NO302524B1 - Fremgangsmåte for fremstilling av ribonukleotidreduktaseinhibitorer - Google Patents

Fremgangsmåte for fremstilling av ribonukleotidreduktaseinhibitorer

Info

Publication number: NO302524B1
Authority: NO; Norway
Prior art keywords: reductase inhibitors; ribonucleotide reductase; preparation; oxy; methylene
Prior art date: 1992-05-12

Application number

NO944309A

Other languages

English (en)

Norwegian (no)

Other versions

NO944309L (no

NO944309D0 (no

Inventor

James Ray Mccarthy

Donald Paul Matthews

Jeffrey Stephen Sabol

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-12

Filing date

1994-11-11

Publication date

1998-03-16

1994-11-11 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1994-11-11 Publication of NO944309L publication Critical patent/NO944309L/no

1994-11-11 Publication of NO944309D0 publication Critical patent/NO944309D0/no

1998-03-16 Publication of NO302524B1 publication Critical patent/NO302524B1/no

Links

229940127395 Ribonucleotide Reductase Inhibitors Drugs 0.000 title abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 abstract 1
UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 abstract 1
XUCNUKMRBVNAPB-UHFFFAOYSA-N fluoroethene Chemical class FC=C XUCNUKMRBVNAPB-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)

NO944309A 1992-05-12 1994-11-11 Fremgangsmåte for fremstilling av ribonukleotidreduktaseinhibitorer NO302524B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US88197892A	1992-05-12	1992-05-12
US3101293A	1993-03-26	1993-03-26
PCT/US1993/003023 WO1993023414A1 (en)	1992-05-12	1993-04-01	A process for the preparation of ribonucleotide reductase inhibitors

Publications (3)

Publication Number	Publication Date
NO944309L NO944309L (no)	1994-11-11
NO944309D0 NO944309D0 (no)	1994-11-11
NO302524B1 true NO302524B1 (no)	1998-03-16

Family

ID=26706717

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO944309A NO302524B1 (no)	1992-05-12	1994-11-11	Fremgangsmåte for fremstilling av ribonukleotidreduktaseinhibitorer

Country Status (15)

Country	Link
EP (1)	EP0640092B1 (de)
JP (1)	JP3265548B2 (de)
KR (1)	KR100255258B1 (de)
AT (1)	ATE146183T1 (de)
AU (1)	AU662630B2 (de)
CA (1)	CA2133961C (de)
DE (1)	DE69306570T2 (de)
DK (1)	DK0640092T3 (de)
ES (1)	ES2098032T3 (de)
FI (1)	FI106127B (de)
GR (1)	GR3022400T3 (de)
HU (1)	HU217963B (de)
NO (1)	NO302524B1 (de)
NZ (1)	NZ251886A (de)
WO (1)	WO1993023414A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995018815A1 (en) *	1994-01-07	1995-07-13	Merrell Pharmaceuticals Inc.	Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine
AU2768295A (en) *	1994-07-11	1996-02-09	Hoechst Marion Roussel, Inc.	Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
EP1480982A4 (de) *	2002-02-14	2007-08-01	Pharmasset Inc	Modifizierte fluorinierte nukleosidanaloga
KR102072041B1 (ko)	2011-12-22	2020-01-31	앨리오스 바이오파마 인크.	치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU204843B (en) *	1988-09-27	1992-02-28	Merrell Dow Pharma	Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
CA2002648C (en) *	1988-11-15	2000-02-29	James R. Mccarthy	2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives
JP2559917B2 (ja)	1990-06-15	1996-12-04	三共株式会社	ピリミジンヌクレオシド誘導体

1993
- 1993-04-01 DK DK93909461.1T patent/DK0640092T3/da active
- 1993-04-01 WO PCT/US1993/003023 patent/WO1993023414A1/en not_active Ceased
- 1993-04-01 AU AU40247/93A patent/AU662630B2/en not_active Ceased
- 1993-04-01 JP JP52020493A patent/JP3265548B2/ja not_active Expired - Fee Related
- 1993-04-01 CA CA002133961A patent/CA2133961C/en not_active Expired - Fee Related
- 1993-04-01 EP EP93909461A patent/EP0640092B1/de not_active Expired - Lifetime
- 1993-04-01 ES ES93909461T patent/ES2098032T3/es not_active Expired - Lifetime
- 1993-04-01 HU HU9403252A patent/HU217963B/hu not_active IP Right Cessation
- 1993-04-01 DE DE69306570T patent/DE69306570T2/de not_active Expired - Fee Related
- 1993-04-01 KR KR1019940704030A patent/KR100255258B1/ko not_active Expired - Fee Related
- 1993-04-01 NZ NZ251886A patent/NZ251886A/en not_active IP Right Cessation
- 1993-04-01 AT AT93909461T patent/ATE146183T1/de not_active IP Right Cessation
1994
- 1994-11-10 FI FI945290A patent/FI106127B/fi not_active IP Right Cessation
- 1994-11-11 NO NO944309A patent/NO302524B1/no unknown
1997
- 1997-01-29 GR GR960403606T patent/GR3022400T3/el unknown

