NO308603B1 - Pyrimidinylderivater som interleukininhibitorer, farmasøytisk preparat inneholdende slike derivater samt deres anvendelse - Google Patents

Pyrimidinylderivater som interleukininhibitorer, farmasøytisk preparat inneholdende slike derivater samt deres anvendelse

Info

Publication number: NO308603B1
Authority: NO; Norway
Prior art keywords: derivatives; beta; pyrimidinyl; compounds; pharmaceutical preparations
Prior art date: 1994-03-31

Application number

NO964058A

Other languages

English (en)

Other versions

NO964058L (no

NO964058D0 (no

Inventor

Roland E Dolle

Catherine P Prouty

Prasad V Chaturvedula

Stanley J Schmidt

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-31

Filing date

1996-09-26

Publication date

2000-10-02

1996-09-26 Application filed by Vertex Pharma filed Critical Vertex Pharma

1996-09-26 Publication of NO964058L publication Critical patent/NO964058L/no

1996-09-26 Publication of NO964058D0 publication Critical patent/NO964058D0/no

2000-10-02 Publication of NO308603B1 publication Critical patent/NO308603B1/no

Links

229940046732 interleukin inhibitors Drugs 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000714 pyrimidinyl group Chemical group 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
108091005804 Peptidases Proteins 0.000 abstract 2
239000004365 Protease Substances 0.000 abstract 2
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
TVZJDRYAFYBTRU-YFKPBYRVSA-N (2s)-2-(pyrimidin-2-ylamino)butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NC1=NC=CC=N1 TVZJDRYAFYBTRU-YFKPBYRVSA-N 0.000 abstract 1
LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 abstract 1
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical class CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000003777 Interleukin-1 beta Human genes 0.000 abstract 1
108090000193 Interleukin-1 beta Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
235000003704 aspartic acid Nutrition 0.000 abstract 1
-1 aspartic acid aldehydes Chemical class 0.000 abstract 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)

NO964058A 1994-03-31 1996-09-26 Pyrimidinylderivater som interleukininhibitorer, farmasøytisk preparat inneholdende slike derivater samt deres anvendelse NO308603B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22171294A	1994-03-31	1994-03-31
PCT/US1995/003909 WO1995026958A1 (en)	1994-03-31	1995-03-29	Pyrimidinyl derivatives as interleukin inhibitors

Publications (3)

Publication Number	Publication Date
NO964058L NO964058L (no)	1996-09-26
NO964058D0 NO964058D0 (no)	1996-09-26
NO308603B1 true NO308603B1 (no)	2000-10-02

Family

ID=22829018

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO964058A NO308603B1 (no)	1994-03-31	1996-09-26	Pyrimidinylderivater som interleukininhibitorer, farmasøytisk preparat inneholdende slike derivater samt deres anvendelse

Country Status (17)

