NO313384B1 - Benzotiofen-, benzofuran- og indol-tiazepinoner, - oksazepinoner og -diazepinoner som inhibitorer av celleadhesjon ogsom inhibitorer av celleadhesjon og som inhibitorer av HIV - Google Patents

Benzotiofen-, benzofuran- og indol-tiazepinoner, - oksazepinoner og -diazepinoner som inhibitorer av celleadhesjon ogsom inhibitorer av celleadhesjon og som inhibitorer av HIV Download PDF

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Publication number
NO313384B1
NO313384B1 NO19963744A NO963744A NO313384B1 NO 313384 B1 NO313384 B1 NO 313384B1 NO 19963744 A NO19963744 A NO 19963744A NO 963744 A NO963744 A NO 963744A NO 313384 B1 NO313384 B1 NO 313384B1
Authority
NO
Norway
Prior art keywords
dihydro
methoxy
hiv
benzothieno
inhibitors
Prior art date
Application number
NO19963744A
Other languages
English (en)
Norwegian (no)
Other versions
NO963744L (no
NO963744D0 (no
Inventor
Diane Harris Boschelli
David Thomas Connor
James Bernard Kramer
Paul Charles Unangst
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO963744L publication Critical patent/NO963744L/no
Publication of NO963744D0 publication Critical patent/NO963744D0/no
Publication of NO313384B1 publication Critical patent/NO313384B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
NO19963744A 1994-03-07 1996-09-06 Benzotiofen-, benzofuran- og indol-tiazepinoner, - oksazepinoner og -diazepinoner som inhibitorer av celleadhesjon ogsom inhibitorer av celleadhesjon og som inhibitorer av HIV NO313384B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20733094A 1994-03-07 1994-03-07
US08/351,611 US5489586A (en) 1994-03-07 1994-12-12 Method for treating inflammatory disease in humans
PCT/US1995/001275 WO1995024408A1 (en) 1994-03-07 1995-01-30 Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of hiv

Publications (3)

Publication Number Publication Date
NO963744L NO963744L (no) 1996-09-06
NO963744D0 NO963744D0 (no) 1996-09-06
NO313384B1 true NO313384B1 (no) 2002-09-23

Family

ID=22770077

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19963744A NO313384B1 (no) 1994-03-07 1996-09-06 Benzotiofen-, benzofuran- og indol-tiazepinoner, - oksazepinoner og -diazepinoner som inhibitorer av celleadhesjon ogsom inhibitorer av celleadhesjon og som inhibitorer av HIV

Country Status (28)

Country Link
US (2) US5489586A (cs)
EP (1) EP0749434B1 (cs)
JP (1) JPH09509961A (cs)
KR (2) KR100325881B1 (cs)
AT (1) ATE187728T1 (cs)
AU (1) AU688466B2 (cs)
BG (1) BG62698B1 (cs)
CA (1) CA2181354A1 (cs)
CZ (1) CZ292009B6 (cs)
DE (1) DE69513961T2 (cs)
DK (1) DK0749434T3 (cs)
ES (1) ES2141922T3 (cs)
FI (1) FI963462L (cs)
GE (1) GEP19991835B (cs)
GR (1) GR3032861T3 (cs)
HU (1) HUT77403A (cs)
MD (1) MD1688G2 (cs)
NO (1) NO313384B1 (cs)
NZ (1) NZ279737A (cs)
PH (1) PH31163A (cs)
PL (1) PL180457B1 (cs)
RO (1) RO117919B1 (cs)
RU (1) RU2144033C1 (cs)
SK (1) SK282962B6 (cs)
TJ (1) TJ252B (cs)
UA (1) UA45967C2 (cs)
WO (1) WO1995024408A1 (cs)
ZA (1) ZA951844B (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612330A (en) * 1994-03-07 1997-03-18 Warner-Lambert Company Methods for inhibiting and controlling viral growth
DK1076657T3 (da) * 1998-04-28 2004-11-08 Elbion Ag Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
DE19944829A1 (de) * 1999-09-18 2001-06-13 Kundo Systemtechnik Gmbh Ultraschall-Durchflußmesser
WO2002014324A2 (en) * 2000-08-16 2002-02-21 Warner-Lambert Company Diazepinones as antiviral agents
JP2005089298A (ja) * 2001-09-18 2005-04-07 Japan Tobacco Inc ナフタレン化合物及びその医薬用途
AU2003225131A1 (en) * 2002-04-23 2003-11-10 Aventis Pharmaceuticals Inc. 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino-benzo' b! thiophene-2-carboxylic acid derivatives as interieukin-4 gene expression inhibitors
GB0217920D0 (en) 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
US7045552B2 (en) * 2002-09-27 2006-05-16 Trimeris, Inc. Pharmaceutical composition for improved administration of HIV gp41-derived peptides, and its use in therapy
EP1615885A1 (en) * 2003-04-15 2006-01-18 Warner-Lambert Company LLC B -fused bicyclic proline derivatives and their use for treating arthritic conditions
CN1238357C (zh) * 2003-10-22 2006-01-25 中国科学院昆明植物研究所 炭球菌素及其制备方法和应用
WO2005081960A2 (en) * 2004-02-25 2005-09-09 Wyeth Inhibitors of protein tyrosine phosphatase 1b
AU2005305609B2 (en) 2004-09-17 2011-10-06 Idenix Pharmaceuticals, Inc. Phosphoindoles as HIV inhibitors
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
JP2009062278A (ja) * 2005-12-29 2009-03-26 Nippon Chemiphar Co Ltd Ｐ２ｘ４受容体拮抗剤
AU2007265966B2 (en) 2006-06-27 2012-05-17 Takeda Pharmaceutical Company Limited Fused cyclic compounds
ES2488922T3 (es) * 2006-09-29 2014-09-01 Idenix Pharmaceuticals, Inc. Fosfoindoles enantiómeramente puros como inhibidores del HIV
CA2817896A1 (en) * 2010-11-15 2012-05-24 Viiv Healthcare Uk Limited Inhibitors of hiv replication
RU2506082C2 (ru) * 2011-05-24 2014-02-10 Государственное учебно-научное учреждение Химический факультет Московского государственного университета им. М.В. Ломоносова Антигипотоническое средство
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
US20250171460A1 (en) * 2022-02-07 2025-05-29 Riparian Pharmaceuticals, Inc. Inducers of klf2 and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013641A (en) * 1975-10-08 1977-03-22 Xerox Corporation Indolobenzoxazepines
WO1994017075A1 (en) * 1993-01-20 1994-08-04 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Diazepin derivatives and antiviral compositions

Also Published As

Publication number Publication date
EP0749434A1 (en) 1996-12-27
CZ292009B6 (cs) 2003-07-16
BG62698B1 (bg) 2000-05-31
DK0749434T3 (da) 2000-05-29
SK114196A3 (en) 1997-03-05
TJ252B (en) 1999-12-23
ZA951844B (en) 1995-12-12
DE69513961T2 (de) 2000-06-29
MD1688G2 (ro) 2002-01-31
DE69513961D1 (de) 2000-01-20
SK282962B6 (sk) 2003-01-09
HU9602451D0 (en) 1996-11-28
CA2181354A1 (en) 1995-09-14
GR3032861T3 (en) 2000-07-31
PL180457B1 (pl) 2001-02-28
GEP19991835B (en) 1999-11-05
KR100325881B1 (ko) 2002-03-20
KR100338017B1 (ko) 2002-11-23
FI963462A7 (fi) 1996-09-04
HUT77403A (hu) 1998-04-28
US5565446A (en) 1996-10-15
PL316197A1 (en) 1996-12-23
NO963744L (no) 1996-09-06
AU688466B2 (en) 1998-03-12
JPH09509961A (ja) 1997-10-07
US5489586A (en) 1996-02-06
FI963462A0 (fi) 1996-09-04
PH31163A (en) 1998-03-20
ES2141922T3 (es) 2000-04-01
UA45967C2 (uk) 2002-05-15
BG100829A (bg) 1997-10-31
NZ279737A (en) 1997-07-27
MD1688F2 (en) 2001-06-30
EP0749434B1 (en) 1999-12-15
AU1697395A (en) 1995-09-25
RU2144033C1 (ru) 2000-01-10
FI963462L (fi) 1996-09-04
RO117919B1 (ro) 2002-09-30
ATE187728T1 (de) 2000-01-15
CZ259796A3 (en) 1997-06-11
NO963744D0 (no) 1996-09-06
WO1995024408A1 (en) 1995-09-14
MD960230A (ro) 1997-10-31

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