NO20083000L - Tetomilast polymorfer - Google Patents

Tetomilast polymorfer

Info

Publication number
NO20083000L
NO20083000L NO20083000A NO20083000A NO20083000L NO 20083000 L NO20083000 L NO 20083000L NO 20083000 A NO20083000 A NO 20083000A NO 20083000 A NO20083000 A NO 20083000A NO 20083000 L NO20083000 L NO 20083000L
Authority
NO
Norway
Prior art keywords
powder
ray diffraction
diffraction spectrum
crystal
tetomilast
Prior art date
Application number
NO20083000A
Other languages
English (en)
Inventor
Satoshi Aoki
Kenji Nakaya
Masahiro Sota
Masashi Ishigami
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
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Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of NO20083000L publication Critical patent/NO20083000L/no

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Abstract

Foreliggende oppfinnelse tilveiebringer en tetomilast krystall som er industrielt enkelt å fremstille i en stort volum. (1) En tetomilast hydratkrystall som har et pulverrøntgendiffraksjonsspekter som er i det vesentlige det samme som pulverrøntgendiffraksjonsspekteret som er vist i fig. 2; (2) en vannfri tetomilast type A krystall som har et pulverrøntgendiffraksjonsspekter som er i det vesentlige det samme som pulverrøntgendiffraksjonsspekteret vist i fig. 4; (3) en vannfri tetomilast type C krystall som har et pulverrøntgendiffraksjonsspekter som er i det vesentlige det samme som pulverrøntgendiffraksjonsspekteret vist i fig. 8; (4) en tetomilast acetonitril solvatkrystall som har et pulverrøntgendiffraksjonsspekter som er i det vesentlige det samme som pulverrøntgendiffraksjonsspektret vist i fig. 10; og (5) en blanding som består av den ovenfor nevnte vannfrie tetomilast type A krystallen og en vannfri tetomilast type B krystall. Disse krystallene er stabile overfor varme og fuktighet og er også svært tilfredsstillende når det gjelder desintegreringsegenskaper og oppløsningsegenskaper for tabletter. Følgelig blir disse krystallene foretrukket anvendt som farmasøytiske sammensetninger.
NO20083000A 2006-03-17 2008-07-07 Tetomilast polymorfer NO20083000L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006075307 2006-03-17
PCT/JP2007/055931 WO2007119496A1 (en) 2006-03-17 2007-03-15 Tetomilast polymorphs

Publications (1)

Publication Number Publication Date
NO20083000L true NO20083000L (no) 2008-09-30

Family

ID=38069222

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083000A NO20083000L (no) 2006-03-17 2008-07-07 Tetomilast polymorfer

Country Status (26)

Country Link
US (4) US8501949B2 (no)
EP (4) EP2311832B1 (no)
JP (2) JP4182363B2 (no)
KR (6) KR20110136902A (no)
CN (4) CN101365697B (no)
AR (1) AR059911A1 (no)
AT (1) ATE476433T1 (no)
AU (1) AU2007239906B2 (no)
BR (1) BRPI0706224A2 (no)
CA (4) CA2725698C (no)
CY (3) CY1111046T1 (no)
DE (1) DE602007008212D1 (no)
DK (3) DK1999128T3 (no)
ES (3) ES2348630T3 (no)
IL (4) IL192237A (no)
MY (2) MY151343A (no)
NO (1) NO20083000L (no)
PH (1) PH12015502374A1 (no)
PL (3) PL2311832T3 (no)
PT (3) PT2206711E (no)
RU (2) RU2408597C2 (no)
SG (4) SG172707A1 (no)
SI (3) SI2311832T1 (no)
TW (1) TWI394753B (no)
WO (1) WO2007119496A1 (no)
ZA (2) ZA200805235B (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117069780A (zh) 2016-10-06 2023-11-17 协和发酵生化株式会社 胞苷二磷酸胆碱的晶体及其制造方法

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JP3282731B2 (ja) * 1990-06-15 2002-05-20 メルク エンド カムパニー インコーポレーテッド 結晶の構造および大きさを改良する結晶化方法
DK0513387T3 (da) 1990-11-30 2000-06-05 Otsuka Pharma Co Ltd Thiazolderivater som inhibitorer af aktivt oxygen
MY128323A (en) * 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
JP4300373B2 (ja) 1996-09-30 2009-07-22 大塚製薬株式会社 サイトカイン産生抑制剤及び接着抑制剤
US6221153B1 (en) * 1998-06-09 2001-04-24 Trevor Percival Castor Method for producing large crystals of complex molecules
SA99191255B1 (ar) * 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
JP4336913B2 (ja) 1999-02-12 2009-09-30 大塚製薬株式会社 アミド誘導体の製造方法
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
JP3713577B2 (ja) 2001-07-24 2005-11-09 大塚製薬株式会社 慢性閉塞性肺疾患治療薬
DK1411936T3 (da) 2001-07-24 2005-12-27 Otsuka Pharma Co Ltd Anvendelse af thiazolderivater i fremstillingen af et medikament til behandling af kronisk obstruktiv lungesygdom
AR033485A1 (es) * 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
PT1613598E (pt) * 2003-12-16 2012-01-13 Teva Pharma Métodos para preparar formas cristalinas de aripiprazol

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US8993601B2 (en) 2015-03-31
ATE476433T1 (de) 2010-08-15
US20130184312A1 (en) 2013-07-18
CN102174044B (zh) 2014-02-26
HK1159079A1 (en) 2012-07-27
SG172706A1 (en) 2011-07-28
KR101118943B1 (ko) 2012-02-27
DK2311832T3 (da) 2012-10-08
AU2007239906B2 (en) 2010-07-29
DK2206711T3 (da) 2012-10-08
TW200813041A (en) 2008-03-16
IL192237A0 (en) 2009-02-11
CN102174046A (zh) 2011-09-07
CA2725810A1 (en) 2007-10-25
CN101365697A (zh) 2009-02-11
CA2725649C (en) 2013-05-14
SG10201408225VA (en) 2015-01-29
JP2008285498A (ja) 2008-11-27
AR059911A1 (es) 2008-05-07
EP2206711A3 (en) 2010-10-13
DK1999128T3 (da) 2010-11-08
EP2311832B1 (en) 2012-08-22
US20150352095A1 (en) 2015-12-10
PL1999128T3 (pl) 2010-12-31
CN101365697B (zh) 2011-11-23
KR20080077260A (ko) 2008-08-21
IL214254A0 (en) 2011-08-31
PT2206711E (pt) 2012-08-31
IL214253A (en) 2014-01-30
RU2009147223A (ru) 2011-06-27
CA2725698C (en) 2013-06-18
US9145404B2 (en) 2015-09-29
JP5197196B2 (ja) 2013-05-15
ES2348630T3 (es) 2010-12-10
KR101252994B1 (ko) 2013-04-15
IL214252A0 (en) 2011-08-31
KR20130003041A (ko) 2013-01-08
RU2441002C2 (ru) 2012-01-27
IL214253A0 (en) 2011-08-31
RU2408597C2 (ru) 2011-01-10
WO2007119496A1 (en) 2007-10-25
JP2007277235A (ja) 2007-10-25
DE602007008212D1 (de) 2010-09-16
SI1999128T1 (sl) 2010-12-31
MY143808A (en) 2011-07-15
PL2311832T3 (pl) 2013-01-31
CN102174046B (zh) 2013-12-25
CY1111046T1 (el) 2015-06-11
ZA201001687B (en) 2010-11-24
CA2634100A1 (en) 2007-10-25
SG172708A1 (en) 2011-07-28
KR20110087350A (ko) 2011-08-02
PT2311832E (pt) 2012-08-30
SG172707A1 (en) 2011-07-28
JP4182363B2 (ja) 2008-11-19
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CA2634100C (en) 2011-08-23
US20140113937A1 (en) 2014-04-24
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KR20110136902A (ko) 2011-12-21
CA2725698A1 (en) 2007-10-25
AU2007239906A1 (en) 2007-10-25
IL192237A (en) 2013-06-27
KR101083611B1 (ko) 2011-11-16
KR20110135427A (ko) 2011-12-16
US20100222590A1 (en) 2010-09-02
HK1124062A1 (en) 2009-07-03
PL2206711T3 (pl) 2013-01-31
EP1999128B1 (en) 2010-08-04
EP2206711A2 (en) 2010-07-14
SI2311832T1 (sl) 2012-12-31
PT1999128E (pt) 2011-01-20
CA2725810C (en) 2013-01-22
KR101168630B1 (ko) 2012-07-30
US8501949B2 (en) 2013-08-06
KR20100127886A (ko) 2010-12-06
KR101482374B1 (ko) 2015-01-14
CY1113263T1 (el) 2016-04-13
RU2008127324A (ru) 2010-01-10
HK1159080A1 (en) 2012-07-27
MY151343A (en) 2014-05-15
ZA200805235B (en) 2010-07-28
TWI394753B (zh) 2013-05-01
CY1113262T1 (el) 2016-04-13
EP2311832A1 (en) 2011-04-20
EP2206711B1 (en) 2012-08-22
BRPI0706224A2 (pt) 2011-03-22

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