|
US5681714A
(en)
*
|
1992-07-30 |
1997-10-28 |
Mount Sinai Hospital Corporation |
Nucleic acid encoding tek receptor tyrosine kinase
|
|
US6245530B1
(en)
|
1995-08-01 |
2001-06-12 |
Ludwig Institute For Cancer Research |
Receptor ligand
|
|
US6130071A
(en)
*
|
1997-02-05 |
2000-10-10 |
Helsinki University Licensing, Ltd. |
Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof
|
|
US6403088B1
(en)
|
1995-08-01 |
2002-06-11 |
Helsinki University Licensing, Ltd. |
Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3)
|
|
US6221839B1
(en)
|
1994-11-14 |
2001-04-24 |
Helsinki University Licensing Ltd. Oy |
FIt4 ligand and methods of use
|
|
US6645933B1
(en)
|
1995-08-01 |
2003-11-11 |
Helsinki University Licensing Ltd. Oy |
Receptor ligand VEGF-C
|
|
US6818220B1
(en)
|
1994-11-14 |
2004-11-16 |
Licentia Ltd. |
Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof
|
|
AU755337B2
(en)
*
|
1995-04-06 |
2002-12-12 |
Regeneron Pharmaceuticals, Inc. |
New uses of tie-2 ligands
|
|
JP4122056B2
(ja)
*
|
1995-04-06 |
2008-07-23 |
リジエネロン ファーマシューティカルズ,インコーポレイテッド |
Tie−2リガンド、その作製方法および使用方法
|
|
US6361946B1
(en)
|
1997-02-05 |
2002-03-26 |
Licentia Ltd |
Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
|
|
US7423125B2
(en)
|
1995-08-01 |
2008-09-09 |
Vegenics Limited |
Antibodies to VEGF-C
|
|
DE69638142D1
(de)
|
1995-09-29 |
2010-04-15 |
Univ Siena |
Regulierte Gene und ihre Verwendungen
|
|
US7063965B2
(en)
*
|
1996-04-05 |
2006-06-20 |
Regeneron Pharmaceuticals, Inc. |
Nucleic acid encoding TIE-2 ligand
|
|
DE19623850A1
(de)
*
|
1996-06-14 |
1997-12-18 |
Wacker Chemie Gmbh |
Homogenisierung von Dispersionen
|
|
IL127623A0
(en)
*
|
1996-06-19 |
1999-10-28 |
Regeneron Pharma |
Tie-2 receptor ligands (tie ligand-3; tie ligand-4) and their uses
|
|
US6846914B2
(en)
|
1996-06-19 |
2005-01-25 |
Regeneron Pharmaceuticals, Inc. |
Tie-2 ligand-3
|
|
US5851797A
(en)
*
|
1996-06-19 |
1998-12-22 |
Regeneron Pharmaceuticals, Inc. |
Tie ligand-3, methods of making and uses thereof
|
|
US6265564B1
(en)
*
|
1996-08-02 |
2001-07-24 |
Regeneron Pharmaceuticals, Inc. |
Expressed ligand-vascular intercellular signalling molecule
|
|
EP1283268A3
(en)
|
1996-08-23 |
2004-01-02 |
Ludwig Institute For Cancer Research |
Recombinant vascular endothelial cell growth factor D (VEGF-D)
|
|
US7125714B2
(en)
|
1997-02-05 |
2006-10-24 |
Licentia Ltd. |
Progenitor cell materials and methods
|
|
US5972338A
(en)
|
1997-09-19 |
1999-10-26 |
Genentech, Inc. |
Tie ligands homologues
|
|
US6350450B1
(en)
|
1997-09-19 |
2002-02-26 |
Genentech, Inc. |
TIE ligand homologue antibody
|
|
US6057435A
(en)
*
|
1997-09-19 |
2000-05-02 |
Genentech, Inc. |
Tie ligand homologues
|
|
US6030831A
(en)
*
|
1997-09-19 |
2000-02-29 |
Genetech, Inc. |
Tie ligand homologues
|
|
US6348350B1
(en)
|
1997-09-19 |
2002-02-19 |
Genentech, Inc. |
Ligand homologues
|
|
AU1931599A
(en)
*
|
1997-12-19 |
1999-07-12 |
Zymogenetics Inc. |
Angiopoietin homolog, dna encoding it, and method of making it
|
|
AU2000399A
(en)
*
|
1997-12-19 |
1999-07-12 |
Regeneron Pharmaceuticals, Inc. |
Receptor tyrosine kinase, ar-1, is a regulator of angiogenesis
|
|
AU2493699A
(en)
*
|
1998-02-04 |
1999-08-23 |
Zymogenetics Inc. |
Angiopoietin homolog zapo3, dna encoding it, and method of making it
|
|
IL138216A0
(en)
*
|
1998-03-02 |
2001-10-31 |
Millennium Pharm Inc |
Novel fdrg protein and nucleic acid molecules and uses therefor
|
|
ES2341926T3
(es)
|
1998-03-02 |
2010-06-29 |
Massachusetts Institute Of Technology |
Poliproteinas con dedos de cinc que tienen enlazadores mejorados.
|
|
US7488590B2
(en)
*
|
1998-10-23 |
2009-02-10 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
ATE556090T1
(de)
|
1998-11-10 |
2012-05-15 |
Ludwig Inst Cancer Res |
Verkürzter, von blutplättchen abstammender wachstumsfaktor d, dafür kodierendes dns und deren verwendung
|
|
IL143558A0
(en)
|
1998-12-23 |
2002-04-21 |
Regeneron Pharma |
Method of enhancing the biological activity of ligands
|
|
WO2000052167A1
(en)
*
|
1999-03-02 |
2000-09-08 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietin-related protein and nucleic acids
|
|
US6455035B1
(en)
|
1999-03-26 |
2002-09-24 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
US6342219B1
(en)
|
1999-04-28 |
2002-01-29 |
Board Of Regents, The University Of Texas System |
Antibody compositions for selectively inhibiting VEGF
|
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
|
US6521424B2
(en)
|
1999-06-07 |
2003-02-18 |
Immunex Corporation |
Recombinant expression of Tek antagonists
|
|
ATE324444T1
(de)
*
|
1999-06-07 |
2006-05-15 |
Immunex Corp |
Tek-antagonisten
|
|
DE60043367D1
(de)
|
1999-06-15 |
2009-12-31 |
Genentech Inc |
Sekretierte und Transmembran-Polypeptide sowie Nukleinsäuren zu deren Kodierung
|
|
US6689035B1
(en)
|
2000-04-11 |
2004-02-10 |
Gerber Scientific Products, Inc. |
Method and apparatus for designing and creating a package
|
|
AU2002228841C1
(en)
|
2000-12-07 |
2006-11-23 |
Sangamo Biosciences, Inc |
Regulation of angiogenesis with zinc finger proteins
|
|
US7067317B2
(en)
|
2000-12-07 |
2006-06-27 |
Sangamo Biosciences, Inc. |
Regulation of angiogenesis with zinc finger proteins
|
|
US7205275B2
(en)
*
|
2001-10-11 |
2007-04-17 |
Amgen Inc. |
Methods of treatment using specific binding agents of human angiopoietin-2
|
|
AU2006228095B2
(en)
*
|
2001-10-11 |
2010-11-04 |
Amgen Inc. |
Angiopoietin-2 specific binding agents
|
|
US7658924B2
(en)
*
|
2001-10-11 |
2010-02-09 |
Amgen Inc. |
Angiopoietin-2 specific binding agents
|
|
US7138370B2
(en)
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
|
US7521053B2
(en)
|
2001-10-11 |
2009-04-21 |
Amgen Inc. |
Angiopoietin-2 specific binding agents
|
|
US20050123925A1
(en)
|
2002-11-15 |
