NO321343B1 - Pulver av reverserte vesikler, fremgangsmater for fremstilling av pulveret og en dispersjon derav, samt en blanding fremstilt med pulveret - Google Patents

Pulver av reverserte vesikler, fremgangsmater for fremstilling av pulveret og en dispersjon derav, samt en blanding fremstilt med pulveret Download PDF

Info

Publication number: NO321343B1
Authority: NO; Norway
Prior art keywords: powder; vesicles; dispersion; weight; reversed
Prior art date: 1996-05-10

Application number

NO19985212A

Other languages

English (en)

Norwegian (no)

Other versions

NO985212L (no

NO985212D0 (no

Inventor

Hinderikus Marius Mollee

Tom De Vringer

Original Assignee

Astellas Pharma Europ Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-10

Filing date

1998-11-09

Publication date

2006-05-02

1998-11-09 Application filed by Astellas Pharma Europ Bv filed Critical Astellas Pharma Europ Bv

1998-11-09 Publication of NO985212L publication Critical patent/NO985212L/no

1998-11-09 Publication of NO985212D0 publication Critical patent/NO985212D0/no

2006-05-02 Publication of NO321343B1 publication Critical patent/NO321343B1/no

Links

239000006185 dispersion Substances 0.000 title claims abstract description 42
239000000843 powder Substances 0.000 title claims abstract description 30
239000000203 mixture Substances 0.000 title claims abstract description 22
238000000034 method Methods 0.000 title claims description 19
239000002736 nonionic surfactant Substances 0.000 claims abstract description 11
239000012867 bioactive agent Substances 0.000 claims abstract description 10
150000001875 compounds Chemical class 0.000 claims description 14
229920002545 silicone oil Polymers 0.000 claims description 12
230000000087 stabilizing effect Effects 0.000 claims description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
-1 fatty acid ester Chemical class 0.000 claims description 11
239000003921 oil Substances 0.000 claims description 10
235000014113 dietary fatty acids Nutrition 0.000 claims description 9
229930195729 fatty acid Natural products 0.000 claims description 9
239000000194 fatty acid Substances 0.000 claims description 9
238000002360 preparation method Methods 0.000 claims description 8
239000004094 surface-active agent Substances 0.000 claims description 8
238000001704 evaporation Methods 0.000 claims description 6
230000008020 evaporation Effects 0.000 claims description 6
150000002402 hexoses Chemical class 0.000 claims description 6
150000002972 pentoses Chemical class 0.000 claims description 6
229930006000 Sucrose Natural products 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 5
239000005720 sucrose Substances 0.000 claims description 5
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
230000000975 bioactive effect Effects 0.000 claims description 2
239000003039 volatile agent Substances 0.000 claims 2
239000000546 pharmaceutical excipient Substances 0.000 abstract description 5
230000003019 stabilising effect Effects 0.000 abstract 1
ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 14
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
235000019198 oils Nutrition 0.000 description 8
229960004050 aminobenzoic acid Drugs 0.000 description 7
238000001816 cooling Methods 0.000 description 7
238000005538 encapsulation Methods 0.000 description 7
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 4
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 4
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
239000005642 Oleic acid Substances 0.000 description 4
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 4
235000019483 Peanut oil Nutrition 0.000 description 4
ZPVGIKNDGJGLCO-VGAMQAOUSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O ZPVGIKNDGJGLCO-VGAMQAOUSA-N 0.000 description 4
239000000969 carrier Substances 0.000 description 4
239000003795 chemical substances by application Substances 0.000 description 4
235000012000 cholesterol Nutrition 0.000 description 4
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 4
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
150000002430 hydrocarbons Chemical class 0.000 description 4
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 4
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 4
235000021313 oleic acid Nutrition 0.000 description 4
239000000312 peanut oil Substances 0.000 description 4
238000003860 storage Methods 0.000 description 4
239000004359 castor oil Substances 0.000 description 3
235000019438 castor oil Nutrition 0.000 description 3
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
239000007788 liquid Substances 0.000 description 3
238000002390 rotary evaporation Methods 0.000 description 3
229920006395 saturated elastomer Polymers 0.000 description 3
238000001694 spray drying Methods 0.000 description 3
238000003756 stirring Methods 0.000 description 3
238000009210 therapy by ultrasound Methods 0.000 description 3
