ATE512134T1 - Verfahren zur herstellung von 5-benzyloxy-2-(4- benzyloxyphenyl)-3-methyl-1h-indol - Google Patents
Verfahren zur herstellung von 5-benzyloxy-2-(4- benzyloxyphenyl)-3-methyl-1h-indolInfo
- Publication number
- ATE512134T1 ATE512134T1 AT08706720T AT08706720T ATE512134T1 AT E512134 T1 ATE512134 T1 AT E512134T1 AT 08706720 T AT08706720 T AT 08706720T AT 08706720 T AT08706720 T AT 08706720T AT E512134 T1 ATE512134 T1 AT E512134T1
- Authority
- AT
- Austria
- Prior art keywords
- benzyloxyphenyl
- benzyloxy
- indole
- methyl
- producing
- Prior art date
Links
- KRIJKJMYOVWRSJ-UHFFFAOYSA-N 3-methyl-5-phenylmethoxy-2-(4-phenylmethoxyphenyl)-1h-indole Chemical compound C1=C2C(C)=C(C=3C=CC(OCC=4C=CC=CC=4)=CC=3)NC2=CC=C1OCC1=CC=CC=C1 KRIJKJMYOVWRSJ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 abstract 1
- KQBDLOVXZHOAJI-UHFFFAOYSA-N (4-phenylmethoxyphenyl)azanium;chloride Chemical compound Cl.C1=CC(N)=CC=C1OCC1=CC=CC=C1 KQBDLOVXZHOAJI-UHFFFAOYSA-N 0.000 abstract 1
- LSQLSCUJBXFBRB-UHFFFAOYSA-N 2-bromo-1-(4-phenylmethoxyphenyl)propan-1-one Chemical compound C1=CC(C(=O)C(Br)C)=CC=C1OCC1=CC=CC=C1 LSQLSCUJBXFBRB-UHFFFAOYSA-N 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20070110A CZ302094B6 (cs) | 2007-02-12 | 2007-02-12 | N-(4-Benzyloxyfenyl)-alfa-amino-4-benzyloxypropiofenon, zpusob jeho prípravy a jeho použití |
| PCT/CZ2008/000016 WO2008098527A1 (en) | 2007-02-12 | 2008-02-11 | Method for the preparation of 5-benzyloxy-2-(4-benzyloxphenyl)-3-methyl-1h-indole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE512134T1 true ATE512134T1 (de) | 2011-06-15 |
Family
ID=39588190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08706720T ATE512134T1 (de) | 2007-02-12 | 2008-02-11 | Verfahren zur herstellung von 5-benzyloxy-2-(4- benzyloxyphenyl)-3-methyl-1h-indol |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100087661A1 (de) |
| EP (1) | EP2118058B9 (de) |
| AT (1) | ATE512134T1 (de) |
| CZ (1) | CZ302094B6 (de) |
| EA (1) | EA016419B1 (de) |
| PL (1) | PL2118058T3 (de) |
| UA (1) | UA99725C2 (de) |
| WO (1) | WO2008098527A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8431739B2 (en) | 2010-06-14 | 2013-04-30 | Divi's Laboratories, Ltd. | Process for the preparation of gabapentin |
| US7968732B1 (en) | 2010-09-07 | 2011-06-28 | Divi's Laboratories, Ltd. | Process for the preparation of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-indole |
| CN104098499B (zh) * | 2013-04-08 | 2016-05-04 | 上海医药工业研究院 | 5-苄氧基-2-(4-苄氧基苯基)-3-甲基-1h-吲哚的制备方法 |
| IT201800006562A1 (it) * | 2018-06-21 | 2019-12-21 | Procedimento e intermedi utili per la preparazione di indoli |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE206701T1 (de) * | 1996-04-19 | 2001-10-15 | American Home Prod | Östrogene verbindungen |
| ATE355264T1 (de) * | 1997-10-15 | 2006-03-15 | Wyeth Corp | Neue aryloxy-alkyl-dialkylamine |
-
2007
- 2007-02-11 US US12/526,650 patent/US20100087661A1/en not_active Abandoned
- 2007-02-12 CZ CZ20070110A patent/CZ302094B6/cs not_active IP Right Cessation
-
2008
- 2008-02-11 PL PL08706720T patent/PL2118058T3/pl unknown
- 2008-02-11 AT AT08706720T patent/ATE512134T1/de not_active IP Right Cessation
- 2008-02-11 EA EA200901088A patent/EA016419B1/ru not_active IP Right Cessation
- 2008-02-11 UA UAA200909370A patent/UA99725C2/ru unknown
- 2008-02-11 EP EP08706720A patent/EP2118058B9/de not_active Not-in-force
- 2008-02-11 WO PCT/CZ2008/000016 patent/WO2008098527A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| UA99725C2 (ru) | 2012-09-25 |
| EA016419B1 (ru) | 2012-04-30 |
| US20100087661A1 (en) | 2010-04-08 |
| EP2118058B9 (de) | 2012-03-28 |
| PL2118058T3 (pl) | 2011-10-31 |
| CZ2007110A3 (cs) | 2009-03-04 |
| WO2008098527A1 (en) | 2008-08-21 |
| EP2118058A1 (de) | 2009-11-18 |
| EA200901088A1 (ru) | 2010-02-26 |
| EP2118058B1 (de) | 2011-06-08 |
| CZ302094B6 (cs) | 2010-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |