NO20101420L - Fremgangsmate for fremstilling av en blanding av R- og S-citalopram med mer enn 50 % av S- eller R-enantiomeren - Google Patents

Fremgangsmate for fremstilling av en blanding av R- og S-citalopram med mer enn 50 % av S- eller R-enantiomeren

Info

Publication number
NO20101420L
NO20101420L NO20101420A NO20101420A NO20101420L NO 20101420 L NO20101420 L NO 20101420L NO 20101420 A NO20101420 A NO 20101420A NO 20101420 A NO20101420 A NO 20101420A NO 20101420 L NO20101420 L NO 20101420L
Authority
NO
Norway
Prior art keywords
enantiomer
mixture
citalopram
preparing
benzonitrile
Prior art date
Application number
NO20101420A
Other languages
English (en)
Other versions
NO335106B1 (no
Inventor
Hans Petersen
Ole Nielsen
Michael Harold Rock
Rikke Eva Humble
Troels Volsgaard Christensen
Robert James Dancer
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20101420L publication Critical patent/NO20101420L/no
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of NO335106B1 publication Critical patent/NO335106B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Oppfinnelsen vedrører en fremgangsmåte for fremstillingen av en blanding av R- og S-citalopram med mer enn 50 % av S-enantiomeren hvor en blanding av R- og S-4-[4-(dimetylamino)-1-(4'-fluorfenyl)-1-hydroksybutyl]-3-(hydroksymetyl)benzonitril med mer enn 50 % av R-enantiomeren underkastes ringlukking i nærvær av en syre. Tilsvarende vedrører oppfinnelsen en fremgangsmåte for fremstillingen av en blanding av R- og S-citalopram med mer enn 50 % av R-enantiomeren hvor en blanding av R- og S-4-[4-(dimetylamino)-1-(4'-fluorfenyl)-1-hydroksybutyl]-3-(hydroksymetyl)benzonitril med mer enn 50 % av S-enantiomeren underkastes ringlukking i nærvær av en syre.
NO20101420A 2001-06-25 2010-10-13 Fremgangsmåte for fremstilling av en blanding av R- og S-citalopram med mer enn 50 % av S- eller R-enantiomeren NO335106B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200100991 2001-06-25
PCT/DK2002/000426 WO2003000672A1 (en) 2001-06-25 2002-06-25 Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram

Publications (2)

Publication Number Publication Date
NO20101420L true NO20101420L (no) 2003-12-18
NO335106B1 NO335106B1 (no) 2014-09-15

Family

ID=8160584

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20035671A NO329873B1 (no) 2001-06-25 2003-12-18 Fremgangsmate for fremstilling av racemisk citalopram og/eller R- eller S-citalopram ved separasjon av en blanding av R- og S-citalopram med mer enn 50 % av en av enantiomerene
NO20101420A NO335106B1 (no) 2001-06-25 2010-10-13 Fremgangsmåte for fremstilling av en blanding av R- og S-citalopram med mer enn 50 % av S- eller R-enantiomeren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20035671A NO329873B1 (no) 2001-06-25 2003-12-18 Fremgangsmate for fremstilling av racemisk citalopram og/eller R- eller S-citalopram ved separasjon av en blanding av R- og S-citalopram med mer enn 50 % av en av enantiomerene

Country Status (39)

Country Link
US (1) US7112686B2 (no)
EP (1) EP1412341B1 (no)
JP (2) JP4377219B2 (no)
KR (4) KR20080100498A (no)
CN (2) CN101440079B (no)
AR (2) AR034612A1 (no)
AT (1) ATE284395T1 (no)
BG (1) BG66372B1 (no)
BR (1) BRPI0210574B8 (no)
CA (2) CA2691149C (no)
CO (1) CO5550420A2 (no)
CZ (1) CZ305034B6 (no)
DE (1) DE60202216T2 (no)
DK (1) DK1412341T3 (no)
EA (1) EA006446B1 (no)
ES (1) ES2233834T3 (no)
HR (1) HRP20031075B1 (no)
HU (1) HU228476B1 (no)
IL (1) IL159229A0 (no)
IS (1) IS2426B (no)
JO (1) JO2389B1 (no)
MA (1) MA26260A1 (no)
ME (2) ME00027B (no)
MX (1) MXPA03011770A (no)
MY (1) MY133471A (no)
NO (2) NO329873B1 (no)
NZ (1) NZ530104A (no)
PE (1) PE20030122A1 (no)
PL (1) PL366560A1 (no)
PT (1) PT1412341E (no)
RS (1) RS50673B (no)
SI (1) SI1412341T1 (no)
SK (1) SK287696B6 (no)
TN (1) TNSN02062A1 (no)
TW (1) TWI236473B (no)
UA (1) UA75147C2 (no)
UY (2) UY27356A1 (no)
WO (1) WO2003000672A1 (no)
ZA (1) ZA200309633B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
EP2363389A1 (en) 2002-12-23 2011-09-07 H. Lundbeck A/S A process for the preparation of racemic citalopram diol and/or S- or R-citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram
EA009061B1 (ru) * 2002-12-23 2007-10-26 Х. Лундбекк А/С Способ получения рацемического циталопрамдиола и/или s- или r- циталопрамдиолов и способ получения рацемического циталопрама, r-циталопрама и /или s-циталопрама
AU2003287919B2 (en) 2002-12-23 2009-11-12 H. Lundbeck A/S Escitalopram hydrobromide and a method for the preparation thereof
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20050196453A1 (en) 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
WO2005084643A1 (en) * 2004-03-05 2005-09-15 H. Lundbeck A/S Crystalline composition containing escitalopram oxalate
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
ES2285972T1 (es) 2004-08-23 2007-12-01 Sun Pharmaceutical Industries Limited Procedimiento de fabricacion de citalopram y enantiomeros.
WO2006123243A2 (en) * 2005-05-20 2006-11-23 Aurobindo Pharma Limited Pharmaceutical dosage forms comprising escitalopram in form of granules
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
EA200801081A1 (ru) 2005-10-14 2008-10-30 Х. Лундбекк А/С Способы лечения расстройств центральной нервной системы комбинацией малых доз эсциталопрама и бупропиона
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
FI121570B (fi) 2007-09-11 2011-01-14 Lundbeck & Co As H Menetelmä essitalopraamin valmistamiseksi
US8022232B2 (en) * 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN101560199B (zh) * 2008-04-16 2013-09-18 北京德众万全药物技术开发有限公司 一种依地普仑的制备方法
TWI381813B (zh) 2010-01-12 2013-01-11 Taiwan Paiho Ltd A Velcro assembly for a foamed article and a foamed article comprising the adhesive tape assembly

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
HRP20020344B1 (hr) * 1999-10-25 2010-10-31 H. Lundbeck A/S Način priprave citaloprama

Also Published As

Publication number Publication date
HRP20031075A2 (en) 2004-04-30
BG108532A (bg) 2005-04-30
UY27356A1 (es) 2003-01-31
NO20035671L (no) 2003-12-18
JP4377219B2 (ja) 2009-12-02
JP2004536093A (ja) 2004-12-02
NZ530104A (en) 2006-08-31
NO335106B1 (no) 2014-09-15
EA200400082A1 (ru) 2004-06-24
KR20090031958A (ko) 2009-03-30
DE60202216D1 (de) 2005-01-13
BR0210574B1 (pt) 2014-03-04
EA006446B1 (ru) 2005-12-29
MA26260A1 (fr) 2004-09-01
NO329873B1 (no) 2011-01-17
CZ2004131A3 (cs) 2004-04-14
KR100902530B1 (ko) 2009-06-15
TWI236473B (en) 2005-07-21
HK1132729A1 (en) 2010-03-05
MEP1508A (xx) 2010-02-10
SK512004A3 (en) 2004-05-04
IS2426B (is) 2008-10-15
CN101440079B (zh) 2011-05-25
NO20035671D0 (no) 2003-12-18
CA2691149C (en) 2011-09-13
AR034612A1 (es) 2004-03-03
TNSN02062A1 (en) 2005-12-23
AU2002344948B2 (en) 2007-08-16
JO2389B1 (en) 2007-06-17
HK1068627A1 (zh) 2005-04-29
BR0210574A (pt) 2004-08-03
WO2003000672A1 (en) 2003-01-03
RS50673B (sr) 2010-06-30
KR20080100498A (ko) 2008-11-18
RS101403A (sr) 2007-02-05
DE60202216T2 (de) 2005-12-08
ZA200309633B (en) 2005-02-23
CN1520405A (zh) 2004-08-11
KR20040030702A (ko) 2004-04-09
PT1412341E (pt) 2005-04-29
AR083483A2 (es) 2013-02-27
DK1412341T3 (da) 2005-04-04
CA2450890A1 (en) 2003-01-03
JP2009203233A (ja) 2009-09-10
US7112686B2 (en) 2006-09-26
CA2450890C (en) 2011-02-15
JP5064436B2 (ja) 2012-10-31
BRPI0210574B8 (pt) 2021-05-25
IS7068A (is) 2003-12-08
ME00027B (me) 2010-02-10
EP1412341A1 (en) 2004-04-28
CO5550420A2 (es) 2005-08-31
UY35850A (es) 2016-06-30
HUP0400293A2 (hu) 2004-09-28
HU228476B1 (en) 2013-03-28
US20040259940A1 (en) 2004-12-23
UA75147C2 (en) 2006-03-15
CN101440079A (zh) 2009-05-27
PL366560A1 (en) 2005-02-07
SK287696B6 (sk) 2011-06-06
MY133471A (en) 2007-11-30
BG66372B1 (bg) 2013-10-31
ES2233834T3 (es) 2005-06-16
KR20100052550A (ko) 2010-05-19
SI1412341T1 (en) 2005-04-30
CA2691149A1 (en) 2003-01-03
CN100429208C (zh) 2008-10-29
HUP0400293A3 (en) 2007-05-29
IL159229A0 (en) 2004-06-01
KR100939945B1 (ko) 2010-02-04
MXPA03011770A (es) 2004-04-02
CZ305034B6 (cs) 2015-04-08
ATE284395T1 (de) 2004-12-15
PE20030122A1 (es) 2003-02-12
EP1412341B1 (en) 2004-12-08
HRP20031075B1 (en) 2011-12-31

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