NO20082876L - Fremgangsmate for produksjon av forbindelse merket med radioaktivt fluor - Google Patents
Fremgangsmate for produksjon av forbindelse merket med radioaktivt fluorInfo
- Publication number
- NO20082876L NO20082876L NO20082876A NO20082876A NO20082876L NO 20082876 L NO20082876 L NO 20082876L NO 20082876 A NO20082876 A NO 20082876A NO 20082876 A NO20082876 A NO 20082876A NO 20082876 L NO20082876 L NO 20082876L
- Authority
- NO
- Norway
- Prior art keywords
- fdg
- preparing
- conditions
- compound labeled
- radioactive fluorine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229910052731 fluorine Inorganic materials 0.000 title abstract 2
- 239000011737 fluorine Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002285 radioactive effect Effects 0.000 title abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- OIBDVHSTOUGZTJ-PEBLQZBPSA-N [(2r,3r,4s,5s,6s)-3,4,6-triacetyloxy-5-(trifluoromethylsulfonyloxy)oxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@@H](OS(=O)(=O)C(F)(F)F)[C@@H](OC(C)=O)[C@@H]1OC(C)=O OIBDVHSTOUGZTJ-PEBLQZBPSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 229910001414 potassium ion Inorganic materials 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Det beskrives en fremgangsmåte for fremstilling av 18F-FDG som kan produsere l8F-FDG i høyt og stabilt utbytte ved syntesen. En fremgangsmåte for fremstilling av en forbindelse merket med radioaktivt fluor omfatter trinnene: fremstilling av en reaksjons-oppløsning ved tilsetning, under hermetiske betingelser, TATM og et inert, organisk oppløsningsmiddel til en blanding inneholdende -[18F] fluoridioner, en faseoverførings-katalysator og kaliumioner, og gir reaksjonsbetingelser for reaksjonsoppløsningen under hermetiske tilstander for å oppnå 18F-TAFDG, og å underkaste den oppnådde l8F-TAFDG en debeskyttelsesprosess og eventuelt en renseprosess for å oppnå l8F-FDG.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005349091 | 2005-12-02 | ||
| PCT/JP2006/323932 WO2007063940A1 (ja) | 2005-12-02 | 2006-11-30 | 放射性フッ素標識化合物の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20082876L true NO20082876L (no) | 2008-08-14 |
Family
ID=38092274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20082876A NO20082876L (no) | 2005-12-02 | 2008-06-24 | Fremgangsmate for produksjon av forbindelse merket med radioaktivt fluor |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090030192A1 (no) |
| EP (1) | EP1958953A4 (no) |
| JP (1) | JP4342586B2 (no) |
| KR (1) | KR20080072023A (no) |
| CN (1) | CN101346391A (no) |
| AU (1) | AU2006319847A1 (no) |
| CA (1) | CA2632553A1 (no) |
| NO (1) | NO20082876L (no) |
| WO (1) | WO2007063940A1 (no) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008029734A1 (en) * | 2006-09-06 | 2008-03-13 | Nihon Medi-Physics Co., Ltd. | Process for producing radioactive fluorine labeled organic compound, and relevant synthetic apparatus and program |
