NO2012020I2 - Piksantron dimaleatsalt - Google Patents

Piksantron dimaleatsalt

Info

Publication number: NO2012020I2
Authority: NO; Norway
Prior art keywords: piksantron; dimaleate salt; compound; salt; dimaleate
Prior art date: 1994-03-28

Application number

NO2012020C

Other languages

English (en)

Other versions

NO2012020I1 (no

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-28

Filing date

2012-12-11

Publication date

2013-11-11

2012-12-11 Application filed filed Critical

2012-12-27 Publication of NO2012020I1 publication Critical patent/NO2012020I1/no

2013-11-11 Publication of NO2012020I2 publication Critical patent/NO2012020I2/no

Links

150000003839 salts Chemical class 0.000 title 1
SVAGFBGXEWPNJC-SPIKMXEPSA-N 6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione;(z)-but-2-enedioic acid Chemical compound OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.O=C1C2=CN=CC=C2C(=O)C2=C1C(NCCN)=CC=C2NCCN SVAGFBGXEWPNJC-SPIKMXEPSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
RGHILYZRVFRRNK-UHFFFAOYSA-N anthracene-1,2-dione Chemical class C1=CC=C2C=C(C(C(=O)C=C3)=O)C3=CC2=C1 RGHILYZRVFRRNK-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

NO2012020C 1994-03-28 2012-12-11 Piksantron dimaleatsalt NO2012020I2 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/220,007 US5506232A (en)	1994-03-28	1994-03-28	6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
PCT/IB1995/000230 WO1995026189A1 (en)	1994-03-28	1995-03-27	AN IMPROVED METHOD OF SYNTHESIS FOR 6,9-BIS[(2-AMINOETHYL)AMINO]BENZO[g]ISOQUINOLINE-5,10-DIONE AND ITS DIMALEATE SALT

Publications (2)

Publication Number	Publication Date
NO2012020I1 NO2012020I1 (no)	2012-12-27
NO2012020I2 true NO2012020I2 (no)	2013-11-11

Family

ID=22821665

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO19964082A NO307564B1 (no)	1994-03-28	1996-09-27	Fremgangsmate for syntese av 6,9-bis[(2-aminoetyl)amino]benzo[g]isokinolin-5,10-dion og dets dimaleatsalt, samt dimaleatsaltet fremstilt ved fremgangsmaten
NO2012020C NO2012020I2 (no)	1994-03-28	2012-12-11	Piksantron dimaleatsalt

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO19964082A NO307564B1 (no)	1994-03-28	1996-09-27	Fremgangsmate for syntese av 6,9-bis[(2-aminoetyl)amino]benzo[g]isokinolin-5,10-dion og dets dimaleatsalt, samt dimaleatsaltet fremstilt ved fremgangsmaten

Country Status (24)

Country	Link
US (3)	US5506232A (no)
EP (1)	EP0752857B1 (no)
JP (2)	JP3151462B2 (no)
KR (1)	KR100224153B1 (no)
CN (2)	CN1130199C (no)
AT (1)	ATE203408T1 (no)
AU (1)	AU679627B2 (no)
BR (1)	BR9507257A (no)
CA (1)	CA2186485C (no)
CZ (2)	CZ285139B6 (no)
DE (1)	DE69521887T2 (no)
DK (1)	DK0752857T3 (no)
ES (1)	ES2159313T3 (no)
FI (1)	FI113861B (no)
GR (1)	GR3037014T3 (no)
HU (1)	HU223311B1 (no)
LU (1)	LU92089I2 (no)
NO (2)	NO307564B1 (no)
NZ (1)	NZ282480A (no)
PT (1)	PT752857E (no)
RU (1)	RU2144028C1 (no)
TW (1)	TW397826B (no)
WO (1)	WO1995026189A1 (no)
ZA (1)	ZA952477B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5506232A (en) *	1994-03-28	1996-04-09	Boehringer Mannheim Italia S.P.A.	6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
SG43383A1 (en) *	1995-07-13	1997-10-17	Smithkline Beecham Corp	N n-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2- propanamine dimaleate
IT1315253B1 (it) *	1999-10-22	2003-02-03	Novuspharma Spa	Preparazione liposomiale di 6,9-bis-(2-amminoetil)ammino\|benzog\|isochinolin-5,10-dione dimaleato
WO2005097128A1 (en) *	2004-03-30	2005-10-20	Novacea, Inc.	1,4-bis-n-oxide azaanthracenediones and the use thereof
WO2008042611A2 (en) *	2006-09-29	2008-04-10	Centocor, Inc.	Method of using il6 antagonists with mitoxantrone for prostate cancer
CN104513201B (zh) *	2013-09-28	2017-12-26	正大天晴药业集团股份有限公司	马来酸匹杉琼的结晶
CN104557704B (zh) *	2013-10-28	2017-05-10	北京凯莱天成医药科技有限公司	一种匹杉琼马来酸盐的制备方法
CN103787970A (zh) *	2014-01-14	2014-05-14	北京万全德众医药生物技术有限公司	一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺
CN110873765B (zh) *	2018-09-04	2022-05-17	北京凯莱天成医药科技有限公司	一种马来酸匹杉琼有关物质的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2242454A1 (de) *	1972-08-29	1974-03-07	Bayer Ag	1-aethyl-imidazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
NZ241868A (en) *	1991-03-08	1995-05-26	Univ Vermont	6,9-bis(substituted-amino)benzo[g]isoquinoline-5,10-diones, preparation and pharmaceutical compositions thereof
US5506232A (en) *	1994-03-28	1996-04-09	Boehringer Mannheim Italia S.P.A.	6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt

1994
- 1994-03-28 US US08/220,007 patent/US5506232A/en not_active Expired - Lifetime
1995
- 1995-03-25 TW TW084102901A patent/TW397826B/zh not_active IP Right Cessation
- 1995-03-27 HU HU9602655A patent/HU223311B1/hu active Protection Beyond IP Right Term
- 1995-03-27 PT PT95912387T patent/PT752857E/pt unknown
- 1995-03-27 JP JP51977895A patent/JP3151462B2/ja not_active Expired - Lifetime
- 1995-03-27 DK DK95912387T patent/DK0752857T3/da active
- 1995-03-27 RU RU96121255A patent/RU2144028C1/ru active
- 1995-03-27 CZ CZ985A patent/CZ285139B6/cs not_active IP Right Cessation
- 1995-03-27 CN CN95192356A patent/CN1130199C/zh not_active Expired - Lifetime
- 1995-03-27 AU AU19589/95A patent/AU679627B2/en not_active Expired
- 1995-03-27 EP EP95912387A patent/EP0752857B1/en not_active Expired - Lifetime
- 1995-03-27 CA CA002186485A patent/CA2186485C/en not_active Expired - Lifetime
- 1995-03-27 WO PCT/IB1995/000230 patent/WO1995026189A1/en not_active Ceased
- 1995-03-27 KR KR1019960704105A patent/KR100224153B1/ko not_active Expired - Lifetime
- 1995-03-27 DE DE69521887T patent/DE69521887T2/de not_active Expired - Lifetime
- 1995-03-27 CZ CZ962767A patent/CZ284937B6/cs not_active IP Right Cessation
- 1995-03-27 ZA ZA952477A patent/ZA952477B/xx unknown
- 1995-03-27 AT AT95912387T patent/ATE203408T1/de active
- 1995-03-27 BR BR9507257A patent/BR9507257A/pt not_active Application Discontinuation
- 1995-03-27 ES ES95912387T patent/ES2159313T3/es not_active Expired - Lifetime
- 1995-03-27 NZ NZ282480A patent/NZ282480A/en not_active IP Right Cessation
- 1995-06-07 US US08/482,575 patent/US5616709A/en not_active Expired - Lifetime
1996
- 1996-08-01 US US08/695,767 patent/US5717099A/en not_active Expired - Lifetime
- 1996-09-27 FI FI963864A patent/FI113861B/fi not_active IP Right Cessation
- 1996-09-27 NO NO19964082A patent/NO307564B1/no not_active IP Right Cessation
2000
- 2000-03-29 CN CN00104930A patent/CN1282738A/zh active Pending
- 2000-07-21 JP JP2000226223A patent/JP3548099B2/ja not_active Expired - Lifetime
2001
- 2001-10-25 GR GR20010401881T patent/GR3037014T3/el unknown
2012
- 2012-10-25 LU LU92089C patent/LU92089I2/fr unknown
- 2012-12-11 NO NO2012020C patent/NO2012020I2/no unknown

Also Published As

Publication number	Publication date
JP3548099B2 (ja)	2004-07-28
ES2159313T3 (es)	2001-10-01
HUT75654A (en)	1997-05-28
BR9507257A (pt)	1997-10-07
RU2144028C1 (ru)	2000-01-10
CZ598A3 (cs)	1999-05-12
FI963864A0 (fi)	1996-09-27
US5506232A (en)	1996-04-09
EP0752857B1 (en)	2001-07-25
CA2186485C (en)	1999-12-14
ZA952477B (en)	1996-09-27
DE69521887D1 (de)	2001-08-30
NO964082D0 (no)	1996-09-27
CZ276796A3 (en)	1997-02-12
CN1145028A (zh)	1997-03-12
GR3037014T3 (en)	2002-01-31
CA2186485A1 (en)	1995-10-05
ATE203408T1 (de)	2001-08-15
US5717099A (en)	1998-02-10
JPH09507674A (ja)	1997-08-05
HU223311B1 (hu)	2004-05-28
CZ284937B6 (cs)	1999-04-14
NO964082L (no)	1996-09-27
JP3151462B2 (ja)	2001-04-03
AU679627B2 (en)	1997-07-03
CN1130199C (zh)	2003-12-10
FI113861B (fi)	2004-06-30
JP2001089454A (ja)	2001-04-03
DE69521887T2 (de)	2001-11-22
LU92089I2 (fr)	2012-12-27
PT752857E (pt)	2001-11-30
CZ285139B6 (cs)	1999-05-12
NO307564B1 (no)	2000-04-25
FI963864L (fi)	1996-09-27
EP0752857A1 (en)	1997-01-15
WO1995026189A1 (en)	1995-10-05
DK0752857T3 (da)	2001-09-24
CN1282738A (zh)	2001-02-07
MX9603994A (es)	1997-12-31
HU9602655D0 (en)	1996-11-28
US5616709A (en)	1997-04-01
NO2012020I1 (no)	2012-12-27
AU1958995A (en)	1995-10-17
NZ282480A (en)	1997-04-24
TW397826B (en)	2000-07-11
KR100224153B1 (ko)	1999-10-15

Legal Events

Date	Code	Title	Description
2014-12-29	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: CTI BIOPHARMA CORP., US

Publication	Publication Date	Title
NO2012020I2 (no)	2013-11-11	Piksantron dimaleatsalt
DK0629608T3 (da)	1999-07-05	Fremgangsmåde til fremstilling af N-acyl-N,N',N'-ethylendiamintrieddikesyrederivater
AU4869990A (en)	1990-08-02	Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
KR960702830A (ko)	1996-05-23	방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents)
DE59409672D1 (de)	2001-04-12	Festphasensynthese von Oligoribonucleotiden
DK1100789T3 (da)	2005-05-23	Substituerede benzoylcyclohexandioner
AU9281198A (en)	1999-04-23	Benzofuran derivatives
DK0828721T3 (da)	2002-03-04	2-Aminobenzoxazinoner til behandling af virale infektioner
EA200200101A1 (ru)	2002-06-27	Получение замещенных пиперидин-4-онов
IT1251202B (it)	1995-05-04	6-amminochinoloni, sintesi ed impiego come antibatterici
SE9602416D0 (sv)	1996-06-18	New forms of an organic salt of N'N-diacetylcystine
NO305556B1 (no)	1999-06-21	Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer
NO20004685D0 (no)	2000-09-19	Nye forbindelser
FR2705971B1 (fr)	1995-08-25	Production de gamma-décalactone par bioconversion.
PT90831A (pt)	1989-12-29	Processo para a preparacao de eteres da 2-amino-7-hidroxitetralina
ATE168683T1 (de)	1998-08-15	Substituierte iminoacetonitrile mit myokardprotektiver wirkung