NO20091607L - Rasjonalt designet media for cellekultur - Google Patents

Rasjonalt designet media for cellekultur

Info

Publication number
NO20091607L
NO20091607L NO20091607A NO20091607A NO20091607L NO 20091607 L NO20091607 L NO 20091607L NO 20091607 A NO20091607 A NO 20091607A NO 20091607 A NO20091607 A NO 20091607A NO 20091607 L NO20091607 L NO 20091607L
Authority
NO
Norway
Prior art keywords
concentration
amino acid
cell
media
cell culture
Prior art date
Application number
NO20091607A
Other languages
English (en)
Inventor
Denis Drapeau
Wenge Wang
Yen-Tung Luan
Ryan Nolan
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39430451&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20091607(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20091607L publication Critical patent/NO20091607L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse angår metoder for rasjonalt design av celledyrkingsmedia for anvendelse i cellekulturer, f.eks. cellekulturer anvendt i polypeptid-produksjon; celledyrkingsmedier designet med de beskrevne metodene; fremgangsmåter for å produsere et polypeptid av interesse, f.eks. et antistoff, ved anvendelse av slike media; polypeptider produsert ved anvendelse av fremgangsmåte og media beskrevet her; og farmasøytiske sammensetninger inneholdende slike polypeptider. De rasjonalt designede media inneholder en konsentrasjon av en aminosyre som er beregnet for anvendelse i cellemasse, en konsentrasjon av aminosyren som er beregnet for anvendelse i celle opprettholdelse og en konsentrasjon av aminosyren som er beregnet for inkorporering inn i polypeptidet av interesse. De rasjonalt designede media kan inneholde en baselinje-regulert konsentrasjon, A, av minst én aminosyre som blir beregnet i henhold til formelen A=[(M*X)+(N*P)+(Y*M*X)]*F, hvor X er konsentrasjonen av aminosyren som blir anvendt pr. enhet av cellemasse, P er konsentrasjonen av aminosyren som blir anvendt for inkorporering inn i polypeptidet av interesse pr. enhet av polypeptid-titer, M er multiplikatoren for den ønskede maksimale celletettheten av cellekulturen, N er multiplikatoren for den ønskede konsentrasjonen av polypeptidet av interesse, Y er celle opprettholdelses faktoren; og F er baselinje-faktoren. Disse rasjonalt designede media kan også anvendes for å fremstille et start celledyrkingsmedium omfattende en konsentrasjon, B, av minst én aminosyre i henhold til formelen B=[A-(Z*V)]/(1-V), hvor Z er en konsentrasjon av aminosyren i tilførings celledyrkingsmediet og V er et volum av tilførings dyrkningsmediet som en proporsjon av det ønskede celledyrkingsmedium-volumet.
NO20091607A 2006-11-08 2009-04-22 Rasjonalt designet media for cellekultur NO20091607L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85828906P 2006-11-08 2006-11-08
PCT/US2007/083947 WO2008063892A2 (en) 2006-11-08 2007-11-07 Rationally designed media for cell culture

Publications (1)

Publication Number Publication Date
NO20091607L true NO20091607L (no) 2009-05-28

Family

ID=39430451

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091607A NO20091607L (no) 2006-11-08 2009-04-22 Rasjonalt designet media for cellekultur

Country Status (25)

