NO20082748L - Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater - Google Patents

Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater

Info

Publication number
NO20082748L
NO20082748L NO20082748A NO20082748A NO20082748L NO 20082748 L NO20082748 L NO 20082748L NO 20082748 A NO20082748 A NO 20082748A NO 20082748 A NO20082748 A NO 20082748A NO 20082748 L NO20082748 L NO 20082748L
Authority
NO
Norway
Prior art keywords
lower alkyl
hydrogen
aryl
isoxazol
imidazo
Prior art date
Application number
NO20082748A
Other languages
English (en)
Inventor
Bernd Buettelmann
Bo Han
Henner Knust
Andrew Thomas
Jiaqiang Dong
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20082748L publication Critical patent/NO20082748L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår aryl-isoksazol-4-yl-imidazo[1,5-a]pyridinderivater med formel (I): hvor R1 er hydrogen, halogen, hydroksy, lavere alkyl, benzyloksy eller 5- eller 6-leddet -O-(CH2)-(CO)-heteroaryl eventuelt substituert med aryl og lavere alkyl; R2 er hydrogen, lavere alkyl eller -(CO)-Ra; R3 er hydrogen, halogen, cyano, lavere alkyl eller -(CO)-Ra; Ra er hydroksy, lavere alkoksy, NR'R'', hvor R' og R'' hver, uavhengig, er hydrogen, cykloalkyl, 5- eller 6-leddet heterocykloalkyl eller lavere alkyl eventuelt substituert med cykloalkyl, cyano, 5- eller 6-leddet heterocykloalkyl eller 5- eller 6-leddet heteroaryl; så vel som farmasøytisk akseptable syreaddisjonssalter derav. Det er funnet at denne klasse forbindelser viser høy affinitet til, og selektivitet overfor, GABA A ?5-reseptor-bindingsseter, og kan være anvendelige som kognitiv forbedrer eller for behandling av kognitive lidelser som Alzheimers sykdom.
NO20082748A 2005-12-27 2008-06-13 Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater NO20082748L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05112988 2005-12-27
PCT/EP2006/069792 WO2007074089A1 (en) 2005-12-27 2006-12-18 Aryl-isoxazol-4-yl-imidazo[1, 5-a]pyridine derivatives

Publications (1)

Publication Number Publication Date
NO20082748L true NO20082748L (no) 2008-09-24

Family

ID=37909303

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082748A NO20082748L (no) 2005-12-27 2008-06-13 Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater

Country Status (17)

Country Link
US (1) US7399769B2 (no)
EP (1) EP1968977B1 (no)
JP (1) JP4864982B2 (no)
KR (1) KR101033719B1 (no)
CN (1) CN101346377B (no)
AR (1) AR058728A1 (no)
AT (1) ATE537171T1 (no)
AU (1) AU2006331363B2 (no)
BR (1) BRPI0620760A2 (no)
CA (1) CA2633536A1 (no)
ES (1) ES2376357T3 (no)
IL (1) IL192236A0 (no)
NO (1) NO20082748L (no)
RU (1) RU2420527C2 (no)
TW (1) TWI324156B (no)
WO (1) WO2007074089A1 (no)
ZA (1) ZA200805354B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE527255T1 (de) 2005-12-27 2011-10-15 Hoffmann La Roche Aryl-isoxazol-4-yl-imidazol-derivate
MX2009014001A (es) 2007-06-22 2010-01-28 Hoffmann La Roche Derivados de isoxazol-imidazol.
KR101237576B1 (ko) 2007-12-04 2013-03-04 에프. 호프만-라 로슈 아게 아이속사졸로-피리딘 유도체
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2876780A1 (en) 2012-06-26 2014-01-03 Saniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001281A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
SI3105218T1 (sl) 2014-02-13 2019-11-29 Incyte Corp Ciklopropilamini kot inhibitorji LSD1
MX373103B (es) 2014-02-13 2020-04-17 Incyte Holdings Corp Ciclopropilaminas como inhibidores de desmetilasa específica de lisina 1 (lsd1).
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
EP3277689B1 (en) 2015-04-03 2019-09-04 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
LT3334709T (lt) 2015-08-12 2025-03-10 Incyte Holdings Corporation Lsd1 inhibitoriaus druskos
BR102019014802A2 (pt) 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0203052A3 (en) * 1999-10-08 2004-06-28 Gruenenthal Gmbh Bicyclic imidazo-3-yl-amine derivatives, process for their preparation, pharmaceutical compositions containing them and their use
CN1390217A (zh) * 1999-11-12 2003-01-08 神经原公司 二环和三环杂芳族化合物
AU2002353844A1 (en) 2001-11-20 2003-06-10 Eli Lilly And Company Beta 3 adrenergic agonists

Also Published As

Publication number Publication date
BRPI0620760A2 (pt) 2011-11-22
JP4864982B2 (ja) 2012-02-01
RU2420527C2 (ru) 2011-06-10
AU2006331363B2 (en) 2012-07-05
TW200734328A (en) 2007-09-16
AR058728A1 (es) 2008-02-20
ATE537171T1 (de) 2011-12-15
US20070191421A1 (en) 2007-08-16
AU2006331363A1 (en) 2007-07-05
US7399769B2 (en) 2008-07-15
WO2007074089A1 (en) 2007-07-05
ZA200805354B (en) 2009-10-28
KR101033719B1 (ko) 2011-05-09
ES2376357T3 (es) 2012-03-13
CA2633536A1 (en) 2007-07-05
CN101346377B (zh) 2011-05-11
EP1968977B1 (en) 2011-12-14
KR20080072072A (ko) 2008-08-05
CN101346377A (zh) 2009-01-14
IL192236A0 (en) 2008-12-29
JP2009521517A (ja) 2009-06-04
TWI324156B (en) 2010-05-01
RU2008125040A (ru) 2010-02-10
EP1968977A1 (en) 2008-09-17

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