NO20083246L - Nye benzimidazolderivater som vanilloid-reseptor 1 (VRL) inhibitorer - Google Patents

Nye benzimidazolderivater som vanilloid-reseptor 1 (VRL) inhibitorer

Info

Publication number: NO20083246L
Authority: NO; Norway
Prior art keywords: vrl; inhibitors; benzimidazole derivatives; vanilloid receptor; novel benzimidazole
Prior art date: 2005-12-23

Application number

NO20083246A

Other languages

English (en)

Norwegian (no)

Inventor

Yevgeni Besidski

Paul Jones

Inger Kers

Martin Nylof

Andrew Griffin

Denis Labrecque

Shawn Johnstone

Karin Skogholm

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-23

Filing date

2008-07-22

Publication date

2008-09-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38189102&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083246(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-07-22 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2008-09-11 Publication of NO20083246L publication Critical patent/NO20083246L/no

Links

102100029613 Transient receptor potential cation channel subfamily V member 1 Human genes 0.000 title 1
108050004388 Transient receptor potential cation channel subfamily V member 1 Proteins 0.000 title 1
229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hematology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20083246A 2005-12-23 2008-07-22 Nye benzimidazolderivater som vanilloid-reseptor 1 (VRL) inhibitorer NO20083246L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75360405P	2005-12-23	2005-12-23
PCT/SE2006/001467 WO2007073303A2 (en)	2005-12-23	2006-12-21	Novel benzimidazole derivatives as vanilloid receptor 1 (vrl) inhibitors

Publications (1)

Publication Number	Publication Date
NO20083246L true NO20083246L (no)	2008-09-11

Family

ID=38189102

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20083246A NO20083246L (no)	2005-12-23	2008-07-22	Nye benzimidazolderivater som vanilloid-reseptor 1 (VRL) inhibitorer

Country Status (21)

Country	Link
US (2)	US7618993B2 (de)
EP (1)	EP1966156B1 (de)
JP (1)	JP2009521431A (de)
KR (1)	KR20080080212A (de)
CN (1)	CN101389610B (de)
AR (1)	AR058705A1 (de)
AT (1)	ATE538101T1 (de)
AU (1)	AU2006327320B2 (de)
BR (1)	BRPI0620410A2 (de)
CA (1)	CA2634804A1 (de)
EC (1)	ECSP088584A (de)
ES (1)	ES2377661T3 (de)
IL (1)	IL191753A0 (de)
NO (1)	NO20083246L (de)
NZ (1)	NZ569923A (de)
RU (1)	RU2427573C2 (de)
TW (1)	TW200736227A (de)
UA (1)	UA96277C2 (de)
UY (1)	UY30048A1 (de)
WO (1)	WO2007073303A2 (de)
ZA (1)	ZA200805162B (de)

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WO2011157339A1 (de)	2010-06-15	2011-12-22	Merck Patent Gmbh	Metallkomplexe
KR101293384B1 (ko)	2010-10-13	2013-08-05	주식회사 대웅제약	신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
CA2963772A1 (en) *	2014-10-08	2016-04-14	Thomas Helledays Stiftelse For Medicinsk Forskning	Heterocyclic compounds as dctpp1 modulators
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WO2021224680A1 (en)	2020-05-08	2021-11-11	Takeda Pharmaceutical Company Limited	Substituted benzotriazinone metabolites of a gpr139 agonist
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US20030158188A1 (en)	2002-02-20	2003-08-21	Chih-Hung Lee	Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
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SE0301446D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	New Compounds
SE0301701D0 (sv)	2003-06-10	2003-06-10	Astrazeneca Ab	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
KR100738784B1 (ko) *	2003-09-03	2007-07-12	화이자 인코포레이티드	5-ｈｔ4 수용체 효능 활성을 갖는 벤즈이미다졸론
JP4775259B2 (ja)	2004-03-31	2011-09-21	味の素株式会社	アニリン誘導体
SE0402284D0 (sv) *	2004-09-21	2004-09-21	Astrazeneca Ab	New heterocyclic amides
TW200736227A (en) *	2005-12-23	2007-10-01	Astrazeneca Ab	New compounds III
RU2424233C2 (ru) *	2006-06-29	2011-07-20	Ф.Хоффманн-Ля Рош Аг	Производные бензимидазола, методы их получения, применение их в качестве агонистов фарнезоид-х-рецептора (fxr) и содержащие их фармацевтические препараты
TWI433839B (zh)	2006-08-11	2014-04-11	Neomed Inst	新穎的苯并咪唑衍生物290

2006
- 2006-12-20 TW TW095148018A patent/TW200736227A/zh unknown
- 2006-12-20 UY UY30048A patent/UY30048A1/es unknown
- 2006-12-20 AR ARP060105673A patent/AR058705A1/es not_active Application Discontinuation
- 2006-12-21 KR KR1020087017908A patent/KR20080080212A/ko not_active Abandoned
- 2006-12-21 JP JP2008547169A patent/JP2009521431A/ja active Pending
- 2006-12-21 WO PCT/SE2006/001467 patent/WO2007073303A2/en not_active Ceased
- 2006-12-21 BR BRPI0620410-4A patent/BRPI0620410A2/pt not_active IP Right Cessation
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- 2006-12-21 AT AT06835882T patent/ATE538101T1/de active
- 2006-12-21 CN CN2006800533688A patent/CN101389610B/zh not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
CN101389610B (zh)	2011-12-07
RU2008122404A (ru)	2010-01-27
US7618993B2 (en)	2009-11-17
ES2377661T3 (es)	2012-03-29
NZ569923A (en)	2011-04-29
AR058705A1 (es)	2008-02-20
IL191753A0 (en)	2008-12-29
WO2007073303A3 (en)	2007-08-30
AU2006327320B2 (en)	2009-12-10
US8168668B2 (en)	2012-05-01
US20100286202A1 (en)	2010-11-11
HK1121755A1 (en)	2009-04-30
UY30048A1 (es)	2007-07-31
UA96277C2 (en)	2011-10-25
CN101389610A (zh)	2009-03-18
KR20080080212A (ko)	2008-09-02
WO2007073303A2 (en)	2007-06-28
JP2009521431A (ja)	2009-06-04
ZA200805162B (en)	2009-11-25
ECSP088584A (es)	2008-07-30
EP1966156A2 (de)	2008-09-10
CA2634804A1 (en)	2007-06-28
EP1966156B1 (de)	2011-12-21
BRPI0620410A2 (pt)	2011-11-08
AU2006327320A1 (en)	2007-06-28
ATE538101T1 (de)	2012-01-15
RU2427573C2 (ru)	2011-08-27
TW200736227A (en)	2007-10-01
US20080171770A1 (en)	2008-07-17

Legal Events

Date	Code	Title	Description
2012-07-23	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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