NO20092226L - Substituerte pyrazol og triazolforbindelser som KSP-inhibitorer - Google Patents

Substituerte pyrazol og triazolforbindelser som KSP-inhibitorer

Info

Publication number
NO20092226L
NO20092226L NO20092226A NO20092226A NO20092226L NO 20092226 L NO20092226 L NO 20092226L NO 20092226 A NO20092226 A NO 20092226A NO 20092226 A NO20092226 A NO 20092226A NO 20092226 L NO20092226 L NO 20092226L
Authority
NO
Norway
Prior art keywords
triazole compounds
substituted pyrazole
ksp inhibitors
pharmaceutically acceptable
ksp
Prior art date
Application number
NO20092226A
Other languages
English (en)
Inventor
Paul A Renhowe
Yi Xia
Kris Mendenhall
Paul A Barsanti
Annette O Walter
David Duhl
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20092226L publication Critical patent/NO20092226L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Beskrevet er nye substituerte pyrazol- og triazolforbindelser med formel (I) og farmasøytisk akseptable salter, estere eller prodrug derav, sammensetninger av derivatene sammen med farmasøytisk akseptable bærere, og anvendelser derav:
NO20092226A 2006-11-13 2009-06-09 Substituerte pyrazol og triazolforbindelser som KSP-inhibitorer NO20092226L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85896406P 2006-11-13 2006-11-13
PCT/US2007/084154 WO2008063912A1 (en) 2006-11-13 2007-11-08 Substituted pyrazole and triazole compounds as ksp inhibitors

Publications (1)

Publication Number Publication Date
NO20092226L true NO20092226L (no) 2009-08-12

Family

ID=39144618

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092226A NO20092226L (no) 2006-11-13 2009-06-09 Substituerte pyrazol og triazolforbindelser som KSP-inhibitorer

Country Status (32)

Country Link
US (2) US8129358B2 (no)
EP (1) EP2091926B1 (no)
JP (1) JP5264755B2 (no)
KR (1) KR20090081020A (no)
CN (1) CN101558049B (no)
AR (1) AR063805A1 (no)
AU (1) AU2007323998B2 (no)
BR (1) BRPI0719002A2 (no)
CA (1) CA2668661A1 (no)
CL (1) CL2007003272A1 (no)
CO (1) CO6382171A2 (no)
CR (1) CR10787A (no)
DO (1) DOP2009000106A (no)
EA (1) EA017748B1 (no)
EC (1) ECSP099326A (no)
ES (1) ES2557478T3 (no)
GE (1) GEP20125389B (no)
GT (1) GT200900122A (no)
HN (1) HN2009000968A (no)
IL (1) IL198471A0 (no)
MA (1) MA30959B1 (no)
MX (1) MX2009005071A (no)
NI (1) NI200900084A (no)
NO (1) NO20092226L (no)
NZ (1) NZ576640A (no)
PE (1) PE20081169A1 (no)
SM (1) SMP200900045B (no)
TN (1) TN2009000178A1 (no)
TW (1) TW200831480A (no)
UA (1) UA97256C2 (no)
WO (1) WO2008063912A1 (no)
ZA (1) ZA200902940B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009005071A (es) * 2006-11-13 2009-05-25 Novartis Ag Compuestos de pirazol y triazol sustituidos como inhibidores de ksp.
GEP20125415B (en) * 2007-01-05 2012-03-12 Novartis Ag Imidazole derivatives as kinesin spindle protein inhibitors (eg-5)
EP2558450A1 (en) * 2010-04-15 2013-02-20 Novartis AG Triazole compounds as ksp inhibitors
WO2011128388A2 (en) * 2010-04-15 2011-10-20 Novartis Ag Oxazole and thiazole compounds as ksp inhibitors
CN104994855B (zh) * 2012-12-05 2018-06-05 默沙东公司 制备逆转录酶抑制剂的方法
EP2968591A1 (en) * 2013-03-15 2016-01-20 Novartis AG Cell proliferation inhibitors and conjugates thereof
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
KR101803671B1 (ko) 2013-12-04 2017-11-30 머크 샤프 앤드 돔 코포레이션 역전사효소 억제제의 제조 방법
WO2016020791A1 (en) 2014-08-05 2016-02-11 Novartis Ag Ckit antibody drug conjugates
WO2017097927A1 (en) * 2015-12-11 2017-06-15 Syngenta Participations Ag Pesticidally active 1,2,4-triazole derivatives
WO2021138540A1 (en) 2020-01-03 2021-07-08 Berg Llc Polycyclic amides as ube2k modulators for treating cancer

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Also Published As

Publication number Publication date
KR20090081020A (ko) 2009-07-27
AU2007323998A1 (en) 2008-05-29
SMAP200900045A (it) 2009-07-14
EP2091926B1 (en) 2015-10-21
CN101558049A (zh) 2009-10-14
WO2008063912A1 (en) 2008-05-29
ZA200902940B (en) 2010-05-26
ECSP099326A (es) 2009-06-30
HN2009000968A (es) 2011-10-25
EP2091926A1 (en) 2009-08-26
US20080200462A1 (en) 2008-08-21
US8129358B2 (en) 2012-03-06
EA017748B1 (ru) 2013-02-28
SMP200900045B (it) 2010-03-01
CO6382171A2 (es) 2012-02-15
GEP20125389B (en) 2012-01-25
JP5264755B2 (ja) 2013-08-14
EA200900631A1 (ru) 2009-12-30
AR063805A1 (es) 2009-02-18
US7902240B2 (en) 2011-03-08
NI200900084A (es) 2010-01-29
CN101558049B (zh) 2012-08-15
JP2010509365A (ja) 2010-03-25
US20100034813A1 (en) 2010-02-11
CL2007003272A1 (es) 2008-03-24
TN2009000178A1 (en) 2010-10-18
CR10787A (es) 2009-07-02
TW200831480A (en) 2008-08-01
MA30959B1 (fr) 2009-12-01
AU2007323998B2 (en) 2011-09-22
MX2009005071A (es) 2009-05-25
UA97256C2 (ru) 2012-01-25
PE20081169A1 (es) 2008-09-24
ES2557478T3 (es) 2016-01-26
NZ576640A (en) 2011-10-28
BRPI0719002A2 (pt) 2013-12-17
DOP2009000106A (es) 2009-05-31
GT200900122A (es) 2011-09-14
IL198471A0 (en) 2010-02-17
CA2668661A1 (en) 2008-05-29

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