NO302754B1 - Fremgangsmåte ved fremstilling av ergolinderivater - Google Patents

Fremgangsmåte ved fremstilling av ergolinderivater

Info

Publication number: NO302754B1
Authority: NO; Norway
Prior art keywords: preparation; formula; ergoline derivatives; ergoline; image
Prior art date: 1992-03-12

Application number

NO934077A

Other languages

English (en)

Norwegian (no)

Other versions

NO934077D0 (no

NO934077L (no

Inventor

Ilaria Candiani

Walter Cabri

Angelo Bedeschi

Franco Zarini

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-12

Filing date

1993-11-11

Publication date

1998-04-20

1993-11-11 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

1993-11-11 Publication of NO934077D0 publication Critical patent/NO934077D0/no

1993-11-11 Publication of NO934077L publication Critical patent/NO934077L/no

1998-04-20 Publication of NO302754B1 publication Critical patent/NO302754B1/no

Links

AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
-1 ergoline amide Chemical class 0.000 abstract 2
239000000939 antiparkinson agent Substances 0.000 abstract 1
229940125688 antiparkinson agent Drugs 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000012948 isocyanate Substances 0.000 abstract 1
150000002513 isocyanates Chemical class 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
229910052698 phosphorus Inorganic materials 0.000 abstract 1
239000011574 phosphorus Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Psychology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Emergency Protection Circuit Devices (AREA)
Control Of Electric Motors In General (AREA)

NO934077A 1992-03-12 1993-11-11 Fremgangsmåte ved fremstilling av ergolinderivater NO302754B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929205439A GB9205439D0 (en)	1992-03-12	1992-03-12	Process for the synthesis of ergoline derivatives
PCT/EP1993/000360 WO1993018034A1 (fr)	1992-03-12	1993-02-15	Procede de preparation de derives de l'ergoline

Publications (3)

Publication Number	Publication Date
NO934077D0 NO934077D0 (no)	1993-11-11
NO934077L NO934077L (no)	1993-11-11
NO302754B1 true NO302754B1 (no)	1998-04-20

Family

ID=10712024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO934077A NO302754B1 (no)	1992-03-12	1993-11-11	Fremgangsmåte ved fremstilling av ergolinderivater

Country Status (25)

Country	Link
US (1)	US5382669A (fr)
EP (1)	EP0593692B1 (fr)
JP (1)	JP3339858B2 (fr)
KR (1)	KR100274102B1 (fr)
CN (1)	CN1038510C (fr)
AT (1)	ATE180783T1 (fr)
AU (1)	AU653099B2 (fr)
CA (1)	CA2106371C (fr)
CZ (1)	CZ281708B6 (fr)
DE (1)	DE69325138D1 (fr)
FI (1)	FI113473B (fr)
GB (1)	GB9205439D0 (fr)
HU (1)	HU210407B (fr)
IL (1)	IL104973A (fr)
MX (1)	MX9301297A (fr)
MY (1)	MY109152A (fr)
NO (1)	NO302754B1 (fr)
NZ (1)	NZ249115A (fr)
PH (1)	PH30138A (fr)
RU (1)	RU2118323C1 (fr)
SK (1)	SK279039B6 (fr)
TW (1)	TW215089B (fr)
UA (1)	UA26400C2 (fr)
WO (1)	WO1993018034A1 (fr)
ZA (1)	ZA931720B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0007308D0 (en) *	2000-03-24	2000-05-17	Pharmacia & Upjohn Spa	Process for preparing crystalline form \| of cabergoline
US6696568B2 (en)	2001-04-16	2004-02-24	Finetech Ltd.	Process and intermediates for production of cabergoline and related compounds
KR100795425B1 (ko) *	2003-04-11	2008-01-17	소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스.	소마토스타틴-도파민 키메라 유사체
IL155545A (en) *	2003-04-21	2009-12-24	Finetech Pharmaceutical Ltd	Solvate form of cabergoline
HUP0400517A3 (en) *	2004-03-04	2006-05-29	Richter Gedeon Vegyeszet	Process for producing cabergoline
GB0409785D0 (en) *	2004-04-30	2004-06-09	Resolution Chemicals Ltd	Preparation of cabergoline
FR2877945A1 (fr) *	2004-11-18	2006-05-19	Archemis Sa	Procede de la preparation de la cabergoline
EP1858894A1 (fr)	2005-03-17	2007-11-28	Synthon Argentina S.A.	Procede ameliore de preparation de la cabergoline
GB0505965D0 (en) *	2005-03-23	2005-04-27	Resolution Chemicals Ltd	Preparation of cabergoline
EP1925616A1 (fr) *	2006-10-26	2008-05-28	LEK Pharmaceuticals D.D.	Procédé pour la préparation de formes crystallines de la cabergoline via des solvates stables de la cabergoline
US7939665B2 (en) *	2007-05-04	2011-05-10	Apotex Pharmachem Inc.	Efficient process for the preparation of cabergoline and its intermediates
CN105189492A (zh) *	2012-11-19	2015-12-23	萨克·W·金	麦角灵衍生物作为多巴胺受体调节剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2074566B (en) *	1980-04-03	1983-11-02	Erba Farmitalia	Ergoline derivatives
GB2103603B (en) *	1981-08-11	1985-04-11	Erba Farmitalia	Ergoline derivatives

