NO20092336L - O-substituerte-dibenzyl urea-derivater som TRPV 1 reseptorantagonister - Google Patents

O-substituerte-dibenzyl urea-derivater som TRPV 1 reseptorantagonister

Info

Publication number: NO20092336L
Authority: NO; Norway
Prior art keywords: hydroxypropyl; pain; trpv; substituted; dihydroxypropyl
Prior art date: 2006-12-21

Application number

NO20092336A

Other languages

English (en)

Norwegian (no)

Inventor

Pier Giovanni Baraldi

Pier Andrea Borea

Pierangelo Geppetti

Francesca Fruttarolo

Maria Giovanna Pavani

Marcello Trevisani

Original Assignee

Pharmeste Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-21

Filing date

2009-06-18

Publication date

2009-06-18

2009-06-18 Application filed by Pharmeste Srl filed Critical Pharmeste Srl

2009-06-18 Publication of NO20092336L publication Critical patent/NO20092336L/no

Links

108010025083 TRPV1 receptor Proteins 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
-1 2,3-dihydroxypropyl Chemical group 0.000 abstract 9
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 abstract 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 abstract 1
125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 abstract 1
125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 abstract 1
125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
208000004454 Hyperalgesia Diseases 0.000 abstract 1
208000035154 Hyperesthesia Diseases 0.000 abstract 1
206010020853 Hypertonic bladder Diseases 0.000 abstract 1
208000009722 Overactive Urinary Bladder Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
208000018569 Respiratory Tract disease Diseases 0.000 abstract 1
206010045171 Tumour pain Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
208000014617 hemorrhoid Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
230000004968 inflammatory condition Effects 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
125000006203 morpholinoethyl group Chemical group [H]C([H])(*)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 abstract 1
208000004296 neuralgia Diseases 0.000 abstract 1
208000021722 neuropathic pain Diseases 0.000 abstract 1
208000020629 overactive bladder Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
210000002345 respiratory system Anatomy 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
- C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO20092336A 2006-12-21 2009-06-18 O-substituerte-dibenzyl urea-derivater som TRPV 1 reseptorantagonister NO20092336L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06026533A EP1939173A1 (en)	2006-12-21	2006-12-21	O-substituted-dibenzyl urea- or thiourea- derivatives as trpv1 receptor antagonists
PCT/IB2007/003784 WO2008075150A1 (en)	2006-12-21	2007-12-06	O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists

Publications (1)

Publication Number	Publication Date
NO20092336L true NO20092336L (no)	2009-06-18

Family

ID=38139789

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20092336A NO20092336L (no)	2006-12-21	2009-06-18	O-substituerte-dibenzyl urea-derivater som TRPV 1 reseptorantagonister

Country Status (25)

Country	Link
US (1)	US7750049B2 (sr)
EP (2)	EP1939173A1 (sr)
JP (1)	JP5302214B2 (sr)
KR (1)	KR101460177B1 (sr)
CN (1)	CN101563317B (sr)
AT (1)	ATE479652T1 (sr)
BR (1)	BRPI0720421A2 (sr)
CA (1)	CA2673219C (sr)
CY (1)	CY1110833T1 (sr)
DE (1)	DE602007008942D1 (sr)
DK (1)	DK2094653T3 (sr)
EA (1)	EA015152B1 (sr)
ES (1)	ES2347492T3 (sr)
HR (1)	HRP20100588T1 (sr)
IL (1)	IL199422A (sr)
MX (1)	MX2009006582A (sr)
NO (1)	NO20092336L (sr)
NZ (1)	NZ577796A (sr)
PL (1)	PL2094653T3 (sr)
PT (1)	PT2094653E (sr)
RS (1)	RS51555B (sr)
SI (1)	SI2094653T1 (sr)
UA (1)	UA95986C2 (sr)
WO (1)	WO2008075150A1 (sr)
ZA (1)	ZA200904278B (sr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101868443A (zh)	2007-09-20	2010-10-20	特拉维夫大学拉莫特有限公司	N-苯基邻氨基苯甲酸衍生物及其用途
US11123272B2 (en)	2016-12-02	2021-09-21	Symrise Ag	Cosmetic blends
RU2755206C1 (ru)	2020-05-20	2021-09-14	Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН)	Средство пролонгированного анальгетического действия и лекарственный препарат на его основе

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8715357D0 (en) *	1987-06-30	1987-08-05	Sandoz Inst For Medical Resear	Organic compounds
GB9519270D0 (en) *	1995-09-21	1995-11-22	Sandoz Pharma Uk	Organic compounds
CA2417507A1 (en) *	2000-08-21	2002-02-28	Pacific Corporation	Novel thiourea derivatives and the pharmaceutical compositions containing the same
JP2003192660A (ja) *	2001-12-26	2003-07-09	Bayer Ag	尿素誘導体
US6858615B2 (en) *	2002-02-19	2005-02-22	Parion Sciences, Inc.	Phenyl guanidine sodium channel blockers
ITMI20041231A1 (it) *	2004-06-18	2004-09-18	Pharmeste Srl	Antagonisti del recettore dei vanilloidi trpv1

2006
- 2006-12-21 EP EP06026533A patent/EP1939173A1/en not_active Withdrawn
2007
- 2007-06-12 UA UAA200904805A patent/UA95986C2/uk unknown
- 2007-12-06 ES ES07848984T patent/ES2347492T3/es active Active
- 2007-12-06 HR HR20100588T patent/HRP20100588T1/hr unknown
- 2007-12-06 DE DE602007008942T patent/DE602007008942D1/de active Active
- 2007-12-06 KR KR1020097012641A patent/KR101460177B1/ko not_active Expired - Fee Related
- 2007-12-06 JP JP2009542247A patent/JP5302214B2/ja active Active
- 2007-12-06 CA CA2673219A patent/CA2673219C/en active Active
- 2007-12-06 ZA ZA200904278A patent/ZA200904278B/xx unknown
- 2007-12-06 WO PCT/IB2007/003784 patent/WO2008075150A1/en not_active Ceased
- 2007-12-06 PL PL07848984T patent/PL2094653T3/pl unknown
- 2007-12-06 CN CN2007800469258A patent/CN101563317B/zh active Active
- 2007-12-06 US US12/519,753 patent/US7750049B2/en active Active
- 2007-12-06 RS RSP-2010/0441A patent/RS51555B/sr unknown
- 2007-12-06 NZ NZ577796A patent/NZ577796A/en not_active IP Right Cessation
- 2007-12-06 EP EP07848984A patent/EP2094653B1/en active Active
- 2007-12-06 DK DK07848984.6T patent/DK2094653T3/da active
- 2007-12-06 BR BRPI0720421-3A patent/BRPI0720421A2/pt not_active IP Right Cessation
- 2007-12-06 PT PT07848984T patent/PT2094653E/pt unknown
- 2007-12-06 EA EA200900625A patent/EA015152B1/ru not_active IP Right Cessation
- 2007-12-06 SI SI200730412T patent/SI2094653T1/sl unknown
- 2007-12-06 MX MX2009006582A patent/MX2009006582A/es active IP Right Grant
- 2007-12-06 AT AT07848984T patent/ATE479652T1/de active
2009
- 2009-06-18 NO NO20092336A patent/NO20092336L/no not_active Application Discontinuation
- 2009-06-18 IL IL199422A patent/IL199422A/en active IP Right Grant
2010
- 2010-10-18 CY CY20101100925T patent/CY1110833T1/el unknown

Also Published As

Publication number	Publication date
CN101563317A (zh)	2009-10-21
CA2673219C (en)	2015-04-14
MX2009006582A (es)	2009-07-02
EA015152B1 (ru)	2011-06-30
WO2008075150A1 (en)	2008-06-26
ES2347492T3 (es)	2010-10-29
EA200900625A1 (ru)	2009-12-30
EP2094653B1 (en)	2010-09-01
DE602007008942D1 (de)	2010-10-14
IL199422A (en)	2015-01-29
CN101563317B (zh)	2012-12-12
NZ577796A (en)	2011-10-28
RS51555B (sr)	2011-06-30
UA95986C2 (uk)	2011-09-26
BRPI0720421A2 (pt)	2013-12-31
SI2094653T1 (sl)	2011-01-31
PT2094653E (pt)	2010-09-23
JP5302214B2 (ja)	2013-10-02
ZA200904278B (en)	2010-08-25
PL2094653T3 (pl)	2011-02-28
CA2673219A1 (en)	2008-06-26
HRP20100588T1 (hr)	2010-12-31
EP2094653A1 (en)	2009-09-02
ATE479652T1 (de)	2010-09-15
US20100105740A1 (en)	2010-04-29
JP2010513455A (ja)	2010-04-30
EP1939173A1 (en)	2008-07-02
KR20090090347A (ko)	2009-08-25
US7750049B2 (en)	2010-07-06
DK2094653T3 (da)	2010-10-25
KR101460177B1 (ko)	2014-11-10
CY1110833T1 (el)	2015-06-10

Legal Events

Date	Code	Title	Description
2018-07-09	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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