NO320745B1 - Farmasoytisk medikament-kombinasjoner omfattende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl-(metylsulfonyl)-amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksy-hept-6-ensyre og en inhibitor, inducer eller substrat av P450 isoenzym 3A4 samt anvendelse derav - Google Patents

Farmasoytisk medikament-kombinasjoner omfattende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl-(metylsulfonyl)-amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksy-hept-6-ensyre og en inhibitor, inducer eller substrat av P450 isoenzym 3A4 samt anvendelse derav Download PDF

Info

Publication number: NO320745B1
Authority: NO; Norway
Prior art keywords: drug; isoenzyme; inhibitor; combination according; inducer
Prior art date: 1999-02-06

Application number

NO20013811A

Other languages

English (en)

Norwegian (no)

Other versions

NO20013811D0 (no

NO20013811L (no

Inventor

Ali Raza

John Stuart Pears

Howard Gerard Hutchinson

Takahiko Baba

Dennis Schneck

Akira Touchi

Yoshitaka Yamaguchi

Original Assignee

Shionogi & Co

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-06

Filing date

2001-08-03

Publication date

2006-01-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27269637&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO320745(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-02-06 Priority claimed from GBGB9902593.4A external-priority patent/GB9902593D0/en

1999-09-08 Priority claimed from GBGB9921063.5A external-priority patent/GB9921063D0/en

1999-09-08 Priority claimed from GBGB9921064.3A external-priority patent/GB9921064D0/en

2001-08-03 Application filed by Shionogi & Co, Astrazeneca Ab filed Critical Shionogi & Co

2001-08-03 Publication of NO20013811D0 publication Critical patent/NO20013811D0/no

2001-10-02 Publication of NO20013811L publication Critical patent/NO20013811L/no

2006-01-23 Publication of NO320745B1 publication Critical patent/NO320745B1/no

Links

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238000012544 monitoring process Methods 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
210000000663 muscle cell Anatomy 0.000 description 1
208000013465 muscle pain Diseases 0.000 description 1
208000016334 muscle symptom Diseases 0.000 description 1
208000015004 muscle tenderness Diseases 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
229940033757 niaspan Drugs 0.000 description 1
230000000444 normolipidemic effect Effects 0.000 description 1
230000000414 obstructive effect Effects 0.000 description 1
229940127234 oral contraceptive Drugs 0.000 description 1
239000003539 oral contraceptive agent Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
201000008482 osteoarthritis Diseases 0.000 description 1
210000004738 parenchymal cell Anatomy 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
230000000858 peroxisomal effect Effects 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
230000036470 plasma concentration Effects 0.000 description 1
229960004618 prednisone Drugs 0.000 description 1
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
238000009597 pregnancy test Methods 0.000 description 1
230000008569 process Effects 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
239000000186 progesterone Substances 0.000 description 1
229960003387 progesterone Drugs 0.000 description 1
230000002062 proliferating effect Effects 0.000 description 1
239000008213 purified water Substances 0.000 description 1
125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 description 1
238000011002 quantification Methods 0.000 description 1
238000009256 replacement therapy Methods 0.000 description 1
230000000284 resting effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
229960000672 rosuvastatin Drugs 0.000 description 1
230000028327 secretion Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
230000000391 smoking effect Effects 0.000 description 1
239000000243 solution Substances 0.000 description 1
208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
238000003860 storage Methods 0.000 description 1
208000011117 substance-related disease Diseases 0.000 description 1
QWCJHSGMANYXCW-UHFFFAOYSA-N sulfaphenazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CC=NN1C1=CC=CC=C1 QWCJHSGMANYXCW-UHFFFAOYSA-N 0.000 description 1
229960004818 sulfaphenazole Drugs 0.000 description 1
230000001629 suppression Effects 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
235000013616 tea Nutrition 0.000 description 1
238000012360 testing method Methods 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
102000014898 transaminase activity proteins Human genes 0.000 description 1
201000010875 transient cerebral ischemia Diseases 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
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230000003442 weekly effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

NO20013811A 1999-02-06 2001-08-03 Farmasoytisk medikament-kombinasjoner omfattende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl-(metylsulfonyl)-amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksy-hept-6-ensyre og en inhibitor, inducer eller substrat av P450 isoenzym 3A4 samt anvendelse derav NO320745B1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9902593.4A GB9902593D0 (en)	1999-02-06	1999-02-06	Drug combinations
GBGB9921063.5A GB9921063D0 (en)	1999-09-08	1999-09-08	Therapy
GBGB9921064.3A GB9921064D0 (en)	1999-09-08	1999-09-08	Drug combination
PCT/GB2000/000278 WO2000045817A1 (en)	1999-02-06	2000-02-01	Drug combinations comprising (e) -7 - [4 -(4 -fluorophenyl) -6 - isopropyl -2 - [methyl (methylsulfonyl) amino] pyrimidin -5 -yl] (3r,5s) -3,5 - dihydroxyhept -6 - enoic acid and an inhibitor, inducer or substrate of p450 isoenzyme 3a4

