A1 (en) | 2009-05-29 |
| CA2614512C (en) | 2014-01-07 |
| KR101268939B1 (ko) | 2013-05-30 |
| US20150057186A1 (en) | 2015-02-26 |
| WO2007006665A1 (en) | 2007-01-18 |
| MX2008000345A (es) | 2008-04-02 |
| RU2412249C2 (ru) | 2011-02-20 |
| NZ564695A (en) | 2009-02-28 |
| JP2009500027A (ja) | 2009-01-08 |
| US8846577B2 (en) | 2014-09-30 |
| RU2008104174A (ru) | 2009-08-20 |
| AU2006268780A1 (en) | 2007-01-18 |
| IL188518A0 (en) | 2008-04-13 |
| DK1902131T3 (da) | 2010-03-01 |
| DE602006010386D1 (en) | 2009-12-24 |
| ZA200710687B (en) | 2008-11-26 |
| EP1902131B1 (de) | 2009-11-11 |
| CN101213299A (zh) | 2008-07-02 |
| US20110118146A1 (en) | 2011-05-19 |
| US9447142B2 (en) | 2016-09-20 |
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Legal Events
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|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |