NO20082747L - Arylisoksazol-4-yl-imidazolderivater - Google Patents
Arylisoksazol-4-yl-imidazolderivaterInfo
- Publication number
- NO20082747L NO20082747L NO20082747A NO20082747A NO20082747L NO 20082747 L NO20082747 L NO 20082747L NO 20082747 A NO20082747 A NO 20082747A NO 20082747 A NO20082747 A NO 20082747A NO 20082747 L NO20082747 L NO 20082747L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- halogen
- aryl
- substituted
- optionally substituted
- Prior art date
Links
- QLMNERAESCRARF-UHFFFAOYSA-N 4-(1h-imidazol-2-yl)-1,2-oxazole Chemical class C1=CNC(C2=CON=C2)=N1 QLMNERAESCRARF-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 229910052736 halogen Inorganic materials 0.000 abstract 9
- 150000002367 halogens Chemical class 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 239000002475 cognitive enhancer Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05113011 | 2005-12-27 | ||
| PCT/EP2006/069722 WO2007074078A2 (en) | 2005-12-27 | 2006-12-14 | Aryl-isoxazol-4-yl-imidazole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20082747L true NO20082747L (no) | 2008-09-22 |
Family
ID=38218337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20082747A NO20082747L (no) | 2005-12-27 | 2008-06-13 | Arylisoksazol-4-yl-imidazolderivater |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7414061B2 (da) |
| EP (1) | EP1968973B1 (da) |
| JP (1) | JP2009521516A (da) |
| KR (1) | KR101121372B1 (da) |
| CN (1) | CN101351461B (da) |
| AR (1) | AR058760A1 (da) |
| AT (1) | ATE527255T1 (da) |
| AU (1) | AU2006331437B2 (da) |
| BR (1) | BRPI0620773A2 (da) |
| CA (1) | CA2633367A1 (da) |
| DK (1) | DK1968973T3 (da) |
| ES (1) | ES2371935T3 (da) |
| IL (1) | IL192235A0 (da) |
| NO (1) | NO20082747L (da) |
| PL (1) | PL1968973T3 (da) |
| PT (1) | PT1968973E (da) |
| RU (1) | RU2425045C2 (da) |
| TW (1) | TWI324998B (da) |
| WO (1) | WO2007074078A2 (da) |
| ZA (1) | ZA200805353B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI386405B (zh) | 2006-09-05 | 2013-02-21 | 咪唑衍生物 | |
| JP5416103B2 (ja) * | 2007-06-22 | 2014-02-12 | エフ．ホフマン−ラ ロシュ アーゲー | イソオキサゾール−イミダゾール誘導体 |
| UA100132C2 (en) | 2007-12-04 | 2012-11-26 | Ф. Хоффманн-Ля Рош Аг | Isoxazolo-pyridine derivatives |
| TW201033201A (en) * | 2009-02-19 | 2010-09-16 | Hoffmann La Roche | Isoxazole-isoxazole and isoxazole-isothiazole derivatives |
| US8466181B2 (en) * | 2010-12-10 | 2013-06-18 | Hoffmann-La Roche Inc. | 1,2,3-triazole-imidazole compounds |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| WO2014001278A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| CA2876778A1 (en) | 2012-06-26 | 2014-01-03 | Saniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| WO2014001280A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| US9475797B2 (en) | 2012-06-26 | 2016-10-25 | Saniona A/S | Phenyl triazole derivative and its use for modulating the GABAA receptor complex |
| WO2014001279A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| JP5947465B2 (ja) * | 2012-10-01 | 2016-07-06 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｎｓ活性剤としてのベンズイミダゾール類 |
| BR102019014802A2 (pt) | 2018-07-20 | 2020-02-04 | Boehringer Ingelheim Int | difluorometil-fenil triazóis |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4112451A1 (de) * | 1991-04-12 | 1992-10-15 | Schering Ag | Isoxazolylimidazolderivate, verfahren zu deren herstellung und deren verwendung in arzneimitteln |
| WO1999040088A1 (en) * | 1998-02-09 | 1999-08-12 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors, in particular as urokinase inhibitors |
| IT1314191B1 (it) | 1999-10-18 | 2002-12-06 | Recordati Chem Pharm | Derivati isossazolcarbossamidici |
| PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| GB0108475D0 (en) | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
| CA2454613A1 (en) | 2001-07-05 | 2003-01-16 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as mch selective antagonists |
| GB0128160D0 (en) | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Novel compounds |
| EP1546141A1 (en) * | 2002-09-06 | 2005-06-29 | Vertex Pharmaceuticals Incorporated | Isoxazoles and their use in the treatment of ischemic diseases |
| JP2008502687A (ja) | 2004-06-14 | 2008-01-31 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| RU2426731C2 (ru) * | 2005-12-23 | 2011-08-20 | Ф. Хоффманн-Ля Рош Аг | Производные арил-изоксазоло-4-ил-оксадиазола |
| JP4864982B2 (ja) * | 2005-12-27 | 2012-02-01 | エフ．ホフマン−ラ ロシュ アーゲー | アリール−イソオキサゾール−４−イル−イミダゾ［１，５−ａ］ピリジン誘導体 |
