NO304923B1 - Farmas°°ytisk preparat inneholdende 2-(2-nitro-4-trifluormetylbenzoyl)-1,3-cykloheksandion eller et farmas°ytisk godtagbart salt derav - Google Patents

Farmas°°ytisk preparat inneholdende 2-(2-nitro-4-trifluormetylbenzoyl)-1,3-cykloheksandion eller et farmas°ytisk godtagbart salt derav

Info

Publication number: NO304923B1
Authority: NO; Norway
Prior art keywords: cyclohexanedione; trifluoromethylbenzoyl; nitro; pharmaceutically acceptable; acceptable salt
Prior art date: 1991-06-24

Application number

NO934798A

Other languages

English (en)

Norwegian (no)

Other versions

NO934798D0 (no

NO934798L (no

Inventor

Martin Keith Ellis

Sven Torvald Lindstedt

Edward Alan Lock

Maj Elisabeth Holme Markstedt

Linda Carol Mutter

Michael Paul Prisbylla

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-24

Filing date

1993-12-23

Publication date

1999-03-08

1991-06-24 Priority claimed from GB919113622A external-priority patent/GB9113622D0/en

1992-03-24 Priority claimed from GB929206412A external-priority patent/GB9206412D0/en

1993-12-23 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1993-12-23 Publication of NO934798D0 publication Critical patent/NO934798D0/no

1993-12-23 Publication of NO934798L publication Critical patent/NO934798L/no

1999-03-08 Publication of NO304923B1 publication Critical patent/NO304923B1/no

Links

OUBCNLGXQFSTLU-UHFFFAOYSA-N nitisinone Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=CC=C1C(=O)C1C(=O)CCCC1=O OUBCNLGXQFSTLU-UHFFFAOYSA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 abstract 3
102100028626 4-hydroxyphenylpyruvate dioxygenase Human genes 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
QMNFICMPAXFAPC-UHFFFAOYSA-N 2-benzoylcyclohexane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C1C(=O)CCCC1=O QMNFICMPAXFAPC-UHFFFAOYSA-N 0.000 abstract 1
208000032001 Tyrosinemia type 1 Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
201000011296 tyrosinemia Diseases 0.000 abstract 1
201000007972 tyrosinemia type I Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Hydrogenated Pyridines (AREA)

NO934798A 1991-06-24 1993-12-23 Farmas°°ytisk preparat inneholdende 2-(2-nitro-4-trifluormetylbenzoyl)-1,3-cykloheksandion eller et farmas°ytisk godtagbart salt derav NO304923B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB919113622A GB9113622D0 (en)	1991-06-24	1991-06-24	Medicinal agents
GB929206412A GB9206412D0 (en)	1992-03-24	1992-03-24	Pharmaceutical compositions
PCT/GB1992/001094 WO1993000080A1 (en)	1991-06-24	1992-06-18	Use of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione in the treatment of tyrosinaemia and pharmaceutical compositions

Publications (3)

Publication Number	Publication Date
NO934798D0 NO934798D0 (no)	1993-12-23
NO934798L NO934798L (no)	1993-12-23
NO304923B1 true NO304923B1 (no)	1999-03-08

Family

ID=26299120

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO934798A NO304923B1 (no)	1991-06-24	1993-12-23	Farmas°°ytisk preparat inneholdende 2-(2-nitro-4-trifluormetylbenzoyl)-1,3-cykloheksandion eller et farmas°ytisk godtagbart salt derav
NO2005018C NO2005018I2 (no)	1991-06-24	2005-08-31	2-(2-Nitro-4-trifluormetylbenzoyl) 1,3-cykloheksa ndion eller et salt derav (forkortelse:NTBC)
NO2017045C NO2017045I1 (no)	1991-06-24	2017-08-23	Farmasøøytisk preparat inneholdende 2-(2-nitro-4-ifluormetylbenzoyl)-1,3-cykloheksandion eller et farmasøytisk godtagbart salt derav

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
NO2005018C NO2005018I2 (no)	1991-06-24	2005-08-31	2-(2-Nitro-4-trifluormetylbenzoyl) 1,3-cykloheksa ndion eller et salt derav (forkortelse:NTBC)
NO2017045C NO2017045I1 (no)	1991-06-24	2017-08-23	Farmasøøytisk preparat inneholdende 2-(2-nitro-4-ifluormetylbenzoyl)-1,3-cykloheksandion eller et farmasøytisk godtagbart salt derav

Country Status (16)

Country	Link
US (1)	US5550165A (de)
EP (1)	EP0591275B1 (de)
JP (1)	JP3130935B2 (de)
AT (1)	ATE178207T1 (de)
AU (1)	AU672361B2 (de)
CA (1)	CA2072047C (de)
DE (2)	DE122005000032I2 (de)
DK (1)	DK0591275T3 (de)
ES (1)	ES2129448T3 (de)
GR (1)	GR3029841T3 (de)
IE (1)	IE922024A1 (de)
LU (1)	LU91180I2 (de)
NL (1)	NL300198I2 (de)
NO (3)	NO304923B1 (de)
PT (1)	PT100619B (de)
WO (1)	WO1993000080A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4305696A1 (de) *	1993-02-25	1994-09-01	Hoechst Ag	Nachweisverfahren zur Identifizierung von Inhibitoren
ATE276754T1 (de)	1998-07-21	2004-10-15	Cytovia Inc	Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung
GB0504103D0 (en) *	2005-02-28	2005-04-06	Syngenta Ltd	Novel method
BRPI0621959A2 (pt) *	2006-08-18	2011-12-27	Syngenta Ltd	usos de pelo menos um composto capaz de inibir 4-hidroxifenilpiruvato dioxigenase, e de um composto ou uma composiÇço, kit, e, composiÇço farmacÊutica
AU2011211223B2 (en) *	2010-01-29	2014-10-23	Toray Industries, Inc.	Therapeutic or prophylactic agent for biliary diseases
EP2723320B1 (de) *	2011-06-23	2016-01-13	Swedish Orphan Biovitrum International AB	Flüssige pharmazeutische zusammensetzung mit nitisinon
WO2013181292A1 (en) *	2012-05-29	2013-12-05	Biotie Therapies, Inc.	Nitisinone formulations
CN102976948B (zh) *	2012-11-28	2014-07-09	郑州大明药物科技有限公司	尼替西农的制备方法
GB201400117D0 (en)	2014-01-03	2014-02-19	Cycle Pharmaceuticals Ltd	Pharmaceutical composition
ITUB20160650A1 (it) *	2016-02-11	2017-08-11	Dipharma S A	Formulazioni farmaceutiche solide stabili contenenti 2-(2-nitro-4-trifluorometilbenzoil)-1,3-cicloesandione
US9783485B1 (en)	2016-11-30	2017-10-10	Dipharma S.A.	Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and a process of synthesis and crystallization thereof
EP3888684A1 (de)	2020-03-31	2021-10-06	Bayer Animal Health GmbH	Zusammensetzung mit verbesserter freiwilliger akzeptanz
CN112460914A (zh) *	2020-11-01	2021-03-09	江苏珠合新能源科技有限公司	一种干冰机尾气冷量回收调节工艺装置
WO2024047657A1 (en) *	2022-08-28	2024-03-07	Brawn Laboratories Ltd	Process for the preparation of nitisinone

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4780127A (en) *	1982-03-25	1988-10-25	Stauffer Chemical Company	Certain 2-(substituted benzoyl)-1,3-cyclohexanediones and their use as herbicides
IL77349A (en) *	1984-12-20	1990-07-12	Stauffer Chemical Co	2-(2'-nitrobenzoyl)-1,3-cyclohexanediones,their preparation and their use as herbicides
US4774360A (en)	1987-06-29	1988-09-27	Stauffer Chemical Company	Converting enol ester precursor of a benzoyl-1,3-cycloalkyldione to a benzoyl-1,3-cycloalkyldione
US4859234A (en)	1987-09-14	1989-08-22	Ici Americas Inc.	Herbicidal compositions of acylated 1,3-dicarbonyl herbicides and phenoxyalkanoic acids, salts, amides and esters therof as antidotes

1992
- 1992-06-18 EP EP92912215A patent/EP0591275B1/de not_active Expired - Lifetime
- 1992-06-18 AU AU19860/92A patent/AU672361B2/en not_active Expired
- 1992-06-18 JP JP05501383A patent/JP3130935B2/ja not_active Expired - Lifetime
- 1992-06-18 DK DK92912215T patent/DK0591275T3/da active
- 1992-06-18 ES ES92912215T patent/ES2129448T3/es not_active Expired - Lifetime
- 1992-06-18 AT AT92912215T patent/ATE178207T1/de active
- 1992-06-18 WO PCT/GB1992/001094 patent/WO1993000080A1/en not_active Ceased
- 1992-06-18 DE DE1992628813 patent/DE122005000032I2/de active Active
- 1992-06-18 DE DE69228813T patent/DE69228813T2/de not_active Expired - Lifetime
- 1992-06-23 CA CA002072047A patent/CA2072047C/en not_active Expired - Lifetime
- 1992-06-24 PT PT100619A patent/PT100619B/pt not_active IP Right Cessation
- 1992-07-01 IE IE202492A patent/IE922024A1/en not_active IP Right Cessation
1993
- 1993-12-23 NO NO934798A patent/NO304923B1/no active Protection Beyond IP Right Term
1994
- 1994-12-19 US US08/359,361 patent/US5550165A/en not_active Expired - Lifetime
1999
- 1999-04-01 GR GR990400803T patent/GR3029841T3/el unknown
2005
- 2005-06-09 NL NL300198C patent/NL300198I2/nl unknown
- 2005-07-06 LU LU91180C patent/LU91180I2/fr unknown
- 2005-08-31 NO NO2005018C patent/NO2005018I2/no unknown
2017
- 2017-08-23 NO NO2017045C patent/NO2017045I1/no unknown

Also Published As

Publication number	Publication date
EP0591275A1 (de)	1994-04-13
CA2072047C (en)	2003-06-10
DK0591275T3 (da)	1999-10-11
PT100619A (pt)	1994-01-31
NO934798D0 (no)	1993-12-23
AU672361B2 (en)	1996-10-03
NO2017045I1 (no)	2017-08-23
EP0591275B1 (de)	1999-03-31
LU91180I2 (fr)	2005-09-06
GR3029841T3 (en)	1999-07-30
CA2072047A1 (en)	1992-12-25
NO2005018I1 (no)	2005-09-26
NO934798L (no)	1993-12-23
HK1008662A1 (en)	1999-05-14
AU1986092A (en)	1993-01-25
NL300198I2 (nl)	2005-09-01
ES2129448T3 (es)	1999-06-16
DE122005000032I1 (de)	2005-09-29
PT100619B (pt)	1999-07-30
WO1993000080A1 (en)	1993-01-07
JP3130935B2 (ja)	2001-01-31
NO2005018I2 (no)	2008-02-11
ATE178207T1 (de)	1999-04-15
DE69228813D1 (de)	1999-05-06
DE69228813T2 (de)	1999-08-05
JPH06508628A (ja)	1994-09-29
IE922024A1 (en)	1992-12-30
US5550165A (en)	1996-08-27
DE122005000032I2 (de)	2006-06-08
NL300198I1 (nl)	2005-08-01

Legal Events

Date	Code	Title	Description
2005-09-26	SPCF	Filing of supplementary protection certificate	Free format text: PRODUCT NAME: NITISINONE; NAT. REG. NO/DATE: EU104303001NO-003NO 20050317; FIRST REG. NO/DATE: EU , EU104303001-003 20050221 Spc suppl protection certif: 2005018 Filing date: 20050830
2008-02-11	SPCG	Granted supplementary protection certificate	Free format text: PRODUCT NAME: NITISINONE; NAT. REG. NO/DATE: EU104303001NO-003NO 20050317; FIRST REG. NO/DATE: EU , EU104303001-003 20050221 Spc suppl protection certif: 2005018 Filing date: 20050830 Extension date: 20170618
2012-07-16	MK1K	Patent expired
2017-07-10	SPCX	Expiry of an spc	Spc suppl protection certif: 2005018 Effective date: 20170703
2017-09-04	SPCE	Application to extend a supplementary protection certificate (spc)	Free format text: PRODUCT NAME: FARMASOEOEYTISK PREPARAT INNEHOLDENDE 2-(2-NITRO-4-IFLUORMETYLBENZOYL)-1,3-CYKLOHEKSANDION ELLER ET FARMASOEYTISK GODTAGBART SALT DERAV Spc suppl protection certif: 2017045 Filing date: 20170823
2018-08-13	SPCY	Withdrawal, rejection or dismissal of a request for extension of a supplementary protection certificate	Spc suppl protection certif: 2017045

Publication	Publication Date	Title
NO2017045I1 (no)	2017-08-23	Farmasøøytisk preparat inneholdende 2-(2-nitro-4-ifluormetylbenzoyl)-1,3-cykloheksandion eller et farmasøytisk godtagbart salt derav
Meotti et al.	2003	Thiophenes and furans derivatives: a new class of potential pharmacological agents
BR0314943A (pt)	2005-08-02	Inibidores da proteìna reguladora da condutância transmembrana da fibrose cìstica e usos destes
BRPI0509282A (pt)	2007-09-18	compostos contendo hidrazida inibidores de cftr e seus usos
BR0012136A (pt)	2002-06-11	Inibidores de reabsorção de norepinefrina altamente seletivos e métodos de uso dos mesmos
KR840003414A (ko)	1984-09-08	3-히드록시부탄산 또는 이 산으로부터 유도된 염을 함유하는 약학적 조성물과, 의약품으로 사용할 수 있는 3-히드록시부탄산으로부터 유도된 화합물
EP1362846A4 (de)	2006-10-04	Aminoethanolderivate
TNSN07145A1 (fr)	2008-11-21	Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
GEP20043237B (en)	2004-05-25	Pyrazoline Derivatives, Method for Their Preparation and Compositions Containing Them for Treatment of Diseases Mediated by Cyclooxygenase-2
EA199801017A1 (ru)	1999-04-29	Композиции для лечения заболеваний, опосредованных циклооксигеназой-2, способ лечения воспалительного заболевания
EA200001061A1 (ru)	2001-04-23	Фармацевтическая композиция
ES2087623T3 (es)	1996-07-16	Derivados de bencimidazol como agente antimicrobiano contra campylobacter pylon.
HUP9801924A2 (hu)	2000-02-28	Nátrium/hidrogén-csere inhibitorokat és szív- és keringési zavarok kezelésére alkalmas hatóanyagokat tartalmazó gyógyszerkészítmény
MX9304503A (es)	1994-04-29	Compuestos antiinflamatorios.
DE50311048D1 (de)	2009-02-26	Therapie von erkrankungen des auges
NO922531L (no)	1992-08-26	Middel for forhindring av og behandling av fiskesykdommer
ITMI20042475A1 (it)	2005-03-23	Uso di derivati tiazolidinonici come agenti terapeutici
CA2291650A1 (fr)	1999-10-07	Nouveaux composes heteroethynylenes et compositions pharmaceutiques et cosmetiques les contenant
WO1992013540A1 (fr)	1992-08-20	Onguent antalgique
ES2121218T3 (es)	1998-11-16	Fenoxifenilciclopentenilhidroxiureas.
DK0561882T3 (da)	1994-10-03	Hydroxamsyrederivater, som inhiberer lipoxygenase
FR2515961A1 (fr)	1983-05-13	Preparations medicamenteuses contenant un derive d'acide tetraiodothyrocarboxylique notamment pour le traitement de l'hypercholesterolemie
MA27749A1 (fr)	2006-02-01	2-(butyl-1-sulfonylamino)-n-[1(r)-(6-metoxy-pyridin-3-yl)-propyl]-benzamide, utilisation de ce compose sous la forme d'un medicament et preparations pharmaceutiques contenant ledit compose
EP0150186A1 (de)	1985-08-07	Zusammensetzung mit verbesserter arzneimittelwirkung und deren verwendung in tiertherapie
Didem et al.	2019	Methylphenidate-induced priapism in a boy resolved with switching to atomoxetine