NO20081655L - Fremgangsmate for fremstilling av kontrastmidler - Google Patents

Fremgangsmate for fremstilling av kontrastmidler

Info

Publication number
NO20081655L
NO20081655L NO20081655A NO20081655A NO20081655L NO 20081655 L NO20081655 L NO 20081655L NO 20081655 A NO20081655 A NO 20081655A NO 20081655 A NO20081655 A NO 20081655A NO 20081655 L NO20081655 L NO 20081655L
Authority
NO
Norway
Prior art keywords
preparation
contrast agents
compound
formula
preparing
Prior art date
Application number
NO20081655A
Other languages
English (en)
Other versions
NO340308B1 (no
Inventor
Silvia Ceragioli
Giovanni Luca Ciarciello
Luciano Castiglia
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Publication of NO20081655L publication Critical patent/NO20081655L/no
Publication of NO340308B1 publication Critical patent/NO340308B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Det beskrives en fremgangsmåte for fremstilling av en forbindelse med formel (I) ved en karboksymetyleringsreaksjon som skjer i nærvær av et egnet alkyleringsmiddel og en base, uten behov for å styre pH-verdien i reaksjonsomgivelsene. Forbindelsen med formel (I) er et brukbart mellomprodukt ved fremstilling av diagnostiske kontrastmidler for MRI teknikker.
NO20081655A 2005-09-13 2008-04-03 Fremgangsmåte for fremstilling av kontrastmidler NO340308B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05019852A EP1762563A1 (en) 2005-09-13 2005-09-13 Process for the preparation of contrast agents
PCT/EP2006/065634 WO2007031390A1 (en) 2005-09-13 2006-08-24 Process for the preparation of contrast agents

Publications (2)

Publication Number Publication Date
NO20081655L true NO20081655L (no) 2008-04-09
NO340308B1 NO340308B1 (no) 2017-03-27

Family

ID=35501122

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081655A NO340308B1 (no) 2005-09-13 2008-04-03 Fremgangsmåte for fremstilling av kontrastmidler

Country Status (17)

Country Link
US (2) US7592482B2 (no)
EP (2) EP1762563A1 (no)
JP (1) JP5108769B2 (no)
KR (1) KR101358058B1 (no)
CN (1) CN101263108B (no)
AT (1) ATE478040T1 (no)
AU (1) AU2006290947B2 (no)
CA (1) CA2621339C (no)
DE (1) DE602006016320D1 (no)
DK (1) DK1948590T3 (no)
ES (1) ES2351166T3 (no)
HR (1) HRP20100565T1 (no)
IL (1) IL189643A (no)
NO (1) NO340308B1 (no)
PL (1) PL1948590T3 (no)
SI (1) SI1948590T1 (no)
WO (1) WO2007031390A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8501988B2 (en) * 2008-04-17 2013-08-06 Ecolab Usa Inc. Synthesis and applications of amino carboxylates
EP2327395A1 (en) 2009-11-23 2011-06-01 Bracco Imaging S.p.A Process for the preparation of gadobenate dimeglumine complex in a solid form
EP2338874A1 (en) 2009-12-16 2011-06-29 Bracco Imaging S.p.A Process for the preparation of chelated compounds
IT1403988B1 (it) * 2010-07-15 2013-11-08 Bracco Imaging Spa Processo per la preparazione di agenti di contrasto.
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
RU2621896C2 (ru) * 2011-11-25 2017-06-08 Байофор Индиа Фармасьютикалз Пвт. Лтд. Способ очистки полиаминокарбоксилатов
CN102603550B (zh) * 2012-02-16 2014-11-26 佛山普正医药科技有限公司 一种中间体bopta的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3855239T2 (de) * 1987-07-16 1996-10-31 Nycomed Imaging As Aminocarbonsäure und Derivate
EP0703790B1 (en) * 1993-06-02 2000-08-16 BRACCO S.p.A. Iodinated paramagnetic chelates, and their use as contrast agents
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
ITMI981583A1 (it) * 1998-07-10 2000-01-10 Bracco Spa Processo per la preparazione dell'acido 4 -carbossi-5,8,11-tris (carbossimetil)-1-fenil-2-oxa-5,8,11-triazatridecan-13-oico
JP5004438B2 (ja) * 2005-06-09 2012-08-22 行政院原子能委員会核能研究所 Ｄｔｐａ誘導体の製造方法

Also Published As

Publication number Publication date
HRP20100565T1 (hr) 2010-11-30
EP1948590B1 (en) 2010-08-18
US7592482B2 (en) 2009-09-22
JP5108769B2 (ja) 2012-12-26
NO340308B1 (no) 2017-03-27
CN101263108B (zh) 2011-12-21
AU2006290947A1 (en) 2007-03-22
EP1948590A1 (en) 2008-07-30
DK1948590T3 (da) 2010-11-29
ES2351166T3 (es) 2011-02-01
PL1948590T3 (pl) 2011-03-31
CA2621339A1 (en) 2007-03-22
US20090118537A1 (en) 2009-05-07
KR101358058B1 (ko) 2014-02-06
ATE478040T1 (de) 2010-09-15
AU2006290947B2 (en) 2012-01-19
CA2621339C (en) 2011-04-26
IL189643A (en) 2012-03-29
US20090306424A1 (en) 2009-12-10
DE602006016320D1 (no) 2010-09-30
JP2009507882A (ja) 2009-02-26
SI1948590T1 (sl) 2010-12-31
CN101263108A (zh) 2008-09-10
EP1762563A1 (en) 2007-03-14
KR20080045724A (ko) 2008-05-23
WO2007031390A1 (en) 2007-03-22

Similar Documents

Publication Publication Date Title
RU2012103850A (ru) Би-арил-мета-пиримидиновые ингибиторы киназ
NO20080129L (no) Fremgangsmate for fremstilling av dihydrokinazoliner
ES2338590T3 (es) Procedimiento regioselectivo de preparacion de benzoimidazoltiofenos.
MA29539B1 (fr) Procedes de production de derives phenoliques 4-biphenylylazetidin -2-one
CY1109722T1 (el) Ενδιαμεσες ενωσεις για την παρασκευη της trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,73oxepino[4,5-c]pyrrole
CY1113873T1 (el) Παραγωγα hydroxybenzamide σαν παραγοντες καταστολης της hsp90
BRPI0612957B8 (pt) composto, processos de preparação de compostos, composição farmacêutica e uso de um composto
TN2009000063A1 (en) Compounds and methods for 18f labeled agents
NO20083708L (no) 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer
WO2004046122A3 (en) Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors
EA200701470A1 (ru) Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
DE602005012481D1 (de) 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck
DK1948590T3 (da) Fremgangsmåde til frembringelse af kontrastmidler
ATE465152T1 (de) Verfahren zum herstellen von alkylaniliden aus halogenbenzolderivaten
DE602006008962D1 (de) Verfahren zur herstellung von valsartan
NO20064351L (no) Caspaseinhibitorer og anvendelser derav
EA200870038A1 (ru) Способ получения аминов
AR047810A1 (es) Proceso quimico
EA200700550A1 (ru) Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
MX2010007022A (es) Proceso para la síntesis de 3-amino-3-ciclobutilmetil-2-hidroxipro pionamida o sus sales.
EA200701852A1 (ru) Производные аминокислот
BRPI0413741A (pt) métodos para preparar thip e para preparar um composto, e, composto
ATE512134T1 (de) Verfahren zur herstellung von 5-benzyloxy-2-(4- benzyloxyphenyl)-3-methyl-1h-indol
AR051991A1 (es) Procedimiento para la preparacion de anilinas
DE602006014001D1 (de) Herstellung von 2-aminothiazol-5-carbonsäurederivaten