PE20030122A1 - Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram - Google Patents
Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopramInfo
- Publication number
- PE20030122A1 PE20030122A1 PE2002000551A PE2002000551A PE20030122A1 PE 20030122 A1 PE20030122 A1 PE 20030122A1 PE 2002000551 A PE2002000551 A PE 2002000551A PE 2002000551 A PE2002000551 A PE 2002000551A PE 20030122 A1 PE20030122 A1 PE 20030122A1
- Authority
- PE
- Peru
- Prior art keywords
- citalopram
- solvents
- precipitated material
- crystalline
- preparation
- Prior art date
Links
- 229960001653 citalopram Drugs 0.000 title abstract 6
- WSEQXVZVJXJVFP-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000002904 solvent Substances 0.000 abstract 6
- 239000000463 material Substances 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 239000012452 mother liquor Substances 0.000 abstract 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE REFIERE A UN PROCESO PARA LA PREPARACION DE CITALOPRAM RACEMICO EN FORMA DE UNA BASE LIBRE OBTENIDA MEDIANTE LA ADICION DE UN ACIDO (ACIDO BROMHIDRICO) QUE COMPRENDE PRECIPITAR CITALOPRAM A PARTIR DE SOLVENTES (DE PREFERENCIA SOLVENTES PROTICOS COMO AGUA, ALCOHOLES, CETONAS, SOLVENTES APROTICOS COMO ACRILONITRILO, DIGLIMA), SEPARAR EL PRECIPITADO (ACEITE, SOLIDO AMORFO, CRISTALES) FORMADO DEL LICOR MADRE (SOLVENTE QUE QUEDA DESPUES DE LA REMOCION O SEPARACION DEL MATERIAL PRECIPITADO A PARTIR DEL SOLVENTE); SI EL MATERIAL PRECIPITADO ES CRISTALINO, ES OPCIONALMENTE RECRISTALIZADO UNO O MAS VECES PARA FORMAR CITALOPRAM RACEMICO, SI EL MATERIAL PRECIPITADO NO ES CRISTALINO SE REPITEN LOS ANTERIORES PASOS O HASTA OBTENER UN MATERIAL PRECIPITADO CRISTALINO; EL LICOR MADRE ES SOMETIDO A PURIFICACION ADICIONAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100991 | 2001-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030122A1 true PE20030122A1 (es) | 2003-02-12 |
Family
ID=8160584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000551A PE20030122A1 (es) | 2001-06-25 | 2002-06-24 | Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US7112686B2 (es) |
| EP (1) | EP1412341B1 (es) |
| JP (2) | JP4377219B2 (es) |
| KR (4) | KR20080100498A (es) |
| CN (2) | CN101440079B (es) |
| AR (2) | AR034612A1 (es) |
| AT (1) | ATE284395T1 (es) |
| BG (1) | BG66372B1 (es) |
| BR (1) | BRPI0210574B8 (es) |
| CA (2) | CA2691149C (es) |
| CO (1) | CO5550420A2 (es) |
| CZ (1) | CZ305034B6 (es) |
| DE (1) | DE60202216T2 (es) |
| DK (1) | DK1412341T3 (es) |
| EA (1) | EA006446B1 (es) |
| ES (1) | ES2233834T3 (es) |
| HR (1) | HRP20031075B1 (es) |
| HU (1) | HU228476B1 (es) |
| IL (1) | IL159229A0 (es) |
| IS (1) | IS2426B (es) |
| JO (1) | JO2389B1 (es) |
| MA (1) | MA26260A1 (es) |
| ME (2) | ME00027B (es) |
| MX (1) | MXPA03011770A (es) |
| MY (1) | MY133471A (es) |
| NO (2) | NO329873B1 (es) |
| NZ (1) | NZ530104A (es) |
| PE (1) | PE20030122A1 (es) |
| PL (1) | PL366560A1 (es) |
| PT (1) | PT1412341E (es) |
| RS (1) | RS50673B (es) |
| SI (1) | SI1412341T1 (es) |
| SK (1) | SK287696B6 (es) |
| TN (1) | TNSN02062A1 (es) |
| TW (1) | TWI236473B (es) |
| UA (1) | UA75147C2 (es) |
| UY (2) | UY27356A1 (es) |
| WO (1) | WO2003000672A1 (es) |
| ZA (1) | ZA200309633B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR040970A1 (es) | 2002-08-12 | 2005-04-27 | Lundbeck & Co As H | Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram |
| EP2363389A1 (en) | 2002-12-23 | 2011-09-07 | H. Lundbeck A/S | A process for the preparation of racemic citalopram diol and/or S- or R-citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram |
| EA009061B1 (ru) * | 2002-12-23 | 2007-10-26 | Х. Лундбекк А/С | Способ получения рацемического циталопрамдиола и/или s- или r- циталопрамдиолов и способ получения рацемического циталопрама, r-циталопрама и /или s-циталопрама |
| AU2003287919B2 (en) | 2002-12-23 | 2009-11-12 | H. Lundbeck A/S | Escitalopram hydrobromide and a method for the preparation thereof |
| WO2004085416A1 (en) * | 2003-03-24 | 2004-10-07 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
| CN100569765C (zh) | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
| TWI339651B (en) * | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| US20050196453A1 (en) | 2004-03-05 | 2005-09-08 | H. Lundbeck A/S | Crystalline composition containing escitalopram |
| WO2005084643A1 (en) * | 2004-03-05 | 2005-09-15 | H. Lundbeck A/S | Crystalline composition containing escitalopram oxalate |
| ITMI20040717A1 (it) | 2004-04-09 | 2004-07-09 | Adorkem Technology Spa | Procedimento chemo-enzimatico per la preparazione dell'escitalopram |
| JP2006008603A (ja) * | 2004-06-25 | 2006-01-12 | Sumitomo Chemical Co Ltd | 光学活性シタロプラムの製造方法、その中間体およびその製造方法 |
| US7989645B2 (en) * | 2004-08-23 | 2011-08-02 | Sun Pharma Global Fze | Process for preparation of citalopram and enantiomers |
| ES2285972T1 (es) | 2004-08-23 | 2007-12-01 | Sun Pharmaceutical Industries Limited | Procedimiento de fabricacion de citalopram y enantiomeros. |
| WO2006123243A2 (en) * | 2005-05-20 | 2006-11-23 | Aurobindo Pharma Limited | Pharmaceutical dosage forms comprising escitalopram in form of granules |
| TWI347942B (en) * | 2005-06-22 | 2011-09-01 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| US7834201B2 (en) | 2005-06-22 | 2010-11-16 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| EA200801081A1 (ru) | 2005-10-14 | 2008-10-30 | Х. Лундбекк А/С | Способы лечения расстройств центральной нервной системы комбинацией малых доз эсциталопрама и бупропиона |
| WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
| FI121570B (fi) | 2007-09-11 | 2011-01-14 | Lundbeck & Co As H | Menetelmä essitalopraamin valmistamiseksi |
| US8022232B2 (en) * | 2007-09-11 | 2011-09-20 | H. Lundbeck A/S | Method for manufacture of escitalopram |
| CN100548974C (zh) * | 2007-10-11 | 2009-10-14 | 浙江大学 | 西酞普兰中间体的萃取分离方法 |
| CN101560199B (zh) * | 2008-04-16 | 2013-09-18 | 北京德众万全药物技术开发有限公司 | 一种依地普仑的制备方法 |
| TWI381813B (zh) | 2010-01-12 | 2013-01-11 | Taiwan Paiho Ltd | A Velcro assembly for a foamed article and a foamed article comprising the adhesive tape assembly |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| HRP20020344B1 (hr) * | 1999-10-25 | 2010-10-31 | H. Lundbeck A/S | Način priprave citaloprama |
-
2002
- 2002-06-21 AR ARP020102350A patent/AR034612A1/es active IP Right Grant
- 2002-06-23 JO JO200265A patent/JO2389B1/en active
- 2002-06-24 PE PE2002000551A patent/PE20030122A1/es active IP Right Grant
- 2002-06-24 TN TNTNSN02062A patent/TNSN02062A1/en unknown
- 2002-06-25 EP EP02742848A patent/EP1412341B1/en not_active Expired - Lifetime
- 2002-06-25 US US10/482,000 patent/US7112686B2/en not_active Expired - Lifetime
- 2002-06-25 HU HU0400293A patent/HU228476B1/hu unknown
- 2002-06-25 MA MA26713A patent/MA26260A1/fr unknown
- 2002-06-25 UA UA20031211986A patent/UA75147C2/uk unknown
- 2002-06-25 RS YUP-1014/03A patent/RS50673B/sr unknown
- 2002-06-25 WO PCT/DK2002/000426 patent/WO2003000672A1/en not_active Ceased
- 2002-06-25 KR KR1020087026708A patent/KR20080100498A/ko not_active Ceased
- 2002-06-25 CZ CZ2004-131A patent/CZ305034B6/cs not_active IP Right Cessation
- 2002-06-25 SI SI200230078T patent/SI1412341T1/xx unknown
- 2002-06-25 BR BRPI0210574A patent/BRPI0210574B8/pt not_active IP Right Cessation
- 2002-06-25 DE DE60202216T patent/DE60202216T2/de not_active Expired - Lifetime
- 2002-06-25 HR HR20031075A patent/HRP20031075B1/xx not_active IP Right Cessation
- 2002-06-25 EA EA200400082A patent/EA006446B1/ru not_active IP Right Cessation
- 2002-06-25 NZ NZ530104A patent/NZ530104A/en not_active IP Right Cessation
- 2002-06-25 JP JP2003507077A patent/JP4377219B2/ja not_active Expired - Lifetime
- 2002-06-25 ME MEP-2008-15A patent/ME00027B/me unknown
- 2002-06-25 CA CA2691149A patent/CA2691149C/en not_active Expired - Fee Related
- 2002-06-25 SK SK51-2004A patent/SK287696B6/sk unknown
- 2002-06-25 CA CA2450890A patent/CA2450890C/en not_active Expired - Fee Related
- 2002-06-25 ME MEP-15/08A patent/MEP1508A/xx unknown
- 2002-06-25 UY UY27356A patent/UY27356A1/es not_active IP Right Cessation
- 2002-06-25 KR KR1020037016853A patent/KR100902530B1/ko not_active Expired - Lifetime
- 2002-06-25 AT AT02742848T patent/ATE284395T1/de active
- 2002-06-25 DK DK02742848T patent/DK1412341T3/da active
- 2002-06-25 IL IL15922902A patent/IL159229A0/xx active IP Right Grant
- 2002-06-25 PT PT02742848T patent/PT1412341E/pt unknown
- 2002-06-25 MY MYPI20022382A patent/MY133471A/en unknown
- 2002-06-25 CN CN2008102158851A patent/CN101440079B/zh not_active Expired - Lifetime
- 2002-06-25 ES ES02742848T patent/ES2233834T3/es not_active Expired - Lifetime
- 2002-06-25 TW TW091113845A patent/TWI236473B/zh not_active IP Right Cessation
- 2002-06-25 PL PL02366560A patent/PL366560A1/xx not_active Application Discontinuation
- 2002-06-25 CN CNB028126688A patent/CN100429208C/zh not_active Expired - Lifetime
- 2002-06-25 KR KR1020107006751A patent/KR20100052550A/ko not_active Ceased
- 2002-06-25 KR KR1020097004586A patent/KR100939945B1/ko not_active Expired - Lifetime
- 2002-06-25 MX MXPA03011770A patent/MXPA03011770A/es active IP Right Grant
-
2003
- 2003-12-08 IS IS7068A patent/IS2426B/is unknown
- 2003-12-11 ZA ZA2003/09633A patent/ZA200309633B/en unknown
- 2003-12-18 NO NO20035671A patent/NO329873B1/no not_active IP Right Cessation
-
2004
- 2004-01-14 BG BG108532A patent/BG66372B1/bg unknown
- 2004-01-22 CO CO04004620A patent/CO5550420A2/es not_active Application Discontinuation
-
2009
- 2009-04-17 JP JP2009101188A patent/JP5064436B2/ja not_active Expired - Lifetime
-
2010
- 2010-10-13 NO NO20101420A patent/NO335106B1/no not_active IP Right Cessation
-
2011
- 2011-10-19 AR ARP110103869A patent/AR083483A2/es active IP Right Grant
-
2014
- 2014-11-21 UY UY0001035850A patent/UY35850A/es not_active IP Right Cessation
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| Date | Code | Title | Description |
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| FC | Refusal | ||
| FG | Grant, registration |