ATE253571T1 - 2-heterozyklisch-5-hydroxy-1,3-pyrimidinen verwendbar als entzündungswidrigesmittel - Google Patents
2-heterozyklisch-5-hydroxy-1,3-pyrimidinen verwendbar als entzündungswidrigesmittelInfo
- Publication number
- ATE253571T1 ATE253571T1 AT93918407T AT93918407T ATE253571T1 AT E253571 T1 ATE253571 T1 AT E253571T1 AT 93918407 T AT93918407 T AT 93918407T AT 93918407 T AT93918407 T AT 93918407T AT E253571 T1 ATE253571 T1 AT E253571T1
- Authority
- AT
- Austria
- Prior art keywords
- heterocyclic
- hydroxy
- inflammatory agent
- pyrimidines
- pyrimidines used
- Prior art date
Links
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/924,212 US5240929A (en) | 1992-08-03 | 1992-08-03 | 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents |
| PCT/US1993/007034 WO1994003448A1 (en) | 1992-08-03 | 1993-07-27 | 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253571T1 true ATE253571T1 (de) | 2003-11-15 |
Family
ID=25449891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93918407T ATE253571T1 (de) | 1992-08-03 | 1993-07-27 | 2-heterozyklisch-5-hydroxy-1,3-pyrimidinen verwendbar als entzündungswidrigesmittel |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5240929A (de) |
| EP (1) | EP0652874B1 (de) |
| JP (1) | JP3223190B2 (de) |
| KR (1) | KR100275428B1 (de) |
| AT (1) | ATE253571T1 (de) |
| AU (1) | AU672619B2 (de) |
| CA (1) | CA2139731C (de) |
| DE (1) | DE69333285T2 (de) |
| DK (1) | DK0652874T3 (de) |
| ES (1) | ES2206460T3 (de) |
| PT (1) | PT652874E (de) |
| WO (1) | WO1994003448A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2365269A1 (en) * | 1991-01-31 | 1992-08-20 | Warner-Lambert Company | Substituted 4,6-di-tertiary-butyl-5-hydroxy-pyrimidines |
| CZ302448B6 (cs) | 2000-07-20 | 2011-05-25 | Lauras As | Farmaceutický prostredek |
| WO2003009815A2 (en) | 2001-07-25 | 2003-02-06 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| BR0211910A (pt) * | 2001-08-13 | 2004-10-19 | Janssen Pharmaceutica Nv | Derivados de tiazolila 2,4,5-trissubstituìdos e a atividade antiinflamatória dos mesmos |
| DE10329955A1 (de) * | 2003-07-03 | 2005-02-03 | Merck Patent Gmbh | Verwendung eines hydroalkoholischen Extrakts aus Bauhinia zur Herstellung einer Zubereitung |
| SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
| JP5544458B2 (ja) * | 2005-07-12 | 2014-07-09 | アンピオ ファーマシューティカルズ，インコーポレイテッド | 疾病を治療するための医薬製品の製造においてトリロスタンｉｉｉを使用する方法及びトリロスタンｉｉｉを含む医薬製品 |
| EP2063905B1 (de) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen |
| DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
| CN104042617A (zh) | 2009-04-29 | 2014-09-17 | 阿马里纳药物爱尔兰有限公司 | 含有epa和心血管剂的药物组合物以及使用其的方法 |
| SG175896A1 (en) | 2009-05-06 | 2011-12-29 | Lab Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| US9675587B2 (en) | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
| CN117677386A (zh) * | 2021-07-23 | 2024-03-08 | 瓦伦塔有限责任公司 | 具有亲溶酶体和抗病毒活性的化合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4636516A (en) * | 1981-02-19 | 1987-01-13 | Yamanouchi Pharmaceutical Co., Ltd. | 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds |
-
1992
- 1992-08-03 US US07/924,212 patent/US5240929A/en not_active Expired - Lifetime
-
1993
- 1993-04-28 US US08/054,382 patent/US5312821A/en not_active Expired - Fee Related
- 1993-07-27 JP JP50538494A patent/JP3223190B2/ja not_active Expired - Fee Related
- 1993-07-27 EP EP93918407A patent/EP0652874B1/de not_active Expired - Lifetime
- 1993-07-27 KR KR1019950700375A patent/KR100275428B1/ko not_active Expired - Fee Related
- 1993-07-27 DK DK93918407T patent/DK0652874T3/da active
- 1993-07-27 AU AU47870/93A patent/AU672619B2/en not_active Ceased
- 1993-07-27 ES ES93918407T patent/ES2206460T3/es not_active Expired - Lifetime
- 1993-07-27 AT AT93918407T patent/ATE253571T1/de not_active IP Right Cessation
- 1993-07-27 PT PT93918407T patent/PT652874E/pt unknown
- 1993-07-27 DE DE69333285T patent/DE69333285T2/de not_active Expired - Fee Related
- 1993-07-27 WO PCT/US1993/007034 patent/WO1994003448A1/en not_active Ceased
- 1993-07-27 CA CA002139731A patent/CA2139731C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT652874E (pt) | 2004-03-31 |
| ES2206460T3 (es) | 2004-05-16 |
| AU4787093A (en) | 1994-03-03 |
| EP0652874A1 (de) | 1995-05-17 |
| JP3223190B2 (ja) | 2001-10-29 |
| JPH08500101A (ja) | 1996-01-09 |
| DK0652874T3 (da) | 2004-03-22 |
| DE69333285T2 (de) | 2004-08-26 |
| KR100275428B1 (ko) | 2000-12-15 |
| EP0652874B1 (de) | 2003-11-05 |
| CA2139731C (en) | 2004-01-13 |
| DE69333285D1 (de) | 2003-12-11 |
| CA2139731A1 (en) | 1994-02-17 |
| WO1994003448A1 (en) | 1994-02-17 |
| US5312821A (en) | 1994-05-17 |
| KR950702554A (ko) | 1995-07-29 |
| AU672619B2 (en) | 1996-10-10 |
| US5240929A (en) | 1993-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0652874 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |