NO320074B1 - Fremgangsmater for fremstilling av proteosom-amfifil-determinant vaksine, samt multivalent vaksine fremstilt i folge fremgangsmaten. - Google Patents

Fremgangsmater for fremstilling av proteosom-amfifil-determinant vaksine, samt multivalent vaksine fremstilt i folge fremgangsmaten. Download PDF

Info

Publication number: NO320074B1
Authority: NO; Norway
Prior art keywords: proteosome; determinant; amphiphile; vaccine according; vaccine
Prior art date: 1995-09-18

Application number

NO19981189A

Other languages

English (en)

Norwegian (no)

Other versions

NO981189L (no

NO981189D0 (no

Inventor

George H Lowell

Wendell D Zollinger

James F Woods

Original Assignee

Id Biomedical Corp Of Maryland

Us Army Medical Res Material C

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-18

Filing date

1998-03-17

Publication date

2005-10-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21707938&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO320074(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-03-17 Application filed by Id Biomedical Corp Of Maryland, Us Army Medical Res Material C filed Critical Id Biomedical Corp Of Maryland

1998-03-17 Publication of NO981189D0 publication Critical patent/NO981189D0/no

1998-05-14 Publication of NO981189L publication Critical patent/NO981189L/no

2005-10-17 Publication of NO320074B1 publication Critical patent/NO320074B1/no

Links

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Classifications

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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/008—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from microorganisms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Oncology (AREA)
Dispersion Chemistry (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Mycology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

NO19981189A 1995-09-18 1998-03-17 Fremgangsmater for fremstilling av proteosom-amfifil-determinant vaksine, samt multivalent vaksine fremstilt i folge fremgangsmaten. NO320074B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US385995P	1995-09-18	1995-09-18
PCT/US1996/015002 WO1997010844A1 (en)	1995-09-18	1996-09-18	Improved methods for the production of non-covalently complexed and multivalent proteosome sub-unit vaccines

Publications (3)

Publication Number	Publication Date
NO981189D0 NO981189D0 (no)	1998-03-17
NO981189L NO981189L (no)	1998-05-14
NO320074B1 true NO320074B1 (no)	2005-10-17

Family

ID=21707938

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19981189A NO320074B1 (no)	1995-09-18	1998-03-17	Fremgangsmater for fremstilling av proteosom-amfifil-determinant vaksine, samt multivalent vaksine fremstilt i folge fremgangsmaten.

Country Status (20)

Country	Link
US (1)	US6476201B1 (cs)
EP (1)	EP0854729B2 (cs)
JP (2)	JP4033489B2 (cs)
KR (1)	KR19990045763A (cs)
CN (1)	CN1211192A (cs)
AT (1)	ATE261313T1 (cs)
BR (1)	BR9610484A (cs)
CA (1)	CA2232410C (cs)
CZ (1)	CZ298460B6 (cs)
DE (1)	DE69631835T3 (cs)
DK (1)	DK0854729T3 (cs)
EA (1)	EA199800208A1 (cs)
ES (1)	ES2217325T5 (cs)
HU (1)	HUP9901577A3 (cs)
IL (1)	IL123720A (cs)
MX (1)	MX9802128A (cs)
NO (1)	NO320074B1 (cs)
PL (1)	PL325604A1 (cs)
PT (1)	PT854729E (cs)
WO (1)	WO1997010844A1 (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5961970A (en) *	1993-10-29	1999-10-05	Pharmos Corporation	Submicron emulsions as vaccine adjuvants
WO1999061053A1 (en) *	1998-05-29	1999-12-02	Chiron Corporation	Combination meningitidis b/c vaccines
WO2000066741A2 (en)	1999-04-30	2000-11-09	Chiron S.P.A.	Conserved neisserial antigens
NZ515935A (en)	1999-05-19	2004-01-30	Chiron S	Combination Neisserial compositions and vaccines for the prevention of infections due to Neisseria bacteria such as meningococcal meningitis
EP1721618A3 (en) *	2000-02-15	2007-01-10	ID Biomedical Corporation of Quebec	Proteosome influenza vaccine composition
CA2400468C (en)	2000-02-15	2012-12-18	Intellivax International Inc.	Proteosome influenza vaccine
NZ521531A (en)	2000-02-28	2005-12-23	Chiron S	Heterologous expression of neisserial proteins
US7524509B2 (en)	2001-03-09	2009-04-28	Id Biomedical Corporation Of Quebec	Proteosome-liposaccharide vaccine adjuvant
US20060057160A1 (en) *	2002-08-02	2006-03-16	Ralph Biemans	Vaccine composition
HUE031886T2 (en)	2002-10-11	2017-08-28	Glaxosmithkline Biologicals Sa	Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines
US7255867B2 (en) *	2002-11-15	2007-08-14	Id Biomedical Corporation Of Quebec	Vaccine
GB0316560D0 (en) *	2003-07-15	2003-08-20	Chiron Srl	Vesicle filtration
US7368537B2 (en) *	2003-07-15	2008-05-06	Id Biomedical Corporation Of Quebec	Subunit vaccine against respiratory syncytial virus infection
US20050152919A1 (en) *	2003-09-15	2005-07-14	Id Biomedical Corporation Of Quebec	Measles subunit vaccine
WO2005042017A1 (en)	2003-10-22	2005-05-12	Id Biomedical Corporation Of Quebec	Compositions and methods for activating innate and allergic immunity
CN101039691B (zh)	2004-06-25	2013-07-31	魁北克益得生物医学公司	用于治疗神经疾病的组合物和方法
EP1778283A2 (en) *	2004-06-30	2007-05-02	ID Biomedical Corporation of Quebec	Vaccine compositions for treating coronavirus infection
US7552948B2 (en)	2006-03-29	2009-06-30	Tokai Rubber Industries, Ltd.	Quick connector
CN110064053A (zh) *	2006-08-07	2019-07-30	哈佛大学校长及研究员协会	蛋白质基质疫苗及这种疫苗的制备和给药方法
BRPI0715396B8 (pt) *	2006-08-07	2021-05-25	Harvard College	método de produção de uma composição para vacina
EP2069054A1 (en) *	2006-08-30	2009-06-17	GE Healthcare Bio-Sciences Corp.	System and method for characterizing membranes and membrane filtration devices
UA99659C2 (uk) *	2008-05-30	2012-09-10	Дзе Ю.Ес.Ей., Ес Репрезентед Бай Дзе Секретарі Оф Дзе Армі, Он Бехаф Оф Уолтер Рід Армі	Мультивалентна вакцина з нативних везикул зовнішньої мембрани менінгококів, способи її застосування
CN102686238A (zh) *	2009-09-09	2012-09-19	马特里瓦克斯研究和开发公司	具有改善的免疫原性的蛋白质基质疫苗
AU2015321698B2 (en) *	2014-09-24	2018-06-28	The United States Of America As Represented By The Secretary Of The Navy	Combined enterotoxigenic Escherichia coli and Campylobacter jejuni recombinant construct
CA3208643A1 (en)	2021-01-18	2022-07-21	Conserv Bioscience Limited	Coronavirus immunogenic compositions, methods and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4707543A (en) *	1985-09-17	1987-11-17	The United States Of America As Represented By The Secretary Of The Army	Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines
RU1522494C (ru) *	1987-06-16	1994-11-15	Научно-производственное объединение "Иммунопрепарат"	Способ получения инактивированной вакцины гриппа
RU2023448C1 (ru) *	1987-07-30	1994-11-30	Сентро Насьональ Де Биопрепарадос	Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в
US5145702A (en) *	1988-09-19	1992-09-08	Opta Food Ingredients, Inc.	Hydrophobic protein microparticles and preparation thereof
EP0449958B9 (en) *	1988-12-19	2003-05-28	American Cyanamid Company	Meningococcal class 1 outer-membrane protein vaccine
US5102989A (en) *	1991-03-15	1992-04-07	Merck & Co., Inc.	Method of stabilizing recombinant hepatitis B virus surface proteins from recombinant host cells
CA2139517A1 (en) *	1992-07-20	1994-02-03	Paul M. Keller	Immunological conjugates of ompc and hiv-specific selected principal neutralization epitopes
US5576016A (en) *	1993-05-18	1996-11-19	Pharmos Corporation	Solid fat nanoemulsions as drug delivery vehicles
WO1995011700A1 (en) *	1993-10-29	1995-05-04	Pharmos Corp.	Submicron emulsions as vaccine adjuvants
CA2400468C (en) *	2000-02-15	2012-12-18	Intellivax International Inc.	Proteosome influenza vaccine

