NO20092762L - 2-aza-bicyklo[3.1.0]heksanderivater - Google Patents

2-aza-bicyklo[3.1.0]heksanderivater

Info

Publication number
NO20092762L
NO20092762L NO20092762A NO20092762A NO20092762L NO 20092762 L NO20092762 L NO 20092762L NO 20092762 A NO20092762 A NO 20092762A NO 20092762 A NO20092762 A NO 20092762A NO 20092762 L NO20092762 L NO 20092762L
Authority
NO
Norway
Prior art keywords
aza
bicyclo
hexane derivatives
hexane
derivatives
Prior art date
Application number
NO20092762A
Other languages
English (en)
Inventor
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
Thierry Sifferlen
Daniel Trachsel
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of NO20092762L publication Critical patent/NO20092762L/no

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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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Abstract

Oppfinnelsen vedrører nye 2-aza-bicyklo[3.1.0]heksanderivater med formel (I), Formel (I) hvori A, B, n og R1 er som beskrevet i beskrivelsen, og anvendelsen av slike forbindelser, eller av farmasøytisk akseptable salter av slike forbindelser, som medikamenter, spesielt som oreksinreseptorantagonister.
NO20092762A 2006-12-28 2009-07-27 2-aza-bicyklo[3.1.0]heksanderivater NO20092762L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006055042 2006-12-28
PCT/IB2007/055326 WO2008081399A2 (en) 2006-12-28 2007-12-28 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists

Publications (1)

Publication Number Publication Date
NO20092762L true NO20092762L (no) 2009-07-27

Family

ID=39343649

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092762A NO20092762L (no) 2006-12-28 2009-07-27 2-aza-bicyklo[3.1.0]heksanderivater

Country Status (28)

Country Link
US (1) US8288435B2 (no)
EP (1) EP2094690B1 (no)
JP (1) JP2010514751A (no)
KR (1) KR20090094168A (no)
CN (1) CN101568536B (no)
AR (1) AR064561A1 (no)
AT (1) ATE505467T1 (no)
AU (1) AU2007340944B2 (no)
BR (1) BRPI0720876A2 (no)
CA (1) CA2669821A1 (no)
CL (1) CL2007003827A1 (no)
CY (1) CY1111705T1 (no)
DE (1) DE602007013937D1 (no)
DK (1) DK2094690T3 (no)
ES (1) ES2364297T3 (no)
HR (1) HRP20110509T1 (no)
MA (1) MA31000B1 (no)
MX (1) MX2009006860A (no)
MY (1) MY157344A (no)
NO (1) NO20092762L (no)
NZ (1) NZ578642A (no)
PL (1) PL2094690T3 (no)
PT (1) PT2094690E (no)
RU (1) RU2460732C2 (no)
SI (1) SI2094690T1 (no)
TW (1) TW200833328A (no)
WO (1) WO2008081399A2 (no)
ZA (1) ZA200905229B (no)

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US8133901B2 (en) 2006-12-01 2012-03-13 Actelion Pharmaceuticals Ltd. 3-heteroaryl (amino or amido)-1-(biphenyl or phenylthiazolyl) carbonylpiperidine derivatives as orexin receptor inhibitors
CL2008000836A1 (es) * 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras.
US8030495B2 (en) 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
CA2699328A1 (en) * 2007-09-24 2009-04-02 Actelion Pharmaceuticals Ltd Pyrrolidines and piperidines as orexin receptor antagonists
BRPI0908096A2 (pt) * 2008-02-21 2015-08-25 Actelion Pharmaceuticals Ltd Derivado de 2-aza-biciclo [2.2.1] heptano
CN102015645B (zh) * 2008-04-30 2012-11-14 埃科特莱茵药品有限公司 哌啶和吡咯烷化合物
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CA2785957C (en) 2009-12-29 2015-06-16 Suven Life Sciences Limited .alpha.4.beta.2 neuronal nicotinic acetylcholine receptor ligands
SI2626350T1 (sl) * 2010-09-22 2015-09-30 Eisai R&D Management Co., Ltd. Spojina ciklopropana
US9012489B2 (en) * 2011-08-03 2015-04-21 Boehringer Ingelheim International Gmbh Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament
WO2013050938A1 (en) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
ITMI20112329A1 (it) * 2011-12-21 2013-06-22 Rottapharm Spa Nuovi derivati spiro amminici
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WO2013119639A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
ITMI20120424A1 (it) 2012-03-19 2013-09-20 Rottapharm Spa Composti chimici
TWI570120B (zh) 2012-06-04 2017-02-11 艾克泰聯製藥有限公司 苯并咪唑脯胺酸衍生物
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