| JPWO2009014203A1 (ja) * | 2007-07-26 | 2010-10-07 | 北興化学工業株式会社 | （１，３，５／２，４，６）−１−フルオロ−２，３，４，５，６−シクロヘキサンペントールの製造方法 |
| KR101583544B1 (ko) * | 2007-12-19 | 2016-01-08 | 니혼 메디피직스 가부시키가이샤 | 방사성 불소 표식 유기 화합물의 제조방법 |
| US9073802B2 (en) | 2010-02-12 | 2015-07-07 | Tokyo Institute Of Technology | Method for producing 18F-labeled compound and high molecular compound to be used in the method |
| IL235650B (en) * | 2013-11-13 | 2019-10-31 | Ge Healthcare Ltd | Dual play tape |
| WO2016084193A1 (ja) * | 2014-11-27 | 2016-06-02 | 国立大学法人東京工業大学 | ６－デオキシ－６－放射性ヨード－ｄ－グルコースの製造方法、及びその方法に用いる高分子化合物 |
| JP6827709B2 (ja) * | 2016-04-25 | 2021-02-10 | 日本メジフィジックス株式会社 | ２−［１８ｆ］フルオロ−２−デオキシ−ｄ−グルコースの製造方法 |
| CN106770883B (zh) * | 2017-01-03 | 2019-01-29 | 原子高科股份有限公司 | 一种氟[18f]化钠注射液放化纯的薄层色谱分析方法 |
| CN108864213B (zh) * | 2018-07-16 | 2021-06-11 | 陕西正泽生物技术有限公司 | 一种柱水解18F-FDG用C18/tC18 SPE柱分离制备18F-FDG的方法 |
| JP7424574B2 (ja) * | 2018-08-22 | 2024-01-30 | 国立大学法人北海道大学 | 放射性フッ素標識化合物の製造方法及び放射性医薬組成物の製造方法 |
| JP7311642B2 (ja) * | 2019-07-09 | 2023-07-19 | エフ． ホフマン－ラ ロシュ アーゲー | オリゴヌクレオチドを脱保護するための方法 |
| JP7127164B2 (ja) * | 2021-01-19 | 2022-08-29 | 日本メジフィジックス株式会社 | ２－［１８ｆ］フルオロ－２－デオキシ－ｄ－グルコースの製造方法 |
| CN113801173B (zh) * | 2021-09-24 | 2024-03-12 | 上海安迪科正电子技术有限公司 | 一种氟-18标记的脱氧葡糖注射液的制备方法及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6475498A (en) * | 1987-09-14 | 1989-03-22 | Japan Steel Works Ltd | Method and apparatus for synthesizing fluorodeoxyglucose |
| JP2738224B2 (ja) * | 1992-06-15 | 1998-04-08 | 日本鋼管株式会社 | １８ｆ標識有機化合物の製造法 |
| US5264570A (en) * | 1992-08-05 | 1993-11-23 | General Electric Company | Method for making 2-[18 F]fluoro-2-deoxy-D-glucose |
| JP3008329B2 (ja) * | 1995-01-26 | 2000-02-14 | 信彦 中澤 | ラジオアイソトープ標識試薬調整用プレフィルドキット |
-
2006
- 2006-11-30 CA CA002632553A patent/CA2632553A1/en not_active Abandoned
- 2006-11-30 CN CNA2006800489187A patent/CN101346391A/zh active Pending
- 2006-11-30 EP EP06833735A patent/EP1958953A4/en not_active Withdrawn
- 2006-11-30 JP JP2007547996A patent/JP4342586B2/ja active Active
- 2006-11-30 AU AU2006319847A patent/AU2006319847A1/en not_active Abandoned
- 2006-11-30 US US12/085,966 patent/US20090030192A1/en not_active Abandoned
- 2006-11-30 WO PCT/JP2006/323932 patent/WO2007063940A1/ja not_active Ceased
- 2006-11-30 KR KR1020087013011A patent/KR20080072023A/ko not_active Withdrawn
-
2008
- 2008-06-24 NO NO20082876A patent/NO20082876L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006319847A1 (en) | 2007-06-07 |
| EP1958953A1 (en) | 2008-08-20 |
| CA2632553A1 (en) | 2007-06-07 |
| JPWO2007063940A1 (ja) | 2009-05-07 |
| US20090030192A1 (en) | 2009-01-29 |
| EP1958953A4 (en) | 2010-01-06 |
| JP4342586B2 (ja) | 2009-10-14 |
| KR20080072023A (ko) | 2008-08-05 |
| WO2007063940A1 (ja) | 2007-06-07 |
| CN101346391A (zh) | 2009-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |