DK1412341T3 - Fremgangsmåde til fremstilling af racemisk citalopram og/eller S- eller R-citalopram ved separation af en blanding af R- og S-citalopram - Google Patents

Fremgangsmåde til fremstilling af racemisk citalopram og/eller S- eller R-citalopram ved separation af en blanding af R- og S-citalopram

Info

Publication number: DK1412341T3
Authority: DK; Denmark
Prior art keywords: citalopram; separating; mixture; preparation; racemic
Prior art date: 2001-06-25

Application number

DK02742848T

Other languages

English (en)

Inventor

Troels Volsgaard Christensen

Robert Dancer

Rikke Eva Humble

Michael Harold Rock

Ole Nielsen

Hans Petersen

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-25

Filing date

2002-06-25

Publication date

2005-04-04

2002-06-25 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2005-04-04 Application granted granted Critical

2005-04-04 Publication of DK1412341T3 publication Critical patent/DK1412341T3/da

Links

WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title 2
229960001653 citalopram Drugs 0.000 title 2
239000000203 mixture Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK02742848T 2001-06-25 2002-06-25 Fremgangsmåde til fremstilling af racemisk citalopram og/eller S- eller R-citalopram ved separation af en blanding af R- og S-citalopram DK1412341T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DKPA200100991		2001-06-25
EP02742848A EP1412341B1 (en)	2001-06-25	2002-06-25	Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram
PCT/DK2002/000426 WO2003000672A1 (en)	2001-06-25	2002-06-25	Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram

Publications (1)

Publication Number	Publication Date
DK1412341T3 true DK1412341T3 (da)	2005-04-04

Family

ID=8160584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02742848T DK1412341T3 (da)	2001-06-25	2002-06-25	Fremgangsmåde til fremstilling af racemisk citalopram og/eller S- eller R-citalopram ved separation af en blanding af R- og S-citalopram

Country Status (39)

Country	Link
US (1)	US7112686B2 (da)
EP (1)	EP1412341B1 (da)
JP (2)	JP4377219B2 (da)
KR (4)	KR20080100498A (da)
CN (2)	CN100429208C (da)
AR (2)	AR034612A1 (da)
AT (1)	ATE284395T1 (da)
BG (1)	BG66372B1 (da)
BR (1)	BRPI0210574B8 (da)
CA (2)	CA2691149C (da)
CO (1)	CO5550420A2 (da)
CZ (1)	CZ305034B6 (da)
DE (1)	DE60202216T2 (da)
DK (1)	DK1412341T3 (da)
EA (1)	EA006446B1 (da)
ES (1)	ES2233834T3 (da)
HR (1)	HRP20031075B1 (da)
HU (1)	HU228476B1 (da)
IL (1)	IL159229A0 (da)
IS (1)	IS2426B (da)
JO (1)	JO2389B1 (da)
MA (1)	MA26260A1 (da)
ME (2)	MEP1508A (da)
MX (1)	MXPA03011770A (da)
MY (1)	MY133471A (da)
NO (2)	NO329873B1 (da)
NZ (1)	NZ530104A (da)
PE (1)	PE20030122A1 (da)
PL (1)	PL366560A1 (da)
PT (1)	PT1412341E (da)
RS (1)	RS50673B (da)
SI (1)	SI1412341T1 (da)
SK (1)	SK287696B6 (da)
TN (1)	TNSN02062A1 (da)
TW (1)	TWI236473B (da)
UA (1)	UA75147C2 (da)
UY (2)	UY27356A1 (da)
WO (1)	WO2003000672A1 (da)
ZA (1)	ZA200309633B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR040970A1 (es)	2002-08-12	2005-04-27	Lundbeck & Co As H	Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
CN100349885C (zh)	2002-12-23	2007-11-21	H·隆德贝克有限公司	依他普仑氢溴酸盐及其制备方法
KR101076640B1 (ko) *	2002-12-23	2011-10-27	하. 룬트벡 아크티에 셀스카브	라세미 시탈로프람 디올 및/또는 ｓ― 또는 ｒ―시탈로프람디올의 제조 방법 및 라세미 시탈로프람, ｒ―시탈로프람및/또는 ｓ―시탈로프람의 제조를 위한 상기 디올의 용도
WO2004056754A1 (en) *	2002-12-23	2004-07-08	H. Lundbeck A/S	A process for the preparation of racemic citalopram diol and/or s- or r- citalopram diols and the use of such diols for the preparation of racemic citalopram, r-citalopram and/or s-citalopram
TR200504022T1 (tr) *	2003-03-24	2006-08-21	Hetero Drugs Limited	(S)-sitalopram oksalatın yeni sıvı kristal formları.
CN100569765C (zh) *	2003-12-19	2009-12-16	杭州民生药业集团有限公司	西酞普兰中间体晶体碱
TWI339651B (en) *	2004-02-12	2011-04-01	Lundbeck & Co As H	Method for the separation of intermediates which may be used for the preparation of escitalopram
BRPI0508266A (pt) *	2004-03-05	2007-07-31	Lundbeck & Co As H	partìculas cristalinas de oxalato de escitalopram, forma de dosagem única sólida, e, métodos para a fabricação de partìculas cristalinas de oxalato de escitalopram e para reduzir a quantidade de hidroxila que contém impurezas no citalopram, escitalopram ou uma mistura não racêmica de r- e s-citalopram
US20050196453A1 (en)	2004-03-05	2005-09-08	H. Lundbeck A/S	Crystalline composition containing escitalopram
ITMI20040717A1 (it)	2004-04-09	2004-07-09	Adorkem Technology Spa	Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) *	2004-06-25	2006-01-12	Sumitomo Chemical Co Ltd	光学活性シタロプラムの製造方法、その中間体およびその製造方法
US7989645B2 (en) *	2004-08-23	2011-08-02	Sun Pharma Global Fze	Process for preparation of citalopram and enantiomers
KR101166280B1 (ko) *	2004-08-23	2013-11-27	썬 파마 글로벌 에프제트이	시탈로프램 및 에난티오머의 제조 방법
US20110196032A1 (en) *	2005-05-20	2011-08-11	Ashish Gogia	Pharmaceutical Dosage Form of an Antidepressant
TWI347942B (en) *	2005-06-22	2011-09-01	Lundbeck & Co As H	Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US7834201B2 (en)	2005-06-22	2010-11-16	H. Lundbeck A/S	Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
EP1954257A4 (en)	2005-10-14	2009-05-20	Lundbeck & Co As H	METHOD FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM WITH A LOW-DOSED COMBINATION OF ESCITALOPRAM AND BUPROPION
WO2008059514A2 (en) *	2006-07-31	2008-05-22	Cadila Healthcare Limited	Process for preparing escitalopram
NZ570884A (en)	2007-09-11	2010-03-26	Lundbeck & Co As H	Fractionally crystallising 4-[4-(dimethyl amino)-1-(4'-fluorophenyl)-1-hydroxybutyI]-3-(hydroxymethyl)-benzonitrile and manufacturing escitalopram therefrom
US8022232B2 (en)	2007-09-11	2011-09-20	H. Lundbeck A/S	Method for manufacture of escitalopram
CN100548974C (zh) *	2007-10-11	2009-10-14	浙江大学	西酞普兰中间体的萃取分离方法
CN101560199B (zh) *	2008-04-16	2013-09-18	北京德众万全药物技术开发有限公司	一种依地普仑的制备方法
TWI381813B (zh)	2010-01-12	2013-01-11	Taiwan Paiho Ltd	A Velcro assembly for a foamed article and a foamed article comprising the adhesive tape assembly

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8419963D0 (en) *	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
EP1298124B1 (en) *	1999-10-25	2007-02-28	H. Lundbeck A/S	Method For the Preparation of Citalopram

2002
- 2002-06-21 AR ARP020102350A patent/AR034612A1/es active IP Right Grant
- 2002-06-23 JO JO200265A patent/JO2389B1/en active
- 2002-06-24 PE PE2002000551A patent/PE20030122A1/es active IP Right Grant
- 2002-06-24 TN TNTNSN02062A patent/TNSN02062A1/en unknown
- 2002-06-25 WO PCT/DK2002/000426 patent/WO2003000672A1/en not_active Ceased
- 2002-06-25 JP JP2003507077A patent/JP4377219B2/ja not_active Expired - Lifetime
- 2002-06-25 BR BRPI0210574A patent/BRPI0210574B8/pt not_active IP Right Cessation
- 2002-06-25 EA EA200400082A patent/EA006446B1/ru not_active IP Right Cessation
- 2002-06-25 CA CA2691149A patent/CA2691149C/en not_active Expired - Fee Related
- 2002-06-25 PT PT02742848T patent/PT1412341E/pt unknown
- 2002-06-25 IL IL15922902A patent/IL159229A0/xx active IP Right Grant
- 2002-06-25 NZ NZ530104A patent/NZ530104A/en not_active IP Right Cessation
- 2002-06-25 HR HR20031075A patent/HRP20031075B1/xx not_active IP Right Cessation
- 2002-06-25 US US10/482,000 patent/US7112686B2/en not_active Expired - Lifetime
- 2002-06-25 PL PL02366560A patent/PL366560A1/xx not_active Application Discontinuation
- 2002-06-25 KR KR1020087026708A patent/KR20080100498A/ko not_active Ceased
- 2002-06-25 KR KR1020037016853A patent/KR100902530B1/ko not_active Expired - Lifetime
- 2002-06-25 DE DE60202216T patent/DE60202216T2/de not_active Expired - Lifetime
- 2002-06-25 UA UA20031211986A patent/UA75147C2/uk unknown
- 2002-06-25 SK SK51-2004A patent/SK287696B6/sk unknown
- 2002-06-25 MA MA26713A patent/MA26260A1/fr unknown
- 2002-06-25 RS YUP-1014/03A patent/RS50673B/sr unknown
- 2002-06-25 CN CNB028126688A patent/CN100429208C/zh not_active Expired - Lifetime
- 2002-06-25 HU HU0400293A patent/HU228476B1/hu unknown
- 2002-06-25 UY UY27356A patent/UY27356A1/es not_active IP Right Cessation
- 2002-06-25 ME MEP-15/08A patent/MEP1508A/xx unknown
- 2002-06-25 KR KR1020107006751A patent/KR20100052550A/ko not_active Ceased
- 2002-06-25 ES ES02742848T patent/ES2233834T3/es not_active Expired - Lifetime
- 2002-06-25 EP EP02742848A patent/EP1412341B1/en not_active Expired - Lifetime
- 2002-06-25 MY MYPI20022382A patent/MY133471A/en unknown
- 2002-06-25 ME MEP-2008-15A patent/ME00027B/me unknown
- 2002-06-25 KR KR1020097004586A patent/KR100939945B1/ko not_active Expired - Lifetime
- 2002-06-25 DK DK02742848T patent/DK1412341T3/da active
- 2002-06-25 TW TW091113845A patent/TWI236473B/zh not_active IP Right Cessation
- 2002-06-25 SI SI200230078T patent/SI1412341T1/xx unknown
- 2002-06-25 MX MXPA03011770A patent/MXPA03011770A/es active IP Right Grant
- 2002-06-25 CZ CZ2004-131A patent/CZ305034B6/cs not_active IP Right Cessation
- 2002-06-25 CA CA2450890A patent/CA2450890C/en not_active Expired - Fee Related
- 2002-06-25 CN CN2008102158851A patent/CN101440079B/zh not_active Expired - Lifetime
- 2002-06-25 AT AT02742848T patent/ATE284395T1/de active
2003
- 2003-12-08 IS IS7068A patent/IS2426B/is unknown
- 2003-12-11 ZA ZA2003/09633A patent/ZA200309633B/en unknown
- 2003-12-18 NO NO20035671A patent/NO329873B1/no not_active IP Right Cessation
2004
- 2004-01-14 BG BG108532A patent/BG66372B1/bg unknown
- 2004-01-22 CO CO04004620A patent/CO5550420A2/es not_active Application Discontinuation
2009
- 2009-04-17 JP JP2009101188A patent/JP5064436B2/ja not_active Expired - Lifetime
2010
- 2010-10-13 NO NO20101420A patent/NO335106B1/no not_active IP Right Cessation
2011
- 2011-10-19 AR ARP110103869A patent/AR083483A2/es active IP Right Grant
2014
- 2014-11-21 UY UY0001035850A patent/UY35850A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR0210574B1 (pt)	2014-03-04
CZ305034B6 (cs)	2015-04-08
MY133471A (en)	2007-11-30
CA2691149C (en)	2011-09-13
TNSN02062A1 (en)	2005-12-23
SK287696B6 (sk)	2011-06-06
PE20030122A1 (es)	2003-02-12
WO2003000672A1 (en)	2003-01-03
NO20101420L (no)	2003-12-18
BG66372B1 (bg)	2013-10-31
SK512004A3 (en)	2004-05-04
JP4377219B2 (ja)	2009-12-02
NO329873B1 (no)	2011-01-17
KR20040030702A (ko)	2004-04-09
KR100902530B1 (ko)	2009-06-15
HRP20031075B1 (en)	2011-12-31
MEP1508A (xx)	2010-02-10
RS50673B (sr)	2010-06-30
JP2004536093A (ja)	2004-12-02
MXPA03011770A (es)	2004-04-02
BG108532A (bg)	2005-04-30
NO20035671L (no)	2003-12-18
HRP20031075A2 (en)	2004-04-30
PL366560A1 (en)	2005-02-07
ZA200309633B (en)	2005-02-23
IS2426B (is)	2008-10-15
EP1412341A1 (en)	2004-04-28
IS7068A (is)	2003-12-08
CA2691149A1 (en)	2003-01-03
CN100429208C (zh)	2008-10-29
BRPI0210574B8 (pt)	2021-05-25
AU2002344948B2 (en)	2007-08-16
NO20035671D0 (no)	2003-12-18
DE60202216D1 (de)	2005-01-13
CZ2004131A3 (cs)	2004-04-14
UA75147C2 (en)	2006-03-15
UY35850A (es)	2016-06-30
KR20090031958A (ko)	2009-03-30
NO335106B1 (no)	2014-09-15
KR20100052550A (ko)	2010-05-19
EA200400082A1 (ru)	2004-06-24
ME00027B (me)	2010-02-10
SI1412341T1 (en)	2005-04-30
ES2233834T3 (es)	2005-06-16
UY27356A1 (es)	2003-01-31
CN101440079B (zh)	2011-05-25
CA2450890A1 (en)	2003-01-03
EA006446B1 (ru)	2005-12-29
CO5550420A2 (es)	2005-08-31
HUP0400293A3 (en)	2007-05-29
CA2450890C (en)	2011-02-15
DE60202216T2 (de)	2005-12-08
EP1412341B1 (en)	2004-12-08
CN101440079A (zh)	2009-05-27
HU228476B1 (en)	2013-03-28
US20040259940A1 (en)	2004-12-23
JP2009203233A (ja)	2009-09-10
US7112686B2 (en)	2006-09-26
ATE284395T1 (de)	2004-12-15
MA26260A1 (fr)	2004-09-01
AR034612A1 (es)	2004-03-03
NZ530104A (en)	2006-08-31
JP5064436B2 (ja)	2012-10-31
JO2389B1 (en)	2007-06-17
RS101403A (sr)	2007-02-05
IL159229A0 (en)	2004-06-01
HUP0400293A2 (hu)	2004-09-28
AR083483A2 (es)	2013-02-27
PT1412341E (pt)	2005-04-29
CN1520405A (zh)	2004-08-11
HK1132729A1 (en)	2010-03-05
KR20080100498A (ko)	2008-11-18
TWI236473B (en)	2005-07-21
HK1068627A1 (zh)	2005-04-29
KR100939945B1 (ko)	2010-02-04
BR0210574A (pt)	2004-08-03

Publication	Publication Date	Title
NO20035671D0 (no)	2003-12-18	Fremgangsmåte for fremstilling av racemisk citalopram og/eller S- eller R-citalopram ved separasjon av en blanding av R- og S-citalopram
DK1123284T3 (da)	2003-04-28	Fremgangsmåde til fremstilling af citalopram
DK1032566T3 (da)	2003-06-10	Fremgangsmåde til fremstilling af citalopram
NO20023189D0 (no)	2002-07-01	Fremgangsmåte for fremstilling av tolterodin og analoger derav samt intermediater fremstilt ved fremgangsmåten
NO20025848L (no)	2002-12-05	Fremgangsmåte for oksygenseparasjon ved keramiske komposittmembraner
DK1150966T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af 5-cyanophthalid
IS6487A (is)	2002-07-29	Aðferð til framleiðslu á Sítalóprami
ATE107535T1 (de)	1994-07-15	Gaschromatographische methode zur trennung von wasserstoffisotopen.
NO20024007L (no)	2002-10-07	Fremgangsmåte ved fremstillingen av citalopram
FI20011621A0 (fi)	2001-08-09	Menetelmä sitalopraamin valmistamiseksi
DK0879228T3 (da)	2003-03-03	Fremgangsmåde til fremstilling af d-threo-(R,R)-methylphenidat og recirkulering af uønskede enantiomerer ved epimerisering
NO20040027L (no)	2004-01-05	Fremgangsmate for fremstillingen av escitalopram
AU2002339603A1 (en)	2002-12-03	Replicons derived from positive strand rna virus genomes useful for the production of heterologous proteins
NO20041200L (no)	2004-03-23	Fremgangsmate for fremstilling av citalopram.
IL166319A0 (en)	2006-01-15	Method for the separation of intermediates which may be used for the preparation of escitalopram
NO20024180L (no)	2002-09-02	Fremgangsmåte ved fremstillingen av citalopram
NO20024213L (no)	2002-11-13	FremgangsmÕte ved fremstilling av citalopram
NO20024214L (no)	2002-10-31	Fremgangsmåte ved fremstilling av citalopram
EG22991A (en)	2003-12-31	Process for the preparation of racemic citalopram and/or s-or r-citalopram by separation of a mixtu re of r- and s- citalopram
DK2083080T3 (da)	2014-06-23	Fremgangsmåde til fremstilling af L-aminosyrer ved anvendelse af stammer af Enterobacteriaceae-familien, der indeholder et forøget rseA- eller rseC-gen
DK1581483T3 (da)	2012-07-23	Fremgangsmåde til fremstilling af racemisk citalopram-diol og/eller s- eller r-citalopram-dioler og anvendelse deraf til fremstilling af racemisk citalopram, r-citalopram og/eller s-citalopram
DK178586A (da)	1986-10-21	Fremgangsmaade til fremstilling af staebeforme ved komprimering af formstof-styrtgods
EG25364A (en)	2011-12-19	Method for the separation of intermediates which may be used for the preparation of escitalopram.
EP1370545A4 (en)	2005-03-16	PROCESS FOR THE PREPARATION OF CITALOPRAM
AU2002342741A1 (en)	2003-04-14	Process for the preparation of citalopram