Publications (3)

Publication Number	Publication Date
NO20013811D0 NO20013811D0 (no)	2001-08-03
NO20013811L NO20013811L (no)	2001-10-02
NO320745B1 true NO320745B1 (no)	2006-01-23

Family

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Application Number	Title	Priority Date	Filing Date
NO20013811A NO320745B1 (no)	1999-02-06	2001-08-03	Farmasoytisk medikament-kombinasjoner omfattende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl-(metylsulfonyl)-amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksy-hept-6-ensyre og en inhibitor, inducer eller substrat av P450 isoenzym 3A4 samt anvendelse derav

Country Status (28)

Country	Link
US (3)	US6982157B1 (pl)
EP (1)	EP1185274B1 (pl)
JP (2)	JP2002536331A (pl)
KR (2)	KR20010101790A (pl)
CN (1)	CN1165310C (pl)
AR (1)	AR029333A1 (pl)
AT (1)	ATE282415T1 (pl)
AU (1)	AU767304B2 (pl)
BR (1)	BR0007999A (pl)
CA (1)	CA2358632C (pl)
CZ (1)	CZ301296B6 (pl)
DE (1)	DE60015965T2 (pl)
EE (1)	EE04929B1 (pl)
EG (1)	EG23858A (pl)
ES (1)	ES2232418T3 (pl)
GB (1)	GB0000710D0 (pl)
ID (1)	ID30485A (pl)
IL (1)	IL144715A0 (pl)
IS (1)	IS2337B (pl)
MX (1)	MXPA01007905A (pl)
MY (1)	MY130606A (pl)
NO (1)	NO320745B1 (pl)
NZ (1)	NZ512982A (pl)
PL (1)	PL198034B1 (pl)
PT (1)	PT1185274E (pl)
TR (1)	TR200102228T2 (pl)
TW (1)	TWI282738B (pl)
WO (1)	WO2000045817A1 (pl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6489346B1 (en)	1996-01-04	2002-12-03	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US5840737A (en)	1996-01-04	1998-11-24	The Curators Of The University Of Missouri	Omeprazole solution and method for using same
DE19944803A1 (de) *	1999-09-20	2001-03-29	Bayer Ag	Kombination von Dihydropyridinverbindungen und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
GB0001621D0 (en) *	2000-01-26	2000-03-15	Astrazeneca Ab	Pharmaceutical compositions
GB0003305D0 (en)	2000-02-15	2000-04-05	Zeneca Ltd	Pyrimidine derivatives
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
HU230253B1 (hu)	2001-01-26	2015-11-30	Merck Sharp & Dohme Corp	Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére
DK1355644T3 (da)	2001-01-26	2006-10-23	Schering Corp	Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
JP2005504091A (ja)	2001-09-21	2005-02-10	シェーリング　コーポレイション	ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置
WO2004043457A1 (en)	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
CA2517571C (en)	2003-03-07	2011-07-05	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (ja)	2003-03-07	2010-12-01	シェーリングコーポレイション	高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
JP2006519869A (ja)	2003-03-07	2006-08-31	シェーリング　コーポレイション	置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US8993599B2 (en)	2003-07-18	2015-03-31	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
GB0322552D0 (en)	2003-09-26	2003-10-29	Astrazeneca Uk Ltd	Therapeutic treatment
US9173847B2 (en)	2003-10-10	2015-11-03	Veloxis Pharmaceuticals A/S	Tablet comprising a fibrate
CA2540984C (en)	2003-10-10	2011-02-08	Lifecycle Pharma A/S	A solid dosage form comprising a fibrate
US8906940B2 (en)	2004-05-25	2014-12-09	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
JP2008509154A (ja)	2004-08-06	2008-03-27	トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド	新規なスタチン薬剤組成物および関連治療方法
WO2007005941A2 (en)	2005-07-05	2007-01-11	President And Fellows Of Harvard College	Liver targeted conjugates
WO2007071357A2 (en)	2005-12-20	2007-06-28	Lek Pharmaceuticals D.D.	Pharmaceutical composition comprising (e) -7- [4- (4-fluorophenyl) -6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidin-5 -yl- (3r, 5s) -3, 5-dihydr0xyhept-6-en0ic acid
US20080109252A1 (en) *	2006-11-08	2008-05-08	Lafountain Andrea	Predicting patient compliance with medical treatment
US20120130202A1 (en) *	2010-11-24	2012-05-24	Fujitsu Limited	Diagnosis and Monitoring of Musculoskeletal Pathologies
WO2019241519A1 (en) *	2018-06-14	2019-12-19	Astrazeneca Uk Limited	Methods for lowering blood pressure with a dihydropyridine-type calcium channel blocker pharmaceutical composition
BR112022001514A2 (pt) *	2019-07-31	2022-03-22	Intas Pharmaceuticals Ltd	Composição farmacêutica multicamada e processo para a preparação de uma composição farmacêutica
WO2024223797A1 (en)	2023-04-28	2024-10-31	Institut National de la Santé et de la Recherche Médicale	Use of cyp3a4 inhibitors for the treatment of hepatitis d virus (hdv) infections

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2627696B1 (fr) *	1988-02-26	1991-09-13	Fournier Innovation Synergie	Nouvelle forme galenique du fenofibrate
JP2648897B2 (ja) *	1991-07-01	1997-09-03	塩野義製薬株式会社	ピリミジン誘導体
ATE114286T1 (de) *	1991-07-02	1994-12-15	Benckiser Gmbh Joh A	Zusammenfaltbare vorratsflasche.
JP3852621B2 (ja) *	1992-01-21	2006-12-06	あすか製薬株式会社	血管内皮細胞機能改善剤
FR2730231B1 (fr) *	1995-02-02	1997-04-04	Fournier Sca Lab	Association de fenofibrate et de vitamine e, utilisation en therapeutique
EP1027045A4 (en) *	1997-10-31	2004-12-08	Arch Dev Corp	METHODS AND COMPILATIONS FOR REGULATING S-ALPHA REDUCTASE ACTIVITY

2000
- 2000-01-14 GB GBGB0000710.4A patent/GB0000710D0/en not_active Ceased
- 2000-02-01 DE DE60015965T patent/DE60015965T2/de not_active Expired - Lifetime
- 2000-02-01 AT AT00901264T patent/ATE282415T1/de active
- 2000-02-01 CZ CZ20012844A patent/CZ301296B6/cs not_active IP Right Cessation
- 2000-02-01 KR KR1020017009914A patent/KR20010101790A/ko not_active Ceased
- 2000-02-01 PL PL364780A patent/PL198034B1/pl unknown
- 2000-02-01 KR KR1020067021986A patent/KR20060117381A/ko not_active Ceased
- 2000-02-01 EP EP00901264A patent/EP1185274B1/en not_active Expired - Lifetime
- 2000-02-01 ID IDW00200101892A patent/ID30485A/id unknown
- 2000-02-01 TR TR2001/02228T patent/TR200102228T2/xx unknown
- 2000-02-01 CN CNB008034702A patent/CN1165310C/zh not_active Expired - Lifetime
- 2000-02-01 ES ES00901264T patent/ES2232418T3/es not_active Expired - Lifetime
- 2000-02-01 AU AU21218/00A patent/AU767304B2/en not_active Expired
- 2000-02-01 CA CA002358632A patent/CA2358632C/en not_active Expired - Fee Related
- 2000-02-01 IL IL14471500A patent/IL144715A0/xx not_active IP Right Cessation
- 2000-02-01 NZ NZ512982A patent/NZ512982A/en not_active IP Right Cessation
- 2000-02-01 MX MXPA01007905A patent/MXPA01007905A/es not_active IP Right Cessation
- 2000-02-01 PT PT00901264T patent/PT1185274E/pt unknown
- 2000-02-01 EE EEP200100406A patent/EE04929B1/xx unknown
- 2000-02-01 JP JP2000596937A patent/JP2002536331A/ja active Pending
- 2000-02-01 US US09/889,414 patent/US6982157B1/en not_active Expired - Lifetime
- 2000-02-01 WO PCT/GB2000/000278 patent/WO2000045817A1/en not_active Ceased
- 2000-02-01 BR BR0007999-5A patent/BR0007999A/pt not_active Application Discontinuation
- 2000-02-04 MY MYPI20000416A patent/MY130606A/en unknown
- 2000-02-04 AR ARP000100507A patent/AR029333A1/es unknown
- 2000-02-22 EG EG20000124A patent/EG23858A/xx active
- 2000-05-11 TW TW089102105A patent/TWI282738B/zh not_active IP Right Cessation
2001
- 2001-07-17 IS IS6009A patent/IS2337B/is unknown
- 2001-08-03 NO NO20013811A patent/NO320745B1/no not_active IP Right Cessation
2005
- 2005-03-15 US US11/079,530 patent/US20060040969A1/en not_active Abandoned
2007
- 2007-07-27 JP JP2007195798A patent/JP2007277267A/ja active Pending
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Also Published As

