NO316745B1 - Mikrofluidiserte partikler av atovaquon, farmasoytisk preparat inneholdende slike partikler, fremgangsmate for deres fremstilling og fremgangsmate for fremstilling av preparatet - Google Patents

Mikrofluidiserte partikler av atovaquon, farmasoytisk preparat inneholdende slike partikler, fremgangsmate for deres fremstilling og fremgangsmate for fremstilling av preparatet Download PDF

Info

Publication number: NO316745B1
Authority: NO; Norway
Prior art keywords: atovaquone; particles; preparation; pharmaceutical preparation; mixture
Prior art date: 1992-12-24

Application number

NO19952522A

Other languages

English (en)

Norwegian (no)

Other versions

NO952522D0 (no

NO952522L (no

Inventor

Alan Roy Dearn

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-24

Filing date

1995-06-22

Publication date

2004-04-26

1995-06-22 Application filed by Wellcome Found filed Critical Wellcome Found

1995-06-22 Publication of NO952522D0 publication Critical patent/NO952522D0/no

1995-06-22 Publication of NO952522L publication Critical patent/NO952522L/no

2004-04-26 Publication of NO316745B1 publication Critical patent/NO316745B1/no

Links

KUCQYCKVKVOKAY-CTYIDZIISA-N atovaquone Chemical compound C1([C@H]2CC[C@@H](CC2)C2=C(C(C3=CC=CC=C3C2=O)=O)O)=CC=C(Cl)C=C1 KUCQYCKVKVOKAY-CTYIDZIISA-N 0.000 title claims description 38
229960003159 atovaquone Drugs 0.000 title claims description 38
239000002245 particle Substances 0.000 title claims description 32
238000000034 method Methods 0.000 title claims description 18
238000002360 preparation method Methods 0.000 title claims description 18
239000008194 pharmaceutical composition Substances 0.000 title 1
239000000203 mixture Substances 0.000 claims description 17
239000000825 pharmaceutical preparation Substances 0.000 claims description 14
238000004519 manufacturing process Methods 0.000 claims description 8
239000007788 liquid Substances 0.000 claims description 7
239000000375 suspending agent Substances 0.000 claims description 7
239000000725 suspension Substances 0.000 claims description 7
239000003981 vehicle Substances 0.000 claims description 7
239000003937 drug carrier Substances 0.000 claims description 6
238000002156 mixing Methods 0.000 claims description 6
239000004094 surface-active agent Substances 0.000 claims description 5
239000000230 xanthan gum Substances 0.000 claims description 4
229920001285 xanthan gum Polymers 0.000 claims description 4
229940082509 xanthan gum Drugs 0.000 claims description 4
235000010493 xanthan gum Nutrition 0.000 claims description 4
238000011321 prophylaxis Methods 0.000 claims description 3
238000011282 treatment Methods 0.000 claims description 3
CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 claims description 2
241000233872 Pneumocystis carinii Species 0.000 claims description 2
208000010362 Protozoan Infections Diseases 0.000 claims description 2
230000003071 parasitic effect Effects 0.000 claims description 2
229920001993 poloxamer 188 Polymers 0.000 claims description 2
229940044519 poloxamer 188 Drugs 0.000 claims description 2
-1 polyethylene Polymers 0.000 claims description 2
239000004698 Polyethylene Substances 0.000 claims 1
229920000573 polyethylene Polymers 0.000 claims 1
150000001875 compounds Chemical class 0.000 description 6
239000012634 fragment Substances 0.000 description 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
201000005485 Toxoplasmosis Diseases 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
239000012530 fluid Substances 0.000 description 2
229910052736 halogen Inorganic materials 0.000 description 2
150000002367 halogens Chemical class 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
201000004792 malaria Diseases 0.000 description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 1
BSJMWHQBCZFXBR-UHFFFAOYSA-N 3-[4-(p-chlorophenyl)cyclohexyl]-4-hydroxy-1,2-naphthoquinone Chemical compound O=C1C(=O)C2=CC=CC=C2C(O)=C1C(CC1)CCC1C1=CC=C(Cl)C=C1 BSJMWHQBCZFXBR-UHFFFAOYSA-N 0.000 description 1
208000003495 Coccidiosis Diseases 0.000 description 1
208000008953 Cryptosporidiosis Diseases 0.000 description 1
206010011502 Cryptosporidiosis infection Diseases 0.000 description 1
241000223924 Eimeria Species 0.000 description 1
241000223931 Eimeria acervulina Species 0.000 description 1
206010023076 Isosporiasis Diseases 0.000 description 1
241000223960 Plasmodium falciparum Species 0.000 description 1
208000005384 Pneumocystis Pneumonia Diseases 0.000 description 1
206010073755 Pneumocystis jirovecii pneumonia Diseases 0.000 description 1
241000223777 Theileria Species 0.000 description 1
241000223778 Theileria annulata Species 0.000 description 1
241000223779 Theileria parva Species 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
230000000842 anti-protozoal effect Effects 0.000 description 1
125000003710 aryl alkyl group Chemical group 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
210000004262 dental pulp cavity Anatomy 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
239000010419 fine particle Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
239000008297 liquid dosage form Substances 0.000 description 1
YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
229940100692 oral suspension Drugs 0.000 description 1
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
244000045947 parasite Species 0.000 description 1
201000000317 pneumocystosis Diseases 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Fertilizers (AREA)
Medicines Containing Plant Substances (AREA)

NO19952522A 1992-12-24 1995-06-22 Mikrofluidiserte partikler av atovaquon, farmasoytisk preparat inneholdende slike partikler, fremgangsmate for deres fremstilling og fremgangsmate for fremstilling av preparatet NO316745B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929226905A GB9226905D0 (en)	1992-12-24	1992-12-24	Pharmaceutical preparation
PCT/GB1993/002646 WO1994014426A1 (en)	1992-12-24	1993-12-23	Atovaquone pharmaceutical compositions

Publications (3)

Publication Number	Publication Date
NO952522D0 NO952522D0 (no)	1995-06-22
NO952522L NO952522L (no)	1995-06-22
NO316745B1 true NO316745B1 (no)	2004-04-26

Family

ID=10727175

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19952522A NO316745B1 (no)	1992-12-24	1995-06-22	Mikrofluidiserte partikler av atovaquon, farmasoytisk preparat inneholdende slike partikler, fremgangsmate for deres fremstilling og fremgangsmate for fremstilling av preparatet

Country Status (35)

Country	Link
US (2)	US6018080A (cs)
EP (1)	EP0675711B1 (cs)
JP (1)	JP3461353B2 (cs)
KR (1)	KR0175193B1 (cs)
CN (1)	CN1076194C (cs)
AT (1)	ATE169215T1 (cs)
AU (2)	AU675102B2 (cs)
BG (1)	BG61932B1 (cs)
BR (1)	BR9307719A (cs)
CA (1)	CA2152615C (cs)
CZ (1)	CZ289701B6 (cs)
DE (1)	DE69320208T2 (cs)
DK (1)	DK0675711T3 (cs)
ES (1)	ES2122223T3 (cs)
FI (1)	FI114007B (cs)
GB (1)	GB9226905D0 (cs)
GE (1)	GEP19991515B (cs)
HR (1)	HRP931516B1 (cs)
HU (1)	HU220215B (cs)
IL (1)	IL108154A (cs)
MY (1)	MY109990A (cs)
NO (1)	NO316745B1 (cs)
NZ (1)	NZ258995A (cs)
PL (1)	PL175374B1 (cs)
RO (1)	RO119686B1 (cs)
RU (1)	RU2127585C1 (cs)
SA (1)	SA94140644B1 (cs)
SG (1)	SG43901A1 (cs)
SI (1)	SI9300678A (cs)
SK (1)	SK281924B6 (cs)
TW (2)	TW443935B (cs)
UA (1)	UA39879C2 (cs)
WO (1)	WO1994014426A1 (cs)
YU (1)	YU48919B (cs)
ZA (1)	ZA939673B (cs)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9224739D0 (en) *	1992-11-26	1993-01-13	Wellcome Found	Medicaments
GB9226905D0 (en) *	1992-12-24	1993-02-17	Wellcome Found	Pharmaceutical preparation
WO1996013254A1 (en) *	1994-10-26	1996-05-09	Glaxo Wellcome House	Pharmaceutical composition comprising atovaquone
DE4440337A1 (de) *	1994-11-11	1996-05-15	Dds Drug Delivery Services Ges	Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
GB9424013D0 (en) *	1994-11-29	1995-01-18	Wellcome Found	Medicaments
AU753278B2 (en)	1998-02-25	2002-10-10	Abbott Laboratories	Butorphanol sustained release formulations
US6503949B1 (en)	1999-05-17	2003-01-07	Noro Nordisk A/S	Glucagon antagonists/inverse agonists
