NO301117B1 - Nye isatinoksimderivater, farmasöytiske preparater som inneholder en slik forbindelse, samt anvendelse og en fremgangsmåte for fremstilling av slike forbindelser - Google Patents

Nye isatinoksimderivater, farmasöytiske preparater som inneholder en slik forbindelse, samt anvendelse og en fremgangsmåte for fremstilling av slike forbindelser Download PDF

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Publication number
NO301117B1
NO301117B1 NO940676A NO940676A NO301117B1 NO 301117 B1 NO301117 B1 NO 301117B1 NO 940676 A NO940676 A NO 940676A NO 940676 A NO940676 A NO 940676A NO 301117 B1 NO301117 B1 NO 301117B1
Authority
NO
Norway
Prior art keywords
branched
alkyl
cyclic
hydrogen
formula
Prior art date
Application number
NO940676A
Other languages
English (en)
Norwegian (no)
Other versions
NO940676L (pl
NO940676D0 (no
Inventor
Frank Watjen
Bjarne Hugo Dahl
Joergen Drejer
Leif Helth Jensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO940676D0 publication Critical patent/NO940676D0/no
Publication of NO940676L publication Critical patent/NO940676L/no
Publication of NO301117B1 publication Critical patent/NO301117B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
NO940676A 1991-08-28 1994-02-25 Nye isatinoksimderivater, farmasöytiske preparater som inneholder en slik forbindelse, samt anvendelse og en fremgangsmåte for fremstilling av slike forbindelser NO301117B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75116591A 1991-08-28 1991-08-28
US83185192A 1992-02-05 1992-02-05
PCT/EP1992/001999 WO1993005043A1 (en) 1991-08-28 1992-08-27 Novel isatinoxime derivatives, their preparation and use

Publications (3)

Publication Number Publication Date
NO940676D0 NO940676D0 (no) 1994-02-25
NO940676L NO940676L (pl) 1994-04-27
NO301117B1 true NO301117B1 (no) 1997-09-15

Family

ID=27115380

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940676A NO301117B1 (no) 1991-08-28 1994-02-25 Nye isatinoksimderivater, farmasöytiske preparater som inneholder en slik forbindelse, samt anvendelse og en fremgangsmåte for fremstilling av slike forbindelser

Country Status (18)

Country Link
EP (1) EP0529636B1 (pl)
JP (1) JP3170584B2 (pl)
KR (1) KR100277481B1 (pl)
AT (1) ATE181552T1 (pl)
AU (1) AU655672B2 (pl)
CA (1) CA2076948C (pl)
CZ (1) CZ282759B6 (pl)
DE (1) DE69229461T2 (pl)
DK (1) DK0529636T3 (pl)
FI (1) FI107156B (pl)
GE (1) GEP20002329B (pl)
HU (2) HUT70753A (pl)
MX (1) MX9204914A (pl)
NO (1) NO301117B1 (pl)
PL (1) PL170920B1 (pl)
RU (1) RU2114827C1 (pl)
SK (1) SK280578B6 (pl)
WO (1) WO1993005043A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE157977T1 (de) 1992-10-13 1997-09-15 Warner Lambert Co Chinoxalinderivate als eaa antagonisten
US5843945A (en) * 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
NZ267081A (en) * 1993-05-13 1997-11-24 Neurosearch As Hetero-fused indole and quinoxaline compounds and medicaments thereof
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
AU686888B2 (en) * 1994-09-14 1998-02-12 Neurosearch A/S Fused indole and quinoxaline derivatives, their preparation and use
NZ293265A (en) * 1994-09-14 1998-01-26 Neurosearch As 5-aryl-isoquinoline-2-one-3-acyloxime derivatives fused with a n-heterocyclic ring
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2768624B1 (fr) 1997-09-25 1999-11-12 Oreal Utilisation d'un inhibiteur d'acides amines excitateurs dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue
WO2000071102A2 (en) 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
EP1736468A3 (en) 2000-01-24 2007-01-03 NeuroSearch A/S Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation
AU2003273114A1 (en) 2002-10-29 2004-05-25 Sungkyunkwan University Medicament component of berberine for the use of prevention and treatment of psycological dependence on and analgesic tolerance to morphine
KR20080070749A (ko) 2005-11-23 2008-07-30 페인셉터 파마 코포레이션 개폐 이온 통로를 조절하기 위한 조성물 및 방법
CA2895268A1 (en) * 2012-12-19 2014-06-26 Bayer Cropscience Aktiengesellschaft Difluoromethyl-nicotinic-indanyl carboxamides
WO2015129592A1 (ja) * 2014-02-28 2015-09-03 住友化学株式会社 ２－（ハロゲノメチル）－３－メチルニトロベンゼンの製造方法
HUE055651T2 (hu) 2016-03-17 2021-12-28 Fmc Corp Eljárás S-enantiomer konvertálására racém formájává
CN109776451B (zh) * 2017-11-15 2020-12-11 中山光禾医疗科技有限公司 光交联水凝胶材料的制备、原料、产品及应用
CN108912127B (zh) * 2018-08-27 2019-12-10 青岛农业大学 一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use

Also Published As

Publication number Publication date
CA2076948A1 (en) 1993-03-01
ATE181552T1 (de) 1999-07-15
KR100277481B1 (ko) 2001-02-01
AU655672B2 (en) 1995-01-05
AU2482092A (en) 1993-04-05
CZ39594A3 (en) 1994-11-16
JP3170584B2 (ja) 2001-05-28
FI940889A7 (fi) 1994-02-25
CA2076948C (en) 2002-04-16
HUT70753A (en) 1995-10-30
DE69229461D1 (de) 1999-07-29
SK23894A3 (en) 1994-12-07
NO940676L (pl) 1994-04-27
PL170920B1 (pl) 1997-02-28
RU2114827C1 (ru) 1998-07-10
HU211632A9 (en) 1995-12-28
FI940889A0 (fi) 1994-02-25
FI107156B (fi) 2001-06-15
HU9400595D0 (en) 1994-05-30
WO1993005043A1 (en) 1993-03-18
DK0529636T3 (da) 1999-12-13
DE69229461T2 (de) 1999-10-21
EP0529636B1 (en) 1999-06-23
JPH06510056A (ja) 1994-11-10
EP0529636A1 (en) 1993-03-03
NO940676D0 (no) 1994-02-25
CZ282759B6 (cs) 1997-09-17
SK280578B6 (sk) 2000-04-10
GEP20002329B (en) 2000-12-25
MX9204914A (es) 1993-07-01

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