NO20090574L - Nye proteinkonjugater og fremgangsmater for fremstilling derav - Google Patents
Nye proteinkonjugater og fremgangsmater for fremstilling deravInfo
- Publication number
- NO20090574L NO20090574L NO20090574A NO20090574A NO20090574L NO 20090574 L NO20090574 L NO 20090574L NO 20090574 A NO20090574 A NO 20090574A NO 20090574 A NO20090574 A NO 20090574A NO 20090574 L NO20090574 L NO 20090574L
- Authority
- NO
- Norway
- Prior art keywords
- protein conjugates
- processes
- preparation
- novel protein
- heteroarylamines
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 150000001448 anilines Chemical class 0.000 abstract 1
- 125000005241 heteroarylamino group Chemical group 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000006268 reductive amination reaction Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06116776 | 2006-07-07 | ||
| PCT/EP2007/056819 WO2008003750A2 (en) | 2006-07-07 | 2007-07-05 | New protein conjugates and methods for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20090574L true NO20090574L (no) | 2009-03-30 |
Family
ID=38701511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20090574A NO20090574L (no) | 2006-07-07 | 2009-02-05 | Nye proteinkonjugater og fremgangsmater for fremstilling derav |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9175061B2 (pt) |
| EP (1) | EP2040757A2 (pt) |
| JP (1) | JP5252458B2 (pt) |
| KR (1) | KR20100014215A (pt) |
| CN (1) | CN101495155A (pt) |
| AU (1) | AU2007271150A1 (pt) |
| BR (1) | BRPI0713963A2 (pt) |
| CA (1) | CA2655188A1 (pt) |
| IL (1) | IL195839A0 (pt) |
| MX (1) | MX2008016169A (pt) |
| NO (1) | NO20090574L (pt) |
| RU (1) | RU2009103198A (pt) |
| TW (1) | TW200815477A (pt) |
| WO (1) | WO2008003750A2 (pt) |
| ZA (1) | ZA200810821B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
| ES2297889T3 (es) | 1997-07-14 | 2008-05-01 | Bolder Biotechnology, Inc. | Derivados de hormona de crecimiento y proteinas relacionadas. |
| CA2359345A1 (en) | 1999-01-14 | 2000-07-20 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| MX2011000847A (es) * | 2008-08-06 | 2011-02-25 | Novo Nordisk Healthcare Ag | Proteinas conjugadas con eficacia prolongada in vivo. |
| MX2011007736A (es) | 2009-01-22 | 2011-09-06 | Novo Nordisk Healthcare Ag | Compuestos de hormona del crecimiento estables. |
| WO2011015649A1 (en) * | 2009-08-06 | 2011-02-10 | Novo Nordisk Health Care Ag | Growth hormones with prolonged in-vivo efficacy |
| MX338357B (es) | 2010-01-22 | 2016-04-13 | Novo Nordisk Healthcare Ag | Compuestos estables de la hormona de crecimiento. |
| RS59459B1 (sr) * | 2010-01-22 | 2019-11-29 | Novo Nordisk Healthcare Ag | Hormoni rasta sa produženom in-vivo efikasnošću |
| BR112013018628A2 (pt) * | 2011-01-26 | 2017-07-18 | Novo Nordisk As | derivados da leptina |
| EP2842546A4 (en) | 2012-04-27 | 2015-12-30 | Univ Tokyo | PHARMACEUTICAL COMPOSITION WITH UNIT STRUCTURE FOR NUCLEIC ACID RELIEF |
| US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
| WO2016034534A1 (en) * | 2014-09-01 | 2016-03-10 | Novo Nordisk Health Care Ag | Lysine rich basic pre-sequences |
| US10400066B2 (en) | 2015-01-27 | 2019-09-03 | Hewlett-Packard Development Company, L.P. | Polymeric photoactive agents |
| WO2016122452A1 (en) * | 2015-01-27 | 2016-08-04 | Hewlett-Packard Development Company, L.P. | Polymeric amine synergists |
| WO2016122454A1 (en) | 2015-01-27 | 2016-08-04 | Hewlett-Packard Development Company, L.P. | Polymeric photo active agents |
| CN111050752B (zh) | 2017-08-31 | 2022-08-16 | 国立大学法人东京大学 | 搭载核酸的单元型聚离子复合物 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| CA1259923A (en) | 1983-08-17 | 1989-09-26 | Roger Aston | Physiologically active compositions |
| US6673347B1 (en) * | 1986-04-30 | 2004-01-06 | Gryphon Therapeutics | Polypeptide and protein derivatives and process for their preparation |
| GB8610551D0 (en) | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
| DE68924783T2 (de) | 1988-09-30 | 1996-03-28 | Neorx Corp | Wässrige additivsysteme, verfahren und polymerteilchen. |
| US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| AU2147192A (en) | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
| DE69232847T2 (de) | 1991-12-20 | 2003-09-11 | Novo Nordisk A/S, Bagsvaerd | Stabilisierte pharmazeutische formulierung, die wachstumshormon und histidin enthält |
| NZ250375A (en) | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| WO1995032003A1 (en) | 1994-05-24 | 1995-11-30 | Amgen Boulder Inc. | Modified insulin-like growth factors |
| EP0785276A4 (en) | 1994-09-29 | 2002-01-09 | Ajinomoto Kk | MODIFICATION OF A PEPTIDE AND A PROTEIN |
| US5795560A (en) * | 1994-11-01 | 1998-08-18 | Neorx Corporation | Targeting protein-diagnostic/therapeutic agent conjugates having Schiff base linkages |
| CA2204726A1 (en) | 1994-11-09 | 1996-12-27 | Robin E. Offord | Functionalized polymers for site-specific attachment |
| FI972443A7 (fi) * | 1994-12-07 | 1997-06-09 | Novozymes As | Polypeptidi, jonka allergeenisuus on vähentynyt |
| GB9526733D0 (en) * | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| US20020077461A1 (en) | 1996-04-24 | 2002-06-20 | Soren Bjorn | Pharmaceutical formulation |
| EP0964702B1 (en) * | 1996-08-02 | 2006-10-04 | Ortho-McNeil Pharmaceutical, Inc. | Polypeptides having a single covalently bound n-terminal water-soluble polymer |
| CN1231675A (zh) | 1996-09-26 | 1999-10-13 | 味之素株式会社 | 修饰的生理活性蛋白及含有该蛋白的药物组合物 |
| US6340461B1 (en) | 1996-12-17 | 2002-01-22 | David Stephen Terman | Superantigen based methods and compositions for treatment of diseases |
| CA2739933A1 (en) | 2000-02-11 | 2001-08-16 | Bayer Healthcare Llc | Factor vii or viia-like molecules |
| US6800728B2 (en) | 2000-03-22 | 2004-10-05 | Solulink Biosciences, Inc. | Hydrazine-based and carbonyl-based bifunctional crosslinking reagents |
| JP2004501191A (ja) * | 2000-06-28 | 2004-01-15 | テバ ファーマシューティカル インダストリーズ リミティド | カルベジロール |
| AU2002219021A1 (en) * | 2001-01-11 | 2002-07-24 | Maxygen Aps | Variant growth hormone molecules conjugated with macromolecular compounds |
| US7049285B2 (en) * | 2001-10-31 | 2006-05-23 | Myung-Ok Park | Biocompatible polymers including peptide spacer |
| WO2003044056A2 (en) | 2001-11-20 | 2003-05-30 | Pharmacia Corporation | Chemically-modified human growth hormone conjugates |
| UA86744C2 (en) | 2002-06-21 | 2009-05-25 | Ново Нордиск Хэлс Кеа Аг | Pegylated factor vii glycoforms |
| AU2003256566A1 (en) | 2002-07-16 | 2004-02-02 | Stuart Bussell | Methods to construct multimeric dna and polymeric protein sequences as direct fusions or with linkers |
| JP4430344B2 (ja) * | 2002-09-09 | 2010-03-10 | 独立行政法人科学技術振興機構 | 多岐用途型リンカー化合物及びリガンド、並びにそれらの製造方法 |
| TWI281864B (en) * | 2002-11-20 | 2007-06-01 | Pharmacia Corp | N-terminally monopegylated human growth hormone conjugates and process for their preparation |
| CA2527665A1 (en) | 2003-05-30 | 2004-12-16 | Centocor, Inc. | Formation of novel erythropoietin conjugates using transglutaminase |
| BRPI0412671A (pt) | 2003-08-08 | 2006-10-03 | Fresenius Kabi De Gmbh | conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima |
| CN1528797A (zh) | 2003-09-28 | 2004-09-15 | 石油大学(华东) | 含氟碳基团的超高分子量水溶性疏水缔合型聚合物及其制备方法 |
| JP2008502301A (ja) * | 2003-10-10 | 2008-01-31 | ノボ ノルディスク アクティーゼルスカブ | ペプチドの抱合 |
| US7524813B2 (en) * | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
| CN1867581B (zh) | 2003-10-10 | 2012-02-01 | 诺沃挪第克公司 | Il-21衍生物 |
| CN1243022C (zh) | 2003-10-17 | 2006-02-22 | 华东师范大学 | 生物修饰重组人生长激素复合物及其制备方法 |
| US20070105770A1 (en) * | 2004-01-21 | 2007-05-10 | Novo Nordisk A/S | Transglutaminase mediated conjugation of peptides |
| ES2642214T3 (es) | 2004-01-21 | 2017-11-15 | Novo Nordisk Health Care Ag | Conjugación de péptidos mediante transglutaminasa |
| BRPI0507169A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
| KR20070027621A (ko) * | 2004-06-08 | 2007-03-09 | 알자 코포레이션 | 4-성분 축합 반응에 의한 고분자 콘쥬게이트의 제조 |
| EP1805217A2 (en) | 2004-10-18 | 2007-07-11 | Novo Nordisk A/S | Method for the preparation of oxime, thiazolidine, dithiane, dithiolane or hydrazone linked analogues of growth hormone |
| JP2008516621A (ja) | 2004-10-18 | 2008-05-22 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン結合体 |
| BRPI0519430A2 (pt) | 2004-12-22 | 2009-02-10 | Ambrx Inc | hormânio do crescimento humano modificado |
| CN103520735B (zh) * | 2004-12-22 | 2015-11-25 | Ambrx公司 | 包含非天然编码的氨基酸的人生长激素配方 |
| MX2007015676A (es) | 2005-06-15 | 2008-02-20 | Novo Nordisk Healthcare Ag | Conjugacion de la hormona de crecimiento mediada por transglutaminasa. |
| US8293708B2 (en) * | 2005-08-30 | 2012-10-23 | Novo Nordisk Health Care A/G | Liquid formulations N-terminal serine of pegylated growth hormone |
| AU2006201635A1 (en) * | 2005-10-20 | 2007-05-10 | Ludwig Institute For Cancer Research | Novel inhibitors and methods for their preparation |
-
2007
- 2007-07-05 BR BRPI0713963-2A patent/BRPI0713963A2/pt not_active IP Right Cessation
- 2007-07-05 MX MX2008016169A patent/MX2008016169A/es not_active Application Discontinuation
- 2007-07-05 EP EP07802373A patent/EP2040757A2/en not_active Withdrawn
- 2007-07-05 WO PCT/EP2007/056819 patent/WO2008003750A2/en not_active Ceased
- 2007-07-05 JP JP2009518855A patent/JP5252458B2/ja not_active Expired - Fee Related
- 2007-07-05 KR KR20097000749A patent/KR20100014215A/ko not_active Withdrawn
- 2007-07-05 RU RU2009103198/10A patent/RU2009103198A/ru unknown
- 2007-07-05 CN CNA2007800287048A patent/CN101495155A/zh not_active Withdrawn
- 2007-07-05 US US12/309,142 patent/US9175061B2/en not_active Expired - Fee Related
- 2007-07-05 AU AU2007271150A patent/AU2007271150A1/en not_active Abandoned
