NO321527B1 - Pyrroloindoler, pyridoindoler og azepinoindol-derivater, anvendelse av disse ved fremstilling av et medikament, farmasoytisk preparat omfattende slike og fremgangsmate for fremstilling av preparatet. - Google Patents

Pyrroloindoler, pyridoindoler og azepinoindol-derivater, anvendelse av disse ved fremstilling av et medikament, farmasoytisk preparat omfattende slike og fremgangsmate for fremstilling av preparatet. Download PDF

Info

Publication number: NO321527B1
Authority: NO; Norway
Prior art keywords: dihydro; alkyl; disorders; hydrogen; carboxaldehyde
Prior art date: 1998-09-01

Application number

NO20010991A

Other languages

English (en)

Norwegian (no)

Other versions

NO20010991D0 (no

NO20010991L (no

Inventor

David Reginald Adams

Jonathan Mark Bentley

Jonathan Richard Anthon Roffey

Richard John Hamlyn

Suneel Gaur

Matthew Alexander Jame Duncton

James Edward Paul Davidson

Michael John Bickerdike

Ian Anthony Cliffe

Howard Langham Mansell

Original Assignee

Vernalis Res Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-01

Filing date

2001-02-27

Publication date

2006-05-15

2001-02-27 Application filed by Vernalis Res Ltd filed Critical Vernalis Res Ltd

2001-02-27 Publication of NO20010991D0 publication Critical patent/NO20010991D0/no

2001-04-23 Publication of NO20010991L publication Critical patent/NO20010991L/no

2006-05-15 Publication of NO321527B1 publication Critical patent/NO321527B1/no

Links

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238000004519 manufacturing process Methods 0.000 title claims description 7
238000000034 method Methods 0.000 title description 54
IVCGJOSPVGENCT-UHFFFAOYSA-N 1h-pyrrolo[2,3-f]quinoline Chemical class N1=CC=CC2=C(NC=C3)C3=CC=C21 IVCGJOSPVGENCT-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
ISZIQZCZKOFSBT-UHFFFAOYSA-N pyrrolo[2,3-g][1]benzazepine Chemical class N1=CC=CC=C2C3=NC=CC3=CC=C21 ISZIQZCZKOFSBT-UHFFFAOYSA-N 0.000 title 1
150000005592 pyrroloindoles Chemical class 0.000 title 1
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125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
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AYNAVHUTXWVDLR-UHFFFAOYSA-N 1-(6,7-difluoro-2,3-dihydro-1h-pyrrolo[1,2-a]indol-4-yl)propan-2-amine Chemical compound C12=CC(F)=C(F)C=C2C(CC(N)C)=C2N1CCC2 AYNAVHUTXWVDLR-UHFFFAOYSA-N 0.000 claims 1
VCCGTYYMZYICBO-UHFFFAOYSA-N 1-(6-bromo-2,3-dihydro-1h-pyrrolo[1,2-a]indol-4-yl)propan-2-amine Chemical compound C12=CC=C(Br)C=C2C(CC(N)C)=C2N1CCC2 VCCGTYYMZYICBO-UHFFFAOYSA-N 0.000 claims 1
XNFYXIJQNZVXAX-UHFFFAOYSA-N 1-(6-chloro-2,3-dihydro-1h-pyrrolo[1,2-a]indol-4-yl)propan-2-amine Chemical compound C12=CC=C(Cl)C=C2C(CC(N)C)=C2N1CCC2 XNFYXIJQNZVXAX-UHFFFAOYSA-N 0.000 claims 1
YVXUJNPXVWMCCZ-UHFFFAOYSA-N 1-(6-methoxy-2,3-dihydro-1h-pyrrolo[1,2-a]indol-4-yl)propan-2-amine Chemical compound COC1=CC=C2N(CCC3)C3=C(CC(C)N)C2=C1 YVXUJNPXVWMCCZ-UHFFFAOYSA-N 0.000 claims 1
SPMDNODKUUODIS-UHFFFAOYSA-N 1-(6-methylsulfanyl-2,3-dihydro-1h-pyrrolo[1,2-a]indol-4-yl)propan-2-amine Chemical compound CSC1=CC=C2N(CCC3)C3=C(CC(C)N)C2=C1 SPMDNODKUUODIS-UHFFFAOYSA-N 0.000 claims 1
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-1 monoalkylamino Chemical group 0.000 abstract description 16
125000003118 aryl group Chemical group 0.000 abstract description 6
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125000000623 heterocyclic group Chemical group 0.000 abstract description 3
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239000000651 prodrug Substances 0.000 abstract description 3
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MBVFRSJFKMJRHA-UHFFFAOYSA-N 4-fluoro-1-benzofuran-7-carbaldehyde Chemical compound FC1=CC=C(C=O)C2=C1C=CO2 MBVFRSJFKMJRHA-UHFFFAOYSA-N 0.000 abstract description 2
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125000005110 aryl thio group Chemical group 0.000 abstract description 2
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125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract description 2
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125000002837 carbocyclic group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
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239000000243 solution Substances 0.000 description 47
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HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 16
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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NO20010991A 1998-09-01 2001-02-27 Pyrroloindoler, pyridoindoler og azepinoindol-derivater, anvendelse av disse ved fremstilling av et medikament, farmasoytisk preparat omfattende slike og fremgangsmate for fremstilling av preparatet. NO321527B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9819035.8A GB9819035D0 (en)	1998-09-01	1998-09-01	Chemical compounds VII
PCT/GB1999/002884 WO2000012510A1 (en)	1998-09-01	1999-09-01	Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists

Publications (3)

Publication Number	Publication Date
NO20010991D0 NO20010991D0 (no)	2001-02-27
NO20010991L NO20010991L (no)	2001-04-23
NO321527B1 true NO321527B1 (no)	2006-05-15

Family

ID=10838167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20010991A NO321527B1 (no)	1998-09-01	2001-02-27	Pyrroloindoler, pyridoindoler og azepinoindol-derivater, anvendelse av disse ved fremstilling av et medikament, farmasoytisk preparat omfattende slike og fremgangsmate for fremstilling av preparatet.

Country Status (29)

Country	Link
US (1)	US6433175B1 (de)
EP (1)	EP1109813B1 (de)
JP (1)	JP2002523508A (de)
KR (2)	KR20070062609A (de)
CN (1)	CN1165537C (de)
AT (1)	ATE273308T1 (de)
AU (1)	AU758084B2 (de)
BR (1)	BR9913477A (de)
CA (1)	CA2341991C (de)
CZ (1)	CZ296275B6 (de)
DE (1)	DE69919364T2 (de)
DK (1)	DK1109813T3 (de)
ES (1)	ES2226430T3 (de)
GB (1)	GB9819035D0 (de)
HR (1)	HRP20010126B1 (de)
HU (1)	HUP0103333A3 (de)
ID (1)	ID28842A (de)
IL (2)	IL141659A0 (de)
MX (1)	MXPA01002101A (de)
NO (1)	NO321527B1 (de)
NZ (1)	NZ510097A (de)
PL (1)	PL346427A1 (de)
PT (1)	PT1109813E (de)
RU (1)	RU2232162C2 (de)
SI (1)	SI1109813T1 (de)
TR (2)	TR200100659T2 (de)
WO (1)	WO2000012510A1 (de)
YU (1)	YU16001A (de)
ZA (1)	ZA200101457B (de)

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US7476687B2 (en)	2003-11-26	2009-01-13	Alcon, Inc.	Substituted furo[2,3-g]indazoles for the treatment of glaucoma
TW200520760A (en)	2003-12-15	2005-07-01	Alcon Inc	Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma
US7129257B1 (en)	2003-12-15	2006-10-31	Alcon, Inc.	Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en)	2003-12-15	2008-03-04	Alcon, Inc.	Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
EP2248524A3 (de)	2004-08-25	2011-03-09	Takeda Pharmaceutical Company Limited	Mittel zur prävention/behandlung von stressbedingter harninkontinenz und vorsorgeuntersuchungsverfahren dafür
WO2006050007A2 (en)	2004-11-01	2006-05-11	Wyeth	Substituted indolizines and derivatives as cns agents
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AP2007004144A0 (en)	2005-03-31	2007-08-31	Pfizer Prod Inc	Cyclopentapyridine and tetrahydroquinoline derivatives
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EP2742936A1 (de)	2006-05-16	2014-06-18	Takeda Pharmaceutical Company Limited	Kondensierte heterocyclische Verbindung und ihre Verwendung
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EP2789338A3 (de)	2007-11-15	2015-01-14	Takeda Pharmaceutical Company Limited	Kondensiertes Pyridinderivat und seine Verwendung
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1998
- 1998-09-01 GB GBGB9819035.8A patent/GB9819035D0/en not_active Ceased
1999
- 1999-09-01 KR KR1020077011961A patent/KR20070062609A/ko not_active Abandoned
- 1999-09-01 NZ NZ510097A patent/NZ510097A/xx unknown
- 1999-09-01 US US09/763,889 patent/US6433175B1/en not_active Expired - Fee Related
- 1999-09-01 RU RU2001108570/04A patent/RU2232162C2/ru not_active IP Right Cessation
- 1999-09-01 DK DK99943091T patent/DK1109813T3/da active
- 1999-09-01 IL IL14165999A patent/IL141659A0/xx active IP Right Grant
- 1999-09-01 TR TR2001/00659T patent/TR200100659T2/xx unknown
- 1999-09-01 AT AT99943091T patent/ATE273308T1/de not_active IP Right Cessation
- 1999-09-01 EP EP99943091A patent/EP1109813B1/de not_active Expired - Lifetime
- 1999-09-01 PL PL99346427A patent/PL346427A1/xx not_active IP Right Cessation
- 1999-09-01 MX MXPA01002101A patent/MXPA01002101A/es not_active IP Right Cessation
- 1999-09-01 CZ CZ20010772A patent/CZ296275B6/cs not_active IP Right Cessation
- 1999-09-01 JP JP2000567532A patent/JP2002523508A/ja active Pending
- 1999-09-01 CN CNB998128341A patent/CN1165537C/zh not_active Expired - Fee Related
- 1999-09-01 YU YU16001A patent/YU16001A/sh unknown
- 1999-09-01 BR BR9913477-2A patent/BR9913477A/pt not_active Application Discontinuation
- 1999-09-01 ES ES99943091T patent/ES2226430T3/es not_active Expired - Lifetime
- 1999-09-01 SI SI9930677T patent/SI1109813T1/xx unknown
- 1999-09-01 WO PCT/GB1999/002884 patent/WO2000012510A1/en not_active Ceased
- 1999-09-01 PT PT99943091T patent/PT1109813E/pt unknown
- 1999-09-01 CA CA002341991A patent/CA2341991C/en not_active Expired - Fee Related
- 1999-09-01 DE DE69919364T patent/DE69919364T2/de not_active Expired - Fee Related
- 1999-09-01 AU AU56375/99A patent/AU758084B2/en not_active Ceased
- 1999-09-01 ID IDW20010677A patent/ID28842A/id unknown
- 1999-09-01 HR HR20010126A patent/HRP20010126B1/xx not_active IP Right Cessation
- 1999-09-01 HU HU0103333A patent/HUP0103333A3/hu unknown
- 1999-09-01 KR KR1020017002608A patent/KR100768595B1/ko not_active Expired - Fee Related
- 1999-09-01 TR TR2005/01110T patent/TR200501110T2/xx unknown
2001
- 2001-02-21 ZA ZA200101457A patent/ZA200101457B/xx unknown
- 2001-02-26 IL IL141659A patent/IL141659A/en not_active IP Right Cessation
- 2001-02-27 NO NO20010991A patent/NO321527B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1109813A1 (de)	2001-06-27
CZ296275B6 (cs)	2006-02-15
IL141659A (en)	2007-10-31
HUP0103333A2 (hu)	2002-01-28
NZ510097A (en)	2003-06-30
ES2226430T3 (es)	2005-03-16
MXPA01002101A (es)	2002-08-20
CA2341991C (en)	2009-04-07
PT1109813E (pt)	2004-11-30
HUP0103333A3 (en)	2002-07-29
HK1034967A1 (en)	2001-11-09
GB9819035D0 (en)	1998-10-28
CN1325399A (zh)	2001-12-05
NO20010991D0 (no)	2001-02-27
YU16001A (sh)	2003-10-31
PL346427A1 (en)	2002-02-11
CZ2001772A3 (cs)	2001-07-11
EP1109813B1 (de)	2004-08-11
ZA200101457B (en)	2002-02-21
KR20070062609A (ko)	2007-06-15
WO2000012510A1 (en)	2000-03-09
BR9913477A (pt)	2001-10-09
HRP20010126A2 (en)	2002-02-28
AU5637599A (en)	2000-03-21
IL141659A0 (en)	2002-03-10
CN1165537C (zh)	2004-09-08
DK1109813T3 (da)	2004-12-20
CA2341991A1 (en)	2000-03-09
DE69919364D1 (de)	2004-09-16
NO20010991L (no)	2001-04-23
US6433175B1 (en)	2002-08-13
JP2002523508A (ja)	2002-07-30
RU2232162C2 (ru)	2004-07-10
AU758084B2 (en)	2003-03-13
KR100768595B1 (ko)	2007-10-18
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TR200100659T2 (tr)	2001-10-22
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Publication	Publication Date	Title
NO321527B1 (no)	2006-05-15	Pyrroloindoler, pyridoindoler og azepinoindol-derivater, anvendelse av disse ved fremstilling av et medikament, farmasoytisk preparat omfattende slike og fremgangsmate for fremstilling av preparatet.
US7166632B2 (en)	2007-01-23	Condensed indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands
EP1109809B1 (de)	2004-11-17	Pyrrolochinoline zur Behandlung von Fettleibigkeit
MXPA01013235A (es)	2002-06-04	Derivados del indol, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y su aplicacion en la medicina.
HK1034967B (en)	2005-03-04	Pyrroloindoles, pyridoindoles and azepinoindoles as 5-ht2c agonists