Publication number	Publication date
PT1185274E (pt)	2005-03-31
US20060040969A1 (en)	2006-02-23
WO2000045817A1 (en)	2000-08-10
IL144715A0 (en)	2002-06-30
US20090042911A1 (en)	2009-02-12
CZ301296B6 (cs)	2010-01-06
EE04929B1 (et)	2007-12-17
US6982157B1 (en)	2006-01-03
JP2002536331A (ja)	2002-10-29
ID30485A (id)	2001-12-13
NZ512982A (en)	2003-08-29
NO20013811D0 (no)	2001-08-03
IS2337B (is)	2008-02-15
EP1185274A1 (en)	2002-03-13
TWI282738B (en)	2007-06-21
BR0007999A (pt)	2001-11-06
ATE282415T1 (de)	2004-12-15
DE60015965T2 (de)	2006-01-05
ES2232418T3 (es)	2005-06-01
AU2121800A (en)	2000-08-25
CN1338936A (zh)	2002-03-06
KR20010101790A (ko)	2001-11-14
NO20013811L (no)	2001-10-02
IS6009A (is)	2001-07-17
EG23858A (en)	2007-11-18
AU767304B2 (en)	2003-11-06
EE200100406A (et)	2002-10-15
GB0000710D0 (en)	2000-03-08
PL198034B1 (pl)	2008-05-30
PL364780A1 (pl)	2004-12-13
CN1165310C (zh)	2004-09-08
DE60015965D1 (de)	2004-12-23
KR20060117381A (ko)	2006-11-16
CA2358632C (en)	2008-10-28
MY130606A (en)	2007-07-31
AR029333A1 (es)	2003-06-25
TR200102228T2 (tr)	2002-03-21
CA2358632A1 (en)	2000-08-10
CZ20012844A3 (cs)	2001-11-14
JP2007277267A (ja)	2007-10-25
EP1185274B1 (en)	2004-11-17
MXPA01007905A (es)	2003-06-04
HK1041817A1 (en)	2002-07-26

Legal Events

Date	Code	Title	Description
2016-09-26	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO320745B1 (no)	2006-01-23	Farmasoytisk medikament-kombinasjoner omfattende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl-(metylsulfonyl)-amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksy-hept-6-ensyre og en inhibitor, inducer eller substrat av P450 isoenzym 3A4 samt anvendelse derav
Bloomfield et al.	2009	Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients
Terkeltaub	2009	Colchicine update: 2008
Brown et al.	1998	Treating patients with documented atherosclerosis to National Cholesterol Education Program-recommended low-density-lipoprotein cholesterol goals with atorvastatin, fluvastatin, lovastatin and simvastatin
Venero et al.	2009	Managing statin myopathy
RU2294744C2 (ru)	2007-03-10	Применение розувастатина (zd-4522) в лечении гетерозиготной семейной гиперхолестеринемии
Pascual	2000	Gout update: from lab to the clinic and back
EP3122348B1 (en)	2020-05-27	Beta-hydroxy beta-methylbutyrate for alleviating statin myopathy
Dunbar et al.	2005	Demystifying triglycerides: a practical approach for the clinician
Yee et al.	2011	Pitavastatin calcium: clinical review of a new antihyperlipidemic medication
RU2233162C2 (ru)	2004-07-27	Лекарственные комбинации, включающие (е)-7-[-4-(4-фторфенил)-6-изопропил-2-[-метил(метилсульфонил)амино]- пиримидин-5-ил](3r,5s)-3,5-дигидроксигепт-6-еноевую кислоту и ингибитор, индуктор или субстрат изофермента р450-3а4
Shimpi et al.	2023	Bempedoic acid a novel drug used for the treatment of Hyperlipidaemia: A Review
US20060252814A1 (en)	2006-11-09	Formulation comprising a betablocker and optionally a cholestrol-lowering agent
ZA200105838B (en)	2002-10-16	Drug combinations comprising (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-YL] (3R,5S) -3,5-dihydroxyhept-6-enoic acid and an inhibitor inducer or substrate of P450 isoenzyme 3A4.
HK1041817B (en)	2005-05-06	Drug combinations comprising (e)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3r, 5s)-3,5-dihydroxyhept-6-enoic acid and an inhibitor, inducer or substrate of p450 isoenzyme 3a4
JP2007528369A (ja)	2007-10-11	３，３，１４，１４−テトラメチルヘキサデカン−１，１６−ジオイック酸の投与法
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