Also Published As

Publication number	Publication date
FI945290A0 (fi)	1994-11-10
JP3265548B2 (ja)	2002-03-11
JPH07507774A (ja)	1995-08-31
EP0640092A1 (de)	1995-03-01
FI945290L (fi)	1994-11-10
HU9403252D0 (en)	1995-02-28
AU662630B2 (en)	1995-09-07
NZ251886A (en)	1996-02-27
CA2133961C (en)	1998-03-31
HU217963B (hu)	2000-05-28
CA2133961A1 (en)	1993-11-25
ES2098032T3 (es)	1997-04-16
GR3022400T3 (en)	1997-04-30
NO944309L (no)	1994-11-11
ATE146183T1 (de)	1996-12-15
NO944309D0 (no)	1994-11-11
WO1993023414A1 (en)	1993-11-25
DE69306570D1 (de)	1997-01-23
KR100255258B1 (ko)	2000-05-01
DE69306570T2 (de)	1997-04-10
FI106127B (fi)	2000-11-30
AU4024793A (en)	1993-12-13
EP0640092B1 (de)	1996-12-11
HUT68903A (en)	1995-08-28
KR950701641A (ko)	1995-04-28
DK0640092T3 (da)	1996-12-30

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CY2394B1 (en)	2004-09-10	Use of sulphamate derivatives as steroid sulphatase inhibitors.
ES2176402T3 (es)	2002-12-01	Compuestos sulfatos de 2,2-difluoro-3-carbomoil-ribosa y procedimientopara la preparacion de beta-nucleosidos.
DE69914893D1 (de)	2004-03-25	Glycinamidederivate mit funktionalisierter alkyl- und alkenylseitenkette als inhibitoren der farnesyltransferase
MX9500363A (es)	1998-04-30	Monohiddrato de (e)-2'-desoxi-2'- (fluorometilen) citidina.
IT8922768A0 (it)	1989-12-21	Composti attivi come inibitori dell'enzima hmg-coa reduttasi
AU1024288A (en)	1988-07-21	Method of combating termites
PT918776E (pt)	2004-07-30	Sintese total de acilfulvenos antitumorais
MY117764A (en)	2004-08-30	Xanthine derivatives with end-aminated alkynol side chains.
MX9602861A (es)	1997-06-28	Mezcla estabilizante sinergistica.
GB2331988B (en)	2003-04-16	Polycyclic sulphamate inhibitors or oestrone sulphatase
NO944309L (no)	1994-11-11	Fremgangsmåte for fremstilling av ribonukleotidreduktase-inhibitorer
IT1237792B (it)	1993-06-17	Composti attivi come inibitori dell'enzima hmg-coa reduttasi
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NO964522D0 (no)	1996-10-24	Fremgangmåte ved fremstilling av 5,6-dihydroksy-2-amino-1,2,3,4-tetrahydronaftalenderivater
ATE135352T1 (de)	1996-03-15	3-keto-hmg-coa reduktase-inhibitoren
IT1255728B (it)	1995-11-15	Derivati di s-triazina ad azione fotoprotettiva
MX9709955A (es)	1998-03-29	Derivados del acido 5-pirazolilbenzoico.
ES2039270T3 (es)	1993-09-16	Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.
ES2077697T3 (es)	1995-12-01	Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.
AU6524800A (en)	2001-03-13	Processes for the preparation of 2-arylvinyl alkyl ether and 1,4-diaryl-2-fluoro-2-butene compounds
ZA9510964B (en)	1996-06-08	Antiherpes peptidomimetic compounds
ES2151820A1 (es)	2001-01-01	Herbicidas a base de derivados de 1,3-oxazin-4-ona, composiciones que los contienen y procedimiento para su preparacion.