235000015112 vegetable and seed oil Nutrition 0.000 description 3
239000008158 vegetable oil Substances 0.000 description 3
239000004215 Carbon black (E152) Substances 0.000 description 2
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
239000005639 Lauric acid Substances 0.000 description 2
244000027321 Lychnis chalcedonica Species 0.000 description 2
235000021314 Palmitic acid Nutrition 0.000 description 2
235000021355 Stearic acid Nutrition 0.000 description 2
SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 description 2
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
238000000889 atomisation Methods 0.000 description 2
125000004432 carbon atom Chemical group C* 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000002537 cosmetic Substances 0.000 description 2
UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
239000003814 drug Substances 0.000 description 2
229940079593 drug Drugs 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
239000011521 glass Substances 0.000 description 2
229930195733 hydrocarbon Natural products 0.000 description 2
239000000463 material Substances 0.000 description 2
239000004570 mortar (masonry) Substances 0.000 description 2
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
235000019629 palatability Nutrition 0.000 description 2
239000002245 particle Substances 0.000 description 2
238000001907 polarising light microscopy Methods 0.000 description 2
229920000728 polyester Polymers 0.000 description 2
235000003441 saturated fatty acids Nutrition 0.000 description 2
150000004671 saturated fatty acids Chemical class 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
239000008117 stearic acid Substances 0.000 description 2
TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 2
235000021122 unsaturated fatty acids Nutrition 0.000 description 2
150000004670 unsaturated fatty acids Chemical class 0.000 description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
235000021357 Behenic acid Nutrition 0.000 description 1
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
238000012356 Product development Methods 0.000 description 1
WPMWEFXCIYCJSA-UHFFFAOYSA-N Tetraethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCO WPMWEFXCIYCJSA-UHFFFAOYSA-N 0.000 description 1
GCSPRLPXTPMSTL-IBDNADADSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GCSPRLPXTPMSTL-IBDNADADSA-N 0.000 description 1
UEYVMVXJVDAGBB-ZHBLIPIOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl tetradecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O UEYVMVXJVDAGBB-ZHBLIPIOSA-N 0.000 description 1
230000002411 adverse Effects 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
239000008365 aqueous carrier Substances 0.000 description 1
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
235000021342 arachidonic acid Nutrition 0.000 description 1
229940114079 arachidonic acid Drugs 0.000 description 1
229940116226 behenic acid Drugs 0.000 description 1
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
239000002775 capsule Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
239000000498 cooling water Substances 0.000 description 1
239000002577 cryoprotective agent Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
238000009826 distribution Methods 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000000265 homogenisation Methods 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
239000008101 lactose Substances 0.000 description 1
JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
229960000511 lactulose Drugs 0.000 description 1
PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
238000012792 lyophilization process Methods 0.000 description 1
239000000845 maltitol Substances 0.000 description 1
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
229940035436 maltitol Drugs 0.000 description 1
235000010449 maltitol Nutrition 0.000 description 1
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
230000002265 prevention Effects 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
125000005480 straight-chain fatty acid group Chemical group 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000563 toxic property Toxicity 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Dispersion Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Medicines Containing Plant Substances (AREA)
Manufacturing Of Micro-Capsules (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Materials For Medical Uses (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Detergent Compositions (AREA)
Seasonings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19985212A 1996-05-10 1998-11-09 Pulver av reverserte vesikler, fremgangsmater for fremstilling av pulveret og en dispersjon derav, samt en blanding fremstilt med pulveret NO321343B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP96201290		1996-05-10
PCT/EP1997/002598 WO1997042937A1 (en)	1996-05-10	1997-05-12	Instant vesicular product