2005-06-09 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
WO2003034990A2
(en)
|
2001-10-25 |
2003-05-01 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
JP4242590B2
(ja)
*
|
2002-01-11 |
2009-03-25 |
俊一 塩澤 |
慢性関節リウマチの疾患感受性遺伝子、及びその利用
|
|
US7427594B1
(en)
*
|
2002-02-26 |
2008-09-23 |
The Trustees Of The University Of Pennsylvania |
Methods and pharmaceuticals compositions for treating coronary artery disease, ischemia,and vascular disease using angiopoietins
|
|
US7081443B2
(en)
|
2002-05-21 |
2006-07-25 |
Korea Advanced Institutes Of Science And Technology (Kaist) |
Chimeric comp-ang1 molecule
|
|
US20040115640A1
(en)
*
|
2002-12-11 |
2004-06-17 |
Isis Pharmaceuticals Inc. |
Modulation of angiopoietin-2 expression
|
|
AU2003252039A1
(en)
|
2002-07-23 |
2004-02-09 |
Vegenics Limited |
Methods and compositions for activating or inhibiting vegf-d and vegf-c
|
|
AU2003297282A1
(en)
|
2002-11-14 |
2004-06-15 |
Cornell Research Foundation, Inc. |
Protection of cardiac myocardium
|
|
TWI476206B
(zh)
|
2003-07-18 |
2015-03-11 |
Amgen Inc |
對肝細胞生長因子具專一性之結合劑
|
|
CN1323723C
(zh)
*
|
2003-12-26 |
2007-07-04 |
上海新世界基因技术开发有限公司 |
Tie2受体介导的靶向性肿瘤基因治疗的基因转移系统
|
|
US8298532B2
(en)
|
2004-01-16 |
2012-10-30 |
Regeneron Pharmaceuticals, Inc. |
Fusion polypeptides capable of activating receptors
|
|
WO2005087177A2
(en)
|
2004-03-05 |
2005-09-22 |
Ludwig Institute For Cancer Research |
Chimeric anti-vegf-d antibodies and humanized anti-vegf-d antibodies and methods of using same
|
|
SI1771474T1
(sl)
|
2004-07-20 |
2010-06-30 |
Genentech Inc |
Inhibitorji angiopoetinu podobnega proteina kombinacije in njihova uporaba
|
|
US8604185B2
(en)
|
2004-07-20 |
2013-12-10 |
Genentech, Inc. |
Inhibitors of angiopoietin-like 4 protein, combinations, and their use
|
|
ZA200705695B
(en)
|
2004-12-21 |
2009-02-25 |
Astrazeneca Ab |
Antibodies directed to angiopoietin-2 and uses thereof
|
|
AU2006203826A1
(en)
*
|
2005-01-07 |
2006-07-13 |
Emory University |
CXCR4 antagonists for the treatment of HIV infection
|
|
JP4657757B2
(ja)
*
|
2005-02-23 |
2011-03-23 |
株式会社膠原病研究所 |
肺高血圧症発症関連遺伝子を用いた肺高血圧症の診断および治療
|
|
JP2006325528A
(ja)
*
|
2005-05-27 |
2006-12-07 |
Institute For Rheumatic Diseases Co Ltd |
糖尿病性網膜症の診断および予防
|
|
JP4657857B2
(ja)
*
|
2005-08-25 |
2011-03-23 |
株式会社膠原病研究所 |
メタボリックシンドロームの診断および予防
|
|
EP1962903B1
(en)
*
|
2005-12-15 |
2013-03-13 |
MedImmune Limited |
Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or fltl antagonist for treating cancer
|
|
AR059066A1
(es)
*
|
2006-01-27 |
2008-03-12 |
Amgen Inc |
Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
|
|
EP2258700A1
(en)
|
2006-05-09 |
2010-12-08 |
Pfizer Products Inc. |
Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
|
|
PL2188313T3
(pl)
|
2007-08-21 |
2018-04-30 |
Amgen, Inc. |
Białka wiążące ludzki antygen c-fms
|
|
US8227577B2
(en)
*
|
2007-12-21 |
2012-07-24 |
Hoffman-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
US8557242B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
ERBB2 antibodies comprising modular recognition domains
|
|
US8574577B2
(en)
|
2008-01-03 |
2013-11-05 |
The Scripps Research Institute |
VEGF antibodies comprising modular recognition domains
|
|
US8557243B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
EFGR antibodies comprising modular recognition domains
|
|
KR101658247B1
(ko)
|
2008-01-03 |
2016-09-22 |
더 스크립스 리서치 인스티튜트 |
모듈 인식 도메인을 통한 항체 표적화
|
|
US8454960B2
(en)
|
2008-01-03 |
2013-06-04 |
The Scripps Research Institute |
Multispecific antibody targeting and multivalency through modular recognition domains
|
|
MX2010008099A
(es)
|
2008-01-28 |
2010-08-04 |
Medimmune Ltd |
Anticuerpos y angiopoyetina-2 estabilizados y sus usos.
|
|
JO2913B1
(en)
|
2008-02-20 |
2015-09-15 |
امجين إنك, |
Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
|
|
EP2307456B1
(en)
|
2008-06-27 |
2014-10-15 |
Amgen Inc. |
Ang-2 inhibition to treat multiple sclerosis
|
|
US8268314B2
(en)
|
2008-10-08 |
2012-09-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-VEGF/anti-ANG-2 antibodies
|
|
US8133979B2
(en)
|
2008-12-16 |
2012-03-13 |
Hoffmann-La Roche Inc. |
Antibodies against human angiopoietin 2
|
|
CA2756244A1
(en)
*
|
2009-04-02 |
2010-10-07 |
Roche Glycart Ag |
Multispecific antibodies comprising full length antibodies and single chain fab fragments
|
|
SG175077A1
(en)
|
2009-04-07 |
2011-11-28 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
US8980268B2
(en)
|
2009-07-29 |
2015-03-17 |
Regeneron Pharamceuticals, Inc. |
Methods for treating cancer by administering an anti-Ang-2 antibody
|
|
US20120189635A1
(en)
|
2009-07-29 |
2012-07-26 |
Regeneron Pharmaceuticals, Inc. |
Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2)
|
|
JO3182B1
(ar)
|
2009-07-29 |
2018-03-08 |
Regeneron Pharma |
مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
|
|
EP2478013B1
(en)
|
2009-09-16 |
2018-10-24 |
F.Hoffmann-La Roche Ag |
Coiled coil and/or tether containing protein complexes and uses thereof
|
|
US20120183546A1
(en)
|
2009-09-23 |
2012-07-19 |
Amgen Inc. |
Treatment of ovarian cancer using a specific binding agent of human angiopoietin-2 in combination with a taxane
|
|
AR080794A1
(es)
|
2010-03-26 |
2012-05-09 |
Hoffmann La Roche |
Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2
|
|
TW201138821A
(en)
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
|
WO2012009705A1
(en)
|
2010-07-15 |
2012-01-19 |
Zyngenia, Inc. |
Ang-2 binding complexes and uses thereof
|
|
CN103068846B9
(zh)
|
2010-08-24 |
2016-09-28 |
弗·哈夫曼-拉罗切有限公司 |
包含二硫键稳定性Fv片段的双特异性抗体
|
|
SG191153A1
(en)
|
2010-12-23 |
2013-07-31 |
Hoffmann La Roche |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
|
MX342034B
(es)
|
2011-02-28 |
2016-09-12 |
Hoffmann La Roche |
Proteinas monovalentes que se unen a antigenos.
|
|
AR085404A1
(es)
|
2011-02-28 |
2013-09-25 |
Hoffmann La Roche |
Proteinas de union a antigeno
|
|
EP2714738B1
(en)
|
2011-05-24 |
2018-10-10 |
Zyngenia, Inc. |
Multivalent and monovalent multispecific complexes and their uses
|
|
WO2013003606A1
(en)
|
2011-06-29 |
2013-01-03 |
Amgen Inc. |
Predictive biomarker of survival in the treatment of renal cell carcinoma
|
|
KR102063028B1
(ko)
|
2012-01-23 |
2020-01-07 |
리제너론 파아마슈티컬스, 인크. |
항-ang2 항체를 함유하는 안정화된 제형
|
|
CA2861124A1
(en)
|
2012-02-10 |
2013-08-15 |
Genentech, Inc. |
Single-chain antibodies and other heteromultimers
|
|
US20150044227A1
(en)
|
2012-03-08 |
2015-02-12 |
Medimmune, Llc |
Methods of treatment with angiopoietin-2 antibodies
|
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
|
SI2831111T1
(sl)
|
2012-03-30 |
2019-06-28 |
Boehringer Ingelheim International Gmbh |
Ang2-vezavne molekule
|
|
RU2639287C2
(ru)
|
2012-06-27 |
2017-12-20 |
Ф. Хоффманн-Ля Рош Аг |
Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
|
|
KR20150030744A
(ko)
|
2012-06-27 |
2015-03-20 |
에프. 호프만-라 로슈 아게 |
표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Fc-영역 접합체의 제조 방법 및 그의 용도
|
|
SG11201408538PA
(en)
|
2012-07-13 |
2015-02-27 |
Roche Glycart Ag |
Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
|
|
WO2014108854A1
(en)
|
2013-01-09 |
2014-07-17 |
Fusimab Ltd. |
Monospecific anti-hgf and anti-ang2 antibodies and bispecific anti-hgf/anti-ang2 antibodies
|
|
US10150800B2
(en)
|
2013-03-15 |
2018-12-11 |
Zyngenia, Inc. |
EGFR-binding modular recognition domains
|
|
BR112016006929A2
(pt)
|
2013-10-11 |
2017-09-19 |
Hoffmann La Roche |
Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo
|
|
WO2016048388A1
(en)
|
2014-09-26 |
2016-03-31 |
Somalogic, Inc. |
Cardiovascular risk event prediction and uses thereof
|
|
AU2015331602A1
(en)
|
2014-10-17 |
2017-04-27 |
Amgen Inc. |
Antibodies directed to angiopoietin-1 and angiopoietin-2 for ocular therapies
|
|
EP3227332B1
(en)
|
2014-12-03 |
2019-11-06 |
F.Hoffmann-La Roche Ag |
Multispecific antibodies
|
|
EP4008775A1
(en)
|
2015-03-04 |
2022-06-08 |
Mesoblast International Sàrl |
Cell culture method for mesenchymal stem cells
|
|
WO2016209972A1
(en)
|
2015-06-26 |
2016-12-29 |
Amgen Inc. |
Biomarker of survival in the treatment of renal cell carcinoma with a vegfr inhibitor and an ang2 inhibitor
|
|
ES2981791T3
(es)
|
2015-12-16 |
2024-10-10 |
Regeneron Pharma |
Composiciones y métodos para fabricar micropartículas de proteína
|
|
US10836819B2
(en)
|
2016-08-23 |
2020-11-17 |
Medimmune Limited |
Anti-VEGF-A and anti-ANG2 antibodies and uses thereof
|
|
AU2018212974B2
(en)
*
|
2017-01-30 |
2023-08-24 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for reducing bioburden in chromatography
|
|
AU2018347521A1
(en)
|
2017-10-12 |
2020-05-07 |
Immunowake Inc. |
VEGFR-antibody light chain fusion protein
|
|
MY195550A
(en)
|
2018-10-29 |
2023-01-31 |
Hoffmann La Roche |
Antibody Formulation
|