-
2006
- 2006-12-14 BR BRPI0620773-1A patent/BRPI0620773A2/pt not_active IP Right Cessation
- 2006-12-14 EP EP06841367A patent/EP1968973B1/en not_active Not-in-force
- 2006-12-14 AT AT06841367T patent/ATE527255T1/de active
- 2006-12-14 WO PCT/EP2006/069722 patent/WO2007074078A2/en not_active Ceased
- 2006-12-14 PT PT06841367T patent/PT1968973E/pt unknown
- 2006-12-14 PL PL06841367T patent/PL1968973T3/pl unknown
- 2006-12-14 DK DK06841367.3T patent/DK1968973T3/da active
- 2006-12-14 AU AU2006331437A patent/AU2006331437B2/en not_active Ceased
- 2006-12-14 KR KR1020087018343A patent/KR101121372B1/ko not_active Expired - Fee Related
- 2006-12-14 CA CA002633367A patent/CA2633367A1/en not_active Abandoned
- 2006-12-14 ES ES06841367T patent/ES2371935T3/es active Active
- 2006-12-14 CN CN2006800496053A patent/CN101351461B/zh not_active Expired - Fee Related
- 2006-12-14 JP JP2008547937A patent/JP2009521516A/ja active Pending
- 2006-12-14 RU RU2008125039/04A patent/RU2425045C2/ru not_active IP Right Cessation
- 2006-12-18 US US11/640,622 patent/US7414061B2/en not_active Expired - Fee Related
- 2006-12-25 TW TW095148810A patent/TWI324998B/zh active
- 2006-12-27 AR ARP060105809A patent/AR058760A1/es unknown
-
2008
- 2008-06-13 NO NO20082747A patent/NO20082747L/no not_active Application Discontinuation
- 2008-06-16 IL IL192235A patent/IL192235A0/en unknown
- 2008-06-19 ZA ZA200805353A patent/ZA200805353B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE527255T1 (de) | 2011-10-15 |
| TWI324998B (en) | 2010-05-21 |
| KR101121372B1 (ko) | 2012-04-12 |
| CA2633367A1 (en) | 2007-07-05 |
| PT1968973E (pt) | 2011-12-09 |
| CN101351461B (zh) | 2011-09-07 |
| EP1968973B1 (en) | 2011-10-05 |
| BRPI0620773A2 (pt) | 2011-11-22 |
| ZA200805353B (en) | 2009-10-28 |
| KR20080080229A (ko) | 2008-09-02 |
| RU2425045C2 (ru) | 2011-07-27 |
| US20070161654A1 (en) | 2007-07-12 |
| ES2371935T3 (es) | 2012-01-11 |
| CN101351461A (zh) | 2009-01-21 |
| WO2007074078A3 (en) | 2008-01-17 |
| AU2006331437B2 (en) | 2012-07-05 |
| AR058760A1 (es) | 2008-02-20 |
| TW200736251A (en) | 2007-10-01 |
| AU2006331437A1 (en) | 2007-07-05 |
| DK1968973T3 (da) | 2011-10-31 |
| PL1968973T3 (pl) | 2012-03-30 |
| IL192235A0 (en) | 2009-02-11 |
| JP2009521516A (ja) | 2009-06-04 |
| EP1968973A2 (en) | 2008-09-17 |
| RU2008125039A (ru) | 2010-02-10 |
| WO2007074078A2 (en) | 2007-07-05 |
| US7414061B2 (en) | 2008-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20082747L (no) | Arylisoksazol-4-yl-imidazolderivater | |
| NO20082719L (no) | Aryl-isoksazol-4-yl-oksadiazolderivater | |
| EA201000050A1 (ru) | Замещенные бициклолактамные соединения | |
| EP2423207A3 (en) | 2-(cyclic amino)-pyrimidone derivatives as TPK1 inhibitors | |
| NO20082748L (no) | Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater | |
| NO20063761L (no) | Sulfonamidderivater for behandling av sykdommer | |
| NO20055219L (no) | Nye forbindelser | |
| MY156747A (en) | Isoxazolo-pyridine derivatives | |
| NO20063501L (no) | Kinolinintermediater av reseptor-Tyrosin-Kinase-inhibitorer og deres syntese | |
| SE0303180D0 (sv) | Novel compounds | |
| SE0302232D0 (sv) | Novel Compounds | |
| NO20064456L (no) | Thiadiazolidinoner som GSK-3 inhibitorer | |
| EA200701745A1 (ru) | Циклопропанкарбоксамидные производные | |
| NO20062983L (no) | Sulfonamid-derivater for behandling av sykdommer | |
| NO20056192L (no) | Kapaseinhibitorer og anvendelse derav | |
| ATE520651T1 (de) | Substituierte phenylmethylbicyclocarbonsäureamidverbindungen | |
| NO20055854L (no) | (2-hyroksy-2-(4-hydroksy-3-hydroksymetylfenyl)--etylamino)-propylfenylderivater som beta2 agonister | |
| IL183373A0 (en) | 3-[2-(3-acylamino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pentanoic acid derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof | |
| EA201071269A1 (ru) | 3,4-замещенные пиперидиновые производные в качестве ингибиторов ренина | |
| WO2007079163A3 (en) | Prokineticin 1 receptor antagonists | |
| NO20076000L (no) | Aminosyrederivater | |
| WO2007054444A3 (en) | 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives | |
| EA201070367A1 (ru) | Производное 6-пиримидинилпиримид-4-она | |
| NO20064344L (no) | Caspaseinhibitorer og anvendelser derav | |
| NO20073330L (no) | Sulfanylsubstituerte fenylmetanoner som glycintransportor 1 (glyt-1) inhibitorer for behandling av nevrologiske og nevropsykiatriske forstyrrelser |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |