NO20082695L - 3-(4-{[4-(4-{[3-(3,3-dimetyl-1-piperidinyl)propyl]oksy}fenyl)-1-piperidinyl]-karbonyl}-1-naftalenyl)propan- eller propensyre som H1 og H3 reseptorantagonister for behandling av betennelser og/eller allergiske lidelser - Google Patents
3-(4-{[4-(4-{[3-(3,3-dimetyl-1-piperidinyl)propyl]oksy}fenyl)-1-piperidinyl]-karbonyl}-1-naftalenyl)propan- eller propensyre som H1 og H3 reseptorantagonister for behandling av betennelser og/eller allergiske lidelserInfo
- Publication number
- NO20082695L NO20082695L NO20082695A NO20082695A NO20082695L NO 20082695 L NO20082695 L NO 20082695L NO 20082695 A NO20082695 A NO 20082695A NO 20082695 A NO20082695 A NO 20082695A NO 20082695 L NO20082695 L NO 20082695L
- Authority
- NO
- Norway
- Prior art keywords
- piperidinyl
- treatment
- naphthalenyl
- oxy
- inflammation
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 title 2
- -1 3- (4 - {[4- (4 - {[3- (3,3-Dimethyl-1-piperidinyl) propyl] oxy} phenyl) -1-piperidinyl] carbonyl} -1-naphthalenyl) propane Chemical compound 0.000 title 1
- 102000003834 Histamine H1 Receptors Human genes 0.000 title 1
- 108090000110 Histamine H1 Receptors Proteins 0.000 title 1
- 102000004384 Histamine H3 receptors Human genes 0.000 title 1
- 108090000981 Histamine H3 receptors Proteins 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000000172 allergic effect Effects 0.000 title 1
- 208000010668 atopic eczema Diseases 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0525897A GB0525897D0 (en) | 2005-12-20 | 2005-12-20 | Compounds |
| GB0623217A GB0623217D0 (en) | 2006-11-21 | 2006-11-21 | Compounds |
| PCT/EP2006/069943 WO2007071691A1 (en) | 2005-12-20 | 2006-12-19 | 3- (4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] 0xy} phenyl) -1-piperidinyl] carbonyl }-1-naphthalenyl) propanoic or propenoic acid as h1 and h3 receptor antagonists for the treatment of inflammatory and/or allergic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20082695L true NO20082695L (no) | 2008-09-16 |
Family
ID=37845266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20082695A NO20082695L (no) | 2005-12-20 | 2008-06-11 | 3-(4-{[4-(4-{[3-(3,3-dimetyl-1-piperidinyl)propyl]oksy}fenyl)-1-piperidinyl]-karbonyl}-1-naftalenyl)propan- eller propensyre som H1 og H3 reseptorantagonister for behandling av betennelser og/eller allergiske lidelser |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7989629B2 (es) |
| EP (2) | EP2157087A1 (es) |
| JP (2) | JP4445570B2 (es) |
| KR (1) | KR20080087102A (es) |
| AR (1) | AR058109A1 (es) |
| AT (1) | ATE449769T1 (es) |
| AU (1) | AU2006328512B2 (es) |
| BR (1) | BRPI0620218A2 (es) |
| CA (1) | CA2634391A1 (es) |
| CR (1) | CR10102A (es) |
| CY (1) | CY1110601T1 (es) |
| DE (1) | DE602006010737D1 (es) |
| DK (1) | DK1963307T3 (es) |
| EA (1) | EA014354B1 (es) |
| ES (1) | ES2337187T3 (es) |
| IL (1) | IL191967A0 (es) |
| MA (1) | MA30373B1 (es) |
| NO (1) | NO20082695L (es) |
| PE (1) | PE20071068A1 (es) |
| PL (1) | PL1963307T3 (es) |
| PT (1) | PT1963307E (es) |
| SI (1) | SI1963307T1 (es) |
| TW (1) | TW200730498A (es) |
| WO (1) | WO2007071691A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102137858B (zh) | 2008-05-23 | 2014-07-23 | 潘米拉制药有限责任公司 | 5-脂氧合酶-活化蛋白抑制剂 |
| EP2448578A1 (en) | 2009-06-29 | 2012-05-09 | Glaxo Group Limited | New medical use |
| JP4785963B2 (ja) | 2009-10-09 | 2011-10-05 | キヤノン株式会社 | 固体撮像装置 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| WO2015173701A2 (en) | 2014-05-12 | 2015-11-19 | Glaxosmithkline Intellectual Property (No. 2) Limited | Pharmaceutical compositions for treating infectious diseases |
| KR101640756B1 (ko) | 2014-10-28 | 2016-07-19 | 이종찬 | 전동 드릴 장착용 내시경 캡 |
| US20200405728A1 (en) * | 2018-03-01 | 2020-12-31 | Ferox Therapeutics Llc | Methods of preventing and treating hypoglycemia in type 1 and type 2 diabetes patients |
| BR112022019245A2 (pt) | 2020-03-26 | 2022-11-16 | Glaxosmithkline Ip Dev Ltd | Inibidores de catepsina para prevenir ou tratar infecções virais |
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| US5364791A (en) | 1992-05-14 | 1994-11-15 | Elisabetta Vegeto | Progesterone receptor having C. terminal hormone binding domain truncations |
| AU685054C (en) | 1992-05-14 | 2003-02-27 | Baylor College Of Medicine | Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy |
| DK0957087T3 (da) | 1994-06-15 | 2003-03-24 | Wellcome Found | Intermediater, der er anvendelige til fremstilling af enzym-inhibitorer |
| MY117948A (en) | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
| DE19723722A1 (de) | 1997-05-30 | 1998-12-10 | Schering Ag | Nichtsteroidale Gestagene |
| AU9281298A (en) | 1997-10-01 | 1999-04-23 | Kyowa Hakko Kogyo Co. Ltd. | Benzodioxole derivatives |
| US6506766B1 (en) | 1998-02-13 | 2003-01-14 | Abbott Laboratories | Glucocortiocoid-selective antinflammatory agents |
| DK1070056T3 (da) | 1998-03-14 | 2004-11-08 | Altana Pharma Ag | Phthalazinon-PDE III/IV-inhibitorer |
| GB9811599D0 (en) | 1998-05-30 | 1998-07-29 | Glaxo Group Ltd | Nitric oxide synthase inhibitors |
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| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| CO5180649A1 (es) | 1999-09-01 | 2002-07-30 | Abbott Lab | Antagonistas de los receptores de los glucocorticoides para el tratamiento de la diabetes para el tratamiento de la diabetes |
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| US6484903B2 (en) | 2001-01-09 | 2002-11-26 | Riverwood International Corporation | Carton with an improved dispensing feature in combination with a unique handle |
| GB0103630D0 (en) | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
| JP2004526720A (ja) | 2001-03-08 | 2004-09-02 | グラクソ グループ リミテッド | βアドレナリン受容体のアゴニスト |
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| AU2003214879B2 (en) | 2002-01-22 | 2008-02-07 | The Regents Of The University Of California | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof |
| GB0204719D0 (en) | 2002-02-28 | 2002-04-17 | Glaxo Group Ltd | Medicinal compounds |
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| PL373043A1 (en) | 2002-03-26 | 2005-08-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| DE10215316C1 (de) | 2002-04-02 | 2003-12-18 | Schering Ag | Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer |
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| GB0230045D0 (en) | 2002-12-23 | 2003-01-29 | Glaxo Group Ltd | Compounds |
| PT1539753E (pt) | 2002-09-16 | 2009-12-10 | Glaxo Group Ltd | Compostos de pirazolo(3,4-b)piridina e sua utilização como inibidores da fosfodiesterase |
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| GB0224084D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| US20060205790A1 (en) | 2002-10-22 | 2006-09-14 | Coe Diane M | Medicinal arylethanolamine compounds |
| EP1554260A1 (en) * | 2002-10-22 | 2005-07-20 | Glaxo Group Limited | Aryloxyalkylamine derivatives as h3 receptor ligands |
| GB0225030D0 (en) | 2002-10-28 | 2002-12-04 | Glaxo Group Ltd | Medicinal compounds |
| US7442839B2 (en) | 2002-10-28 | 2008-10-28 | Glaxo Group Limited | Phenethanolamine derivative for the treatment of respiratory diseases |
| GB0225535D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Medicinal compounds |
| GB0225540D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Medicinal compounds |
| GB0308333D0 (en) * | 2003-04-10 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
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| PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| WO2006000401A1 (en) | 2004-06-28 | 2006-01-05 | Glaxo Group Limited | Substituted oxazines as glucocorticoid receptor modulators |
| WO2006000398A1 (en) | 2004-06-28 | 2006-01-05 | Glaxo Group Limited | 2,3-benzoxazin derivatives as non-steroidal glucocorticoid receptor modulators |
| GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
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| US20090105225A1 (en) | 2006-04-20 | 2009-04-23 | Glaxo Group Limited | 2-Substituted 4-Benzylphthalazinone Derivatives as Histamine H1 and H3 Antagonists |
-
2006
- 2006-12-18 PE PE2006001620A patent/PE20071068A1/es not_active Application Discontinuation
- 2006-12-18 TW TW095147457A patent/TW200730498A/zh unknown
- 2006-12-18 AR ARP060105590A patent/AR058109A1/es not_active Application Discontinuation
- 2006-12-19 CA CA002634391A patent/CA2634391A1/en not_active Abandoned
- 2006-12-19 KR KR1020087015535A patent/KR20080087102A/ko not_active Ceased
- 2006-12-19 EP EP09176715A patent/EP2157087A1/en not_active Withdrawn
- 2006-12-19 AT AT06841477T patent/ATE449769T1/de active
- 2006-12-19 EA EA200801342A patent/EA014354B1/ru not_active IP Right Cessation
- 2006-12-19 US US12/158,185 patent/US7989629B2/en not_active Expired - Fee Related
- 2006-12-19 SI SI200630560T patent/SI1963307T1/sl unknown
- 2006-12-19 DE DE602006010737T patent/DE602006010737D1/de active Active
- 2006-12-19 ES ES06841477T patent/ES2337187T3/es active Active
- 2006-12-19 AU AU2006328512A patent/AU2006328512B2/en not_active Ceased
- 2006-12-19 DK DK06841477.0T patent/DK1963307T3/da active
- 2006-12-19 PT PT06841477T patent/PT1963307E/pt unknown
- 2006-12-19 BR BRPI0620218-7A patent/BRPI0620218A2/pt not_active IP Right Cessation
- 2006-12-19 WO PCT/EP2006/069943 patent/WO2007071691A1/en not_active Ceased
- 2006-12-19 EP EP06841477A patent/EP1963307B1/en active Active
- 2006-12-19 JP JP2008546432A patent/JP4445570B2/ja not_active Expired - Fee Related
- 2006-12-19 PL PL06841477T patent/PL1963307T3/pl unknown
-
2008
- 2008-06-05 IL IL191967A patent/IL191967A0/en unknown
- 2008-06-11 MA MA31023A patent/MA30373B1/fr unknown
- 2008-06-11 NO NO20082695A patent/NO20082695L/no not_active Application Discontinuation
- 2008-06-20 CR CR10102A patent/CR10102A/es not_active Application Discontinuation
-
2009
- 2009-06-12 JP JP2009140796A patent/JP2009235087A/ja active Pending
-
2010
- 2010-02-19 CY CY20101100170T patent/CY1110601T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI1963307T1 (sl) | 2010-03-31 |
| IL191967A0 (en) | 2008-12-29 |
| AR058109A1 (es) | 2008-01-23 |
| CR10102A (es) | 2008-09-22 |
| PL1963307T3 (pl) | 2010-05-31 |
| HK1120265A1 (en) | 2009-03-27 |
| EP1963307A1 (en) | 2008-09-03 |
| BRPI0620218A2 (pt) | 2011-11-01 |
| EP2157087A1 (en) | 2010-02-24 |
| EA200801342A1 (ru) | 2008-12-30 |
| JP2009520001A (ja) | 2009-05-21 |
| ES2337187T3 (es) | 2010-04-21 |
| DK1963307T3 (da) | 2010-04-06 |
| MA30373B1 (fr) | 2009-05-04 |
| TW200730498A (en) | 2007-08-16 |
| WO2007071691A1 (en) | 2007-06-28 |
| US7989629B2 (en) | 2011-08-02 |
| JP2009235087A (ja) | 2009-10-15 |
| CY1110601T1 (el) | 2015-04-29 |
| KR20080087102A (ko) | 2008-09-30 |
| ATE449769T1 (de) | 2009-12-15 |
| EA014354B1 (ru) | 2010-10-29 |
| JP4445570B2 (ja) | 2010-04-07 |
| DE602006010737D1 (de) | 2010-01-07 |
| AU2006328512B2 (en) | 2011-06-23 |
| CA2634391A1 (en) | 2007-06-28 |
| EP1963307B1 (en) | 2009-11-25 |
| PT1963307E (pt) | 2010-03-03 |
| PE20071068A1 (es) | 2007-12-13 |
| AU2006328512A1 (en) | 2007-06-28 |
| US20080312280A1 (en) | 2008-12-18 |
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