NO20092045L - Makrosykliske quinazolinderivater som VEGFR3-inhibitorer - Google Patents

Makrosykliske quinazolinderivater som VEGFR3-inhibitorer

Info

Publication number: NO20092045L
Authority: NO; Norway
Prior art keywords: vegfr3; quinazoline derivatives; inhibitors; macrocyclic quinazoline; macrocyclic
Prior art date: 2006-10-27

Application number

NO20092045A

Other languages

English (en)

Norwegian (no)

Inventor

Timothy Pietro Suren Perera

Matthias Luc A Versele

Martin John Page

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-27

Filing date

2009-05-26

Publication date

2009-06-26

2009-05-26 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2009-06-26 Publication of NO20092045L publication Critical patent/NO20092045L/no

Links

125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title abstract 2
229940127432 VEGFR3 Inhibitors Drugs 0.000 title 1
101000851030 Homo sapiens Vascular endothelial growth factor receptor 3 Proteins 0.000 abstract 2
102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 abstract 2
230000001404 mediated effect Effects 0.000 abstract 2
108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 abstract 1
108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 abstract 1
102100038232 Vascular endothelial growth factor C Human genes 0.000 abstract 1
102100038234 Vascular endothelial growth factor D Human genes 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Hematology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

NO20092045A 2006-10-27 2009-05-26 Makrosykliske quinazolinderivater som VEGFR3-inhibitorer NO20092045L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US86319806P	2006-10-27	2006-10-27
EP06123056		2006-10-27
US97621007P	2007-09-28	2007-09-28
PCT/EP2007/061499 WO2008049902A2 (en)	2006-10-27	2007-10-25	Macrocyclic quinazoline derivatives as vegfr3 inhibitors

Publications (1)

Publication Number	Publication Date
NO20092045L true NO20092045L (no)	2009-06-26

Family

ID=39324960

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20092045A NO20092045L (no)	2006-10-27	2009-05-26	Makrosykliske quinazolinderivater som VEGFR3-inhibitorer

Country Status (11)

Country	Link
EP (1)	EP2077845A2 (pt)
JP (1)	JP2010507626A (pt)
KR (1)	KR20090089849A (pt)
AU (1)	AU2007310843A1 (pt)
BR (1)	BRPI0718061A2 (pt)
CA (1)	CA2664148A1 (pt)
EA (1)	EA200970419A1 (pt)
IL (1)	IL198346A0 (pt)
MX (1)	MX2009004436A (pt)
NO (1)	NO20092045L (pt)
WO (1)	WO2008049902A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA06007017A (es)	2003-12-18	2006-08-31	Janssen Pharmaceutica Nv	Derivados de pirido y pirimidopirimidina como agentes antiproliferativos.
NI200700147A (es)	2004-12-08	2019-05-10	Janssen Pharmaceutica Nv	Derivados de quinazolina inhibidores de cinasas dirigidos a multip
JP2009542778A (ja)	2006-07-13	2009-12-03	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｍｔｋｉキナゾリン誘導体
AU2008281849B2 (en)	2007-07-27	2013-11-28	Janssen Pharmaceutica Nv	Pyrrolopyrimidines
EP2558122A4 (en) *	2010-04-15	2014-03-05	Vegenics Pty Ltd	COMBINATION TREATMENT WITH VEGF-C ANTAGONISTS
PL2710018T3 (pl)	2011-05-19	2022-04-04	Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO)	Związki makrocykliczne jako inhibitory kinaz białkowych

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JO2785B1 (en) *	2003-05-27	2014-03-15	شركة جانسين فارماسوتيكا ان. في	Quinazoline derivatives
MXPA06007017A (es) *	2003-12-18	2006-08-31	Janssen Pharmaceutica Nv	Derivados de pirido y pirimidopirimidina como agentes antiproliferativos.
JO3088B1 (ar) *	2004-12-08	2017-03-15	Janssen Pharmaceutica Nv	مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف

2007
- 2007-10-25 CA CA002664148A patent/CA2664148A1/en not_active Abandoned
- 2007-10-25 JP JP2009533850A patent/JP2010507626A/ja not_active Withdrawn
- 2007-10-25 MX MX2009004436A patent/MX2009004436A/es unknown
- 2007-10-25 KR KR1020097009081A patent/KR20090089849A/ko not_active Withdrawn
- 2007-10-25 EP EP07821862A patent/EP2077845A2/en not_active Withdrawn
- 2007-10-25 WO PCT/EP2007/061499 patent/WO2008049902A2/en not_active Ceased
- 2007-10-25 EA EA200970419A patent/EA200970419A1/ru unknown
- 2007-10-25 AU AU2007310843A patent/AU2007310843A1/en not_active Abandoned
- 2007-10-25 BR BRPI0718061-6A patent/BRPI0718061A2/pt not_active Application Discontinuation
2009
- 2009-04-23 IL IL198346A patent/IL198346A0/en unknown
- 2009-05-26 NO NO20092045A patent/NO20092045L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
MX2009004436A (es)	2009-05-22
JP2010507626A (ja)	2010-03-11
IL198346A0 (en)	2010-02-17
WO2008049902A3 (en)	2008-10-02
KR20090089849A (ko)	2009-08-24
EP2077845A2 (en)	2009-07-15
EA200970419A1 (ru)	2009-10-30
CA2664148A1 (en)	2008-05-02
BRPI0718061A2 (pt)	2013-11-05
WO2008049902A2 (en)	2008-05-02
AU2007310843A1 (en)	2008-05-02

Legal Events

Date	Code	Title	Description
2011-05-30	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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