US6562807B2 (en)	2000-06-23	2003-05-13	Novo Nordisk A/S	Glucagon antagonists/inverse agonists
JP2004513935A (ja)	2000-11-17	2004-05-13	ノボ　ノルディスク　アクティーゼルスカブ	グルカゴンアンタゴニスト／逆アゴニスト
US6821960B2 (en)	2000-11-17	2004-11-23	Noyo Nordisk Pharmaceuticals, Inc.	Glucagon antagonists/inverse agonists
US6706744B2 (en)	2000-11-17	2004-03-16	Novo Nordisk A/S	Glucagon antagonists/inverse agonists
US6881746B2 (en)	2001-12-03	2005-04-19	Novo Nordick A/S	Glucagon antagonists/inverse agonists
US6762318B2 (en)	2001-12-03	2004-07-13	Novo Nordisk A/S	Glucagon antagonists
US7183518B2 (en) *	2004-09-24	2007-02-27	Michael Near	System of food storage preparation and delivery in finished cooked state
DE102005011786A1 (de) *	2005-03-11	2006-09-14	Pharmasol Gmbh	Verfahren zur Herstellung ultrafeiner Submicron-Suspensionen
JP5080445B2 (ja) *	2005-04-13	2012-11-21	アボットゲーエムベーハーウントコー．カーゲー	超微粒子懸濁液及び超微粒子を穏やかに製造する方法並びにその使用
US20080241254A1 (en) *	2007-01-02	2008-10-02	Suryakant Navale	Pharmaceutical composition comprising atovaquone particles
DE102007001473A1 (de)	2007-01-08	2008-07-10	Andreas Lemke	Verfahren zur Herstellung und Anwendung von Mikro- und/oder Nanosuspensionen durch aufbauende Mikronisierung in Gegenwart von Trockeneis und hohem Druck
WO2009007991A2 (en) *	2007-04-19	2009-01-15	Ipca Laboratories Limited	A new process for preparation of atovaquone and novel intermediates thereof
US20110206770A1 (en) *	2008-07-25	2011-08-25	Alphapharm Pty. Ltd.	Atovaquone with a particle size diameter range (d90) of greater than 3 microns to about 10 microns
US20100099776A1 (en) *	2008-10-20	2010-04-22	Ranbaxy Laboratories Limited	Oily suspension of atovaquone
ES2517366T3 (es)	2009-08-20	2014-11-03	Ipca Laboratories Limited	Nuevo complejo para el tratamiento y/o profilaxis de infecciones parasitarias
US9023886B2 (en)	2009-11-10	2015-05-05	Celgene Corporation	Nanosuspension of a poorly soluble drug via microfluidization process
WO2011151418A2 (en)	2010-06-02	2011-12-08	Abbott Gmbh & Co. Kg	Nanosusupension formulation comprising a polydimethylsiloxane hydrophobic phase
CN105007898A (zh)	2012-12-19	2015-10-28	卡希夫制药有限责任公司	难溶性药物的过饱和的稳定纳米颗粒
WO2015071841A1 (en)	2013-11-12	2015-05-21	Druggability Technologies Holdings Limited	Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US20190321310A1 (en) *	2016-06-16	2019-10-24	The University Of Liverpool	Chemical composition
US20220265566A1 (en) *	2018-10-18	2022-08-25	Tulex Pharmaceuticals Inc.	Atovaquone nanoparticulate compositions

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2533648A (en) *	1949-03-05	1950-12-12	Joseph H Warburg	Circular saw making
NL6411993A (cs) *	1963-10-18	1965-04-20
US3347830A (en) *	1964-07-30	1967-10-17	Grace W R & Co	Process of polymerizing formaldehyde
GB1141735A (en) *	1966-11-23	1969-01-29	Pfizer & Co C	Pharmaceutical anti-tumor composition
US3655699A (en) *	1970-03-02	1972-04-11	Pfizer	Analogues of lapachol as antitumor agents
US4107288A (en)	1974-09-18	1978-08-15	Pharmaceutical Society Of Victoria	Injectable compositions, nanoparticles useful therein, and process of manufacturing same
DE2601458A1 (de) *	1975-01-20	1976-07-22	Ciba Geigy Ag	Loesliche, von phenylindandiaminen abgeleitete polyamide
EP0002228B1 (en) *	1977-11-22	1984-02-29	The Wellcome Foundation Limited	Hydroxy naphthoquinone derivatives, their preparations for treating and preventing theileriosis in cattle and sheep, processes for their synthesis; naphthoquinone derivatives
US4485117A (en)	1981-10-16	1984-11-27	Hudson Alan T	Antiprotozoal compounds
US4485116A (en) *	1981-10-16	1984-11-27	Hudson Alan T	Antiprotozoal compounds
DE3141691A1 (de) *	1981-10-21	1983-05-19	Hoechst Ag, 6230 Frankfurt	Plasmid pac 1, verfahren zu seiner gewinnung und seine verwendung
JPS5920241A (ja) *	1982-07-16	1984-02-01	ザ・ウエルカム・フアウンデ−シヨン・リミテツド	タイレリア症の予防治療剤
US5053432A (en) *	1983-04-14	1991-10-01	Burroughs Wellcome Co.	Naphthoquinone derivatives
GB8310141D0 (en) *	1983-04-14	1983-05-18	Wellcome Found	Naphthoquinone derivatives
US5175319A (en)	1983-04-14	1992-12-29	Burroughs Wellcome Co.	Naphthoquinone derivatives
GB8310140D0 (en) *	1983-04-14	1983-05-18	Wellcome Found	Antiprotozoal agents
US4963367A (en) *	1984-04-27	1990-10-16	Medaphore, Inc.	Drug delivery compositions and methods
PL276385A1 (en) *	1987-01-30	1989-07-24	Exxon Chemical Patents Inc	Method for polymerization of olefines,diolefins and acetylene unsaturated compounds
IL85097A (en) *	1987-01-30	1992-02-16	Exxon Chemical Patents Inc	Catalysts based on derivatives of a bis(cyclopentadienyl)group ivb metal compound,their preparation and their use in polymerization processes
US4783389A (en) *	1987-03-27	1988-11-08	E. I. Du Pont De Nemours And Company	Process for preparation of liquid electrostatic developers
US5225500A (en) *	1988-07-15	1993-07-06	Fina Technology, Inc.	Process and catalyst for producing syndiotactic polyolefins
US5155080A (en) *	1988-07-15	1992-10-13	Fina Technology, Inc.	Process and catalyst for producing syndiotactic polyolefins
US5206268A (en) *	1988-08-16	1993-04-27	Burroughs Wellcome Co.	Medicaments
US5225184A (en) *	1988-08-16	1993-07-06	Burroughs Wellcome Co.	Medicaments
GB8819477D0 (en) *	1988-08-16	1988-09-21	Wellcome Found	Medicaments
JP2804302B2 (ja) *	1988-08-16	1998-09-24	ザウエルカムフアウンデーションリミテッド	治療剤
KR930002411B1 (ko) *	1988-09-14	1993-03-30	미쓰이세끼유 가가꾸고오교오 가부시끼가이샤	벤젠불용성 유기알루미늄 옥시화합물 및 그 제조방법
GB8921516D0 (en) *	1989-09-22	1989-11-08	Wellcome Found	Medicaments
CA2027145C (en) *	1989-10-10	2002-12-10	Michael J. Elder	Metallocene catalysts with lewis acids and aluminum alkyls
GB8923254D0 (en) *	1989-10-16	1989-12-06	Wellcome Found	Medicaments
US5387568A (en) *	1989-10-30	1995-02-07	Fina Technology, Inc.	Preparation of metallocene catalysts for polymerization of olefins
ES2086397T5 (es) *	1989-10-30	2005-07-16	Fina Technology, Inc.	Adicion de alkiloaluminio para un catalizador metaloceno mejorado.
DE3942363A1 (de) *	1989-12-21	1991-06-27	Hoechst Ag	Verfahren zur herstellung einer polypropylen-formmasse
JP2545006B2 (ja) *	1990-07-03	1996-10-16	ザダウケミカルカンパニー	付加重合触媒
JP3076619B2 (ja)	1991-05-14	2000-08-14	三井化学株式会社	ブロック共重合体の製造方法
GB9226905D0 (en) *	1992-12-24	1993-02-17	Wellcome Found	Pharmaceutical preparation
US5510118A (en)	1995-02-14	1996-04-23	Nanosystems Llc	Process for preparing therapeutic compositions containing nanoparticles
US5766522A (en) *	1996-07-19	1998-06-16	Morton International, Inc.	Continuous processing of powder coating compositions
US5976578A (en) *	1996-10-10	1999-11-02	Mcneil-Ppc, Inc.	Liquid antacid compositions
US5914135A (en) *	1997-04-16	1999-06-22	Mcneil-Ppc, Inc.	Liquid antacid compositions

1992
- 1992-12-24 GB GB929226905A patent/GB9226905D0/en active Pending
1993
- 1993-12-20 GE GEAP19931692A patent/GEP19991515B/en unknown
- 1993-12-22 YU YU80893A patent/YU48919B/sh unknown
- 1993-12-23 HU HU9501812A patent/HU220215B/hu unknown
- 1993-12-23 AT AT94902952T patent/ATE169215T1/de active
- 1993-12-23 TW TW082110927A patent/TW443935B/zh not_active IP Right Cessation
- 1993-12-23 CZ CZ19951451A patent/CZ289701B6/cs not_active IP Right Cessation
- 1993-12-23 PL PL93309629A patent/PL175374B1/pl unknown
- 1993-12-23 RO RO95-01191A patent/RO119686B1/ro unknown
- 1993-12-23 SK SK828-95A patent/SK281924B6/sk not_active IP Right Cessation
- 1993-12-23 AU AU57105/94A patent/AU675102B2/en not_active Expired
- 1993-12-23 UA UA95062971A patent/UA39879C2/uk unknown
- 1993-12-23 CA CA002152615A patent/CA2152615C/en not_active Expired - Lifetime
- 1993-12-23 WO PCT/GB1993/002646 patent/WO1994014426A1/en not_active Ceased
- 1993-12-23 HR HR9226905.9A patent/HRP931516B1/xx not_active IP Right Cessation
- 1993-12-23 RU RU95122758A patent/RU2127585C1/ru active
- 1993-12-23 KR KR1019950702217A patent/KR0175193B1/ko not_active Expired - Fee Related
- 1993-12-23 ZA ZA939673A patent/ZA939673B/xx unknown
- 1993-12-23 EP EP94902952A patent/EP0675711B1/en not_active Expired - Lifetime
- 1993-12-23 SG SG1996004546A patent/SG43901A1/en unknown
- 1993-12-23 DK DK94902952T patent/DK0675711T3/da active
- 1993-12-23 NZ NZ258995A patent/NZ258995A/en not_active IP Right Cessation
- 1993-12-23 CN CN93121376A patent/CN1076194C/zh not_active Expired - Fee Related
- 1993-12-23 DE DE69320208T patent/DE69320208T2/de not_active Expired - Lifetime
- 1993-12-23 BR BR9307719-0A patent/BR9307719A/pt not_active Application Discontinuation
- 1993-12-23 MY MYPI93002823A patent/MY109990A/en unknown
- 1993-12-23 SI SI9300678A patent/SI9300678A/sl unknown
- 1993-12-23 TW TW088101847A patent/TW514531B/zh not_active IP Right Cessation
- 1993-12-23 JP JP51496894A patent/JP3461353B2/ja not_active Expired - Lifetime
- 1993-12-23 IL IL10815493A patent/IL108154A/xx not_active IP Right Cessation
- 1993-12-23 ES ES94902952T patent/ES2122223T3/es not_active Expired - Lifetime
1994
- 1994-04-03 SA SA94140644A patent/SA94140644B1/ar unknown
1995
- 1995-06-15 BG BG99723A patent/BG61932B1/bg unknown
- 1995-06-22 NO NO19952522A patent/NO316745B1/no not_active IP Right Cessation
- 1995-06-22 FI FI953139A patent/FI114007B/fi not_active IP Right Cessation
1997
- 1997-03-14 AU AU16279/97A patent/AU696662B2/en not_active Ceased
- 1997-11-19 US US08/974,248 patent/US6018080A/en not_active Expired - Lifetime
1999
- 1999-10-04 US US09/411,381 patent/US6649659B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK0675711T3 (da)	1999-05-03
FI953139A0 (fi)	1995-06-22
SK82895A3 (en)	1995-11-08
CZ289701B6 (cs)	2002-03-13
NO952522D0 (no)	1995-06-22
SA94140644B1 (ar)	2005-06-14
IL108154A (en)	2000-02-17
US6018080A (en)	2000-01-25
HK1004086A1 (en)	1998-11-13
NZ258995A (en)	1997-01-29
DE69320208D1 (de)	1998-09-10
TW443935B (en)	2001-07-01
KR0175193B1 (ko)	1999-02-01
HUT71528A (en)	1995-12-28
SG43901A1 (en)	1997-11-14
CZ145195A3 (en)	1995-10-18
EP0675711A1 (en)	1995-10-11
RO119686B1 (ro)	2005-02-28
YU48919B (sh)	2002-11-15
EP0675711B1 (en)	1998-08-05
CN1076194C (zh)	2001-12-19
HU9501812D0 (en)	1995-08-28
AU675102B2 (en)	1997-01-23
AU1627997A (en)	1997-05-22
CA2152615A1 (en)	1994-07-07
GB9226905D0 (en)	1993-02-17
MY109990A (en)	1997-10-31
PL175374B1 (pl)	1998-12-31
AU5710594A (en)	1994-07-19
CA2152615C (en)	2001-10-16
ES2122223T3 (es)	1998-12-16
SK281924B6 (sk)	2001-09-11
KR950703942A (ko)	1995-11-17
ATE169215T1 (de)	1998-08-15
PL309629A1 (en)	1995-10-30
DE69320208T2 (de)	1999-01-21
RU2127585C1 (ru)	1999-03-20
HRP931516B1 (en)	1999-04-30
ZA939673B (en)	1995-06-23
TW514531B (en)	2002-12-21
BG61932B1 (bg)	1998-10-30
GEP19991515B (en)	1999-03-05
US6649659B1 (en)	2003-11-18
NO952522L (no)	1995-06-22
YU80893A (sh)	1997-03-07
AU696662B2 (en)	1998-09-17
WO1994014426A1 (en)	1994-07-07
FI953139L (fi)	1995-06-22
HRP931516A2 (en)	1995-10-31
UA39879C2 (uk)	2001-07-16
CN1103290A (zh)	1995-06-07
BR9307719A (pt)	1999-08-31
IL108154A0 (en)	1994-04-12
JP3461353B2 (ja)	2003-10-27
BG99723A (bg)	1996-01-31
HU220215B (hu)	2001-11-28
JPH08504805A (ja)	1996-05-28
SI9300678A (en)	1994-09-30
FI114007B (fi)	2004-07-30

