NO20083880L - Fremgangsmate for fremstilling av 2-(4-hydroxy-3-morfolinyl)-2-syklohexenon - Google Patents
Fremgangsmate for fremstilling av 2-(4-hydroxy-3-morfolinyl)-2-syklohexenonInfo
- Publication number
- NO20083880L NO20083880L NO20083880A NO20083880A NO20083880L NO 20083880 L NO20083880 L NO 20083880L NO 20083880 A NO20083880 A NO 20083880A NO 20083880 A NO20083880 A NO 20083880A NO 20083880 L NO20083880 L NO 20083880L
- Authority
- NO
- Norway
- Prior art keywords
- hydroxy
- btg
- preparation
- cycloesenone
- morfolinyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- FGCXTWWWHFWHEA-UHFFFAOYSA-N 2-(4-hydroxymorpholin-3-yl)cyclohex-2-en-1-one Chemical compound ON1CCOCC1C1=CCCCC1=O FGCXTWWWHFWHEA-UHFFFAOYSA-N 0.000 title 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- CIISBYKBBMFLEZ-UHFFFAOYSA-N 1,2-oxazolidine Chemical compound C1CNOC1 CIISBYKBBMFLEZ-UHFFFAOYSA-N 0.000 abstract 2
- OURXRFYZEOUCRM-UHFFFAOYSA-N 4-hydroxymorpholine Chemical compound ON1CCOCC1 OURXRFYZEOUCRM-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- USVVENVKYJZFMW-ONEGZZNKSA-N (e)-carboxyiminocarbamic acid Chemical compound OC(=O)\N=N\C(O)=O USVVENVKYJZFMW-ONEGZZNKSA-N 0.000 abstract 1
- -1 N-hydroxymorpholine Chemical class 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002443 hydroxylamines Chemical class 0.000 abstract 1
- 229910044991 metal oxide Inorganic materials 0.000 abstract 1
- 150000004706 metal oxides Chemical class 0.000 abstract 1
- 238000001665 trituration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Det er beskrevet en fremgangsmåte for fremstilling av 2-(4-hydroksy-3-morfolinyl)-2-sykloesenon (BTG-1675A) som omfatter trinnene: i) å omsette N-hydroksymorfolin med sykloesanon i nærvær av et oksidasjonsmiddel for således å oppnå et isoksazolidin med formel IV; og ii) konvertere isoksazolidinet med formel IV til 2-(4-hydroksy-3-morfolinyl)-2-sykloesenon. Fordelaktig blir oksidasjonsmidlet i trinn i) valgt fra gruppen som består av metalloksider, estere og amider av azodikarboksylsyre og trinnet ii) for konversjon blir utført ved basisk katalyse etterfulgt av triturering i et aromatisk hydrokarbon, fortrinnsvis toluen. Den beskrevne fremgangsmåte tillater at det oppnås BTG-1675A i henhold til oppfinnelsen i en mengde på hundreder av gram og på en industriell skala. Oppfinnelsen angår videre en ny fremgangsmåte til å fremstille hydroksylaminer, særlig N-hydroksymorfolin, som ble brukt i fremgangsmåten til fremstilling av BTG-1675A.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000258A ITMI20060258A1 (it) | 2006-02-13 | 2006-02-13 | Procedimento per la preparazione di 2-4 idrossi-3-morfolini-2-cicloesenone |
| PCT/IT2007/000088 WO2007094022A1 (en) | 2006-02-13 | 2007-02-12 | Process for the preparation of 2-(4-hydroxy-3-morfolynil)-2-cyclohexenone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20083880L true NO20083880L (no) | 2008-09-10 |
Family
ID=38094136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20083880A NO20083880L (no) | 2006-02-13 | 2008-09-10 | Fremgangsmate for fremstilling av 2-(4-hydroxy-3-morfolinyl)-2-syklohexenon |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7872007B2 (no) |
| EP (1) | EP1991534B1 (no) |
| JP (1) | JP2009526838A (no) |
| KR (1) | KR20080110729A (no) |
| CN (1) | CN101384564A (no) |
| AT (1) | ATE449087T1 (no) |
| AU (1) | AU2007216126A1 (no) |
| BR (1) | BRPI0707910A2 (no) |
| CA (1) | CA2641440A1 (no) |
| CY (1) | CY1109794T1 (no) |
| DE (1) | DE602007003326D1 (no) |
| DK (1) | DK1991534T3 (no) |
| ES (1) | ES2336041T3 (no) |
| IT (1) | ITMI20060258A1 (no) |
| NO (1) | NO20083880L (no) |
| PL (1) | PL1991534T3 (no) |
| PT (1) | PT1991534E (no) |
| RU (1) | RU2439066C2 (no) |
| SI (1) | SI1991534T1 (no) |
| WO (1) | WO2007094022A1 (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102804663A (zh) * | 2009-06-26 | 2012-11-28 | 诺基亚西门子通信公司 | 用于确定上行链路harq资源的设备、方法和制造产品 |
| JP6550123B2 (ja) * | 2014-03-18 | 2019-07-24 | フジフイルム エレクトロニック マテリアルズ ユー．エス．エー．， インコーポレイテッド | エッチング組成物 |
| RU2757983C1 (ru) * | 2020-10-06 | 2021-10-25 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт органической химии и технологии" (ФГУП "ГосНИИОХТ") | Способ получения n-гидроксиморфолина |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1004191B (de) | 1955-03-03 | 1957-03-14 | Basf Ag | Verfahren zur Herstellung von organischen Hydroxylaminverbindungen |
| IT1223330B (it) | 1987-10-29 | 1990-09-19 | Montedipe Spa | Processo per la sintesi di una n n dialchil idrossilammina |
| PL1631557T3 (pl) * | 2003-06-12 | 2007-05-31 | Btg Int Ltd | Cykliczne hydroksyloaminy jako związki psychoaktywne |
| DE10344881A1 (de) | 2003-09-26 | 2005-04-14 | Wella Ag | Mittel für die oxidative Haarbehandlung und Verfahren zur dauerhaften Haarverformung |
-
2006
- 2006-02-13 IT IT000258A patent/ITMI20060258A1/it unknown
-
2007
- 2007-02-12 BR BRPI0707910-9A patent/BRPI0707910A2/pt not_active IP Right Cessation
- 2007-02-12 DK DK07713445.0T patent/DK1991534T3/da active
- 2007-02-12 RU RU2008136880/04A patent/RU2439066C2/ru not_active IP Right Cessation
- 2007-02-12 US US12/279,323 patent/US7872007B2/en not_active Expired - Fee Related
- 2007-02-12 PT PT07713445T patent/PT1991534E/pt unknown
- 2007-02-12 CN CNA2007800051393A patent/CN101384564A/zh active Pending
- 2007-02-12 JP JP2008554914A patent/JP2009526838A/ja active Pending
- 2007-02-12 DE DE602007003326T patent/DE602007003326D1/de active Active
- 2007-02-12 WO PCT/IT2007/000088 patent/WO2007094022A1/en not_active Ceased
- 2007-02-12 AU AU2007216126A patent/AU2007216126A1/en not_active Abandoned
- 2007-02-12 EP EP07713445A patent/EP1991534B1/en not_active Not-in-force
- 2007-02-12 ES ES07713445T patent/ES2336041T3/es active Active
- 2007-02-12 AT AT07713445T patent/ATE449087T1/de active
- 2007-02-12 PL PL07713445T patent/PL1991534T3/pl unknown
- 2007-02-12 SI SI200730158T patent/SI1991534T1/sl unknown
- 2007-02-12 CA CA002641440A patent/CA2641440A1/en not_active Abandoned
- 2007-02-12 KR KR1020087018471A patent/KR20080110729A/ko not_active Ceased
-
2008
- 2008-09-10 NO NO20083880A patent/NO20083880L/no not_active Application Discontinuation
-
2010
- 2010-02-09 CY CY20101100119T patent/CY1109794T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090030199A1 (en) | 2009-01-29 |