1996
- 1996-09-18 CN CN96197616A patent/CN1211192A/zh active Pending
- 1996-09-18 KR KR1019980702007A patent/KR19990045763A/ko not_active Withdrawn
- 1996-09-18 PL PL96325604A patent/PL325604A1/xx unknown
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- 1996-09-18 ES ES96932269T patent/ES2217325T5/es not_active Expired - Lifetime
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- 1996-09-18 EA EA199800208A patent/EA199800208A1/ru unknown
- 1996-09-18 CZ CZ0081998A patent/CZ298460B6/cs not_active IP Right Cessation
- 1996-09-18 AT AT96932269T patent/ATE261313T1/de not_active IP Right Cessation
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- 1996-09-18 DK DK96932269T patent/DK0854729T3/da active
- 1996-09-18 HU HU9901577A patent/HUP9901577A3/hu unknown
- 1996-09-18 WO PCT/US1996/015002 patent/WO1997010844A1/en not_active Ceased
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1998
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Publication number	Publication date
NO981189L (no)	1998-05-14
WO1997010844A1 (en)	1997-03-27
DE69631835T2 (de)	2005-02-10
BR9610484A (pt)	2001-09-11
HUP9901577A3 (en)	2000-03-28
ES2217325T5 (es)	2009-04-01
DE69631835T3 (de)	2009-03-05
IL123720A (en)	2002-02-10
CN1211192A (zh)	1999-03-17
MX9802128A (es)	1998-11-29
JP2000507913A (ja)	2000-06-27
US6476201B1 (en)	2002-11-05
CA2232410C (en)	2003-06-17
CZ298460B6 (cs)	2007-10-10
EP0854729A1 (en)	1998-07-29
ES2217325T3 (es)	2004-11-01
US20020164357A1 (en)	2002-11-07
EP0854729B2 (en)	2008-10-22
EP0854729A4 (en)	2000-02-02
DE69631835D1 (de)	2004-04-15
PT854729E (pt)	2004-08-31
KR19990045763A (ko)	1999-06-25
EP0854729B1 (en)	2004-03-10
DK0854729T3 (da)	2004-07-12
JP4033489B2 (ja)	2008-01-16
NO981189D0 (no)	1998-03-17
JP2004099619A (ja)	2004-04-02
CA2232410A1 (en)	1997-03-27
IL123720A0 (en)	1998-10-30
ATE261313T1 (de)	2004-03-15
PL325604A1 (en)	1998-08-03
EA199800208A1 (ru)	1998-10-29
CZ81998A3 (cs)	1998-10-14
HUP9901577A2 (hu)	1999-08-30

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Publication	Publication Date	Title
NO320074B1 (no)	2005-10-17	Fremgangsmater for fremstilling av proteosom-amfifil-determinant vaksine, samt multivalent vaksine fremstilt i folge fremgangsmaten.
CA2123355C (en)	2007-08-28	Preparation and uses of los-depleted outer membrane proteins of gram-negative cocci
US6558677B2 (en)	2003-05-06	Vaccine against gram negative bacteria
EP2483389B1 (en)	2017-05-03	Hyperblebbing shigella strains
Levine et al.	2020	Fimbrial vaccines
Frasch et al.	1982	Protection against group B Neisseria meningitidis disease: preparation of soluble protein and protein-polysaccharide immunogens
Frasch et al.	2001	Outer membrane protein vesicle vaccines for meningococcal disease
US20040131642A1 (en)	2004-07-08	Outer membrane vesicle vaccine against disease caused by neisseria meningitidis serogroup a and process for the production thereof
BE1022875B1 (fr)	2016-09-30	Compositions pour une immunisation contre staphylococcus aureus
WO2012049662A1 (en)	2012-04-19	Hyperblebbing salmonella strains
Gotschlich	1984	Meningococcal meningitis
Blanco et al.	1993	Human cell mediated immunity to porins from Salmonella typhi
AU751063B2 (en)	2002-08-08	Improved methods for the production of non-covalently complexed and multivalent proteosome sub-unit vaccines