NO20091649L - Diaryl-, dipyridinyl- og aryl-pyridinyl-derivater, samt anvendelser derav - Google Patents

Diaryl-, dipyridinyl- og aryl-pyridinyl-derivater, samt anvendelser derav

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Publication number
NO20091649L
NO20091649L NO20091649A NO20091649A NO20091649L NO 20091649 L NO20091649 L NO 20091649L NO 20091649 A NO20091649 A NO 20091649A NO 20091649 A NO20091649 A NO 20091649A NO 20091649 L NO20091649 L NO 20091649L
Authority
NO
Norway
Prior art keywords
dipyridinyl
diaryl
aryl
well
pyridinyl derivatives
Prior art date
Application number
NO20091649A
Other languages
English (en)
Inventor
Roger Benjamin Ruggeri
George Tetteh Magnus-Aryitey
Benjamin Aaron Thuma
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20091649L publication Critical patent/NO20091649L/no

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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
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    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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Abstract

Det beskrives forbindelser av formel (I) som virker som agonister ved mu-, kappa- og/eller delta opoidreseptorer og som derfor er nyttige i behandling av sykdommer, tilstander og/eller forstyrrelser som har en fordel av slik antagonisme i dyr. Formel (I) hvor R, R1, R2a, R2b, R3, R4, V, R6, R7, R8, R9, W og X er beskrevet heri. (I)
NO20091649A 2006-11-13 2009-04-24 Diaryl-, dipyridinyl- og aryl-pyridinyl-derivater, samt anvendelser derav NO20091649L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86547906P 2006-11-13 2006-11-13
PCT/IB2007/003393 WO2008059335A1 (en) 2006-11-13 2007-11-01 Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof

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NO20091649L true NO20091649L (no) 2009-05-20

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US (1) US7615651B2 (no)
EP (1) EP2084127A1 (no)
JP (1) JP2010509392A (no)
KR (1) KR20090064478A (no)
CN (1) CN101583593A (no)
AR (1) AR063790A1 (no)
AU (1) AU2007320906A1 (no)
CA (1) CA2669311C (no)
CL (1) CL2007003198A1 (no)
IL (1) IL198236A0 (no)
MX (1) MX2009004314A (no)
NO (1) NO20091649L (no)
PE (1) PE20081116A1 (no)
TW (1) TW200826927A (no)
UY (1) UY30706A1 (no)
WO (1) WO2008059335A1 (no)

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WO2009030962A1 (en) * 2007-09-07 2009-03-12 Prosidion Limited Bicyclic aryl and heteroaryl receptor modulators
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WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
WO2014028829A1 (en) * 2012-08-16 2014-02-20 The Scripps Research Institute Novel kappa opioid ligands
AU2015249497A1 (en) * 2014-04-25 2016-10-20 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands
ES2910787T3 (es) * 2016-05-12 2022-05-13 Univ Michigan Regents Inhibidores de ASH1L y métodos de tratamiento con los mismos
CN116514645A (zh) * 2023-04-08 2023-08-01 绍兴上虞华伦化工有限公司 二氟-4溴苯甲醛及其制备工艺

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US7615651B2 (en) 2009-11-10
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CA2669311C (en) 2011-09-20
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AU2007320906A1 (en) 2008-05-22
IL198236A0 (en) 2009-12-24
US20080167371A1 (en) 2008-07-10
EP2084127A1 (en) 2009-08-05
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MX2009004314A (es) 2009-05-05
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