ATE146183T1 - Verfahren zur herstellung von ribonukleotid- reduktasehemmern - Google Patents

Verfahren zur herstellung von ribonukleotid- reduktasehemmern

Info

Publication number: ATE146183T1
Authority: AT; Austria
Prior art keywords: reductase inhibitors; ribonucleotide reductase; producing; producing ribonucleotide; oxy
Prior art date: 1992-05-12

Application number

AT93909461T

Other languages

English (en)

Inventor

James R Mccarthy

Donald P Matthews

Jeffrey S Sabol

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-12

Filing date

1993-04-01

Publication date

1996-12-15

1993-04-01 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1996-12-15 Application granted granted Critical

1996-12-15 Publication of ATE146183T1 publication Critical patent/ATE146183T1/de

Links

229940127395 Ribonucleotide Reductase Inhibitors Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 abstract 1
UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 abstract 1
XUCNUKMRBVNAPB-UHFFFAOYSA-N fluoroethene Chemical class FC=C XUCNUKMRBVNAPB-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)

AT93909461T 1992-05-12 1993-04-01 Verfahren zur herstellung von ribonukleotid- reduktasehemmern ATE146183T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US88197892A	1992-05-12	1992-05-12
US3101293A	1993-03-26	1993-03-26

Publications (1)

Publication Number	Publication Date
ATE146183T1 true ATE146183T1 (de)	1996-12-15

Family

ID=26706717

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93909461T ATE146183T1 (de)	1992-05-12	1993-04-01	Verfahren zur herstellung von ribonukleotid- reduktasehemmern

Country Status (15)

Country	Link
EP (1)	EP0640092B1 (de)
JP (1)	JP3265548B2 (de)
KR (1)	KR100255258B1 (de)
AT (1)	ATE146183T1 (de)
AU (1)	AU662630B2 (de)
CA (1)	CA2133961C (de)
DE (1)	DE69306570T2 (de)
DK (1)	DK0640092T3 (de)
ES (1)	ES2098032T3 (de)
FI (1)	FI106127B (de)
GR (1)	GR3022400T3 (de)
HU (1)	HU217963B (de)
NO (1)	NO302524B1 (de)
NZ (1)	NZ251886A (de)
WO (1)	WO1993023414A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE186732T1 (de) *	1994-01-07	1999-12-15	Merrell Pharma Inc	(e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydr t
AU2768295A (en) *	1994-07-11	1996-02-09	Hoechst Marion Roussel, Inc.	Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
JP2005522443A (ja) *	2002-02-14	2005-07-28	フアーマセツト・リミテツド	改変フッ素化ヌクレオシド類似体
SG10201913554YA (en)	2011-12-22	2020-03-30	Alios Biopharma Inc	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU204843B (en) *	1988-09-27	1992-02-28	Merrell Dow Pharma	Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
ZA898567B (en) *	1988-11-15	1990-08-29	Merrell Dow Pharma	Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives
JP2559917B2 (ja)	1990-06-15	1996-12-04	三共株式会社	ピリミジンヌクレオシド誘導体

1993
- 1993-04-01 JP JP52020493A patent/JP3265548B2/ja not_active Expired - Fee Related
- 1993-04-01 AU AU40247/93A patent/AU662630B2/en not_active Ceased
- 1993-04-01 HU HU9403252A patent/HU217963B/hu not_active IP Right Cessation
- 1993-04-01 DK DK93909461.1T patent/DK0640092T3/da active
- 1993-04-01 KR KR1019940704030A patent/KR100255258B1/ko not_active Expired - Fee Related
- 1993-04-01 DE DE69306570T patent/DE69306570T2/de not_active Expired - Fee Related
- 1993-04-01 EP EP93909461A patent/EP0640092B1/de not_active Expired - Lifetime
- 1993-04-01 CA CA002133961A patent/CA2133961C/en not_active Expired - Fee Related
- 1993-04-01 AT AT93909461T patent/ATE146183T1/de not_active IP Right Cessation
- 1993-04-01 ES ES93909461T patent/ES2098032T3/es not_active Expired - Lifetime
- 1993-04-01 NZ NZ251886A patent/NZ251886A/en not_active IP Right Cessation
- 1993-04-01 WO PCT/US1993/003023 patent/WO1993023414A1/en not_active Ceased
1994
- 1994-11-10 FI FI945290A patent/FI106127B/fi not_active IP Right Cessation
- 1994-11-11 NO NO944309A patent/NO302524B1/no unknown
1997
- 1997-01-29 GR GR960403606T patent/GR3022400T3/el unknown