Legal Events

Date	Code	Title	Description
2013-05-21	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: THE WELLCOME FOUNDATION LTD, GB
2014-01-13	MK1K	Patent expired

Publication	Publication Date	Title
EP0675711B1 (en)	1998-08-05	Atovaquone pharmaceutical compositions
EP2254600B1 (en)	2017-05-17	Novel compositions and uses thereof
WO2022222683A1 (zh)	2022-10-27	一种辅酶q10微乳液及其制备方法和应用
JPH04264029A (ja)	1992-09-18	テポキサリンの眼科用水性微細乳濁液
KR20240134147A (ko)	2024-09-06	초미세 화합물 및 이의 제조
FUKUSHIMA et al.	1983	Preparation of and drug release from W/O/W type double emulsions containing anticancer agents
WO2002005850A2 (en)	2002-01-24	Enhancement of the action of anti-infective agents
US8252326B2 (en)	2012-08-28	Self-microemulsifying dosage forms of low solubility active ingredients such as co-enzyme Q10
Patel et al.	2021	Formulation and evaluation of benidipine nanosuspension
Redkar et al.	2007	Onion phases of PEG-8 distearate
KR20230048075A (ko)	2023-04-10	고체 미립자 물질의 제조 방법
CN105254498B (zh)	2017-11-21	化合物1,3‑二油酸‑2‑亚油酸甘油酯、制剂、制备方法及其应用
HK1004086B (en)	2000-03-17	Atovaquone pharmaceutical compositions
Jitendra et al.	2014	Formulation Development and Characterization of Modified Release Microspheres of Antianginal Drug
CN110548004A (zh)	2019-12-10	一种稳定的丁苯酞大容量注射液及其制备方法
Deepak et al.	2013	Recent advancement, technology & applications of the multiple emulsions
Kaewchada et al.	2023	Encapsulation of Alpha-Tocopherol Using Polycaprolactone and Tween 20: Formulation and a Perspective for Scaling up Using Micro-Channel
Raslan	2012	THE USE OF KETOPROFEN NIOSOMES FOR FORMULATION OF SUSTAINED RELEASE TABLET DOSAGE FORM
WO2007064311A1 (en)	2007-06-07	Micronized mirtazapine