NO322826B1 - 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse. - Google Patents

1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse. Download PDF

Info

Publication number
NO322826B1
NO322826B1 NO19990859A NO990859A NO322826B1 NO 322826 B1 NO322826 B1 NO 322826B1 NO 19990859 A NO19990859 A NO 19990859A NO 990859 A NO990859 A NO 990859A NO 322826 B1 NO322826 B1 NO 322826B1
Authority
NO
Norway
Prior art keywords
formula
alkyl
radical
hydrogen
aryl
Prior art date
Application number
NO19990859A
Other languages
English (en)
Norwegian (no)
Other versions
NO990859L (no
NO990859D0 (no
Inventor
Ludo Edmond Josephine Kennis
Francois Paul Bischoff
Christopher John Love
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO990859D0 publication Critical patent/NO990859D0/no
Publication of NO990859L publication Critical patent/NO990859L/no
Publication of NO322826B1 publication Critical patent/NO322826B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NO19990859A 1997-04-08 1999-02-23 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse. NO322826B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97201045 1997-04-08
PCT/EP1998/002136 WO1998045297A1 (en) 1997-04-08 1998-04-02 1,2,3,4-TETRAHYDRO-BENZOFURO[3,2-c]PYRIDINE DERIVATIVES__

Publications (3)

Publication Number Publication Date
NO990859D0 NO990859D0 (no) 1999-02-23
NO990859L NO990859L (no) 1999-09-30
NO322826B1 true NO322826B1 (no) 2006-12-11

Family

ID=8228191

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19990859A NO322826B1 (no) 1997-04-08 1999-02-23 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse.

Country Status (31)

Country Link
US (1) US6156757A (id)
EP (1) EP1019408B1 (id)
JP (1) JP3287577B2 (id)
KR (1) KR100315975B1 (id)
CN (1) CN1097053C (id)
AP (1) AP1138A (id)
AR (1) AR012576A1 (id)
AT (1) ATE270294T1 (id)
AU (1) AU727599B2 (id)
BG (1) BG63848B1 (id)
BR (1) BR9806263A (id)
CA (1) CA2264598C (id)
CZ (1) CZ290008B6 (id)
DE (1) DE69824872T2 (id)
EE (1) EE03691B1 (id)
ES (1) ES2224391T3 (id)
GE (1) GEP20022823B (id)
HU (1) HUP0003624A3 (id)
ID (1) ID22131A (id)
IL (1) IL128701A0 (id)
MY (1) MY120033A (id)
NO (1) NO322826B1 (id)
NZ (1) NZ334501A (id)
PL (1) PL189549B1 (id)
RU (1) RU2198175C2 (id)
SK (1) SK283621B6 (id)
TR (1) TR199900644T2 (id)
TW (1) TW589315B (id)
UA (1) UA52681C2 (id)
WO (1) WO1998045297A1 (id)
ZA (1) ZA982969B (id)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA52681C2 (uk) * 1997-04-08 2003-01-15 Янссен Фармацевтика Н.В. Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі
ID28451A (id) * 1998-10-06 2001-05-24 Janssen Pharmaceutica Nv Trisiklik piperidin-δ3 sebagai bahan farmasi
UA70334C2 (en) 1998-10-06 2004-10-15 Janssen Pharmaceutica N V Jans BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS
AU765751B2 (en) * 1998-12-21 2003-09-25 Janssen Pharmaceutica N.V. Benzisoxazoles and phenones as alpha2-antagonists
EP1404679A2 (en) 2001-07-05 2004-04-07 PHARMACIA & UPJOHN COMPANY (hetero)aryl substituted benzofurans as 5-ht ligands
ATE521593T1 (de) * 2002-04-03 2011-09-15 Orion Corp Verwendung eines alfa2-adrenorezeptorantagonisten bei mit dem zns zusammenhängenden erkrankungen
JP4690043B2 (ja) * 2002-10-04 2011-06-01 プラナ バイオテクノロジー リミティッド 神経に対し活性な化合物
WO2005100355A1 (ja) 2004-04-12 2005-10-27 Taisho Pharmaceutical Co., Ltd. 環状アミン化合物
RU2409582C2 (ru) * 2004-08-31 2011-01-20 Глэксо Груп Лимитед Конденсированные трициклические производные для лечения психотических расстройств
EP2535330A3 (en) * 2006-10-23 2012-12-26 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US8481569B2 (en) 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
AR071392A1 (es) * 2008-04-23 2010-06-16 Takeda Pharmaceutical Derivados de iminopiridina y su uso
US8575186B2 (en) * 2009-10-05 2013-11-05 Albany Molecular Research, Inc. Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
EP2668191A4 (en) 2011-01-19 2014-08-20 Albany Molecular Res Inc BENZOFURO- [3,2-C-] PYRIDINES AND RELATED ANALOGS AS SEROTONIN-SUBTYPE-6 (5-HT6) MODULATORS FOR THE TREATMENT OF ADIPOSITAS, METABOLISM SYNDROME, COGNITION AND SCHIZOPHRENIA
GB201704325D0 (en) * 2017-03-17 2017-05-03 Argonaut Therapeutics Ltd Compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4688803A (en) * 1984-06-25 1987-08-25 Ollington Robert F Casino game table and dice
FR2570701B1 (fr) * 1984-09-27 1987-05-22 Synthelabo Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique
US4686226A (en) * 1985-09-03 1987-08-11 Merck & Co., Inc. Substituted benzo[b]furo- and benzo[b]thieno quinolizines
RU2045529C1 (ru) * 1988-04-26 1995-10-10 Ниссан Кемикал Индастриз Лтд. Способ получения мевалонолактоновых производных
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
DE4308451A1 (de) * 1992-09-10 1994-04-14 Bayer Ag 3-Aryl-pyron-Derivate
UA52681C2 (uk) * 1997-04-08 2003-01-15 Янссен Фармацевтика Н.В. Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі

Also Published As

Publication number Publication date
AP9901650A0 (en) 1999-09-30
TW589315B (en) 2004-06-01
SK28799A3 (en) 2001-03-12
BG103213A (en) 2000-05-31
CZ68299A3 (cs) 2000-08-16
ID22131A (id) 1999-09-09
CN1237179A (zh) 1999-12-01
UA52681C2 (uk) 2003-01-15
KR20000036076A (ko) 2000-06-26
HUP0003624A2 (hu) 2001-04-28
KR100315975B1 (ko) 2001-12-22
NO990859L (no) 1999-09-30
EP1019408B1 (en) 2004-06-30
DE69824872T2 (de) 2005-09-01
WO1998045297A1 (en) 1998-10-15
ATE270294T1 (de) 2004-07-15
BG63848B1 (bg) 2003-03-31
ES2224391T3 (es) 2005-03-01
PL332382A1 (en) 1999-09-13
RU2198175C2 (ru) 2003-02-10
AU727599B2 (en) 2000-12-14
CA2264598A1 (en) 1998-10-15
TR199900644T2 (xx) 2000-09-21
CZ290008B6 (cs) 2002-05-15
GEP20022823B (en) 2002-10-25
SK283621B6 (sk) 2003-10-07
AU7430798A (en) 1998-10-30
EE03691B1 (et) 2002-04-15
JP2000505115A (ja) 2000-04-25
PL189549B1 (pl) 2005-08-31
DE69824872D1 (de) 2004-08-05
CA2264598C (en) 2006-10-24
HUP0003624A3 (en) 2002-09-30
JP3287577B2 (ja) 2002-06-04
IL128701A0 (en) 2000-01-31
NZ334501A (en) 2000-06-23
US6156757A (en) 2000-12-05
BR9806263A (pt) 2000-04-04
NO990859D0 (no) 1999-02-23
ZA982969B (en) 1999-10-07
MY120033A (en) 2005-08-30
EP1019408A1 (en) 2000-07-19
AR012576A1 (es) 2000-11-08
CN1097053C (zh) 2002-12-25
EE9900114A (et) 1999-12-15
AP1138A (en) 2003-01-17

Similar Documents

Publication Publication Date Title
RU2691629C1 (ru) Производные имидазопиримидина в качестве модуляторов активности tnf
NO322826B1 (no) 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse.
NO315236B1 (no) Tetrahydro gamma-karboliner, deres fremstilling og farmasöytiske sammensetninger inneholdende det samme
RU2230744C2 (ru) Трициклические δ3-пиперидины, способы их получения и фармацевтическая композиция на их основе
IL142444A (en) Δ3 - Tricyclic piperidines converted to alkyl are converted in position 1, their preparation and pharmaceutical preparations containing them
CA2355716C (en) Benzisoxazoles and phenones as .alpha.2-antagonists
US6774129B2 (en) Benzothieno[3,2-c]pyridines as α2 antagonists
MXPA01003514A (en) BENZOTHIENO[3,2-c]PYRIDINES AS&agr;2
HK1039113B (en) Benzothieno[3,2-c]pyridines as alpha2 antagonists
MXPA01003512A (en) TRICYCLIC&Dgr;3-PIPERIDINES AS PHARMACEUTICALS
MXPA01003517A (en) TRICYCLIC&Dgr;3-PIPERIDINES AS&agr;2

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees