NO310295B1 - Sykliske peptider, farmasöytisk preparat inneholdende disse samt anvendelse derav - Google Patents

Sykliske peptider, farmasöytisk preparat inneholdende disse samt anvendelse derav Download PDF

Info

Publication number: NO310295B1
Authority: NO; Norway
Prior art keywords: asp; leu; added; trp; filtration
Prior art date: 1991-08-13

Application number

NO19923142A

Other languages

English (en)

Norwegian (no)

Other versions

NO923142L (no

NO923142D0 (no

Inventor

Mitsuhiro Wakimasu

Takashi Kikuchi

Akira Kawada

Hideo Shirafuji

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-13

Filing date

1992-08-12

Publication date

2001-06-18

1992-08-12 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1992-08-12 Publication of NO923142D0 publication Critical patent/NO923142D0/no

1993-02-15 Publication of NO923142L publication Critical patent/NO923142L/no

2001-06-18 Publication of NO310295B1 publication Critical patent/NO310295B1/no

Links

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WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
150000003899 tartaric acid esters Chemical class 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
150000003568 thioethers Chemical group 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO19923142A 1991-08-13 1992-08-12 Sykliske peptider, farmasöytisk preparat inneholdende disse samt anvendelse derav NO310295B1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP20303291		1991-08-13
JP30363591		1991-11-19
JP3543692		1992-02-21
JP11179292		1992-04-30

Publications (3)

Publication Number	Publication Date
NO923142D0 NO923142D0 (no)	1992-08-12
NO923142L NO923142L (no)	1993-02-15
NO310295B1 true NO310295B1 (no)	2001-06-18

Family

ID=27460093

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19923142A NO310295B1 (no)	1991-08-13	1992-08-12	Sykliske peptider, farmasöytisk preparat inneholdende disse samt anvendelse derav

Country Status (11)

Country	Link
US (2)	US5616684A (de)
EP (1)	EP0528312B1 (de)
JP (2)	JP2677489B2 (de)
AT (1)	ATE155486T1 (de)
CA (1)	CA2075878C (de)
DE (1)	DE69220861T2 (de)
DK (1)	DK0528312T3 (de)
ES (1)	ES2103857T3 (de)
FI (1)	FI106031B (de)
GR (1)	GR3024495T3 (de)
NO (1)	NO310295B1 (de)

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US5767310A (en) *	1993-03-19	1998-06-16	Merck & Co., Inc.	Phenoxyphenylacetic acid derivatives
FI941826L (fi)	1993-04-21	1994-10-22	Takeda Chemical Industries Ltd	Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi
CA2126619A1 (en) *	1993-06-24	1994-12-25	Yasutaka Igari	Sustained-release preparation of anti-endothelin substance
US6087324A (en) *	1993-06-24	2000-07-11	Takeda Chemical Industries, Ltd.	Sustained-release preparation
US5811218A (en) *	1993-07-28	1998-09-22	Hitachi Chemical Company, Ltd.	Photoinitiator compositions including amino acids, coumarin and titanocene and photosensitive materials using the same
CA2135151A1 (en) *	1993-11-08	1995-05-09	Mitsuhiro Wakimasu	Cyclic hexapeptides, their production and use
US5521156A (en) *	1994-02-03	1996-05-28	Merrell Pharmaceuticals Inc.	Cyclic neurokinin A antagonists
DE4415310A1 (de) *	1994-04-30	1995-11-02	Merck Patent Gmbh	Cyclopeptide
US5538991A (en) *	1994-09-14	1996-07-23	Merck & Co., Inc.	Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) *	1994-09-14	1996-09-24	Merck & Co., Inc.	Endothelin antagonists bearing pyridyl amides
EP0714909A1 (de)	1994-12-01	1996-06-05	Takeda Chemical Industries, Ltd.	Zusammensetzung zur Vorbeugung und Behandlung von Lungen-Kreislauferkrankungen
EP0822939A1 (de) *	1995-04-28	1998-02-11	Takeda Chemical Industries, Ltd.	Zyklische pentapeptid-lh-rh-rezeptor-antagonisten
US6251861B1 (en)	1996-06-27	2001-06-26	Takeda Chemical Industries, Ltd.	Treatment of cerebral infarction using cyclic hexapeptides
IT1304888B1 (it) *	1998-08-05	2001-04-05	Menarini Ricerche Spa	Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
HK1044954B (en)	1999-03-29	2008-11-21	The Procter & Gamble Company	Melanocortin receptor ligands
WO2003006041A1 (fr) *	2001-07-12	2003-01-23	Takeda Chemical Industries, Ltd.	Agents prophylactiques/therapeutiques contre les tumeurs malignes
GB0326632D0 (en)	2003-11-14	2003-12-17	Jagotec Ag	Dry powder formulations
WO2005085277A1 (en) *	2004-02-06	2005-09-15	Concepcion Gisela P	Cyclic hexapeptides, process and use thereof
US7838102B2 (en) *	2004-10-28	2010-11-23	E. I. Du Pont De Nemours And Company	Filled polyvinyl butyral sheeting for decorative laminated glass and a process for making same
WO2007119214A2 (en) *	2006-04-13	2007-10-25	Actelion Pharmaceuticals Ltd	Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
US8889632B2 (en)	2007-01-31	2014-11-18	Dana-Farber Cancer Institute, Inc.	Stabilized p53 peptides and uses thereof
EP2508531B1 (de)	2007-03-28	2016-10-19	President and Fellows of Harvard College	Geheftete Polypeptide
SI2603600T1 (sl)	2010-08-13	2019-04-30	Aileron Therapeutics, Inc.	Peptidomimetični makrocikli
US20130177651A1 (en)	2010-09-03	2013-07-11	Pharmaterials Limited	Pharmaceutical Composition Suitable for Use in a Dry Powder Inhaler
US9486273B2 (en)	2011-01-21	2016-11-08	Kardium Inc.	High-density electrode-based medical device system
TW201806968A (zh)	2011-10-18	2018-03-01	艾利倫治療公司	擬肽巨環化合物
HK1205454A1 (en)	2012-02-15	2015-12-18	Aileron Therapeutics, Inc.	Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko)	2012-02-15	2020-05-18	에일러론 테라퓨틱스 인코포레이티드	펩티드모방체 마크로사이클
US9605047B2 (en)	2012-04-04	2017-03-28	The Brigham And Womens's Hospital, Inc.	Compositions and methods for treating hypertension
WO2014071241A1 (en)	2012-11-01	2014-05-08	Aileron Therapeutics, Inc.	Disubstituted amino acids and methods of preparation and use thereof
JP2018503595A (ja)	2014-09-24	2018-02-08	エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	ペプチド模倣大環状分子およびその製剤
BR112017005598A2 (pt)	2014-09-24	2017-12-12	Aileron Therapeutics Inc	macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (en)	2015-03-20	2016-09-29	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
US10023613B2 (en)	2015-09-10	2018-07-17	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles as modulators of MCL-1
KR102389725B1 (ko) *	2020-02-14	2022-04-25	서울대학교산학협력단	피페라진산을 함유하는 사이클릭 펩티드 화합물, 이의 생산 방법, 및 이의 용도
WO2024114782A1 (en) *	2022-12-01	2024-06-06	National Institute Of Biological Sciences, Beijing	Small-molecule modulators of spike protein

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CA2032559C (en) *	1989-12-28	2001-11-06	Kiyofumi Ishikawa	Endothelin antagonistic cyclic pentapeptides
IT1241761B (it) *	1990-08-03	1994-02-01	Menarini Farma Ind	Peptidi di sintesi antagonisti della neurochinina a, loro sali e relativi procedimenti di fabbricazione
US5260276A (en) *	1991-06-14	1993-11-09	Warner-Lambert Company	Linear and monocyclic endothelin antagonists

1992
- 1992-08-08 EP EP92113568A patent/EP0528312B1/de not_active Expired - Lifetime
- 1992-08-08 DK DK92113568.7T patent/DK0528312T3/da active
- 1992-08-08 ES ES92113568T patent/ES2103857T3/es not_active Expired - Lifetime
- 1992-08-08 DE DE69220861T patent/DE69220861T2/de not_active Expired - Fee Related
- 1992-08-08 AT AT92113568T patent/ATE155486T1/de not_active IP Right Cessation
- 1992-08-12 CA CA002075878A patent/CA2075878C/en not_active Expired - Fee Related
- 1992-08-12 NO NO19923142A patent/NO310295B1/no unknown
- 1992-08-12 FI FI923619A patent/FI106031B/fi active
- 1992-08-13 JP JP4216019A patent/JP2677489B2/ja not_active Expired - Fee Related
1994
- 1994-04-20 US US08/231,449 patent/US5616684A/en not_active Expired - Fee Related
1995
- 1995-12-28 JP JP7342625A patent/JP2726647B2/ja not_active Expired - Fee Related
1996
- 1996-07-09 US US08/680,534 patent/US5883075A/en not_active Expired - Fee Related
1997
- 1997-08-21 GR GR970402134T patent/GR3024495T3/el unknown

Also Published As

Publication number	Publication date
JP2677489B2 (ja)	1997-11-17
JPH069689A (ja)	1994-01-18
NO923142L (no)	1993-02-15
GR3024495T3 (en)	1997-11-28
DK0528312T3 (da)	1997-12-29
FI106031B (fi)	2000-11-15
NO923142D0 (no)	1992-08-12
DE69220861D1 (de)	1997-08-21
FI923619L (fi)	1993-02-14
CA2075878A1 (en)	1993-02-14
US5616684A (en)	1997-04-01
JP2726647B2 (ja)	1998-03-11
US5883075A (en)	1999-03-16
ATE155486T1 (de)	1997-08-15
FI923619A0 (fi)	1992-08-12
CA2075878C (en)	2002-12-24
ES2103857T3 (es)	1997-10-01
EP0528312A2 (de)	1993-02-24
DE69220861T2 (de)	1997-11-20
EP0528312A3 (de)	1993-04-14
EP0528312B1 (de)	1997-07-16
JPH08225595A (ja)	1996-09-03

Publication	Publication Date	Title
EP0528312B1 (de)	1997-07-16	Zyklische Peptide und ihre Verwendung
AU632043B2 (en)	1992-12-17	Cyclic analogs of atrial natriuretic peptides
US5583108A (en)	1996-12-10	Vasonatrin peptide and analogs thereof
EP0552417B1 (de)	1999-07-07	Zyklische Peptide und ihre Verwendung
AU597919B2 (en)	1990-06-14	Analogs of atrial natriuretic peptides
EP0323740A2 (de)	1989-07-12	Lineare Analoge von atrialen natriuretischen Peptiden
US4716147A (en)	1987-12-29	Synthetic airial peptides
AU8237187A (en)	1988-06-01	Derivatives of atrial natriuretic peptides
EP0283956B1 (de)	1992-11-11	Fluor enthaltende atriale natriuretische Peptide
US5306808A (en)	1994-04-26	Peptide derivatives having vasodilating activity
US5091366A (en)	1992-02-25	Peptides having ANF activity
WO1990014362A1 (en)	1990-11-29	Atrial peptide derivatives
WO1993000108A1 (en)	1993-01-07	Novel inhibitors of platelet aggregation
US5965526A (en)	1999-10-12	Pentapeptide with specific conformation, its production and use
EP0292256A2 (de)	1988-11-23	Peptide mit ANF-Wirksamkeit
JP3042782B2 (ja)	2000-05-22	心房性ナトリウム尿排泄亢進ペプチド類似化合物
US6872803B1 (en)	2005-03-29	Peptides
Sobolewski et al.	2007	Influence of conformationally constrained amino acids replacing positions 2 and 3 of arginine vasopressin (AVP) and its analogues on their pharmacological properties
AU676770B2 (en)	1997-03-20	Cyclic peptide with higher stability and/or higher activity
Yamamoto et al.	1994	Synthesis and NMR Studies of RGDSPASS-Containing Cystine Peptides.
JPH05194589A (ja)	1993-08-03	環状ペプチド、その製造法および用途
EP0316769A2 (de)	1989-05-24	Zyklische Peptide mit Disulfidbrücke, welche eine Cgridri-Sequenz enthalten und deren Verwendung bei der Kontrolle von Hypertension
JPH07126288A (ja)	1995-05-16	環状ヘキサペプチド、その製造法および用途
JPH05194592A (ja)	1993-08-03	ペプチド誘導体およびその用途