NO311529B1 - Fremgangsmåte og reagens for bestemmelse av spesifikke nukleotidvariasjoner - Google Patents

Fremgangsmåte og reagens for bestemmelse av spesifikke nukleotidvariasjoner Download PDF

Info

Publication number
NO311529B1
NO311529B1 NO19923116A NO923116A NO311529B1 NO 311529 B1 NO311529 B1 NO 311529B1 NO 19923116 A NO19923116 A NO 19923116A NO 923116 A NO923116 A NO 923116A NO 311529 B1 NO311529 B1 NO 311529B1
Authority
NO
Norway
Prior art keywords
nucleotide
detection
primer
sequence
nucleic acid
Prior art date
Application number
NO19923116A
Other languages
English (en)
Norwegian (no)
Other versions
NO923116D0 (no
NO923116L (no
Inventor
Hans Soederlund
Ann-Christine Syvaenen
Original Assignee
Sangtec Medical Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sangtec Medical Ab filed Critical Sangtec Medical Ab
Publication of NO923116D0 publication Critical patent/NO923116D0/no
Publication of NO923116L publication Critical patent/NO923116L/no
Publication of NO311529B1 publication Critical patent/NO311529B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/702Specific hybridization probes for retroviruses
    • C12Q1/703Viruses associated with AIDS
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
NO19923116A 1990-02-16 1992-08-10 Fremgangsmåte og reagens for bestemmelse av spesifikke nukleotidvariasjoner NO311529B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48200590A 1990-02-16 1990-02-16
PCT/FI1991/000046 WO1991013075A2 (fr) 1990-02-16 1991-02-15 Procede et reactif permettant de determiner des variations specifique de nucleotides

Publications (3)

Publication Number Publication Date
NO923116D0 NO923116D0 (no) 1992-08-10
NO923116L NO923116L (no) 1992-08-10
NO311529B1 true NO311529B1 (no) 2001-12-03

Family

ID=23914258

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19923116A NO311529B1 (no) 1990-02-16 1992-08-10 Fremgangsmåte og reagens for bestemmelse av spesifikke nukleotidvariasjoner

Country Status (18)

Country Link
EP (1) EP0648280B1 (fr)
JP (1) JP2786011B2 (fr)
AT (1) ATE180019T1 (fr)
AU (1) AU642709B2 (fr)
CA (1) CA2071537C (fr)
DE (2) DE648280T1 (fr)
DK (1) DK0648280T3 (fr)
ES (1) ES2072235T3 (fr)
FI (1) FI102297B (fr)
GR (2) GR950300047T1 (fr)
HU (1) HU211058B (fr)
IE (1) IE910525A1 (fr)
IL (1) IL97222A (fr)
NO (1) NO311529B1 (fr)
NZ (1) NZ237134A (fr)
PT (1) PT96776B (fr)
WO (1) WO1991013075A2 (fr)
ZA (1) ZA911152B (fr)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
AU1741692A (en) * 1991-03-13 1992-10-21 Regents Of The University Of California, The Detection of 3'-azido-3'-deoxythymidine resistance
US7026115B1 (en) 1991-09-24 2006-04-11 Keygene N.V. Selective restriction fragment amplification: fingerprinting
US20100267023A1 (en) 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
GB9208000D0 (en) * 1992-04-10 1992-05-27 Univ London Quantitative viral assay
WO1993022457A1 (fr) * 1992-04-24 1993-11-11 Massachusetts Institute Of Technology Criblage servant a detecter une variation genetique
JP2001507921A (ja) * 1992-04-27 2001-06-19 トラスティーズ オブ ダートマス カレッジ 生物学的液体中の遺伝子配列の検出
GB9210176D0 (en) * 1992-05-12 1992-06-24 Cemu Bioteknik Ab Chemical method
WO1993025563A1 (fr) * 1992-06-17 1993-12-23 City Of Hope Procede de detection de sequences d'acide nucleique et de discrimination entre ces sequences
EP1302547A3 (fr) * 1992-06-17 2003-11-12 City Of Hope Procédé de détection de séquences d'acide nuclèique et de discrimination entre ces séquences
US5981176A (en) 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
US5710028A (en) * 1992-07-02 1998-01-20 Eyal; Nurit Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
EP0648222B1 (fr) * 1992-07-02 2003-01-29 Savyon Diagnostics Ltd. Procede d'allongement d'amorce de nucleotide simple brin destine a detecter des alleles specifiques et trousses permettant d'appliquer ledit procede
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US7001722B1 (en) 1993-06-22 2006-02-21 Baylor College Of Medicine Parallel primer extension approach to nucleic acid sequence analysis
US6153379A (en) * 1993-06-22 2000-11-28 Baylor College Of Medicine Parallel primer extension approach to nucleic acid sequence analysis
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
CA2111503A1 (fr) * 1993-12-15 1995-06-16 Mcgill University Polymorphisme de l'apolipoproteine e et maladie d'alzheimer
US6428955B1 (en) 1995-03-17 2002-08-06 Sequenom, Inc. DNA diagnostics based on mass spectrometry
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
GB9517914D0 (en) * 1995-09-02 1995-11-01 Tepnel Medical Ltd Identification of bases in nucleic acid sequences
NO954667D0 (no) * 1995-11-17 1995-11-17 Dagfinn Oegreid Fremgangsmåte til deteksjon av Ki-ras mutasjoner
AU2320597A (en) 1996-03-19 1997-10-10 Molecular Tool, Inc. Method for determining the nucleotide sequence of a polynucleotide
WO1998002574A1 (fr) * 1996-07-11 1998-01-22 Wakunaga Pharmaceutical Co., Ltd. Procede pour l'examen d'acides nucleiques et kits d'examen
JP2000516468A (ja) 1996-08-14 2000-12-12 ライフ テクノロジーズ,インコーポレイテッド 核酸増幅および配列決定のための安定な組成物
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
EP0954612A2 (fr) 1996-11-06 1999-11-10 Sequenom, Inc. Diagnostics de l'adn fondes sur la spectrometrie de masse
US6133436A (en) * 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US6140053A (en) 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US6309829B1 (en) 1997-05-27 2001-10-30 Pe Corporation (Ny) Length determination of nucleic acid repeat sequences by discontinuous primer extension
US5945284A (en) * 1997-05-27 1999-08-31 The Perkin-Elmer Corporation Length determination of nucleic acid repeat sequences by discontinuous primer extension
US5888778A (en) * 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
US6566101B1 (en) 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
US7105353B2 (en) 1997-07-18 2006-09-12 Serono Genetics Institute S.A. Methods of identifying individuals for inclusion in drug studies
GB9715034D0 (en) * 1997-07-18 1997-09-24 Zeneca Ltd Assay
EP0892068A1 (fr) * 1997-07-18 1999-01-20 Genset Sa Méthode pour la génération d'une carte du génome humain avec haute densité basée sur linkage diséquilibrium
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US6982431B2 (en) 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6537751B1 (en) 1998-04-21 2003-03-25 Genset S.A. Biallelic markers for use in constructing a high density disequilibrium map of the human genome
CA2245039A1 (fr) * 1998-08-13 2000-02-13 Vito Scalia Inhibiteur specifique et dosage par allongement non-identique pour identifier une variation genetique