| US7872007B2 (en) | 2011-01-18 |
| ES2336041T3 (es) | 2010-04-07 |
| RU2008136880A (ru) | 2010-03-20 |
| EP1991534A1 (en) | 2008-11-19 |
| HK1125647A1 (en) | 2009-08-14 |
| AU2007216126A1 (en) | 2007-08-23 |
| CN101384564A (zh) | 2009-03-11 |
| PT1991534E (pt) | 2010-03-19 |
| WO2007094022A1 (en) | 2007-08-23 |
| DK1991534T3 (da) | 2010-03-08 |
| CA2641440A1 (en) | 2007-08-23 |
| ITMI20060258A1 (it) | 2007-08-14 |
| RU2439066C2 (ru) | 2012-01-10 |
| KR20080110729A (ko) | 2008-12-19 |
| ATE449087T1 (de) | 2009-12-15 |
| CY1109794T1 (el) | 2014-09-10 |
| JP2009526838A (ja) | 2009-07-23 |
| PL1991534T3 (pl) | 2010-04-30 |
| EP1991534B1 (en) | 2009-11-18 |
| SI1991534T1 (sl) | 2010-03-31 |
| DE602007003326D1 (de) | 2009-12-31 |
| BRPI0707910A2 (pt) | 2011-05-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW200726754A (en) | Chemical process | |
| WO2009035130A3 (en) | Process for producing 2,3,3,3-tetrafluoropropene | |
| MX2009012020A (es) | Procedimiento para la preparacion de (3-dihalometil-1-metil-pirazo l-4-il) carboxamidas n-sustituidas. | |
| MX2009005392A (es) | Proceso para preparar carboxamidas mediante hidrolisis de carbonitrilos en la presencia de un catalizador que comprende dioxido de manganesio. | |
| UA83910C2 (ru) | Способ получения 5-гидрокси-4-тиометилпиразольного соединения | |
| WO2012099736A3 (en) | Improved process for preparation of high molecular weight molybdenum succinimide complexes | |
| MY157193A (en) | Process for production of olefin | |
| MY158755A (en) | Catalyst for reacting carboxylic acid nitriles | |
| MX2015002419A (es) | Procedimiento de descarboxilacion de derivados de acido 3,5-bis(haloalquil)-pirazol-4-carboxilico. | |
| TW200732375A (en) | Process for producing polytrimethylene ether glycol | |
| NO20083880L (no) | Fremgangsmate for fremstilling av 2-(4-hydroxy-3-morfolinyl)-2-syklohexenon | |
| NZ605608A (en) | Method of synthesis of ferroquine by convergent reductive amination | |
| WO2006040527A8 (en) | Process for making phenoxy benzamide compounds | |
| TW200833640A (en) | Process for producing cyclic olefin | |
| BR112012014347A2 (pt) | processo de epoxidação e microestrutura | |
| SG178864A1 (en) | Method for producing a compound with a double bond | |
| BRPI0507422A (pt) | processo para produção de ácido 2,5-dimetilfenilacético | |
| MX2013004193A (es) | Procedimiento para la preparacion de derivados de acido 3-(6-amino-piridin-3-il)-2-acrilico. | |
| PH12012501251A1 (en) | Method for producing tertiary amine | |
| IN2015DN00763A (no) | ||
| PL1817274T3 (pl) | Sposób wytwarzania amino- albo hydroksybenzonitryli | |
| SI2265580T1 (sl) | Novi postopek za pripravo sulfonilpirolov kot inhibitorjev HDAC | |
| SG169376A1 (en) | Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof | |
| MX343024B (es) | Nuevo procedimiento para la produccion de 4-aminobut-2-enolidas partiendo de 4-alcoxifuran-2(5h)-ona o 4-arilalcoxifuran-2-(5h)-on a. | |
| UA107368C2 (en) | Method for preparing a deperoxidation catalyst |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |