ATE181552T1 - Isatinoximderivate, ihre herstellung und anwendung - Google Patents

Isatinoximderivate, ihre herstellung und anwendung

Info

Publication number: ATE181552T1
Authority: AT; Austria
Prior art keywords: cyclic; branched; alkyl; hydrogen; straight
Prior art date: 1991-08-28

Application number

AT92114654T

Other languages

English (en)

Inventor

Frank Waetjen

Bjarne Hugo Dahl

Jorgen Drejer

Leif Helth Jensen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-28

Filing date

1992-08-27

Publication date

1999-07-15

1992-08-27 Application filed by Neurosearch As filed Critical Neurosearch As

1999-07-15 Application granted granted Critical

1999-07-15 Publication of ATE181552T1 publication Critical patent/ATE181552T1/de

Links

NGXLTYPELAIUHE-UHFFFAOYSA-N 2-(hydroxyamino)indol-3-one Chemical class C1=CC=C2C(=O)C(NO)=NC2=C1 NGXLTYPELAIUHE-UHFFFAOYSA-N 0.000 title 1
125000004122 cyclic group Chemical group 0.000 abstract 5
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
OZDAOHVKBFBBMZ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydrate Chemical compound O.OC(=O)C(N)CCC(O)=O OZDAOHVKBFBBMZ-UHFFFAOYSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
108010011562 aspartic acid receptor Proteins 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
235000013922 glutamic acid Nutrition 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Medicinal Preparation (AREA)

AT92114654T 1991-08-28 1992-08-27 Isatinoximderivate, ihre herstellung und anwendung ATE181552T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75116591A	1991-08-28	1991-08-28
US83185192A	1992-02-05	1992-02-05

Publications (1)

Publication Number	Publication Date
ATE181552T1 true ATE181552T1 (de)	1999-07-15

Family

ID=27115380

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92114654T ATE181552T1 (de)	1991-08-28	1992-08-27	Isatinoximderivate, ihre herstellung und anwendung

Country Status (18)

Country	Link
EP (1)	EP0529636B1 (de)
JP (1)	JP3170584B2 (de)
KR (1)	KR100277481B1 (de)
AT (1)	ATE181552T1 (de)
AU (1)	AU655672B2 (de)
CA (1)	CA2076948C (de)
CZ (1)	CZ282759B6 (de)
DE (1)	DE69229461T2 (de)
DK (1)	DK0529636T3 (de)
FI (1)	FI107156B (de)
GE (1)	GEP20002329B (de)
HU (2)	HUT70753A (de)
MX (1)	MX9204914A (de)
NO (1)	NO301117B1 (de)
PL (1)	PL170920B1 (de)
RU (1)	RU2114827C1 (de)
SK (1)	SK280578B6 (de)
WO (1)	WO1993005043A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU680632B2 (en)	1992-10-13	1997-08-07	Neurosearch A/S	Quinoxalinedione derivatives as EAA antagonists
US5843945A (en) *	1993-05-13	1998-12-01	Neurosearch A/S	AMPA antagonists and a method of treatment
CA2161783C (en) *	1993-05-13	2006-08-15	Frank Watjen	Ampa antagonists and a method of treatment therewith
DK81593D0 (da) *	1993-07-07	1993-07-07	Neurosearch As	Nye isatinoximderivater, deres fremstilling og anvendelse
US5917053A (en) *	1994-09-14	1999-06-29	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives, their preparation and use
NZ293266A (en) *	1994-09-14	1998-01-26	Neurosearch As	Fused indole and quinoxaline dione and dione oxime derivatives, preparation and pharmaceutical compositions
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2768624B1 (fr)	1997-09-25	1999-11-12	Oreal	Utilisation d'un inhibiteur d'acides amines excitateurs dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue
ATE420636T1 (de)	1999-05-19	2009-01-15	Painceptor Pharma Corp	Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
JP2003520851A (ja)	2000-01-24	2003-07-08	ニューロサーチ、アクティーゼルスカブ	神経栄養活性を有するイサチン誘導体
US7250422B2 (en)	2002-10-29	2007-07-31	Sungkyunkwan University	Pharmaceutical composition containing berberine as effective ingredient for preventing and treating addiction or tolerance to morphine
CN101346375B (zh)	2005-11-23	2013-04-10	阿罗斯药物有限责任公司	调节门离子通道用组合物和方法
CN104995171B (zh) *	2012-12-19	2018-02-06	拜耳作物科学股份公司	作为杀真菌剂的二氟甲基‑烟碱‑茚满基甲酰胺
JP6380524B2 (ja) *	2014-02-28	2018-08-29	住友化学株式会社	２−（ハロゲノメチル）−３−メチルニトロベンゼンの製造方法
CN108777958B (zh)	2016-03-17	2021-03-12	Fmc有限公司	将s-对映体转换成其消旋形式的方法
CN112266368B (zh) *	2017-11-15	2024-03-19	中山光禾医疗科技有限公司	光交联水凝胶材料的制备、原料、产品及应用
CN108912127B (zh) *	2018-08-27	2019-12-10	青岛农业大学	一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE69677B1 (en) *	1989-12-11	1996-10-02	Neurosearch As	Isatine derivatives their preparation and use

1992
- 1992-08-26 MX MX9204914A patent/MX9204914A/es not_active IP Right Cessation
- 1992-08-26 CA CA002076948A patent/CA2076948C/en not_active Expired - Fee Related
- 1992-08-27 EP EP92114654A patent/EP0529636B1/de not_active Expired - Lifetime
- 1992-08-27 SK SK238-94A patent/SK280578B6/sk unknown
- 1992-08-27 KR KR1019940700676A patent/KR100277481B1/ko not_active Expired - Fee Related
- 1992-08-27 DE DE69229461T patent/DE69229461T2/de not_active Expired - Lifetime
- 1992-08-27 JP JP50493393A patent/JP3170584B2/ja not_active Expired - Fee Related
- 1992-08-27 DK DK92114654T patent/DK0529636T3/da active
- 1992-08-27 WO PCT/EP1992/001999 patent/WO1993005043A1/en not_active Ceased
- 1992-08-27 GE GEAP19922683A patent/GEP20002329B/en unknown
- 1992-08-27 RU RU94019425/04A patent/RU2114827C1/ru not_active IP Right Cessation
- 1992-08-27 CZ CZ94395A patent/CZ282759B6/cs not_active IP Right Cessation
- 1992-08-27 HU HU9400595A patent/HUT70753A/hu unknown
- 1992-08-27 AT AT92114654T patent/ATE181552T1/de not_active IP Right Cessation
- 1992-08-27 AU AU24820/92A patent/AU655672B2/en not_active Ceased
- 1992-08-27 PL PL92302584A patent/PL170920B1/pl unknown
1994
- 1994-02-25 NO NO940676A patent/NO301117B1/no unknown
- 1994-02-25 FI FI940889A patent/FI107156B/fi active
1995
- 1995-06-21 HU HU95P/P00323P patent/HU211632A9/hu unknown

Also Published As

Publication number	Publication date
NO940676L (de)	1994-04-27
DK0529636T3 (da)	1999-12-13
JPH06510056A (ja)	1994-11-10
CZ282759B6 (cs)	1997-09-17
JP3170584B2 (ja)	2001-05-28
DE69229461T2 (de)	1999-10-21
NO940676D0 (no)	1994-02-25
SK23894A3 (en)	1994-12-07
RU2114827C1 (ru)	1998-07-10
WO1993005043A1 (en)	1993-03-18
NO301117B1 (no)	1997-09-15
HUT70753A (en)	1995-10-30
GEP20002329B (en)	2000-12-25
FI940889A0 (fi)	1994-02-25
CZ39594A3 (en)	1994-11-16
AU2482092A (en)	1993-04-05
EP0529636A1 (de)	1993-03-03
FI940889A7 (fi)	1994-02-25
CA2076948C (en)	2002-04-16
SK280578B6 (sk)	2000-04-10
HU211632A9 (en)	1995-12-28
MX9204914A (es)	1993-07-01
CA2076948A1 (en)	1993-03-01
AU655672B2 (en)	1995-01-05
HU9400595D0 (en)	1994-05-30
FI107156B (fi)	2001-06-15
DE69229461D1 (de)	1999-07-29
EP0529636B1 (de)	1999-06-23
PL170920B1 (pl)	1997-02-28
KR100277481B1 (ko)	2001-02-01

Legal Events

Date	Code	Title	Description
2000-01-15	UEP	Publication of translation of european patent specification
2004-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE181552T1 (de)	1999-07-15	Isatinoximderivate, ihre herstellung und anwendung
ATE117295T1 (de)	1995-02-15	4-oxochinolin-3-carbonsäure-derivate, ihre herstellung und ihre verwendung.
ATE119887T1 (de)	1995-04-15	Benzimidazolderivate, ihre herstellung und ihre verwendung.
ATE116639T1 (de)	1995-01-15	Hydrazonderivate, ihre herstellung und verwendung.
ATE115128T1 (de)	1994-12-15	3-arylindol- und 3-arylindazolderivate.
RU94019425A (ru)	1995-09-27	Производные изатиноксима, способ их получения, фармацевтическая композиция и способ лечения
DE3888340D1 (de)	1994-04-14	Verwendung von 1,4-disubstituierten-Piperidinyl-Verbindungen zur Herstellung eines Arzneimittels zur Behandlung von Schlaflosigkeit.
ATE102600T1 (de)	1994-03-15	Aryloxyphenylpropylamine und deren verwendung.
ATE99296T1 (de)	1994-01-15	Chinoxalin-verbindungen und deren herstellung und verwendung.
NO903148L (no)	1991-01-15	Hemoreguleringspeptider.
ATE121395T1 (de)	1995-05-15	Cumarinderivate, ihre herstellung und ihre verwendung zur behandlung von zerebrovaskulären störungen.
ATE198750T1 (de)	2001-02-15	Isatinoxim-derivate, ihre herstellung und verwendung
ES515872A0 (es)	1983-06-01	"procedimiento para la preparacion de nuevos derivados de acidos 4-fenoxialcarboxilicos sustituidos con radicales haterociclicos".
ES2088903T3 (es)	1996-10-01	Nuevos inhibidores de la s-adenosilmetionina descarboxilasa.
ATE143659T1 (de)	1996-10-15	Neue isatineoxime derivate, ihre herstellung und verwendung
DE69105865D1 (de)	1995-01-26	Biphenyl-5,5'-bis-Alkansäurederivate, deren Herstellung und Verwendung.
ATE157539T1 (de)	1997-09-15	3-benzoyl-3,7-diazabicyclo(3,3,1)nonan- verbindungen mit anti-arrhythmischer wirkung
ATE115858T1 (de)	1995-01-15	Behandlung von schlaf-apnoea mit azapironderivaten.
ATE22289T1 (de)	1986-10-15	N-(3-trifluormethylphenyl)-n'-propargylpiperazi , seine herstellung und verwendung.
DE69407042D1 (de)	1998-01-08	Psoralen-derivate, deren herstellung und verwendung als arzneimittel
ATE108444T1 (de)	1994-07-15	3-isoxazolonderivate, ihre herstellung und ihre anwendung in der therapeutik.