1992
- 1992-03-12 GB GB929205439A patent/GB9205439D0/en active Pending
1993
- 1993-02-15 RU RU93058546A patent/RU2118323C1/ru not_active IP Right Cessation
- 1993-02-15 SK SK1401-93A patent/SK279039B6/sk unknown
- 1993-02-15 DE DE69325138T patent/DE69325138D1/de not_active Expired - Lifetime
- 1993-02-15 HU HU9303541A patent/HU210407B/hu unknown
- 1993-02-15 WO PCT/EP1993/000360 patent/WO1993018034A1/fr not_active Ceased
- 1993-02-15 UA UA93003963A patent/UA26400C2/uk unknown
- 1993-02-15 AU AU34974/93A patent/AU653099B2/en not_active Ceased
- 1993-02-15 JP JP51527993A patent/JP3339858B2/ja not_active Expired - Fee Related
- 1993-02-15 AT AT93903972T patent/ATE180783T1/de active
- 1993-02-15 NZ NZ249115A patent/NZ249115A/en not_active IP Right Cessation
- 1993-02-15 KR KR1019930703386A patent/KR100274102B1/ko not_active Expired - Fee Related
- 1993-02-15 CZ CZ932715A patent/CZ281708B6/cs not_active IP Right Cessation
- 1993-02-15 CA CA002106371A patent/CA2106371C/fr not_active Expired - Fee Related
- 1993-02-15 EP EP93903972A patent/EP0593692B1/fr not_active Expired - Lifetime
- 1993-02-16 TW TW082101067A patent/TW215089B/zh active
- 1993-03-08 IL IL104973A patent/IL104973A/xx not_active IP Right Cessation
- 1993-03-09 CN CN93102663A patent/CN1038510C/zh not_active Expired - Fee Related
- 1993-03-09 MX MX9301297A patent/MX9301297A/es not_active IP Right Cessation
- 1993-03-09 US US08/028,286 patent/US5382669A/en not_active Expired - Lifetime
- 1993-03-09 PH PH45839A patent/PH30138A/en unknown
- 1993-03-10 ZA ZA931720A patent/ZA931720B/xx unknown
- 1993-03-11 MY MYPI93000439A patent/MY109152A/en unknown
- 1993-11-08 FI FI934933A patent/FI113473B/fi active
- 1993-11-11 NO NO934077A patent/NO302754B1/no unknown

Also Published As

Publication number	Publication date
FI113473B (fi)	2004-04-30
TW215089B (fr)	1993-10-21
JPH06507648A (ja)	1994-09-01
IL104973A (en)	1997-06-10
UA26400C2 (uk)	1999-08-30
EP0593692A1 (fr)	1994-04-27
HUT66712A (en)	1994-12-28
CA2106371C (fr)	2003-09-23
US5382669A (en)	1995-01-17
MX9301297A (es)	1993-09-01
FI934933A0 (fi)	1993-11-08
HU210407B (en)	1995-04-28
JP3339858B2 (ja)	2002-10-28
CN1038510C (zh)	1998-05-27
SK140193A3 (en)	1994-11-09
DE69325138D1 (de)	1999-07-08
EP0593692B1 (fr)	1999-06-02
CN1076196A (zh)	1993-09-15
AU3497493A (en)	1993-10-05
FI934933A7 (fi)	1993-11-08
AU653099B2 (en)	1994-09-15
GB9205439D0 (en)	1992-04-22
MY109152A (en)	1996-12-31
SK279039B6 (sk)	1998-05-06
NO934077D0 (no)	1993-11-11
IL104973A0 (en)	1993-07-08
KR100274102B1 (ko)	2000-12-15
NO934077L (no)	1993-11-11
WO1993018034A1 (fr)	1993-09-16
CZ281708B6 (cs)	1996-12-11
RU2118323C1 (ru)	1998-08-27
PH30138A (en)	1997-01-21
ZA931720B (en)	1993-11-01
NZ249115A (en)	1995-04-27
CA2106371A1 (fr)	1993-09-13
ATE180783T1 (de)	1999-06-15
CZ271593A3 (en)	1994-04-13

Publication	Publication Date	Title
ES2070660A1 (es)	1995-06-01	Un procedimiento para la preparacion de 2,5-damino-3-hidroxihexanos sustituidos, utiles como inhibidores de proteasas retrovirales.
IL106676A0 (en)	1993-12-08	Novel 7-(substituted)-8-(substituted-9-(substituted glycyl)amido)-6-demethyl-6-deoxytetracyclines
CA2110693A1 (fr)	1992-12-10	Derive d'acide amine anticonvulsif
MY113806A (en)	2002-05-31	Antiparasitic marcfortines and paraherquamides
CA2502856A1 (fr)	1994-06-30	Intermediaires pour les composes inhibant la protease retrovirale
NO934077L (no)	1993-11-11	Fremgangsmaate ved fremstilling av ergolinderivater
TW232013B (fr)	1994-10-11
NO20002676D0 (no)	2000-05-25	Androgene steroidforbindelser og en fremgangsmÕte for fremstilling og anvendelse av samme
RU93058546A (ru)	1996-12-27	Способ получения производных эрголина, фармацевтическая композиция
NO940018D0 (no)	1994-01-04	Fremgangsmaate for fremstilling av svovelholdige imidazolderivater
PL312613A1 (en)	1996-04-29	Method of manufacturing hiv protease inhibitors
GR1002598B (el)	1997-02-12	Παραγωγα επι-επιβατιδινης.
NO944238D0 (no)	1994-11-07	Fremgangsmåte for fremstilling av hydroxyalkancarboxylsyreamider
IN184319B (fr)	2000-08-05
NO951094D0 (no)	1995-03-22	Fremgangsmåte for syntese av anvendelige mellomprodukter av substituerte imidazolforbindelser
GB9516143D0 (en)	1995-10-04	Improved chemical synthesis
HRP940174A2 (en)	1996-08-31	A chemical process for a synthesis of an antibacterial agent with an intermediate
CA2032311A1 (fr)	1991-06-21	Steroides a ponts 2,19-methyleneoxy et 2,19-methylenethio comme inhibiteurs de l'aromatase et de la 19-hydroxylase
TW328903B (en)	1998-04-01	Substituted quinoline herbicide intermediates and process
ES8507520A1 (es)	1985-09-01	Un procedimiento para la preparacion de nuevos compuestos de b-lactama
ES2067388A1 (es)	1995-03-16	Procedimiento para la produccion de derivados de piroglutamato de configuracion 2,4-cis
RU93054009A (ru)	1996-12-27	Гиспидоспермидин