Country Link
US (2) US8232075B2 (no)
EP (2) EP2921552A1 (no)
JP (2) JP5564259B2 (no)
KR (1) KR101523782B1 (no)
CN (2) CN101535469A (no)
AR (1) AR063623A1 (no)
AU (1) AU2007323978B2 (no)
BR (1) BRPI0718713B1 (no)
CA (1) CA2668771C (no)
CL (1) CL2007003221A1 (no)
CR (1) CR10781A (no)
DK (1) DK2078071T3 (no)
EC (1) ECSP099313A (no)
ES (1) ES2538986T3 (no)
IL (1) IL198486A (no)
MX (1) MX2009004974A (no)
NO (1) NO20091607L (no)
PE (1) PE20081655A1 (no)
PL (1) PL2078071T3 (no)
PT (1) PT2078071E (no)
RU (1) RU2520810C2 (no)
SI (1) SI2078071T1 (no)
TW (1) TW200827445A (no)
WO (1) WO2008063892A2 (no)
ZA (1) ZA200903170B (no)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009004974A (es) * 2006-11-08 2009-05-20 Wyeth Corp Medios diseñado racionalmente para cultivo celular.
WO2008136398A1 (ja) 2007-04-26 2008-11-13 Chugai Seiyaku Kabushiki Kaisha 高濃度アミノ酸含有培地を用いた細胞の培養方法
WO2009023562A2 (en) * 2007-08-09 2009-02-19 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
US8178318B2 (en) * 2008-08-06 2012-05-15 Praxair Technology, Inc. Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield
CA2733152C (en) * 2008-08-06 2014-03-11 Praxair Technology, Inc. System and method for controlling a mammalian cell culture process using upward directed culture medium flow
EP4786482A2 (en) 2009-08-06 2026-08-05 F. Hoffmann-La Roche AG Virus filtration methods
US20110262965A1 (en) * 2010-04-23 2011-10-27 Life Technologies Corporation Cell culture medium comprising small peptides
LT2563906T (lt) 2010-04-26 2018-02-26 Novartis Ag Cho ląstelių kultivavimo būdas
AU2011246503B2 (en) * 2010-04-26 2013-09-26 Novartis Ag Improved cell culture medium
ES2434737T3 (es) * 2010-10-27 2013-12-17 Lonza Biologics Plc. Procedimiento rápido de selección de células (líneas celulares) dirigida
PT105484A (pt) 2011-01-14 2012-07-16 Univ Nova De Lisboa Um método de ambientómica funcional para engenharia de meio de cultura celular
SI2726600T1 (sl) 2011-07-01 2017-07-31 Amgen Inc. Sesalska celična kultura
CN103717729B (zh) 2011-07-08 2017-11-21 动量制药公司 细胞培养方法
PL3395423T3 (pl) * 2013-03-14 2024-03-18 Amgen Inc. Usuwanie wypłukanych ligandów do oczyszczania na zasadzie powinowactwa
AR095196A1 (es) * 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（一）
IL259404B2 (en) 2015-11-17 2025-08-01 Pfizer Media and fermentation methods for producing polysaccharides in bacterial cell culture
EP3440190B1 (en) * 2016-04-05 2024-08-28 Pfizer Inc. Cell culture process
CN106096077B (zh) * 2016-05-26 2019-05-21 新乡医学院 培养基优化方法
JP6314201B1 (ja) * 2016-11-21 2018-04-18 テラファーマ株式会社 樹状細胞洗浄液及びこれを用いた樹状細胞の洗浄方法、並びに樹状細胞含有組成物の調製方法
MX2019009372A (es) * 2017-02-08 2019-12-11 Pfizer Produccion a gran escala para cisteinas de anticuerpo protegidas y no protegidas y su uso en la conjugacion de proteinas terapeuticas.
GB201708655D0 (en) * 2017-05-31 2017-07-12 Ucb Biopharma Sprl Cell culture methods
IL272472B2 (en) * 2017-10-16 2026-05-01 Regeneron Pharma In-situ Raman spectroscopy systems and methods for controlling process variables in cell cultures
CN111492050A (zh) * 2017-11-16 2020-08-04 生命技术公司 用于制备液体培养基的精简型方法
JP6385607B2 (ja) * 2018-02-13 2018-09-05 テラファーマ株式会社 樹状細胞ワクチン
IL279782B2 (en) 2018-07-03 2026-05-01 Bristol Myers Squibb Co Methods for producing recombinant proteins
CN108823173A (zh) * 2018-07-24 2018-11-16 郑州伊美诺生物技术有限公司 用于杂交瘤细胞培养的补料培养基及其制备方法
CN109576203B (zh) * 2018-12-20 2021-03-23 吉林省浦生泰生物技术有限责任公司 一种基于中药添加剂的复合益生菌培养基及其制备方法
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
CN111748527B (zh) * 2020-05-15 2021-01-29 上海多宁生物科技有限公司 化学成分限定高效补料培养基及其制备方法和应用
CN113450882B (zh) * 2020-09-27 2022-03-01 深圳太力生物技术有限责任公司 一种基于人工智能的基础培养基配方开发方法及系统
JP7822149B2 (ja) 2020-10-02 2026-03-02 ファイザー・インク Ｒｓｖ ｆタンパク質生産のための細胞培養工程
GB202105424D0 (en) * 2021-04-16 2021-06-02 UCB Biopharma SRL Cell culture processes
JP2022184798A (ja) 2021-06-01 2022-12-13 ファイザー・インク ｓＦＧＦＲ３ポリペプチドを生産するための細胞培養方法
JP7190534B1 (ja) * 2021-06-14 2022-12-15 アサヒ飲料株式会社 微生物の検出方法
JP7820943B2 (ja) * 2021-10-28 2026-02-26 花王株式会社 Ｖｈｈ抗体の製造方法
CN119816584A (zh) * 2022-10-17 2025-04-11 普和希控股公司 培养控制装置以及培养控制方法
CN116334007A (zh) * 2023-04-10 2023-06-27 珠海市丽珠单抗生物技术有限公司 一种慢病毒的包装方法
KR102974214B1 (ko) * 2023-06-20 2026-06-08 (주)엑셀세라퓨틱스 세포 특성 맞춤형 배지 조성 설계 플랫폼

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282326A (en) 1978-10-12 1981-08-04 Jeanne Moldenhauer Cell culture medium supplement
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
GB8927546D0 (en) 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5122469A (en) * 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
GB2251249B (en) 1990-12-28 1995-06-21 Mogam Biotech Res Inst High-density medium for animal cell culture
USH1532H (en) 1993-11-03 1996-05-07 Genetics Institute, Inc. Adaption of mammalian cell lines to high cell densities
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
RU2141531C1 (ru) * 1999-05-26 1999-11-20 Российское акционерное общество открытого типа "Биопрепарат" Способ получения рекомбинантного инсулина человека
CA2388245C (en) 1999-10-19 2012-01-10 Kyowa Kirin Co., Ltd. The use of serum-free adapted rat cells for producing heterologous polypeptides
DE602004027905D1 (de) 2003-05-15 2010-08-12 Wyeth Llc Kontrollierte glukosezufuhr für tierzellkultur
AU2004280064A1 (en) 2003-10-09 2005-04-21 Kyowa Hakko Kirin Co., Ltd. Genomically modified cell neutralized to serum-free system
US7294484B2 (en) * 2004-08-27 2007-11-13 Wyeth Research Ireland Limited Production of polypeptides
US7300773B2 (en) * 2004-08-27 2007-11-27 Wyeth Research Ireland Limited Production of TNFR-Ig
US7335491B2 (en) * 2004-08-27 2008-02-26 Wyeth Research Ireland Limited Production of anti-abeta
JP5523674B2 (ja) 2005-02-11 2014-06-18 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 植物タンパク質加水分解産物を含有する血清フリーの細胞培養液におけるポリペプチドの生産
BRPI0608584B8 (pt) 2005-03-11 2021-05-25 Wyeth Corp métodos de recuperar um produto purificado
MX2009004974A (es) * 2006-11-08 2009-05-20 Wyeth Corp Medios diseñado racionalmente para cultivo celular.

