NO310817B1 - Akryloylsubstituert distamycinderivater, fremgangsmåte til fremstilling av disse, deres anvendelse til fremstilling avantitumor- og antivirusmidler samt et farmasöytisk preparatinneholdende disse - Google Patents

Akryloylsubstituert distamycinderivater, fremgangsmåte til fremstilling av disse, deres anvendelse til fremstilling avantitumor- og antivirusmidler samt et farmasöytisk preparatinneholdende disse Download PDF

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Publication number
NO310817B1
NO310817B1 NO19990246A NO990246A NO310817B1 NO 310817 B1 NO310817 B1 NO 310817B1 NO 19990246 A NO19990246 A NO 19990246A NO 990246 A NO990246 A NO 990246A NO 310817 B1 NO310817 B1 NO 310817B1
Authority
NO
Norway
Prior art keywords
methyl
pyrrole
carboxamido
bromoacrylamido
propion
Prior art date
Application number
NO19990246A
Other languages
English (en)
Norwegian (no)
Other versions
NO990246D0 (no
NO990246L (no
Inventor
Paolo Cozzi
Italo Beria
Giovanni Biasoli
Marina Caldarelli
Laura Capolongo
Cristina Franzetti
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of NO990246D0 publication Critical patent/NO990246D0/no
Publication of NO990246L publication Critical patent/NO990246L/no
Publication of NO310817B1 publication Critical patent/NO310817B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO19990246A 1996-07-25 1999-01-20 Akryloylsubstituert distamycinderivater, fremgangsmåte til fremstilling av disse, deres anvendelse til fremstilling avantitumor- og antivirusmidler samt et farmasöytisk preparatinneholdende disse NO310817B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9615692.2A GB9615692D0 (en) 1996-07-25 1996-07-25 Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
PCT/EP1997/003719 WO1998004524A1 (en) 1996-07-25 1997-07-10 Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Publications (3)

Publication Number Publication Date
NO990246D0 NO990246D0 (no) 1999-01-20
NO990246L NO990246L (no) 1999-01-20
NO310817B1 true NO310817B1 (no) 2001-09-03

Family

ID=10797527

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19990246A NO310817B1 (no) 1996-07-25 1999-01-20 Akryloylsubstituert distamycinderivater, fremgangsmåte til fremstilling av disse, deres anvendelse til fremstilling avantitumor- og antivirusmidler samt et farmasöytisk preparatinneholdende disse

Country Status (26)

Country Link
US (2) US6482920B1 (da)
EP (1) EP0915845B1 (da)
JP (1) JP4312264B2 (da)
KR (1) KR100408538B1 (da)
CN (1) CN1116281C (da)
AR (1) AR007997A1 (da)
AT (1) ATE205476T1 (da)
AU (1) AU724511B2 (da)
BR (1) BR9710717A (da)
CA (1) CA2260060C (da)
DE (1) DE69706690T2 (da)
DK (1) DK0915845T3 (da)
EA (1) EA001863B1 (da)
ES (1) ES2164366T3 (da)
GB (1) GB9615692D0 (da)
HU (1) HU224635B1 (da)
IL (1) IL127689A (da)
MY (1) MY124103A (da)
NO (1) NO310817B1 (da)
NZ (1) NZ334082A (da)
PL (1) PL199865B1 (da)
PT (1) PT915845E (da)
TW (1) TW360652B (da)
UA (1) UA61922C2 (da)
WO (1) WO1998004524A1 (da)
ZA (1) ZA976549B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9928703D0 (en) * 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
PE20011277A1 (es) * 2000-04-14 2002-01-07 Agouron Pharma Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
GB0011059D0 (en) * 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
GB0017852D0 (en) * 2000-07-20 2000-09-06 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
GB0029004D0 (en) * 2000-11-28 2001-01-10 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
EP1470119A4 (en) * 2001-06-13 2005-10-19 Genesoft Pharmaceuticals Inc BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
ES2263835T3 (es) * 2002-01-02 2006-12-16 Nerviano Medical Sciences S.R.L. Terapia combinada contra tumores que comprende derivados de distamicina acriloil sustituidos e inhibidores proteina quinasa (serina/treonina quinasa).
BR0308976A (pt) * 2002-04-02 2005-01-11 Pharmacia Italia Spa Terapia combinada contra tumores compreendendo derivados de acriloil distamicina substituìda e radioterapia
AU2016301745B2 (en) 2015-08-06 2020-07-16 Ube Industries, Ltd. Substituted guanidine derivative
GB202114032D0 (en) * 2021-09-30 2021-11-17 Univ Strathclyde Antivirals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE468642B (sv) * 1985-07-16 1993-02-22 Erba Farmitalia Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives

Also Published As

Publication number Publication date
CA2260060A1 (en) 1998-02-05
JP4312264B2 (ja) 2009-08-12
US6482920B1 (en) 2002-11-19
CA2260060C (en) 2007-01-30
MY124103A (en) 2006-06-30
GB9615692D0 (en) 1996-09-04
EP0915845A1 (en) 1999-05-19
TW360652B (en) 1999-06-11
ATE205476T1 (de) 2001-09-15
ES2164366T3 (es) 2002-02-16
IL127689A0 (en) 1999-10-28
BR9710717A (pt) 1999-08-17
US20030023031A1 (en) 2003-01-30
NZ334082A (en) 1999-08-30
NO990246D0 (no) 1999-01-20
PT915845E (pt) 2002-03-28
DK0915845T3 (da) 2002-01-07
EA199900163A1 (ru) 1999-08-26
EP0915845B1 (en) 2001-09-12
HK1020948A1 (en) 2000-05-26
KR100408538B1 (ko) 2004-01-13
PL331344A1 (en) 1999-07-05
CN1226232A (zh) 1999-08-18
AU724511B2 (en) 2000-09-21
JP2000515164A (ja) 2000-11-14
UA61922C2 (uk) 2003-12-15
AR007997A1 (es) 1999-11-24
HU224635B1 (hu) 2005-12-28
IL127689A (en) 2003-07-31
NO990246L (no) 1999-01-20
DE69706690D1 (de) 2001-10-18
AU4009897A (en) 1998-02-20
PL199865B1 (pl) 2008-11-28
DE69706690T2 (de) 2002-06-20
HUP9903253A3 (en) 2002-01-28
CN1116281C (zh) 2003-07-30
EA001863B1 (ru) 2001-10-22
HUP9903253A2 (hu) 2000-02-28
KR20000029448A (ko) 2000-05-25
WO1998004524A1 (en) 1998-02-05
ZA976549B (en) 1998-02-03

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