DK0915845T3 - Acryloylsubstituerede distamycinderivater, fremgangsmåde til fremstilling deraf og anvendelse som antitumormidler og antivirale midler - Google Patents

Acryloylsubstituerede distamycinderivater, fremgangsmåde til fremstilling deraf og anvendelse som antitumormidler og antivirale midler

Info

Publication number: DK0915845T3
Authority: DK; Denmark
Prior art keywords: acryloyl; antitumor; preparation; antiviral agents; distamycin derivatives
Prior art date: 1996-07-25

Application number

DK97937474T

Other languages

English (en)

Inventor

Paolo Cozzi

Italo Beria

Giovanni Biasoli

Marina Caldarelli

Laura Capolongo

Cristina Franzetti

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1997-07-10

Publication date

2002-01-07

1997-07-10 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

2002-01-07 Application granted granted Critical

2002-01-07 Publication of DK0915845T3 publication Critical patent/DK0915845T3/da

Links

230000000259 anti-tumor effect Effects 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
239000003443 antiviral agent Substances 0.000 title 1
UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical class CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK97937474T 1996-07-25 1997-07-10 Acryloylsubstituerede distamycinderivater, fremgangsmåde til fremstilling deraf og anvendelse som antitumormidler og antivirale midler DK0915845T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9615692.2A GB9615692D0 (en)	1996-07-25	1996-07-25	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
PCT/EP1997/003719 WO1998004524A1 (en)	1996-07-25	1997-07-10	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Publications (1)

Publication Number	Publication Date
DK0915845T3 true DK0915845T3 (da)	2002-01-07

Family

ID=10797527

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97937474T DK0915845T3 (da)	1996-07-25	1997-07-10	Acryloylsubstituerede distamycinderivater, fremgangsmåde til fremstilling deraf og anvendelse som antitumormidler og antivirale midler

Country Status (26)

Country	Link
US (2)	US6482920B1 (da)
EP (1)	EP0915845B1 (da)
JP (1)	JP4312264B2 (da)
KR (1)	KR100408538B1 (da)
CN (1)	CN1116281C (da)
AR (1)	AR007997A1 (da)
AT (1)	ATE205476T1 (da)
AU (1)	AU724511B2 (da)
BR (1)	BR9710717A (da)
CA (1)	CA2260060C (da)
DE (1)	DE69706690T2 (da)
DK (1)	DK0915845T3 (da)
EA (1)	EA001863B1 (da)
ES (1)	ES2164366T3 (da)
GB (1)	GB9615692D0 (da)
HU (1)	HU224635B1 (da)
IL (1)	IL127689A (da)
MY (1)	MY124103A (da)
NO (1)	NO310817B1 (da)
NZ (1)	NZ334082A (da)
PL (1)	PL199865B1 (da)
PT (1)	PT915845E (da)
TW (1)	TW360652B (da)
UA (1)	UA61922C2 (da)
WO (1)	WO1998004524A1 (da)
ZA (1)	ZA976549B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9806689D0 (en) *	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9928703D0 (en) *	1999-12-03	2000-02-02	Pharmacia & Upjohn Spa	Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
US6559125B1 (en)	2000-01-28	2003-05-06	California Institute Of Technology	Polyamide-alkylator conjugates and related products and method
PE20011277A1 (es) *	2000-04-14	2002-01-07	Agouron Pharma	Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis
GB0011059D0 (en) *	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015444D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
GB0016447D0 (en)	2000-07-04	2000-08-23	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
GB0017852D0 (en) *	2000-07-20	2000-09-06	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
US6576612B1 (en) *	2000-10-02	2003-06-10	Pharmacia Italia S.P.A.	Antitumor therapy comprising distamycin derivatives
GB0029004D0 (en) *	2000-11-28	2001-01-10	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
EP1470119A4 (en) *	2001-06-13	2005-10-19	Genesoft Pharmaceuticals Inc	BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY
US6969592B2 (en)	2001-09-26	2005-11-29	Pharmacia Italia S.P.A.	Method for predicting the sensitivity to chemotherapy
AU2002352090B8 (en) *	2002-01-02	2008-06-19	Nerviano Medical Sciences S.R.L.	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors
RU2314807C2 (ru) *	2002-04-02	2008-01-20	НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л.	Комбинированная противоопухолевая терапия, включающая использование замещенных акрилоилпроизводных дистамицина и лучевой терапии
US10759781B2 (en)	2015-08-06	2020-09-01	Ube Industries, Ltd.	Substituted guanidine derivatives
GB202114032D0 (en) *	2021-09-30	2021-11-17	Univ Strathclyde	Antivirals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT387013B (de) *	1985-07-16	1988-11-25	Erba Farmitalia	Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) *	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
GB8906709D0 (en) *	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives

1996
- 1996-07-25 GB GBGB9615692.2A patent/GB9615692D0/en active Pending
1997
- 1997-07-10 DK DK97937474T patent/DK0915845T3/da active
- 1997-07-10 AU AU40098/97A patent/AU724511B2/en not_active Ceased
- 1997-07-10 EA EA199900163A patent/EA001863B1/ru not_active IP Right Cessation
- 1997-07-10 WO PCT/EP1997/003719 patent/WO1998004524A1/en not_active Ceased
- 1997-07-10 JP JP50842898A patent/JP4312264B2/ja not_active Expired - Fee Related
- 1997-07-10 ES ES97937474T patent/ES2164366T3/es not_active Expired - Lifetime
- 1997-07-10 DE DE69706690T patent/DE69706690T2/de not_active Expired - Lifetime
- 1997-07-10 AT AT97937474T patent/ATE205476T1/de active
- 1997-07-10 IL IL12768997A patent/IL127689A/xx not_active IP Right Cessation
- 1997-07-10 US US09/147,573 patent/US6482920B1/en not_active Expired - Lifetime
- 1997-07-10 PL PL331344A patent/PL199865B1/pl unknown
- 1997-07-10 EP EP97937474A patent/EP0915845B1/en not_active Expired - Lifetime
- 1997-07-10 BR BR9710717A patent/BR9710717A/pt not_active IP Right Cessation
- 1997-07-10 NZ NZ334082A patent/NZ334082A/xx not_active IP Right Cessation
- 1997-07-10 CN CN97196737A patent/CN1116281C/zh not_active Expired - Fee Related
- 1997-07-10 PT PT97937474T patent/PT915845E/pt unknown
- 1997-07-10 CA CA002260060A patent/CA2260060C/en not_active Expired - Fee Related
- 1997-07-10 KR KR10-1999-7000409A patent/KR100408538B1/ko not_active Expired - Fee Related
- 1997-07-10 HU HU9903253A patent/HU224635B1/hu not_active IP Right Cessation
- 1997-07-18 TW TW086110294A patent/TW360652B/zh not_active IP Right Cessation
- 1997-07-23 ZA ZA9706549A patent/ZA976549B/xx unknown
- 1997-07-25 AR ARP970103377A patent/AR007997A1/es active IP Right Grant
- 1997-07-25 MY MYPI97003389A patent/MY124103A/en unknown
- 1997-10-07 UA UA99021068A patent/UA61922C2/uk unknown
1999
- 1999-01-20 NO NO19990246A patent/NO310817B1/no not_active IP Right Cessation
2002
- 2002-07-17 US US10/196,363 patent/US20030023031A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EA001863B1 (ru)	2001-10-22
AR007997A1 (es)	1999-11-24
ATE205476T1 (de)	2001-09-15
AU724511B2 (en)	2000-09-21
EP0915845A1 (en)	1999-05-19
JP4312264B2 (ja)	2009-08-12
KR20000029448A (ko)	2000-05-25
IL127689A0 (en)	1999-10-28
EA199900163A1 (ru)	1999-08-26
PL199865B1 (pl)	2008-11-28
MY124103A (en)	2006-06-30
NO310817B1 (no)	2001-09-03
DE69706690D1 (de)	2001-10-18
PL331344A1 (en)	1999-07-05
AU4009897A (en)	1998-02-20
PT915845E (pt)	2002-03-28
TW360652B (en)	1999-06-11
HUP9903253A3 (en)	2002-01-28
US20030023031A1 (en)	2003-01-30
EP0915845B1 (en)	2001-09-12
HUP9903253A2 (hu)	2000-02-28
NO990246D0 (no)	1999-01-20
UA61922C2 (uk)	2003-12-15
HK1020948A1 (en)	2000-05-26
IL127689A (en)	2003-07-31
NZ334082A (en)	1999-08-30
HU224635B1 (hu)	2005-12-28
CN1116281C (zh)	2003-07-30
BR9710717A (pt)	1999-08-17
NO990246L (no)	1999-01-20
DE69706690T2 (de)	2002-06-20
US6482920B1 (en)	2002-11-19
ZA976549B (en)	1998-02-03
CN1226232A (zh)	1999-08-18
WO1998004524A1 (en)	1998-02-05
CA2260060C (en)	2007-01-30
CA2260060A1 (en)	1998-02-05
GB9615692D0 (en)	1996-09-04
JP2000515164A (ja)	2000-11-14
KR100408538B1 (ko)	2004-01-13
ES2164366T3 (es)	2002-02-16

Publication	Publication Date	Title
DK0740668T3 (da)	1999-05-03	Tetracykliske derivater, fremgangsmåde til deres fremstilling og deres anvendelse
NO20012058L (no)	2001-06-28	2-ureido-tiazolderivater, fremgangsmåte for deres fremstilling og anvendelse som antitumormidler
DK1202733T3 (da)	2005-10-31	3(5)-amino-pyrazolderivater, fremgangsmåde til deres fremstilling og deres anvendelse som antitumormidler
NO20001409L (no)	2000-05-16	Karboksamidotiazolderivater, fremgangsmÕte for fremstilling derav og farmasøytiske blandinger
NO975977L (no)	1998-06-22	Substituerte purinderivater, fremgangsmÕter for fremstilling og anvendelse derav
NO963506D0 (no)	1996-08-22	4-Heterocyklyl-substituerte kinazolin-derivater, fremgangsmåte for fremstilling derav og deres anvendelse som anti-kreftmidler
NO20012057D0 (no)	2001-04-26	2-amino-tiazolderivater, fremgangsmåte for deres fremstilling og anvendelse som antitumormidler
DK0915845T3 (da)	2002-01-07	Acryloylsubstituerede distamycinderivater, fremgangsmåde til fremstilling deraf og anvendelse som antitumormidler og antivirale midler
DK0676409T3 (da)	2003-06-23	Erythromycinderivater, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
DK0847388T3 (da)	2003-08-18	Heterocyklisk substituerede biphenylamidderivater, fremstilling heraf og anvendelse heraf som fungicider
EE04721B1 (et)	2006-10-16	Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
IS2076B (is)	2006-02-15	Asýl-píperasínil-pýrimídínafleiður, framleiðsla og notkun þeirra sem lyfja
NO980720D0 (no)	1998-02-20	Pyridazin-3-on-derivater, deres anvendelse og mellomprodukter for deres fremstilling
DK1015444T3 (da)	2003-08-18	Pyrimidinderivater og fremgangsmåder til fremstilling deraf
ZA979997B (en)	1998-05-25	Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents.
DK0912509T3 (da)	2001-10-22	Distamycinderivater, fremgangsmåde til fremstilling deraf og deres anvendelse som antitumor- og antivirale midler
AU1596097A (en)	1997-08-22	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
DK1025100T3 (da)	2002-05-06	3-substituerede tetrahydropyridopyrimidinonderivater, fremstilling og anvendelsen heraf
NO971142D0 (no)	1997-03-12	Bis-(2-halogenetyl)aminofenylsubstituerte distamycinderivater som antitumor- og antivirale midler
DK0880524T3 (da)	2000-07-17	Adenosinantagonister, fremgangsmåde til fremstilling deraf og deres anvendelse som medikamenter
DK0889879T3 (da)	2002-09-09	Butadienderivater og fremgangsmåde til fremstilling deraf
NO951812D0 (no)	1995-05-09	Pyrrolderivater, deres fremstilling og anvendelse
GB9613987D0 (en)	1996-09-04	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9602163D0 (en)	1996-04-03	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
FI963073L (fi)	1996-08-02	Makrosykliset difluorisatonijohdannaiset, jotka ovat käyttökelpoisia viruksia vastustavina aineina