NO20091712L - Nye anti-CD38-antistoffer for behandling av cancer - Google Patents

Nye anti-CD38-antistoffer for behandling av cancer

Info

Publication number
NO20091712L
NO20091712L NO20091712A NO20091712A NO20091712L NO 20091712 L NO20091712 L NO 20091712L NO 20091712 A NO20091712 A NO 20091712A NO 20091712 A NO20091712 A NO 20091712A NO 20091712 L NO20091712 L NO 20091712L
Authority
NO
Norway
Prior art keywords
antibodies
treatment
cytotoxic
conjugates
antibody
Prior art date
Application number
NO20091712A
Other languages
English (en)
Other versions
NO345911B1 (no
Inventor
Peter U Park
Laura M Bartle
Anna Skaletskaya
Viktor S Golmakher
Daniel Tavares
Jutta Deckert
Vincent Mikol
Veronique Blanc
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37831721&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20091712(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20091712L publication Critical patent/NO20091712L/no
Publication of NO345911B1 publication Critical patent/NO345911B1/no

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  • Orthopedic Medicine & Surgery (AREA)

Abstract

Sammendrag Det beskrives antistoffer, humaniserte antistoffer, resurfaserte antistoffer, antistoff-fragmenter, derivatiserte antistoffer og konjugater av disse med cytotoksiske midler, som spesifikt binder til CD38 og er i stand til å avlive CD38+-celler ved apoptose, antistoffavhengig cellemediert cytotoksisitet (ADCC) og/eller komplementavhengig cytotoksisitet (CDC). Disse antistoffer og fragmenter kan benyttes ved behandling av tumorer som uttrykker CD38-protein som multippelt myelom, kronisk lymfocytisk leukemi, kronisk myelogen leukemi, akutt myelogen leukemi eller akutt lymfocytisk leukemi, eller behandling av autoimmune og inflammatoriske sykdommer som systemisk lupus erytematose, reumatoid artritt, multiple sklerose og astma. De derivatiserte antistoffer kan benyttes ved diagnose og avbildning av tumorer som uttrykker forhøyede nivåer av CD38. Det tilveiebringes videre cytotoksiske konjugater omfattende et cellebindingsmiddel og et cytotoksisk middel, terapeutiske preparater omfattende konjugatet, metoder for å benytte konjugatene ved inhibering av cellevekst og behandling av sykdom, og et sett omfattende det cytotoksiske konjugat. Særlig et det cellebindende middel et monoklonalt antistoff, eller et epitopbindende fragment derav, som gjenkjenner og binder CD38-proteinet.
NO20091712A 2006-10-19 2007-10-16 konjugater omfattende disse og farmasøytiske preparater for behandling av cancer, samt polynukleotider som koder for antistoffene, rekombinant vektor og vertscelle. NO345911B1 (no)

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NO20211026A NO348288B1 (no) 2006-10-19 2021-08-26 Polynukleotider som koder anti-CD38 antistoffer.
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