NO308305B1 - FremgangsmÕte for rensing og isolering av et <beta>- anomeranriket nukleosid - Google Patents

FremgangsmÕte for rensing og isolering av et <beta>- anomeranriket nukleosid

Info

Publication number
NO308305B1
NO308305B1 NO972214A NO972214A NO308305B1 NO 308305 B1 NO308305 B1 NO 308305B1 NO 972214 A NO972214 A NO 972214A NO 972214 A NO972214 A NO 972214A NO 308305 B1 NO308305 B1 NO 308305B1
Authority
NO
Norway
Prior art keywords
beta
isolation
purification
procedure
anomer enriched
Prior art date
Application number
NO972214A
Other languages
English (en)
Norwegian (no)
Other versions
NO972214D0 (no
NO972214L (no
Inventor
Ta-Sen Chou
Laurie Michelle Poteet
Douglas Patton Kjell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23335711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO308305(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO972214D0 publication Critical patent/NO972214D0/no
Publication of NO972214L publication Critical patent/NO972214L/no
Publication of NO308305B1 publication Critical patent/NO308305B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
NO972214A 1994-11-17 1997-05-14 FremgangsmÕte for rensing og isolering av et <beta>- anomeranriket nukleosid NO308305B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/340,972 US5606048A (en) 1992-06-22 1994-11-17 Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
PCT/US1995/014086 WO1996016072A1 (fr) 1994-11-17 1995-11-01 Procede permettant de purifier et d'isoler des 2'-desoxy-2',2'-difluoronucleosides

Publications (3)

Publication Number Publication Date
NO972214D0 NO972214D0 (no) 1997-05-14
NO972214L NO972214L (no) 1997-05-14
NO308305B1 true NO308305B1 (no) 2000-08-28

Family

ID=23335711

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972214A NO308305B1 (no) 1994-11-17 1997-05-14 FremgangsmÕte for rensing og isolering av et <beta>- anomeranriket nukleosid

Country Status (34)

Country Link
US (1) US5606048A (fr)
EP (1) EP0712860B1 (fr)
JP (1) JPH10509170A (fr)
KR (1) KR100424990B1 (fr)
CN (1) CN1044119C (fr)
AR (1) AR001045A1 (fr)
AT (1) ATE210142T1 (fr)
AU (1) AU702588B2 (fr)
BG (1) BG62737B1 (fr)
BR (1) BR9509904A (fr)
CA (1) CA2205350C (fr)
CO (1) CO4600741A1 (fr)
CZ (1) CZ292013B6 (fr)
DE (1) DE69524365T2 (fr)
DK (1) DK0712860T3 (fr)
ES (1) ES2164745T3 (fr)
HU (1) HU219019B (fr)
IL (1) IL115854A (fr)
MX (1) MX9703548A (fr)
MY (1) MY115183A (fr)
NO (1) NO308305B1 (fr)
NZ (1) NZ296712A (fr)
PE (1) PE50196A1 (fr)
PL (1) PL182052B1 (fr)
PT (1) PT712860E (fr)
RO (1) RO118296B1 (fr)
RU (1) RU2161622C2 (fr)
SI (1) SI0712860T1 (fr)
SK (1) SK283160B6 (fr)
TW (1) TW377356B (fr)
UA (1) UA53614C2 (fr)
WO (1) WO1996016072A1 (fr)
YU (1) YU49446B (fr)
ZA (1) ZA959321B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326507B1 (en) * 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
PY0111577A (es) * 2000-05-23 2017-01-02 Idenix Cayman Ltd Métodos y composiciones para el tratamiento del virus de la hepatitis c
AP2006003708A0 (en) 2000-05-26 2006-08-31 Idenix Cayman Ltd Methods and compositions for treating flavivirusesand pestiviruses
US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
US7176237B2 (en) * 2002-01-15 2007-02-13 The Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN1678326A (zh) * 2002-06-28 2005-10-05 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
US7265096B2 (en) * 2002-11-04 2007-09-04 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
RU2005118421A (ru) * 2002-11-15 2006-01-20 Айденикс (Кайман) Лимитед (Ky) 2'-разветвленные нуклеозиды и мутация flaviviridae
PL377287A1 (pl) * 2002-12-12 2006-01-23 Idenix (Cayman) Limited Sposób wytwarzania 2'-rozgałęzionych nukleozydów
WO2006000922A2 (fr) * 2004-06-23 2006-01-05 Idenix (Cayman) Limited Derives de 5-aza-7-deazapurine pour le traitement des flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
EP1819718A1 (fr) * 2004-12-08 2007-08-22 Sicor Inc. Difluoronucleosides et procede de preparation de ceux-ci
WO2006070985A1 (fr) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. Méthode de synthèse de la 2’-désoxy-2’,2’-difluorocytidine
EP1831236A4 (fr) * 2004-12-30 2013-11-20 Hanmi Science Co Ltd Methode servant a preparer 2'-deoxy-2',2'-difluorocytidine
KR20070112774A (ko) * 2005-03-04 2007-11-27 다브르 파마 리미티드 베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
US7572898B2 (en) * 2005-06-03 2009-08-11 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
JP2009513623A (ja) 2005-10-28 2009-04-02 アーチ ファーマラブズ リミテッド 塩酸ジェムシタビンの改良された製造方法
JP5254033B2 (ja) * 2005-12-23 2013-08-07 イデニク プハルマセウティカルス，インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
EP1994042A4 (fr) * 2006-02-06 2009-03-18 Reddys Lab Ltd Dr Préparation de gemcitabine
US8299046B2 (en) * 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
WO2008064133A1 (fr) * 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthèse et activités biologiques de nouveaux composés tricycliques-bis-énones (tbe)
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008117955A1 (fr) * 2007-03-23 2008-10-02 Dongwoo Syntech Co., Ltd. Procédé de préparation de la 2'-désoxy-2',2'-difluorocytidine
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
US20090048205A1 (en) * 2007-08-15 2009-02-19 Colin Meyer Combination therapy with synthetic triterpenoids and gemcitabine
EP2050757A1 (fr) 2007-10-10 2009-04-22 Cilag AG Procédé de fabrication de 2' -désoxy-5-azacytidine (Décitabine)
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
HUE043175T2 (hu) 2008-01-11 2019-08-28 Reata Pharmaceuticals Inc Szintetikus triterpenoidok és alkalmazásuk betegség kezelésében
MX339476B (es) 2008-04-18 2016-05-27 Reata Pharmaceuticals Inc Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso.
CN104250280A (zh) * 2008-04-18 2014-12-31 里亚塔医药公司 抗氧化剂炎症调节剂:c-17同系化齐墩果酸衍生物
ES2703274T3 (es) 2008-04-18 2019-03-07 Reata Pharmaceuticals Inc Moduladores de la inflamación antioxidantes: derivados del ácido oleanólico con modificaciones amino y otras en C-17
KR101713140B1 (ko) 2008-04-18 2017-03-08 리타 파마슈티컬스 잉크. Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체
US8071632B2 (en) * 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
EP2309860B1 (fr) 2008-07-22 2014-01-08 Trustees of Dartmouth College Cyanoénones monocycliques et leurs procédés d'utilisation
ES2628609T3 (es) * 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de fármacos antineoplásicos a base de citidina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
WO2010118010A1 (fr) * 2009-04-06 2010-10-14 Eisai Inc. Association de décitabine et d'un inhibiteur de la cytidine désaminase et utilisation de cette association dans le traitement du cancer
EP2417146B1 (fr) * 2009-04-06 2016-07-13 Otsuka Pharmaceutical Co., Ltd. (2'-desoxy-ribofuranosyl)-1,3,4,7-tetrahydro-(1,3)diazepin-2-on derivate zur behandlung von krebs
NZ700073A (en) 2012-04-04 2016-08-26 Halozyme Inc Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282921A (en) * 1964-06-04 1966-11-01 Syntex Corp Halo-deoxynucleosides and processes for the preparation thereof
US3721664A (en) * 1970-01-27 1973-03-20 Hoffmann La Roche Preparation of 5-cytosine nucleosides
DE2628202A1 (de) * 1976-06-23 1977-12-29 Max Planck Gesellschaft Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
FR2531962B1 (fr) * 1982-08-17 1986-11-14 Sandoz Sa Nouveaux derives de la desoxyuridine, leur preparation et leur utilisation comme medicaments
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
CA1295998C (fr) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides et leur utilisation en tant qu'agents antineoplasiques
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
EP0339161A1 (fr) * 1988-04-01 1989-11-02 Merrell Dow Pharmaceuticals Inc. Dérivés de nucléotides de fluorophosphonates
JPH0232093A (ja) * 1988-06-08 1990-02-01 Merrell Dow Pharmaceut Inc 抗レトロウィルスジフルオロ化ヌクレオシド類
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
US5175267A (en) * 1990-03-02 1992-12-29 University Of Georgia Research Foundation, Inc. Stereoselective glycosylation of hetercyclic bases
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Also Published As

Publication number Publication date
AU4139396A (en) 1996-06-17
CZ292013B6 (cs) 2003-07-16
EP0712860A3 (fr) 1996-09-25
WO1996016072A1 (fr) 1996-05-30
RU2161622C2 (ru) 2001-01-10
DK0712860T3 (da) 2002-03-04
PL182052B1 (pl) 2001-10-31
DE69524365T2 (de) 2002-08-14
MX9703548A (es) 1997-08-30
BR9509904A (pt) 1997-10-14
JPH10509170A (ja) 1998-09-08
US5606048A (en) 1997-02-25
DE69524365D1 (de) 2002-01-17
NO972214D0 (no) 1997-05-14
SK283160B6 (sk) 2003-03-04
CN1165519A (zh) 1997-11-19
NZ296712A (en) 1999-01-28
PL320634A1 (en) 1997-10-13
BG62737B1 (bg) 2000-06-30
CN1044119C (zh) 1999-07-14
KR970707143A (ko) 1997-12-01
NO972214L (no) 1997-05-14
SI0712860T1 (en) 2002-04-30
IL115854A0 (en) 1996-01-31
CA2205350C (fr) 2007-09-04
MY115183A (en) 2003-04-30
HUT77926A (hu) 1998-11-30
RO118296B1 (ro) 2003-04-30
YU70995A (sh) 1998-09-18
ATE210142T1 (de) 2001-12-15
UA53614C2 (uk) 2003-02-17
BG101485A (en) 1998-03-31
AR001045A1 (es) 1997-09-24
KR100424990B1 (ko) 2004-05-20
CZ148197A3 (en) 1997-08-13
ZA959321B (en) 1997-05-05
PE50196A1 (es) 1996-11-30
EP0712860B1 (fr) 2001-12-05
AU702588B2 (en) 1999-02-25
HU219019B (hu) 2001-01-29
CO4600741A1 (es) 1998-05-08
TW377356B (en) 1999-12-21
EP0712860A2 (fr) 1996-05-22
YU49446B (sh) 2006-03-03
PT712860E (pt) 2002-05-31
ES2164745T3 (es) 2002-03-01
CA2205350A1 (fr) 1996-05-30
SK48597A3 (en) 1997-11-05
IL115854A (en) 2000-07-16

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