Also Published As

Publication number Publication date
EP2078071B1 (en) 2015-03-18
US8232075B2 (en) 2012-07-31
IL198486A (en) 2015-06-30
SI2078071T1 (sl) 2015-05-29
AU2007323978B2 (en) 2012-08-16
ECSP099313A (es) 2009-06-30
EP2921552A1 (en) 2015-09-23
RU2009114855A (ru) 2010-12-20
AU2007323978A1 (en) 2008-05-29
IL198486A0 (en) 2011-08-01
CR10781A (es) 2009-06-09
JP2010508853A (ja) 2010-03-25
EP2078071A2 (en) 2009-07-15
CA2668771C (en) 2016-03-15
WO2008063892A2 (en) 2008-05-29
JP5564259B2 (ja) 2014-07-30
KR20090079254A (ko) 2009-07-21
RU2520810C2 (ru) 2014-06-27
MX2009004974A (es) 2009-05-20
CN104152395A (zh) 2014-11-19
US20130084593A1 (en) 2013-04-04
PE20081655A1 (es) 2008-12-03
BRPI0718713B1 (pt) 2019-12-24
WO2008063892A3 (en) 2008-08-28
CN104152395B (zh) 2020-03-10
HK1132300A1 (en) 2010-02-19
PL2078071T3 (pl) 2015-07-31
DK2078071T3 (en) 2015-04-20
TW200827445A (en) 2008-07-01
KR101523782B1 (ko) 2015-05-28
ZA200903170B (en) 2010-03-31
BRPI0718713A2 (pt) 2013-11-26
ES2538986T3 (es) 2015-06-25
CN101535469A (zh) 2009-09-16
CL2007003221A1 (es) 2008-05-16
JP2014128276A (ja) 2014-07-10
AR063623A1 (es) 2009-02-04
PT2078071E (pt) 2015-07-16
US20080108553A1 (en) 2008-05-08
CA2668771A1 (en) 2008-05-29

Similar Documents

Publication Publication Date Title
MX2009004974A (es) Medios diseñado racionalmente para cultivo celular.
NZ717429A (en) Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
WO2008005847A3 (en) Method of producing factor viii proteins by recombinant methods
WO2008006038A3 (en) Methods and compositions for butanol production
MY185040A (en) Cell culture improvements
EA201001435A1 (ru) Клетка, ферментирующая сахар-пентозу
PH12013501911A1 (en) Compositions and methods to sequester flue gas mercury in concrete
BRPI0914440A8 (pt) Método para produção biogênica de etanol e cianobactéria geneticamente modificada
IN2012DN01087A (no)
TN2009000190A1 (en) Lingo binding molecules and pharmaceutical use thereof
JP2008500279A5 (no)
El-Sheekh et al. Algae processing by plasma discharge technology: A review
BRPI0613543B8 (pt) Método para produção de 1,3-propanodiol usando glicerol bruto, um subproduto da produção de biodiesel
MX2010001723A (es) Formulaciones de anticuerpos y moleculas de fusion-fc usando policationes.
MY155608A (en) Powder, method for producing same, and resin composition containing same
Cai et al. Combustion behaviors and unregular emission characteristics in an ammonia–diesel engine
ATE473049T1 (de) Verfahren zur umwandlung von metallnitraten
WO2012149160A3 (en) Viruses modified with unnatural moieties and methods of use thereof
WO2012011962A3 (en) Production of arabitol
WO2008071632A3 (de) Verfahren zur isolierung von n2o
Siauciunas et al. Factors Influencing the Carbonation Kinetics of Calcium Silicate-Based Binders—An Overview
Mielcarzewicz et al. The influence of helium addition on the combustion process in a hydrogen-fueled turbulent jet ignition engine
TW200720243A (en) Process for stably operating a continuous preparation process for obtaining acrolein or acrylic acid or a mixture thereof from propane
US20170107121A1 (en) Water-soluble electrolyzed/hydrolyzed clinoptilolite fragments and nutraceutical, pharmaceutical, and environmental products based thereon
Xu et al. Optimizing Mechanical Properties and Environmental Benefits of CFBFA Composite Gravels Through Gypsum, Hydrated Lime Addition, and CO2 Carbonation Curing

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application