- 2007-07-05 CA CA 2655188 patent/CA2655188A1/en not_active Abandoned
- 2007-07-06 TW TW96124584A patent/TW200815477A/zh unknown
-
2008
- 2008-12-10 IL IL195839A patent/IL195839A0/en unknown
- 2008-12-23 ZA ZA200810821A patent/ZA200810821B/xx unknown
-
2009
- 2009-02-05 NO NO20090574A patent/NO20090574L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL195839A0 (en) | 2009-09-01 |
| CN101495155A (zh) | 2009-07-29 |
| WO2008003750A2 (en) | 2008-01-10 |
| TW200815477A (en) | 2008-04-01 |
| BRPI0713963A2 (pt) | 2012-11-27 |
| JP5252458B2 (ja) | 2013-07-31 |
| WO2008003750A3 (en) | 2008-03-20 |
| US20110144017A1 (en) | 2011-06-16 |
| MX2008016169A (es) | 2009-01-15 |
| RU2009103198A (ru) | 2010-08-20 |
| CA2655188A1 (en) | 2008-01-10 |
| EP2040757A2 (en) | 2009-04-01 |
| KR20100014215A (ko) | 2010-02-10 |
| US9175061B2 (en) | 2015-11-03 |
| JP2009542769A (ja) | 2009-12-03 |
| ZA200810821B (en) | 2009-12-30 |
| AU2007271150A1 (en) | 2008-01-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20090574L (no) | Nye proteinkonjugater og fremgangsmater for fremstilling derav | |
| ECSP088733A (es) | Anticuerpos anti-5t4 y usos de los mismos | |
| CY1123952T1 (el) | Απομονωση και καθαρισμος αντισωματων αντι-il-13 με την χρηση χρωματογραφιας χημικης συγγενειας πρωτεινης α | |
| NO20092611L (no) | Krystallinsk faststoff Rasagilin base | |
| CY1117963T1 (el) | Αντισωματα που προσδενουν τα il-17a και il-17f | |
| EP1962838A4 (en) | Farnesoid X RECEPTOR AGONISTS | |
| NO20092052L (no) | Antistoffer og immunkonjugater, og anvendelser derav | |
| MX350375B (es) | Moleculas de union especificas de virus sincitial respiratorio y medios para producirlas. | |
| BRPI0809366B8 (pt) | polipeptídeo substancialmente alfa-helicoidal, método para fabricação do mesmo, aminoácido e composição farmacêutica | |
| CR20120371A (es) | Antagonistas de pcsk9 | |
| MX2009008430A (es) | Anticuerpos anti-robo4 y sus usos. | |
| DK2135091T3 (da) | MS-fremgangsmåder til evaluering af glykaner | |
| BRPI0819819A2 (pt) | Preparações, método e kits ùteis para o tratamento de tosse | |
| AR061246A1 (es) | Anticuerpos anti- dill4 y metodos que los usan | |
| CY1118640T1 (el) | Μορια αντισωματος που εχουν ειδικοτητα προσδεσης για την ανθρωπινη il-13 | |
| MX2011010012A (es) | NUEVOS ANTICUERPOS ANTI-A5ß1 Y SUS USOS. | |
| BRPI0508064A (pt) | flavivìrus, composição de vacina e molécula de ácido nucléico | |
| WO2011019932A3 (en) | Compositions and methods for the therapy and diagnosis of influenza | |
| CU20120021A7 (es) | Derivados amido espirocíclicos | |
| CY1115577T1 (el) | Μεθοδος για την παρασκευη εναντιομερικως καθαρων αμινων | |
| BRPI0815378A2 (pt) | as160 como proteína do tipo as160, sistemas de teste, métodos e usos envolvendo a mesma para identificação de terapêutica para diabetes tipo 2 | |
| BRPI0721386B8 (pt) | Processo para preparação de 2-substituídas -5-(1-alquiltio)-alquil piridinas, e intermediário | |
| BR112012013325A2 (pt) | Composição farmacêutica e uso | |
| BRPI0921371A2 (pt) | Células-tronco para uso terapêutico que são derivados de monócito humano, e método para induzir as mesmas. | |
| NO20091386L (no) | Fenyloksyanilinderivater |