Country	Link
US (3)	US5670494A (no)
EP (1)	EP0752987B1 (no)
JP (1)	JP3703836B2 (no)
CN (2)	CN1118458C (no)
AT (1)	ATE254111T1 (no)
AU (1)	AU703451B2 (no)
CA (1)	CA2186511C (no)
DE (1)	DE69532113T2 (no)
DK (1)	DK0752987T3 (no)
ES (1)	ES2210289T3 (no)
FI (1)	FI112943B (no)
HU (1)	HU224731B1 (no)
MX (1)	MX9604420A (no)
NO (1)	NO308603B1 (no)
NZ (1)	NZ283876A (no)
PT (1)	PT752987E (no)
WO (1)	WO1995026958A1 (no)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6008217A (en) *	1995-12-20	1999-12-28	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en)	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US5874424A (en) *	1995-12-20	1999-02-23	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5714484A (en) *	1993-12-08	1998-02-03	Prototek, Inc.	α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors
CN1118458C (zh)	1994-03-31	2003-08-20	弗特克斯药品有限公司	作为白细胞介素抑制剂的嘧啶基衍生物
US5847135A (en) *	1994-06-17	1998-12-08	Vertex Pharmaceuticals, Incorporated	Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en)	1995-06-05	2002-07-16	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US5716929A (en) *	1994-06-17	1998-02-10	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5756466A (en) *	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US6001814A (en) *	1994-11-21	1999-12-14	Cortech Inc.	Serine protease inhibitors
US6011158A (en) *	1994-12-13	2000-01-04	Corvas International, Inc.	Aromatic heterocyclic derivatives as enzyme inhibitors
EP0804464B1 (en) *	1994-12-13	2002-05-08	Corvas International, Inc.	Aromatic heterocyclic derivatives as enzyme inhibitors
EP0820464A2 (en) *	1995-03-31	1998-01-28	Takeda Chemical Industries, Ltd.	Cysteine protease inhibitor
US5948785A (en) *	1995-04-27	1999-09-07	The Green Cross Corporation	Heterocyclic amide compounds and pharmaceutical use of the same
US5843904A (en) *	1995-12-20	1998-12-01	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1βconverting enzyme
US6136834A (en) *	1995-12-27	2000-10-24	Ono Pharmaceutical Co., Ltd.	Tetrazole compounds and pharmaceutical agents containing such derivative
NZ334906A (en)	1996-10-11	2000-09-29	Basf Ag	A sulphonamido pentanoic acid derivative useful as an interleukin-1-beta converting enzyme inhibitor
CA2268103A1 (en) *	1996-10-11	1998-04-23	Warner-Lambert Company	Sulfonamide substituted aspartic acid interleukin-1.beta. converting enzyme inhibitors
US5919790A (en) *	1996-10-11	1999-07-06	Warner-Lambert Company	Hydroxamate inhibitors of interleukin-1β converting enzyme
JP2002509153A (ja) *	1998-01-20	2002-03-26	ワーナー−ランバート・カンパニー	インターロイキン−１β変換酵素（ＩＣＥ）のインビボ阻害剤としてのＮ−［２−（５−ベンジルオキシカルボニル−アミノ−６−オキソ−２−（４−フルオロフェニル）−１，６−ジヒドロ−１−ピリミジニル）アセトキシル］−Ｌ−アスパラギン酸アルデヒド
DE69925581T2 (de)	1998-03-09	2006-04-27	Vertex Pharmaceuticals Inc., Cambridge	1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
DK1064298T3 (da)	1998-03-19	2009-01-19	Vertex Pharma	Inhibitorer af caspaser
AU4330899A (en) *	1998-06-03	2000-06-19	Cortech, Inc.	Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
ES2527760T3 (es) *	1998-07-23	2015-01-29	Yeda Research And Development Co., Ltd.	Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
WO2000005250A1 (en)	1998-07-23	2000-02-03	Yeda Research And Development Co., Ltd	Treatment of autoimmune conditions with copolymer 1 and related copolymers and peptides
US6800287B2 (en) *	1998-09-25	2004-10-05	Yeda Research And Development Co., Ltd.	Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US6972296B2 (en)	1999-05-07	2005-12-06	Encysive Pharmaceuticals Inc.	Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
US7022663B2 (en) *	2000-02-18	2006-04-04	Yeda Research And Development Co., Ltd.	Oral, nasal and pulmonary dosage formulations of copolymer 1
US20010053764A1 (en)	2000-05-12	2001-12-20	Sims John E.	Interleukin-1 inhibitors in the treatment of diseases
PE20011350A1 (es)	2000-05-19	2002-01-15	Vertex Pharma	PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
US20020077278A1 (en)	2000-06-05	2002-06-20	Yong V. Wee	Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (en) *	2000-06-20	2002-10-03	Mayo Foundation For Medical Education And Research	Treatment of central nervous system diseases by antibodies against glatiramer acetate
JP2004504302A (ja) *	2000-07-18	2004-02-12	ニューロジェン・コーポレーション	５−置換２−アリール−４−ピリミジノン
SI1459065T1 (sl) *	2001-12-04	2010-11-30	Teva Pharma	Postopki za merjenje potentnosti glatiramer acetata
US7410956B2 (en) *	2002-02-11	2008-08-12	Vertex Pharmaceuticals Incorporated	Caspase inhibitor prodrugs
US7001899B2 (en) *	2002-06-10	2006-02-21	The Procter & Gamble Company	Interleukin converting enzyme inhibitors
WO2003106434A1 (ja) *	2002-06-14	2003-12-24	味の素株式会社	ピリミジン化合物の製造方法
PE20050159A1 (es)	2003-05-27	2005-04-19	Vertex Pharma	Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
MXPA06013256A (es) *	2004-05-15	2007-02-08	Vertex Pharma	Tratamiento de crisis convulsivas utilizando inhibidores ice.
CA2567080A1 (en)	2004-05-27	2005-12-15	Vertex Pharmaceuticals Incorporated	Ice inhibitors for the treatment of autoinflammatory diseases
ATE543803T1 (de)	2004-11-24	2012-02-15	Vertex Pharma	3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren
WO2009019115A1 (en)	2007-08-03	2009-02-12	Sanofi-Aventis	Caspase imaging probes
WO2009103432A2 (en) *	2008-02-21	2009-08-27	Sanofi-Aventis	Covalently binding imaging probes
US9116157B2 (en)	2010-11-05	2015-08-25	Brandeis University	Ice-cleaved alpha-synuclein as a biomarker
US9956260B1 (en)	2011-07-22	2018-05-01	The J. David Gladstone Institutes	Treatment of HIV-1 infection and AIDS
EP2848696A1 (en)	2013-09-13	2015-03-18	Sanofi-Aventis Deutschland GmbH	Caspase-1 imaging probes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5441960A (en) *	1992-04-16	1995-08-15	Zeneca Limited	1-pyrimidinylacetamide human leukocyte elastate inhibitors
CN1118458C (zh) *	1994-03-31	2003-08-20	弗特克斯药品有限公司	作为白细胞介素抑制剂的嘧啶基衍生物

1995
- 1995-03-29 CN CN95193258A patent/CN1118458C/zh not_active Expired - Fee Related
- 1995-03-29 AU AU22323/95A patent/AU703451B2/en not_active Ceased
- 1995-03-29 EP EP95915448A patent/EP0752987B1/en not_active Expired - Lifetime
- 1995-03-29 CN CNA031452183A patent/CN1504462A/zh active Pending
- 1995-03-29 JP JP52582195A patent/JP3703836B2/ja not_active Expired - Fee Related
- 1995-03-29 AT AT95915448T patent/ATE254111T1/de not_active IP Right Cessation
- 1995-03-29 HU HU9602664A patent/HU224731B1/hu not_active IP Right Cessation
- 1995-03-29 ES ES95915448T patent/ES2210289T3/es not_active Expired - Lifetime
- 1995-03-29 NZ NZ283876A patent/NZ283876A/en not_active IP Right Cessation
- 1995-03-29 PT PT95915448T patent/PT752987E/pt unknown
- 1995-03-29 DE DE69532113T patent/DE69532113T2/de not_active Expired - Lifetime
- 1995-03-29 WO PCT/US1995/003909 patent/WO1995026958A1/en not_active Ceased
- 1995-03-29 CA CA002186511A patent/CA2186511C/en not_active Expired - Fee Related
- 1995-03-29 DK DK95915448T patent/DK0752987T3/da active
- 1995-03-29 MX MX9604420A patent/MX9604420A/es active IP Right Grant
- 1995-11-20 US US08/559,870 patent/US5670494A/en not_active Expired - Lifetime
1996
- 1996-09-26 NO NO964058A patent/NO308603B1/no unknown
- 1996-09-27 FI FI963897A patent/FI112943B/fi not_active IP Right Cessation
1997
- 1997-06-17 US US08/877,380 patent/US6162800A/en not_active Expired - Lifetime
2000
- 2000-12-19 US US09/740,623 patent/US6407080B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1504462A (zh)	2004-06-16
WO1995026958A1 (en)	1995-10-12
FI963897L (fi)	1996-09-27
HU9602664D0 (en)	1996-11-28
NZ283876A (en)	2001-03-30
US6162800A (en)	2000-12-19
NO964058L (no)	1996-09-26
PT752987E (pt)	2004-03-31
JPH09511249A (ja)	1997-11-11
AU703451B2 (en)	1999-03-25
ATE254111T1 (de)	2003-11-15
EP0752987A1 (en)	1997-01-15
EP0752987A4 (en)	1997-04-09
NO964058D0 (no)	1996-09-26
DE69532113T2 (de)	2004-07-29
DE69532113D1 (de)	2003-12-18
JP3703836B2 (ja)	2005-10-05
DK0752987T3 (da)	2004-03-15
CN1118458C (zh)	2003-08-20
HU224731B1 (en)	2006-01-30
AU2232395A (en)	1995-10-23
HUT75715A (en)	1997-05-28
CA2186511C (en)	2009-02-10
MX9604420A (es)	1997-12-31
FI963897A0 (fi)	1996-09-27
ES2210289T3 (es)	2004-07-01
FI112943B (fi)	2004-02-13
HK1012623A1 (en)	1999-08-06
US20010003750A1 (en)	2001-06-14
US5670494A (en)	1997-09-23
CN1149292A (zh)	1997-05-07
EP0752987B1 (en)	2003-11-12
US6407080B2 (en)	2002-06-18
CA2186511A1 (en)	1995-10-12

Publication	Publication Date	Title
NO308603B1 (no)	2000-10-02	Pyrimidinylderivater som interleukininhibitorer, farmasøytisk preparat inneholdende slike derivater samt deres anvendelse
NO20052864L (no)	2005-06-13	Nye hydroksyindoler, deres anvendelse som fosfordiesterase 4 inhibitorer samt fremstilling av forbindelser
DE69232929D1 (de)	2003-04-03	Saccharinderivate als proteolytische Enzyminhibitoren
FI942423A0 (fi)	1994-05-25	Sakkariinijohdannisia proteolyyttisen entsyymin inhibiittoreina
EP1034164A4 (en)	2001-07-11	BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS
MX9206008A (es)	1993-11-01	Inhibidores de enzima proteolitica, derivados de sacarina 2-substituida.
EP0928789A4 (en)	2001-11-07	6-PHENYLTETRAHYDRO-1,3-OXAZINE-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS BASED ON SUCH COMPOUNDS
HUP0100941A2 (hu)	2001-09-28	Kinolin, kinazolin és pirido-pirimidin-származékok és ezeket tartalmazó gyógyszerkészítmények
FI932390A0 (fi)	1993-05-26	Nya hydroxiaminsyra- och N-hydroxiureaderivat samt deras anvaendning
ATE170868T1 (de)	1998-09-15	Peptid-phosphinyloxymethyl-ketonen als inhibitoren von interleukin-1 beta- konvertierenden enzymen
MY129363A (en)	2007-03-30	Factor vlla inhibitory (thio)urea derivatives, their preparation and their use
BR0315662A (pt)	2005-08-30	Derivados de 1-(4-benzil-piperazin-1-il)-3-fenil-propenona
NO20025510D0 (no)	2002-11-15	Tienodibenzoazulenforbindelser som tumor nekrose faktor inhibitorer
MD382C2 (ro)	1996-06-30	Procedeu de obţinere a piperazinilalchil-3(2H)-piridazinonelor sau a sărurilor lor farmaceutice admisibile
ATE253571T1 (de)	2003-11-15	2-heterozyklisch-5-hydroxy-1,3-pyrimidinen verwendbar als entzündungswidrigesmittel
TR200103550T2 (tr)	2002-05-21	Faktör VIIa inhibitörler.
TW200505916A (en)	2005-02-16	7-azaindoles and the use thereof as therapeutic agents
FI932654A0 (fi)	1993-06-10	Hydroxamsyraderivat, som hindrar lipoxigenas
BR0014759A (pt)	2002-07-02	Inibidores de metaloprotease beta dissubstituìdos
TW200503693A (en)	2005-02-01	4-, 6- or 7-hydroxyindoles with n-oxide groups and the use thereof as therapeutic agents
CO5660084A1 (es)	2006-07-31	Nuevos derivados de fenilheteroalquilamina, proceso para su prepraracion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia
BR0010748A (pt)	2002-02-19	Compostos heterocìclicos contendo imidazo, suas composições e usos