NO20080665L - Fag-fremvisning i a benytte kontraslasjonell translokasjon av fusjonspolypeptider - Google Patents

Fag-fremvisning i a benytte kontraslasjonell translokasjon av fusjonspolypeptider

Info

Publication number
NO20080665L
NO20080665L NO20080665A NO20080665A NO20080665L NO 20080665 L NO20080665 L NO 20080665L NO 20080665 A NO20080665 A NO 20080665A NO 20080665 A NO20080665 A NO 20080665A NO 20080665 L NO20080665 L NO 20080665L
Authority
NO
Norway
Prior art keywords
phage
translocation
polypeptides
phage display
contralateral
Prior art date
Application number
NO20080665A
Other languages
English (en)
Norwegian (no)
Inventor
Daniel Steiner
Patrik Forrer
Michael T Stumpp
Andreas Plueckthun
Original Assignee
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich filed Critical Univ Zuerich
Publication of NO20080665L publication Critical patent/NO20080665L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Control Of Indicators Other Than Cathode Ray Tubes (AREA)
NO20080665A 2005-07-08 2008-02-05 Fag-fremvisning i a benytte kontraslasjonell translokasjon av fusjonspolypeptider NO20080665L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05106236 2005-07-08
PCT/EP2006/063729 WO2007006665A1 (fr) 2005-07-08 2006-06-30 Affichage de phage effectue par translocation cotranslationnelle de polypeptides de fusion

Publications (1)

Publication Number Publication Date
NO20080665L true NO20080665L (no) 2008-02-05

Family

ID=35063135

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080665A NO20080665L (no) 2005-07-08 2008-02-05 Fag-fremvisning i a benytte kontraslasjonell translokasjon av fusjonspolypeptider

Country Status (20)

Country Link
US (2) US8846577B2 (fr)
EP (1) EP1902131B1 (fr)
JP (1) JP5042218B2 (fr)
KR (1) KR101268939B1 (fr)
CN (1) CN101213299B (fr)
AT (1) ATE448305T1 (fr)
AU (1) AU2006268780B2 (fr)
BR (1) BRPI0613593A2 (fr)
CA (1) CA2614512C (fr)
DE (1) DE602006010386D1 (fr)
DK (1) DK1902131T3 (fr)
ES (1) ES2335136T3 (fr)
IL (1) IL188518A (fr)
MX (1) MX2008000345A (fr)
NO (1) NO20080665L (fr)
NZ (1) NZ564695A (fr)
PL (1) PL1902131T3 (fr)
RU (1) RU2412249C2 (fr)
WO (1) WO2007006665A1 (fr)
ZA (1) ZA200710687B (fr)