WO2000012757A1 (fr) * 1998-08-28 2000-03-09 Sangtec Molecular Diagnostics Ab Procede de mesure de l'aptitude d'un patient a metaboliser certains medicaments
DE19855469C2 (de) * 1998-12-01 2001-01-11 Michael Esrich Verfahren zur Bestimmung des Apolipoprotein-E-Genotyps in einer menschlichen Probe
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6573047B1 (en) 1999-04-13 2003-06-03 Dna Sciences, Inc. Detection of nucleotide sequence variation through fluorescence resonance energy transfer label generation
CA2370976C (fr) 1999-04-20 2009-10-20 Illumina, Inc. Detection de reactions d'acide nucleique sur microsupports de billes en reseau
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
JP2001245698A (ja) * 1999-11-22 2001-09-11 Xiao Bing Wang 核酸検出法
JP2003517309A (ja) 1999-12-02 2003-05-27 ディーエヌエー サイエンシーズ インコーポレーテッド 単一ヌクレオチドの変異及びジェノタイピングの決定方法
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
US6762018B1 (en) 1999-12-23 2004-07-13 Tetragen Sa Analysis of nucleotide polymorphisms at a site
ATE412774T1 (de) 2000-02-16 2008-11-15 Illumina Inc Parallele genotypisierung mehrerer patientenproben
US6355433B1 (en) 2000-06-02 2002-03-12 Dna Sciences, Inc. Determination of nucleotide sequence variations through limited primer extension
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
SG115374A1 (en) * 2000-07-17 2005-10-28 Xiao Bing Wang Detection of sequence variation of nucleic acid by shifted termination analysis
CH699253B1 (de) * 2000-09-18 2010-02-15 Eidgenoessische Forschungsanst Verfahren zur Charakterisierung und/oder Identifikation von Genomen.
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US6803201B2 (en) 2002-01-24 2004-10-12 Stratagene Compositions and methods for polynucleotide sequence determination
US7432342B2 (en) 2002-05-03 2008-10-07 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related documents
JP4143756B2 (ja) 2002-06-21 2008-09-03 財団法人名古屋産業科学研究所 心筋梗塞のリスク診断方法
DE10245145B4 (de) * 2002-09-27 2004-12-02 IPK-Institut für Pflanzengenetik und Kulturpflanzenforschung Verfahren zum Nachweis von SNPs auf polydimensionalen Microarrays
AU2003280603A1 (en) 2002-10-29 2004-05-25 Kabushiki Kaisha Dnaform Method of amplifying nucleic acid
TW200525026A (en) 2003-12-25 2005-08-01 Riken Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US20060062531A1 (en) 2004-09-17 2006-03-23 Stephen Turner Fabrication of optical confinements
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
WO2007044071A2 (fr) 2005-04-21 2007-04-19 Exact Sciences Corporation Analyse d'echantillons d'acide nucleique heterogenes
EP3269824A1 (fr) 2008-03-28 2018-01-17 Pacific Biosciences Of California, Inc. Compositions et procédés deséquençage d'acide nucléique
WO2012049279A1 (fr) 2010-10-14 2012-04-19 Universitaet Des Saarlandes Moyens et procédés d'application d'extension d'amorce de nucléotide simple avec une chromatographie hplc de paire d'ions en phase inverse (sirph) pour le diagnostic de polymorphismes de nucléotides simples (snp)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311018D0 (en) * 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
AU622104B2 (en) * 1987-03-11 1992-04-02 Sangtec Molecular Diagnostics Ab Method of assaying of nucleic acids, a reagent combination and kit therefore
FI80476C (fi) * 1987-10-09 1990-06-11 Orion Yhtymae Oy Foerbaettrat hybridisationsfoerfarande, vid foerfarandet anvaent redskap och reagensfoerpackning.
IE61148B1 (en) * 1988-03-10 1994-10-05 Ici Plc Method of detecting nucleotide sequences
DE68916671T2 (de) * 1988-03-18 1995-03-02 Baylor College Medicine Mutationsnachweis durch kompetitiven Oligonukleotid-Priming.
AU3539089A (en) * 1988-04-08 1989-11-03 Salk Institute For Biological Studies, The Ligase-based amplification method
AU3694689A (en) * 1988-04-28 1989-11-24 Mark H. Skolnick Amplified sequence polymorphisms (asps)
AU629845B2 (en) * 1988-08-30 1992-10-15 Abbott Laboratories Detection and amplification of target nucleic acid sequences
CA2002076A1 (fr) * 1988-11-21 1990-05-21 Brent A. Burdick Trousse de diagnostic et methode utilisant un moyen de capture en phase solide pour la detection des acides nucleiques
IL92474A (en) * 1988-11-29 1994-04-12 Orion Yhtymae Oy Reaction method and combination for determining nucleotide sequences
AU656514B2 (en) * 1989-02-13 1995-02-09 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
WO1990012115A1 (fr) * 1989-03-21 1990-10-18 Collaborative Research, Inc. Test de diagnostic de l'adn utilisant une activite d'exonuclease

Also Published As

Publication number Publication date
GR950300047T1 (en) 1995-07-31
NO923116D0 (no) 1992-08-10
GR3030790T3 (en) 1999-11-30
ES2072235T1 (es) 1995-07-16
ZA911152B (en) 1991-11-27
JPH05504477A (ja) 1993-07-15
AU7235191A (en) 1991-09-18
DE648280T1 (de) 1995-11-30
PT96776A (pt) 1991-10-31
DE69131233T2 (de) 1999-11-04
DK0648280T3 (da) 1999-11-01
DE69131233D1 (de) 1999-06-17
ATE180019T1 (de) 1999-05-15
FI923653L (fi) 1992-08-14
EP0648280B1 (fr) 1999-05-12
NO923116L (no) 1992-08-10
AU642709B2 (en) 1993-10-28
FI923653A0 (fi) 1992-08-14
JP2786011B2 (ja) 1998-08-13
IL97222A0 (en) 1992-05-25
PT96776B (pt) 1998-05-29
WO1991013075A3 (fr) 1991-10-17
ES2072235T3 (es) 1999-07-16
HU910516D0 (en) 1991-09-30
IE910525A1 (en) 1991-08-28
CA2071537C (fr) 2003-02-11
HU211058B (en) 1995-10-30
IL97222A (en) 1995-08-31
WO1991013075A2 (fr) 1991-09-05
FI102297B1 (fi) 1998-11-13
EP0648280A1 (fr) 1995-04-19
HUT61330A (en) 1992-12-28
NZ237134A (en) 1992-06-25
CA2071537A1 (fr) 1991-08-17
FI102297B (fi) 1998-11-13

Similar Documents

Publication Publication Date Title
EP0648280B1 (fr) Procede et reactif permettant de determiner des variations specifique de nucleotides
US7132235B2 (en) Reagent kit for determining specific nucleotide variations
CA2393482C (fr) Detection de polymorphisme basee sur une amplification
US6537748B1 (en) Reagent for nucleic acid typing by primer extension
US5512441A (en) Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
EP0672173B1 (fr) Procede d'amplification en phase solide
Liu et al. Extended blood group molecular typing and next-generation sequencing
EP1241266A1 (fr) Procede de detection de polymorphisme nucleotidique
US20050191636A1 (en) Detection of STRP, such as fragile X syndrome
US20030148301A1 (en) Method of detecting nucleotide polymorphism
US20020098484A1 (en) Method of analyzing single nucleotide polymorphisms using melting curve and restriction endonuclease digestion
CA2374406A1 (fr) Analyse des variations de sequences polynucleotidiques par micro-echantillons
JP4909413B2 (ja) 一般化された方法―特異的な配列補完(dsf)により可能になる連続的アダプター連結および増幅を用いたハイスループット突然変異スクリーニング法およびキット
EP2450443B1 (fr) Procédé d'amplification de séquences cibles, procédé de détection de polymorphisme, et réactifs convenant à ces procédés
EP1300473B1 (fr) Procede de detection de polymorphismes nucleotidiques
EP1108065A1 (fr) Procede de mesure de l'aptitude d'un patient a metaboliser certains medicaments
JP2000513202A (ja) 核酸の塩基配列決定または遺伝的置換の大量スクリーニング法
Farkas et al. The suitability of matrix assisted laser desorption/ionization time of flight mass spectrometry in a laboratory developed test using cystic fibrosis carrier screening as a model
US20040038258A1 (en) Methods for detecting DNA polymorphisms
US20010006780A1 (en) Process for detecting a known sequence in genomic dna
WO1999024608A1 (fr) Procede de marquage de polynucleotides
WO2002004679A1 (fr) Procede servant a detecter une cible d'acide nucleique
HK1106553A (en) Detection of chromosomal disorders