NO322826B1 - 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse. - Google Patents

1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse. Download PDF

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Publication number
NO322826B1
NO322826B1 NO19990859A NO990859A NO322826B1 NO 322826 B1 NO322826 B1 NO 322826B1 NO 19990859 A NO19990859 A NO 19990859A NO 990859 A NO990859 A NO 990859A NO 322826 B1 NO322826 B1 NO 322826B1
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NO
Norway
Prior art keywords
formula
alkyl
radical
hydrogen
aryl
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NO19990859A
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English (en)
Norwegian (no)
Other versions
NO990859L (no
NO990859D0 (no
Inventor
Ludo Edmond Josephine Kennis
Francois Paul Bischoff
Christopher John Love
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO990859D0 publication Critical patent/NO990859D0/no
Publication of NO990859L publication Critical patent/NO990859L/no
Publication of NO322826B1 publication Critical patent/NO322826B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NO19990859A 1997-04-08 1999-02-23 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse. NO322826B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97201045 1997-04-08
PCT/EP1998/002136 WO1998045297A1 (en) 1997-04-08 1998-04-02 1,2,3,4-TETRAHYDRO-BENZOFURO[3,2-c]PYRIDINE DERIVATIVES__

Publications (3)

Publication Number Publication Date
NO990859D0 NO990859D0 (no) 1999-02-23
NO990859L NO990859L (no) 1999-09-30
NO322826B1 true NO322826B1 (no) 2006-12-11

Family

ID=8228191

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19990859A NO322826B1 (no) 1997-04-08 1999-02-23 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse.

Country Status (31)

Country Link
US (1) US6156757A (pl)
EP (1) EP1019408B1 (pl)
JP (1) JP3287577B2 (pl)
KR (1) KR100315975B1 (pl)
CN (1) CN1097053C (pl)
AP (1) AP1138A (pl)
AR (1) AR012576A1 (pl)
AT (1) ATE270294T1 (pl)
AU (1) AU727599B2 (pl)
BG (1) BG63848B1 (pl)
BR (1) BR9806263A (pl)
CA (1) CA2264598C (pl)
CZ (1) CZ290008B6 (pl)
DE (1) DE69824872T2 (pl)
EE (1) EE03691B1 (pl)
ES (1) ES2224391T3 (pl)
GE (1) GEP20022823B (pl)
HU (1) HUP0003624A3 (pl)
ID (1) ID22131A (pl)
IL (1) IL128701A0 (pl)
MY (1) MY120033A (pl)
NO (1) NO322826B1 (pl)
NZ (1) NZ334501A (pl)
PL (1) PL189549B1 (pl)
RU (1) RU2198175C2 (pl)
SK (1) SK283621B6 (pl)
TR (1) TR199900644T2 (pl)
TW (1) TW589315B (pl)
UA (1) UA52681C2 (pl)
WO (1) WO1998045297A1 (pl)
ZA (1) ZA982969B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA52681C2 (uk) * 1997-04-08 2003-01-15 Янссен Фармацевтика Н.В. Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі
UA70334C2 (en) 1998-10-06 2004-10-15 Janssen Pharmaceutica N V Jans BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS
JP4590102B2 (ja) * 1998-10-06 2010-12-01 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 医薬としての三環性δ３−ピペリジン類
CZ294532B6 (cs) * 1998-12-21 2005-01-12 Janssen Pharmaceutica N. V. Benzisoxazoly a fenony jako alfa2-antagonisté, způsob jejich přípravy a použití a farmaceutický prostředek
WO2003004501A2 (en) * 2001-07-05 2003-01-16 Pharmacia & Upjohn Company (hetero) aryl substituted benzofurans as 5-ht ligands
AU2003219199A1 (en) * 2002-04-03 2003-10-13 Orion Corporation Use of an alfa2-adrenoreceptor antagonist for cns-related diseases
EP1558585B1 (en) * 2002-10-04 2013-09-25 Prana Biotechnology Limited Neurologically-active compounds
AU2005233456A1 (en) 2004-04-12 2005-10-27 Taisho Pharmaceutical Co., Ltd. Cyclic amine compound
RU2409582C2 (ru) * 2004-08-31 2011-01-20 Глэксо Груп Лимитед Конденсированные трициклические производные для лечения психотических расстройств
US8470859B2 (en) * 2006-10-23 2013-06-25 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
CL2009000964A1 (es) * 2008-04-23 2010-03-26 Takeda Pharmaceuticals Co Compuestos derivados de 1-aril-2-imino-1,2-dihidropiridina-3-carboxamida, antagonista del receptor adrenergico alfa 1d, composicion farmaceutica que los comprende; y su uso para el tratamiento o profilaxis de enfermedades del tracto urinario inferior.
US8481569B2 (en) 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
WO2011044134A1 (en) * 2009-10-05 2011-04-14 Albany Molecular Research, Inc. Epiminocycloalkyl(b)indole derivatives as serotonin sub-type 6 (5-ht6) modulators and uses thereof
AU2012207335A1 (en) 2011-01-19 2013-07-25 Albany Molecular Research, Inc. Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
GB201704325D0 (en) * 2017-03-17 2017-05-03 Argonaut Therapeutics Ltd Compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4688803A (en) * 1984-06-25 1987-08-25 Ollington Robert F Casino game table and dice
FR2570701B1 (fr) * 1984-09-27 1987-05-22 Synthelabo Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique
US4686226A (en) * 1985-09-03 1987-08-11 Merck & Co., Inc. Substituted benzo[b]furo- and benzo[b]thieno quinolizines
RU2045529C1 (ru) * 1988-04-26 1995-10-10 Ниссан Кемикал Индастриз Лтд. Способ получения мевалонолактоновых производных
EP0339959A3 (en) * 1988-04-27 1991-03-20 Glaxo Group Limited Lactam derivatives
DE4308451A1 (de) * 1992-09-10 1994-04-14 Bayer Ag 3-Aryl-pyron-Derivate
UA52681C2 (uk) * 1997-04-08 2003-01-15 Янссен Фармацевтика Н.В. Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі

Also Published As

Publication number Publication date
AR012576A1 (es) 2000-11-08
EE03691B1 (et) 2002-04-15
EP1019408B1 (en) 2004-06-30
AU7430798A (en) 1998-10-30
PL332382A1 (en) 1999-09-13
CA2264598C (en) 2006-10-24
US6156757A (en) 2000-12-05
CN1237179A (zh) 1999-12-01
WO1998045297A1 (en) 1998-10-15
TR199900644T2 (xx) 2000-09-21
AP9901650A0 (en) 1999-09-30
UA52681C2 (uk) 2003-01-15
HUP0003624A3 (en) 2002-09-30
AU727599B2 (en) 2000-12-14
SK28799A3 (en) 2001-03-12
ATE270294T1 (de) 2004-07-15
BG103213A (en) 2000-05-31
KR20000036076A (ko) 2000-06-26
CN1097053C (zh) 2002-12-25
AP1138A (en) 2003-01-17
NO990859L (no) 1999-09-30
GEP20022823B (en) 2002-10-25
ZA982969B (en) 1999-10-07
PL189549B1 (pl) 2005-08-31
JP3287577B2 (ja) 2002-06-04
MY120033A (en) 2005-08-30
ES2224391T3 (es) 2005-03-01
KR100315975B1 (ko) 2001-12-22
TW589315B (en) 2004-06-01
EP1019408A1 (en) 2000-07-19
CZ290008B6 (cs) 2002-05-15
BG63848B1 (bg) 2003-03-31
CA2264598A1 (en) 1998-10-15
DE69824872T2 (de) 2005-09-01
NZ334501A (en) 2000-06-23
SK283621B6 (sk) 2003-10-07
CZ68299A3 (cs) 2000-08-16
JP2000505115A (ja) 2000-04-25
BR9806263A (pt) 2000-04-04
NO990859D0 (no) 1999-02-23
RU2198175C2 (ru) 2003-02-10
IL128701A0 (en) 2000-01-31
HUP0003624A2 (hu) 2001-04-28
DE69824872D1 (de) 2004-08-05
ID22131A (id) 1999-09-09
EE9900114A (et) 1999-12-15

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