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EP3785735A1 (fr) 2008-11-03 2021-03-03 Molecular Partners AG Protéines de liaison inhibant l'interaction du récepteur vegf-a
GB0917647D0 (en) * 2009-10-08 2009-11-25 Glaxosmithkline Biolog Sa Expression system
BR112012010153B1 (pt) * 2009-11-05 2022-05-03 Genentech, Inc Método de produção de um anticorpo
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質
DK2643349T3 (da) 2010-11-26 2019-11-25 Molecular Partners Ag Designede repeat-proteiner, der binder til serumalbumin
JP6049642B2 (ja) 2011-02-15 2016-12-21 イミュノジェン・インコーポレーテッド 複合体の調製方法
TW201302779A (zh) 2011-04-13 2013-01-16 Glaxosmithkline Biolog Sa 融合蛋白質及組合疫苗
EP2702069A4 (fr) 2011-04-29 2015-04-29 Janssen Biotech Inc Protéines de répétition de liaison à il4/il13 et leurs utilisations
CN103648532A (zh) 2011-06-21 2014-03-19 伊缪诺金公司 具有肽连接子的新型美登木素生物碱衍生物及其偶联物
CA2877584A1 (fr) 2012-06-28 2014-01-03 Molecular Partners Ag Conception de proteines a motifs ankyrine repetes liees au facteur de croissance derive des plaquettes
US9956341B2 (en) 2012-07-03 2018-05-01 Milestone Scientific, Inc. Drug infusion with pressure sensing and non-continuous flow for identification of and injection into fluid-filled anatomic spaces
HK1211208A1 (zh) 2012-08-22 2016-05-20 Immunogen, Inc. 細胞毒性苯並二氮呯衍生物
EP2738180A1 (fr) 2012-11-30 2014-06-04 Molecular Partners AG Protéines de liaison comportant au moins deux domaines de liaison ciblant HER2
WO2014134486A2 (fr) 2013-02-28 2014-09-04 Immunogen, Inc. Conjugués comprenant des agents de liaison cellulaire (cba) et des agents cytotoxiques
JP6494533B2 (ja) 2013-02-28 2019-04-03 イミュノジェン・インコーポレーテッド 細胞結合剤及び細胞毒性剤としてのマイタンシノイドを含む複合体
US11453708B2 (en) 2013-05-31 2022-09-27 Molecular Partners Ag Designed ankyrin repeat proteins binding to hepatocyte growth factor
WO2014194030A2 (fr) 2013-05-31 2014-12-04 Immunogen, Inc. Conjugués comprenant des agents de liaison cellulaire et des agents cytotoxiques
EP3116999B1 (fr) * 2014-03-14 2021-09-15 F. Hoffmann-La Roche AG Compositions de sécrétion de polypeptides hétérologues et procédés associés
EP3122900A1 (fr) 2014-03-24 2017-02-01 F. Hoffmann-La Roche AG Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf
EP3189057A1 (fr) 2014-09-03 2017-07-12 ImmunoGen, Inc. Dérivés de benzodiazépine cytotoxique
ES2815353T3 (es) 2014-09-03 2021-03-29 Immunogen Inc Derivados de benzodiazepina citotóxicos
AU2016240220B2 (en) 2015-04-02 2019-11-21 Molecular Partners Ag Designed ankyrin repeat domains with binding specificity for serum albumin
US10220180B2 (en) 2015-10-16 2019-03-05 Milestone Scientific, Inc. Method and apparatus for performing a peripheral nerve block
US11278577B2 (en) 2016-08-31 2022-03-22 President And Fellows Of Harvard College Engineered bacteria secreting therapeutic proteins and methods of use thereof
US10717772B2 (en) 2016-09-22 2020-07-21 Molecular Partners Ag Recombinant binding proteins targeting HER2 and serum albumin, and their uses
US10632255B2 (en) 2017-02-15 2020-04-28 Milestone Scientific, Inc. Drug infusion device
KR20250171447A (ko) 2017-02-28 2025-12-08 이뮤노젠 아이엔씨 자기희생적 펩티드 링커 및 이들의 접합체를 갖는 메이탄시노이드 유도체
WO2018195243A1 (fr) 2017-04-20 2018-10-25 Immunogen, Inc. Dérivés de benzodiazépine cytotoxiques et leurs conjugués
US11471595B2 (en) 2017-05-04 2022-10-18 Milestone Scientific, Inc. Method and apparatus for performing a peripheral nerve block
TW202413360A (zh) 2017-12-28 2024-04-01 美商伊繆諾金公司 苯二氮平衍生物
US11833214B2 (en) 2019-03-21 2023-12-05 Immunogen, Inc. Methods of preparing cell-binding agent-drug conjugates
EP3947395A1 (fr) 2019-03-29 2022-02-09 ImmunoGen, Inc. Dérivés de bis-benzodiazépine cytotoxiques et leurs conjugués avec des agents de liaison à une cellule pour inhiber la croissance cellulaire anormale ou pour traiter des maladies prolifératives
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Also Published As

Publication number Publication date
EP1902131A1 (fr) 2008-03-26
IL188518A (en) 2011-04-28
US8846577B2 (en) 2014-09-30
RU2008104174A (ru) 2009-08-20
MX2008000345A (es) 2008-04-02
ES2335136T3 (es) 2010-03-22
JP2009500027A (ja) 2009-01-08
DE602006010386D1 (en) 2009-12-24
AU2006268780A1 (en) 2007-01-18
WO2007006665A1 (fr) 2007-01-18
CN101213299B (zh) 2013-03-27
RU2412249C2 (ru) 2011-02-20
KR20080035603A (ko) 2008-04-23
ATE448305T1 (de) 2009-11-15
BRPI0613593A2 (pt) 2011-01-18
ZA200710687B (en) 2008-11-26
US20150057186A1 (en) 2015-02-26
CA2614512C (fr) 2014-01-07
CN101213299A (zh) 2008-07-02
IL188518A0 (en) 2008-04-13
PL1902131T3 (pl) 2010-05-31
US20110118146A1 (en) 2011-05-19
EP1902131B1 (fr) 2009-11-11
US9447142B2 (en) 2016-09-20
DK1902131T3 (da) 2010-03-01
CA2614512A1 (fr) 2007-01-18
JP5042218B2 (ja) 2012-10-03
AU2006268780B2 (en) 2011-03-24
NZ564695A (en) 2009-02-28
HK1122839A1 (en) 2009-05-29
KR101268939B1 (ko) 2013-05-30

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