Publications (3)

Publication Number	Publication Date
NO985212L NO985212L (no)	1998-11-09
NO985212D0 NO985212D0 (no)	1998-11-09
NO321343B1 true NO321343B1 (no)	2006-05-02

Family

ID=8223974

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19985212A NO321343B1 (no)	1996-05-10	1998-11-09	Pulver av reverserte vesikler, fremgangsmater for fremstilling av pulveret og en dispersjon derav, samt en blanding fremstilt med pulveret

Country Status (24)

Country	Link
US (2)	US20090291105A1 (da)
EP (1)	EP0909164B1 (da)
JP (2)	JP4263771B2 (da)
AT (1)	ATE222486T1 (da)
AU (1)	AU706076B2 (da)
BG (1)	BG63659B1 (da)
CA (1)	CA2253358C (da)
CZ (1)	CZ292346B6 (da)
DE (1)	DE69714847T2 (da)
DK (1)	DK0909164T3 (da)
EA (1)	EA001116B1 (da)
ES (1)	ES2182076T3 (da)
HU (1)	HU225106B1 (da)
IS (1)	IS1996B (da)
NO (1)	NO321343B1 (da)
NZ (1)	NZ331693A (da)
PL (1)	PL187045B1 (da)
PT (1)	PT909164E (da)
SI (1)	SI0909164T1 (da)
SK (1)	SK283405B6 (da)
TR (1)	TR199802278T2 (da)
UA (1)	UA70286C2 (da)
WO (1)	WO1997042937A1 (da)
ZA (1)	ZA974083B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ331693A (en) *	1996-05-10	2000-04-28	Yamanouchi Europ Bv	reversed vesicules containing powder having one or more non ionic surfactant
FR2936704B1 (fr) *	2008-10-03	2011-01-07	Bcm Cosmetique	Composition cosmetique de base comprenant une dispersion de vesicules inversees destinee a incorporer des principes actifs hydrophiles dans des compositions de maquillage.
JP6239822B2 (ja) *	2012-12-27	2017-11-29	ポーラ化成工業株式会社	逆ベシクル組成物
WO2014103742A1 (ja) *	2012-12-25	2014-07-03	ポーラ化成工業株式会社	逆ベシクル組成物及びその製造方法
JP6242581B2 (ja) *	2013-04-01	2017-12-06	ポーラ化成工業株式会社	逆ベシクル組成物の製造方法
WO2022107622A1 (ja) *	2020-11-20	2022-05-27	株式会社カネカ	逆ナノディスク

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4021083C2 (de) *	1990-07-03	1995-08-17	Hans Dr Lautenschlaeger	Phospholipidformulierungen und ihre Verwendung für die Zubereitung liposomaler medizinischer und kosmetischer Bäder
ATE233547T1 (de) *	1991-06-26	2003-03-15	Yamanouchi Europ Bv	Vesiculae in nichtpolaren medien
EP0815852A1 (en) *	1993-08-06	1998-01-07	Opperbas Holding B.V.	A method for high loading of vesicles with biopolymeric substances
GB9323588D0 (en) *	1993-11-16	1994-01-05	Cortecs Ltd	Hydrophobic preparation
CA2182577C (en) *	1994-02-04	2002-08-20	Anders Carlsson	Lipophilic carrier preparations
IT1269569B (it) *	1994-04-22	1997-04-08	Ugo Citernesi	Procedimento per la preparazione di complessi fra fosfolipidi e principi attivi utili per la produzione di liposomi e principi attivi e liposomi ottenuti con il procedimento
US5693516A (en) *	1995-11-27	1997-12-02	Novo Nordisk Biotech, Inc.	Method for solubilizing proteins in organic solvents
NZ331693A (en) *	1996-05-10	2000-04-28	Yamanouchi Europ Bv	reversed vesicules containing powder having one or more non ionic surfactant
DE19713096A1 (de) *	1997-03-27	1998-10-01	Sueddeutsche Kalkstickstoff	Ölfreie Glycerophospholipid-Formulierungen und Verfahren zu deren Herstellung

1997
- 1997-05-12 NZ NZ331693A patent/NZ331693A/xx not_active IP Right Cessation
- 1997-05-12 CZ CZ19983624A patent/CZ292346B6/cs not_active IP Right Cessation
- 1997-05-12 JP JP54054497A patent/JP4263771B2/ja not_active Expired - Fee Related
- 1997-05-12 EP EP97923963A patent/EP0909164B1/en not_active Expired - Lifetime
- 1997-05-12 HU HU9903958A patent/HU225106B1/hu not_active IP Right Cessation
- 1997-05-12 DK DK97923963T patent/DK0909164T3/da active
- 1997-05-12 ES ES97923963T patent/ES2182076T3/es not_active Expired - Lifetime
- 1997-05-12 PT PT97923963T patent/PT909164E/pt unknown
- 1997-05-12 CA CA002253358A patent/CA2253358C/en not_active Expired - Fee Related
- 1997-05-12 WO PCT/EP1997/002598 patent/WO1997042937A1/en not_active Ceased
- 1997-05-12 AU AU29590/97A patent/AU706076B2/en not_active Ceased
- 1997-05-12 DE DE69714847T patent/DE69714847T2/de not_active Expired - Lifetime
- 1997-05-12 ZA ZA974083A patent/ZA974083B/xx unknown
- 1997-05-12 SK SK1513-98A patent/SK283405B6/sk not_active IP Right Cessation
- 1997-05-12 PL PL97329764A patent/PL187045B1/pl not_active IP Right Cessation
- 1997-05-12 SI SI9730337T patent/SI0909164T1/xx unknown
- 1997-05-12 EA EA199800997A patent/EA001116B1/ru not_active IP Right Cessation
- 1997-05-12 AT AT97923963T patent/ATE222486T1/de active
- 1997-05-12 TR TR1998/02278T patent/TR199802278T2/xx unknown
- 1997-12-05 UA UA98126510A patent/UA70286C2/uk unknown
1998
- 1998-09-09 IS IS4845A patent/IS1996B/is unknown
- 1998-11-09 NO NO19985212A patent/NO321343B1/no not_active IP Right Cessation
- 1998-11-09 BG BG102909A patent/BG63659B1/bg unknown
2008
- 2008-10-22 JP JP2008272186A patent/JP2009062386A/ja not_active Withdrawn
- 2008-11-26 US US12/324,177 patent/US20090291105A1/en not_active Abandoned
2011
- 2011-03-11 US US13/046,285 patent/US20120039948A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0909164A1 (en)	1999-04-21
HUP9903958A2 (hu)	2000-04-28
BG102909A (en)	1999-05-31
NO985212L (no)	1998-11-09
HUP9903958A3 (en)	2000-05-29
AU2959097A (en)	1997-12-05
EA001116B1 (ru)	2000-10-30
IS4845A (is)	1998-09-09
US20120039948A1 (en)	2012-02-16
SK283405B6 (sk)	2003-07-01
DE69714847D1 (de)	2002-09-26
AU706076B2 (en)	1999-06-10
NZ331693A (en)	2000-04-28
US20090291105A1 (en)	2009-11-26
HU225106B1 (en)	2006-06-28
BG63659B1 (bg)	2002-08-30
JP2000510474A (ja)	2000-08-15
DE69714847T2 (de)	2003-04-30
EA199800997A1 (ru)	1999-04-29
EP0909164B1 (en)	2002-08-21
CZ362498A3 (cs)	1999-02-17
JP2009062386A (ja)	2009-03-26
CZ292346B6 (cs)	2003-09-17
DK0909164T3 (da)	2002-12-16
UA70286C2 (en)	2004-10-15
CA2253358A1 (en)	1997-11-20
ZA974083B (en)	1998-11-12
NO985212D0 (no)	1998-11-09
JP4263771B2 (ja)	2009-05-13
ATE222486T1 (de)	2002-09-15
SI0909164T1 (en)	2002-10-31
IS1996B (is)	2005-03-15
WO1997042937A1 (en)	1997-11-20
CA2253358C (en)	2007-12-04
PL187045B1 (pl)	2004-05-31
ES2182076T3 (es)	2003-03-01
PL329764A1 (en)	1999-04-12
PT909164E (pt)	2002-12-31
TR199802278T2 (xx)	1999-02-22
SK151398A3 (en)	1999-05-07

Legal Events

Date	Code	Title	Description
2013-12-23	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
AU648573B2 (en)	1994-04-28	Self-emulsifying glasses
US6652880B1 (en)	2003-11-25	Oral pharmaceutical compositions containing long-chain triglycerides and liphophilic surfactants
CN101584663B (zh)	2013-02-20	新型的注射用多西他赛脂质体给药系统及其制备方法
US5096629A (en)	1992-03-17	Method for preparing lipid powder for use in preparing liposomes and method for preparing liposomes
JPH09508414A (ja)	1997-08-26	二重層製剤
NO168154B (no)	1991-10-14	Fremgangsmaate for fremstilling av unilamellaere liposomer
JPH09508415A (ja)	1997-08-26	親油性担体製剤
US20120039948A1 (en)	2012-02-16	Instant Vesicular Product
NO303205B1 (no)	1998-06-15	FremgangsmÕte for fremstilling av lipidkompleksoppslemming
CA2375371A1 (en)	2000-12-14	Oil-core compositions for the sustained release of hydrophobic drugs
IE913246A1 (en)	1992-04-08	Lipid Formulation Systems
JP3609827B2 (ja)	2005-01-12	非極性基剤における小胞
JP3187622B2 (ja)	2001-07-11	リポソーム
JP2942556B2 (ja)	1999-08-30	シクロスポリンを含有する新規組成物
KR100468226B1 (ko)	2005-03-16	순간소포생성물
CN101199510B (zh)	2010-06-02	水飞蓟宾前体多相脂质体制剂及其制备方法
WO2024056062A1 (zh)	2024-03-21	一种甾体类激素磷脂组合物及其制备方法
JPS58152812A (ja)	1983-09-10	水性相中単層脂質顆粒の製造方法
Jain et al.	0	Solid Dispersion-Method of Enhancement of Dissolution Rate and Increase Bioavailability
NL8102794A (nl)	1981-11-02	Werkwijze voor het bereiden van een dispersie van kleine bolvormige deeltjes.