Also Published As

Publication number	Publication date
NO944309L (no)	1994-11-11
FI945290L (fi)	1994-11-10
DE69306570T2 (de)	1997-04-10
HU217963B (hu)	2000-05-28
CA2133961C (en)	1998-03-31
KR100255258B1 (ko)	2000-05-01
NO944309D0 (no)	1994-11-11
AU4024793A (en)	1993-12-13
EP0640092A1 (de)	1995-03-01
HUT68903A (en)	1995-08-28
CA2133961A1 (en)	1993-11-25
DK0640092T3 (da)	1996-12-30
NO302524B1 (no)	1998-03-16
KR950701641A (ko)	1995-04-28
FI106127B (fi)	2000-11-30
JPH07507774A (ja)	1995-08-31
GR3022400T3 (en)	1997-04-30
EP0640092B1 (de)	1996-12-11
JP3265548B2 (ja)	2002-03-11
WO1993023414A1 (en)	1993-11-25
NZ251886A (en)	1996-02-27
ES2098032T3 (es)	1997-04-16
FI945290A0 (fi)	1994-11-10
AU662630B2 (en)	1995-09-07
HU9403252D0 (en)	1995-02-28
DE69306570D1 (de)	1997-01-23

Similar Documents

Publication	Publication Date	Title
ATE282020T1 (de)	2004-11-15	Verfahren zur herstellung von 2-aminomalonsäure- derivaten
ATE217634T1 (de)	2002-06-15	2,2-difluor-3-carbamoylribosesulfonat- verbindungen und verfahren zur herstellung von beta-nukleosiden
ES2103516T3 (es)	1997-09-16	Procedimiento para reticular.
ATE259374T1 (de)	2004-02-15	Verfahren zur herstellung von isoguanosin und 2'- derivaten davon
HUT63419A (en)	1993-08-30	Process for producing mercaptoacetamide derivatives of pyrrolo-, pyrido- and oxazinobenzazepine having encephalinase- and angiotensin-converting enzyme-inhibiting activity
DE3882382D1 (de)	1993-08-26	Verfahren zur termitenbekaempfung.
DE69814635D1 (de)	2003-06-18	Verfahren zur herstellung von 2-hydroxybenzamidderivaten
ATE158579T1 (de)	1997-10-15	Verfahren zur herstellung von (3r,5s)6-hydroxy- 3,5-0-isopropyliden-3,5-dihydroxy-hexansäure- tert.-butylester
ATE153073T1 (de)	1997-05-15	Verfahren zur herstellung von n- acetylneuraminsäure
ATE210136T1 (de)	2001-12-15	Verfahren zur herstellung von alkylhydrogenchlorsilanen
ATE197150T1 (de)	2000-11-15	Verfahren zur herstellung von dihydroxypyrimidin- derivaten
DE69722111D1 (de)	2003-06-26	Verfahren zur reduktion von carbonylverbindungen
ATE146183T1 (de)	1996-12-15	Verfahren zur herstellung von ribonukleotid- reduktasehemmern
MX9500363A (es)	1998-04-30	Monohiddrato de (e)-2'-desoxi-2'- (fluorometilen) citidina.
DE69328969D1 (de)	2000-08-10	Verfahren zur stereospezifischen hydrolyse von piperidin-dion derivaten
HUT72591A (en)	1996-05-28	Piperazine derivatives for producing alkyl-trazodon derivatives and process for producing them
DE69518252D1 (de)	2000-09-07	Verfahren zur herstellung von 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalin-derivaten
DE59908429D1 (de)	2004-03-04	Verfahren zur herstellung von (1r,4s)-2-azabicyclo 2.2.1 hept-5-en-3-on-derivaten
ATE449063T1 (de)	2009-12-15	Verfahren zur herstellung von beta- hydroxyalkylamiden
ATE234800T1 (de)	2003-04-15	Verfahren zur synthese von taxanen
ATE242218T1 (de)	2003-06-15	Verfahren zur herstellung von imidazolinderivaten
DE69809205D1 (de)	2002-12-12	Verfahren zur herstellung von azyklischen nukleosiden
ATE253125T1 (de)	2003-11-15	Verfahren zur herstellung von optisch aktiven 1- amino-4- (hydroxymethyl)- cyclopent-2- en- derivaten
ATE247618T1 (de)	2003-09-15	Verfahren zur herstellung von 1,4-diaryl-2-fluor- 1,3-butadien- und 1,4-diaryl-2-fluor-2- butenverbindungen
DE69616801D1 (de)	2001-12-13	Eintopfverfahren zur herstellung von 2-oxazolidinonderivate

Legal Events

Date	Code	Title	Description
1997-06-15	UEP	Publication of translation of european patent specification
2009-01-15	REN	Ceased due to non-payment of the annual fee